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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20233 results in Negative / Null Result Report · page 314 of 675

Negative / Null Result ReportMedicine

Radiographic Detection of Intrathoracic Lymphadenomegaly in Dogs: How Useful Is It?

Lye G, Pollard RE, Hartman A et al. · 2026 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

The intrathoracic lymph nodes (LN) of clinical interest in dogs are the sternal (STLN), cranial mediastinal (CrMLN), and tracheobronchial (TBLN) groups. Although computed tomography (CT) depicts and measures these nodes well, thoracic…

View details →DOI: 10.1111/vru.70113
Negative / Null Result ReportMedicine

Detection of cross-reactivity of antibodies to the N proteins of feline morbillivirus and canine distemper virus in Japanese cat plasma samples

Khin STMM, Jafar SM, Ju M et al. · 2025 · Journal of virological methods

Feline morbillivirus (FeMV) is a globally emerging virus that has been linked to chronic kidney disease (CKD) in infected cats. Immunological assays, such as enzyme-linked immunosorbent assay (ELISA), are important for studying the virus…

Negative / Null Result ReportMedicine

Using EEG to detect lapses in sustained attention to moving stimuli.

Lowe BG, Woolgar A, Smit S et al. · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior

Sustaining attention is effortful but crucial for daily life. Despite this, attentional lapses are common and can have fatal consequences (e.g., when driving). The spontaneous nature of these lapses makes studying their underlying…

View details →DOI: 10.1016/j.cortex.2025.12.002
Negative / Null Result ReportMedicine

Limitations of short-read NGS in detecting <i>RP1 Alu</i> insertions: a case emphasizing Sanger confirmation.

Hayashi T, Mizobuchi K, Higa N et al. · 2026 · Ophthalmic genetics

Purpose To assess the detectability of the pathogenic RP1 Alu insertion using the PrismGuide™ inherited retinal dystrophy (IRD) panel, which targets 82 IRD genes, and whole-exome sequencing (WES). Methods A girl diagnosed with early-onset…

View details →DOI: 10.1080/13816810.2025.2590162
Negative / Null Result ReportMedicine

Host whole genome sequence data represent an untapped resource for characterising affiliated parasite diversity.

Nichols S, Estandía A, Young CM et al. · 2026 · International journal for parasitology

Parasites are ubiquitous and exert varied ecological and evolutionary pressures on their hosts. Yet, characterising parasite diversity and distributions can be challenging and costly. Leveraging existing data to identify parasites is thus…

View details →DOI: 10.1016/j.ijpara.2025.104768
Negative / Null Result ReportOpen accessMedicine

Impact of hepatitis B virus surface antigen mutations in the major hydrophilic region on antigen detectability.

He C, Gu X, Liu Y et al. · 2026 · Frontiers in cellular and infection microbiology

Objective This study aims to investigate the impact of mutations within the major hydrophilic region (MHR) of the hepatitis B virus (HBV) S gene on the expression, secretion, and antigenicity of hepatitis B surface antigen (HBsAg), and…

View details →DOI: 10.3389/fcimb.2026.1831437
Negative / Null Result ReportOpen accessMedicine

European ring test on the differentiation of wild-type Mycoplasma synoviae and the MS-H vaccine strains in clinical samples.

Jimenez CM, Kreizinger Z, Gyuranecz M et al. · 2026 · Poultry science

The control and prevention of Mycoplasma (M.) synoviae infections have been significantly improved by the use of the MS-H live vaccine strain. This vaccine has been used globally for decades; therefore, many technical approaches have been…

View details →DOI: 10.1016/j.psj.2026.107166
Negative / Null Result Report

Explainable Deep Learning for Lesion-Level Detection of Diabetic Retinopathy: A Segmentation Approach Using Fundus Images Graded as Mild-to-Moderate Nonproliferative Diabetic Retinopathy

Sato T, Nishitsuka K, Itoh T et al. · 2025 · Preprint

Deep learning has shown promise in diabetic retinopathy screening using fundus images. However, many existing models operate as “black boxes,” providing limited interpretability at the lesion level. This study aimed to develop an…

View details →DOI: 10.1101/2025.10.01.25337115
Negative / Null Result ReportOpen accessMedicine

AcrIIA8 is a putative phage structural protein of the HTJ2 family that does not inhibit Streptococcus pyogenes Cas9.

An SY, Kim I, Hong SH et al. · 2026 · Protein science : a publication of the Protein Society

Anti-CRISPR (Acr) proteins are phage-encoded anti-defense factors that suppress CRISPR-Cas immunity in bacteria. AcrIIA8 was previously identified as an inhibitor of Streptococcus pyogenes Cas9 (SpyCas9) through functional assays of…

View details →DOI: 10.1002/pro.70651
Negative / Null Result ReportOpen accessMedicine

Detectability of Automated Tumor-feeder Detection Software Using Angio-computed Tomography in Transarterial Chemoembolization for Hepatocellular Carcinoma.

Ueda M, Mitani H, Nakaki Y et al. · 2025 · Interventional radiology (Higashimatsuyama-shi (Japan)

Purpose: To evaluate the performance of automated tumor-feeder detection software in transarterial chemoembolization for hepatocellular carcinoma using angio-computed tomography. Material and Methods: This was a retrospective study of 107…

View details →DOI: 10.22575/interventionalradiology.2025-0007
Negative / Null Result ReportMedicine

The severity and outcomes in acute pancreatitis do not differ between the elderly and non-elderly patients: Experience in a clinical tertiary center.

Ruiz-Rebollo ML, Muñoz-Moreno MF · 2025 · Medicina clinica

Background Acute pancreatitis can affect elderly people. Conflicting results have been published regarding the role of age in the course of this life-threatening disease. Aim To assess the clinical outcomes of acute pancreatitis in…

View details →DOI: 10.1016/j.medcli.2025.107112
Negative / Null Result ReportMedicine

Optical Genome Mapping in Myelodysplastic Syndromes: Clinical Value and Limitations Derived From a Cohort of 236 Patients.

Wei Q, Wang SA, Garcia-Manero G et al. · 2025 · Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Identification of cytogenetic abnormalities is critical for the classification and risk stratification of myelodysplastic syndromes (MDS). Optical genome mapping (OGM) is an emerging cytogenomic platform that enables high-resolution…

View details →DOI: 10.1016/j.modpat.2025.100862
Negative / Null Result ReportOpen accessMedicine

Comparative Diagnostic Accuracy of MRI and Ultrasound in Meniscal Tear Detection: Evaluating Reliability and Limitations Against Arthroscopic Outcomes.

Noorelahi Y · 2025 · Radiology research and practice

Objective Accurate meniscal tear diagnosis is essential for proper knee injury management. While MRI is the gold standard, ultrasound (US) offers a cost-effective alternative. However, its accuracy compared to arthroscopy remains…

View details →DOI: 10.1155/rrp/6270476
Negative / Null Result ReportMedicine

West Nile Virus Antibody Prevalence in Horses During the 2023 Outbreak in Tunisia, North Africa.

Dachraoui K, Ben Osman R, Ben Slama S et al. · 2025 · Vector borne and zoonotic diseases (Larchmont, N.Y.)

A total of 20 horses belonging to the Pasteur Institute of Tunis used for the production of therapeutic serum antiscorpion venom were tested for the presence of antibodies anti-West Nile virus (WNV) during the 2023 outbreak of West Nile…

View details →DOI: 10.1177/15303667251359822
Negative / Null Result ReportMedicine

Performance of creatinine and cystatin C-based equations to estimate glomerular filtration rate in African children with sickle cell anemia.

Nkoy AB, Mumaka FM, Matoka TT et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Serum creatinine (SCr), the most used biomarker to evaluate glomerular filtration rate (GFR), might be inaccurate in children with sickle cell anemia (SCA). In this context, cystatin C (SCys) could be of interest. This study…

View details →DOI: 10.1007/s00467-025-06986-w
Negative / Null Result ReportOpen accessMedicine

Genome-resolved metagenomics reveals unexpected diversity and host range of Candidatus Lariskella (Rickettsiales: Midichloriaceae).

Hagenbeek A, Masukagami Y, Palanichamy P et al. · 2026 · BMC genomics

The intracellular endosymbiont Candidatus Lariskella (Alphaproteobacteria, Candidatus Midichloriaceae) has been found across a wide diversity of terrestrial arthropods, including ticks, true bugs, beetles, fleas, wasps and moths. Despite…

View details →DOI: 10.1186/s12864-026-12881-x
Negative / Null Result ReportMedicine

Nationwide Survey of Laboratory Practices for Factor VIII Inhibitor Detection in China.

Wang Y, Kong X, Wei H et al. · 2025 · Haemophilia : the official journal of the World Federation of Hemophilia

Introduction The Bethesda assay (BA) and the Nijmegen-Bethesda assay (NBA) are commonly used to measure inhibitors in patients with haemophilia A (HA). The laboratory results of inhibitor assays have been demonstrated to be highly…

View details →DOI: 10.1111/hae.70084
Negative / Null Result ReportMedicine

Polymerase chain reaction fails to detect mixed malaria infections in siblings from Ethiopia.

Hall AD, Whitehurst DA, Mortensen JE et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Malaria remains a significant public health concern in sub-Saharan Africa, particularly in Ethiopia where Plasmodium falciparum and Plasmodium vivax are co-endemic. Most cases in the United States are acquired abroad and imported.…

View details →DOI: 10.1016/j.jiac.2025.102777