A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19847 results in Negative / Null Result Report · page 315 of 662
Diao Z, Zhang Y, Chen Y et al. · 2023 · Clinical chemistry
Background Laboratory-developed metagenomic next-generation sequencing (mNGS) assays are increasingly being used for the diagnosis of infectious disease. To ensure comparable results and advance the quality control for the mNGS assay, we…
Yu J, Lu Y, Zhao L · 2026 · Frontiers in public health
Purpose Health inequalities rooted in social stratification remain a persistent structural public-health challenge. While physical activity is recognized as a health-enhancing behavior, limited longitudinal evidence exists on how its…
Krasieva K, Gencer B, Locatelli I et al. · 2024 · Circulation. Cardiovascular quality and outcomes
Background Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with and…
Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging
Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…
El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology
Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…
Zöller M, Mastalerz M, Dick E et al. · 2026 · Scientific reports
The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS…
Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons
Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…
Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health
Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…
Sambol S, Suleyman E, Scarfo J et al. · 2023 · Acta psychologica
The unity/diversity framework, originally published by Miyake et al. (2000) has become the most cited model of executive functioning. Consequently, when researchers operationalise executive function (EF) they often exclusively assess the…
Murugesan M, Niveditha LP, Sindhu ER et al. · 2026 · Hematology, transfusion and cell therapy
Introduction Derived hematological indices reflect immune activation, but their dynamics during the plerixafor era and their predictive value for stem cell yield remain unclear. Objectives To assess changes in derived hematological…
Kumar S, Kumar A, Ameta N et al. · 2026 · Annals of cardiac anaesthesia
Background In-hospital cardiac arrest demands immediate response to improve survival outcomes. The Code Blue Response System (CBRS) was designed to streamline emergency interventions by reducing response times. This study aimed to evaluate…
Minion S, Kiene J, Dellavalle R · 2023 · JMIR dermatology
Gender disparities exist across all facets of academic medicine including within the editorial boards of dermatology journals. Only 22% of these editorial boards comprised women, even though 51% of full-time, faculty dermatologists are…
Bloch RJ, Traficante M, Mariot V et al. · 2025 · Neuromuscular disorders : NMD
Facioscapulohumeral muscular dystrophy is a progressive muscle disorder that is likely linked to aberrant DUX4 expression. Losmapimod, a p38 kinase inhibitor, was utilized to suppress DUX4 and its downstream effects. Phase I/II clinical…
de Barros B, Sultana F, Maximus N et al. · 2026 · Preprint
ABSTRACT Background Erythema nodosum leprosum (ENL) is a severe inflammatory complication of leprosy that often requires prolonged corticosteroid therapy which is associated with adverse effects. Methotrexate is an affordable…
Garg AX · 2026 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text] Nephrology: [Formula: see text].
Dodd TS, Borzak S · 2026 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Hematology: [Formula: see text].
Jain S, Jha AK, Chawla D et al. · 2026 · Indian journal of pediatrics
OBJECTIVES: To determine the effect of prone positioning on the duration of respiratory support in neonates receiving non-invasive mode of ventilation. METHODS: This open label randomized controlled trial was conducted in the NICU of a…
Brasher MI, Patil MS · 2026 · Acta paediatrica (Oslo, Norway : 1992)
The LAKANA trial: a randomized control trial evaluating the impact of mass administration of azithromycin to infants 1 to 11 months of age in Mali showed no reduction in mortality.
Legnani C, Ventura A, Oriani G · 2026 · Journal of clinical practice and research
A retrospective study was conducted to evaluate the need for perioperative autotransfusions and the amount of blood loss by comparing patients receiving different tranexamic acid (TXA) regimens following total joint replacement (TJR). A…
Holl CK, Bonilla Yanez M, Finley JM et al. · 2026 · Preprint
Background and Purpose Walking after stroke is often characterized by persistent biomechanical impairments and reduced walking capacity. While visual biofeedback can improve gait mechanics and fast walking can enhance capacity, it is…
Greenway RR, Coulter AA, Zhang D et al. · 2026 · Journal of medicinal food
Gallic acid, a catechin polyphenol in tea, completely inhibited angiogenesis in assays of human tissue at 10 -3 M. Psoriasis is a skin disease caused by excessive secretion of angiogenenic factors by keratinocytes and stromal skin cells.…
Fantasia ME, Penick CA · 2026 · Journal of economic entomology
Climate change intensifies drought frequency, posing risks to pollinators both directly and indirectly through changes in floral resource availability. We tested how water limitation alters pollinator-relevant floral traits, visitation,…
Kasige RH, Johnson SN, Frew A · 2026 · Preprint
Abstract Background and aims. Plant susceptibility to insect herbivores is shaped by interacting soil-based biotic and abiotic factors, particularly arbuscular mycorrhizal (AM) fungi and silicon (Si) availability. AM fungi influence plant…
Ge H, Calero C, Costas R · 2026 · Preprint
Abstract Global scientific mobility is central to the circulation of knowledge, skills and opportunities, but its recent evolution remains unclear. Using the Dimensions database, we reconstruct publication-based career trajectories for…
Rebel HG, de Gruijl FR · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
We reported earlier that adult FabplCre;Apc 15lox/+ mice with either daily UV exposure or vitamin D supplementation developed not significantly fewer intestinal tumours but less tumour bulk (reduced outgrowth) than control mice that…
De Grandi D, LuTheryn G, Stoffels M et al. · 2026 · Ultrasound in medicine & biology
Objective Dental biofilms are responsible for the majority of oral cavity diseases (e.g., caries, periodontitis and gingivitis). In this work, we evaluate the effects of therapeutic ultrasound on a Streptococcus mutans biofilm model. The…
Uyoga MA, Baumgartner J, Malan L et al. · 2026 · The Journal of nutrition
Background Young South African women face a double-burden of overweight or obesity and iron deficiency, with the former predicting the latter. Omega-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation can reduce inflammation.…
Lim LS · 2025 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].
Pak MA, Güzel Altıntaş F, Okyar G et al. · 2026 · Scientific reports
Anastomotic leakage is a serious complication after colorectal surgery. Smoking is known to impair anastomotic healing. The use of electronic cigarettes is increasing worldwide, and information about their effects on wound healing remains…
Amoroso F, Miere A, Kodjikian L et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose This study aimed to compare exudative recurrence features detected by optical coherence tomography angiography (OCTA) with those identified by spectral domain optical coherence tomography (SD-OCT), considered the gold standard, and…