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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20233 results in Negative / Null Result Report · page 317 of 675

Negative / Null Result ReportMedicine

Dupilumab in the treatment of severe chronic rhinosinusitis with nasal polyps (CRSwNP) in cystic fibrosis patients.

Di Girolamo A, Cristallo M, Daddato MF et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Chronic rhinosinusitis with nasal polyps (CRSwNP) manifests as either a solitary upper airway involvement or as part of a more intricate clinical picture, such as Cystic Fibrosis (CF). The altered viscoelastic properties of mucus…

View details →DOI: 10.1016/j.jcf.2026.04.003
Negative / Null Result ReportMedicine

Tight stomatal regulation and high intrinsic capacity of carbon assimilation inferred from isotopic composition negatively correlate with drought-driven decline in sclerophyllous species.

Piper FI, Paula S, Urrutia-Jalabert R · 2026 · Annals of botany

Background and aims Long-term droughts reduce the carbon (C) and water pools of trees, causing mortality. However, the underlying physiological mechanisms explaining tree mortality remain unclear, and evidence from mature forests is…

View details →DOI: 10.1093/aob/mcag100
Negative / Null Result ReportMedicine

A Comparison of Recovery Curves in Total Knee Arthroplasty With and Without Soft-Tissue Releases.

Metz AK, Loughmiller SK, Braathen DL et al. · 2026 · The Journal of arthroplasty

Background The use of alternative alignment strategies has become commonplace in performing total knee arthroplasty (TKA). A primary reported benefit of these techniques is a reduction in the need for soft-tissue releases for appropriate…

View details →DOI: 10.1016/j.arth.2026.03.082
Negative / Null Result ReportMedicine

Resting energy expenditure in children with cancer undergoing chemotherapy using indirect calorimetry: A longitudinal study.

Froon-Torenstra D, Renting L, Ijpma I et al. · 2026 · Clinical nutrition ESPEN

Background and aims Malnutrition is common among children with cancer and is related to treatment-related toxicity, mortality and lower quality of life. So far, it remains unknown whether changes in resting energy expenditure (REE)…

View details →DOI: 10.1016/j.clnesp.2026.103331
Negative / Null Result ReportMedicine

From Referral to Service: Initial Outcomes of a Mental Health Outreach Program for Sexual Assault Survivors.

Mai K, Salim SR, Tilstra-Ferrell E et al. · 2026 · Journal of forensic nursing

Aims To examine data from an early intervention program for mental health following recent sexual assault (SA) to compare referral and service utilization rates before and after a community-based outreach model was implemented. Methods In…

View details →DOI: 10.1097/jfn.0000000000000598
Negative / Null Result ReportMedicine

Linezolid-Induced Serotonin Release from QGP-1 Cells.

Tsutsumi T, Kashiwagi H, Imai S et al. · 2026 · Drug research

Background Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting…

View details →DOI: 10.1055/a-2815-4097
Negative / Null Result ReportMedicine

Octa evaluation of macular and optic disc vascular changes after PRP.

Karabacak DD, Doğruya S, Altınışık M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This study aimed to evaluate the impact of panretinal photocoagulation (PRP) on macular and optic nerve head microvascular parameters using optical coherence tomography angiography (OCTA) in eyes with proliferative diabetic…

View details →DOI: 10.1007/s00417-026-07220-5
Negative / Null Result ReportMedicine

Interaction of ambient temperature and conditioning temperatures on moisture addition throughout pelleting, the pelleting process, and enzyme activity

Renner A, Estanich EB, Lynch EA et al. · 2026 · Journal of Applied Poultry Research.

Thermal processes during steam conditioning and pellet die extrusion aid in pelleting but may degrade exogenous feed enzymes. This study determined how ambient temperature interacts with varying steam conditioning temperatures to influence…

Negative / Null Result ReportMedicine

Mindful Self-Compassion for Infertility-Related Distress: A Single-Group Intervention Study.

Halleran M, Balsom AA, Gordon JL · 2026 · Journal of integrative and complementary medicine

Objectives Women experiencing infertility report heightened levels of anxiety, depression, and distress. However, access to affordable mental health care is limited in most areas of the world. Self-directed interventions, including…

View details →DOI: 10.1177/27683605261427699
Negative / Null Result ReportMedicine

Beyond traditional sets: A longitudinal comparison of cluster and superset strength training in male basketball players.

Janicijevic D, Cuevas-Aburto J, Zhang X et al. · 2026 · Journal of sports sciences

This randomised study compared mid-term effects of supersets (SS) and cluster sets (CL) on neuromuscular performance in amateur male basketball players. Thirty participants were allocated to SS (n = 15) or CL (n = 15) and completed a…

View details →DOI: 10.1080/02640414.2026.2637204
Negative / Null Result ReportMedicine

Effect of Three Types of Specially-Designed Myopia Control Spectacle Lenses on Astigmatism: A Two-Year Result.

Wen K, Yang B, Liu L et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose This study sought to determine whether specially-designed myopia control spectacle lenses had any effect on astigmatism in clinical practice. Methods Medical records of 74 patients (age: 6 to 12 years old) involving the use of…

View details →DOI: 10.1007/s44402-026-00077-5
Negative / Null Result ReportMedicine

Age and sex differences in longitudinal CPAP adherence patterns.

Vodapally M, Chan-Golston AM, Sandhu J et al. · 2026 · Respiratory medicine

Study objective This study investigated long-term adherence to continuous positive airway pressure (CPAP) therapy among adult patients with obstructive sleep apnea (OSA), with a focus on identifying associations between age, sex, residual…

View details →DOI: 10.1016/j.rmed.2026.108755
Negative / Null Result ReportMedicine

Inflammation may explain part of atherosclerotic cardiovascular disease risk conferred by elevated remnant lipoproteins: a cohort and Mendelian randomization study.

Wadström BN, Wulff AB, Pedersen KM et al. · 2026 · Atherosclerosis

Background and aims Elevated remnant lipoproteins are a causal risk factor for atherosclerotic cardiovascular disease. We tested the hypothesis that low-grade inflammation can explain part of the increased risk of peripheral artery disease…

View details →DOI: 10.1016/j.atherosclerosis.2026.120772
Negative / Null Result ReportOpen accessMedicine

Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort.

Talathi R, Juhasz V, Delgado M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Data on the metabolic effects of contemporaneous gender-affirming hormone therapy (GAHT) are limited. Objective To characterize the metabolic effects of GAHT ie, estradiol with anti-androgen therapy. Design Prospective…

View details →DOI: 10.1210/clinem/dgaf665
Negative / Null Result ReportMedicine

Active Aging: Learning English and Developing Fine Psychomotor Abilities.

Baranowska K, Dylewski R, Fugiel J et al. · 2026 · Experimental aging research

Background Recent studies highlight that cognitive processes involved in learning share neural pathways with those controlling fine motor skills. Building on this insight, the mini-EDUball method was developed to integrate cognitive and…

View details →DOI: 10.1080/0361073x.2026.2635284
Negative / Null Result ReportMedicine

Profession-Specific Ageism Changes Following a Two-Day Long-Term Care Placement in Dental Students.

Izumi M, Mizutani S, Fujimoto A et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Background Ageism among dental students can impede equitable geriatric care. Developing educational interventions to reduce profession-specific and general ageist attitudes is an urgent priority in aging societies. Objective To determine…

View details →DOI: 10.1111/eje.70116
Negative / Null Result ReportOpen accessMedicine

Use of a digital rescue inhaler and at-home spirometer among inner-city children with asthma: a real-world experience.

Izadi N, Hill TD, Boe A et al. · 2025 · Frontiers in allergy

Background Across all age groups, asthma disproportionally affects inner-city underserved populations. Studies on the use of at-home spirometry and digital inhalers have limited real-world evaluation in pediatric asthma. Objectives In this…

View details →DOI: 10.3389/falgy.2025.1641312
Negative / Null Result ReportMedicine

Impact of Emicizumab on Coagulation Potential in Plasma From Healthy Women and Carriers of Haemophilia A During Late Pregnancy.

Takeyama M, Kimura F, Furukawa S et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Background Intra-cranial haemorrhage (ICH) in neonates with haemophilia A (HA) remains a serious perinatal complication. Prophylactic administration of emicizumab (Emi) to pregnant HA carriers has been discussed as a potential preventive…

View details →DOI: 10.1111/hae.70269
Negative / Null Result ReportOpen accessMedicine

Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.

Beaudoin DL, Hassan AR, Shehu A et al. · 2026 · Communications biology

A fundamental feature of the visual system is its ability to detect image contrast. The contrast processing starts in the first synapse of the retina where parallel pathways are established to compute contrast to bright (ON pathway) and…

View details →DOI: 10.1038/s42003-026-09885-4
Negative / Null Result ReportMedicine

Effect of intravitreal injection of dexamethasone implant on the corneal morphology of young adults with central retinal vein occlusion.

Niu TT, Xin WJ · 2026 · International journal of ophthalmology

Aim To investigate the effect of intravitreal injection of dexamethasone (DEX) implants on the corneal morphology of young adults with central retinal vein occlusion (CRVO). Methods This was a retrospective study. The information of all…

View details →DOI: 10.18240/ijo.2026.05.10
Negative / Null Result ReportMedicine

Transient elastography in acute hospital inpatients with harmful alcohol use: a service evaluation.

Balston AJ, Conti I, Darko S et al. · 2026 · Alcohol and alcoholism (Oxford, Oxfordshire)

Aims Hospital admissions are frequently alcohol related and are an opportunity for health promotion. Transient Elastography (TE), an ultrasound-based method of assessing liver health, may be beneficial when used by inpatient Alcohol Care…

View details →DOI: 10.1093/alcalc/agaf079
Negative / Null Result ReportMedicine

Dietary Sodium Reduction Reveals Aldosterone Dysregulation in Patients With Essential Hypertension.

Duus CL, Nielsen SF, Hornstrup BG et al. · 2026 · Journal of clinical hypertension (Greenwich, Conn.)

Dietary sodium reduction affects blood pressure (BP), the renin-angiotensin-aldosterone system (RAAS) and natriuretic peptides. Whether baseline levels of these hormones impact BP response to sodium reduction remains unknown. Aldosterone…

View details →DOI: 10.1111/jch.70229
Negative / Null Result ReportOpen accessMedicine

An Online Pilates Program for People with Hypermobility: A Pragmatic Clinical Trial Looking at Function, Interoception, Kinesiophobia, and Physical Activity Levels.

Russek LN, Di Bon J, Herbland A et al. · 2026 · Journal of multidisciplinary healthcare

Purpose This study evaluated whether an independent, online modified Pilates program alters function, interoception (internal body awareness), activity levels, and kinesiophobia (fear of movement) in people with symptomatic joint…

View details →DOI: 10.2147/jmdh.s564972
Negative / Null Result ReportMedicine

Variations in outcomes following burn injury and admission to an Australian or New Zealand intensive care unit: A retrospective data linkage cohort study.

Garside T, Udy A, Reade MC et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Introduction The Burns Registry of Australia and New Zealand (BRANZ) has been used to identify significant variation in burn injury management and outcomes across Australia and New Zealand. This study aimed to assess variation in clinical…

View details →DOI: 10.1016/j.burns.2026.107992