A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19847 results in Negative / Null Result Report · page 314 of 662
Pilas LB, Gur O, Berger G · 2023 · The Israel Medical Association journal : IMAJ
Background In the past decade, numerous new imaging and laboratory tests have been implemented that significantly contribute to improved medical diagnostic capabilities. However, inappropriate utilization, which occurs on a large scale,…
Jones CMP, Lin CC, Zadro J et al. · 2024 · Brazilian journal of physical therapy
Background The Brief Pain Inventory-Interference Subscale (BPI-IS) is a subscale of the BPI assessment tool developed to rapidly assess the impact of a person's pain on their function. It is uncertain whether it has one or two factors, and…
Risi M, Greco G, Masciocchi S et al. · 2024 · Journal of neurology
Background Live cell-based assay (LCBA) is the gold standard for MOG-IgG detection, and fixed CBA (FCBA) is a widely used commercial alternative. Recent criteria attributed a diagnostic value to MOG-IgG titration with both LCBA and FCBA,…
Ilmakunnas I, Sten-Gahmberg S · 2026 · Journal of aging & social policy
Flexible partial retirement schemes are intended to give individuals the opportunity to reduce working hours before moving into full retirement, the expectation being that the reduced workload will contribute to postponed old-age…
Stapley V, Anderson RS, Saunders K et al. · 2025 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Introduction Previous research suggests that the electroretinogram (ERG) is reduced and delayed in non-pathological myopia. However, the invasive nature of the electrode and cumbersome equipment required has prevented the widescale uptake…
Fowler PV, Keall H, Kennedy D et al. · 2025 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectivesTo investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand.DesignA retrospective nationwide study.SettingsVirtual 3D orthodontic…
Rachuene PA, Dey R, Kauta NJ et al. · 2024 · SICOT-J
Background Pre-operative planning for reverse shoulder arthroplasty (RSA) poses challenges, particularly when dealing with glenoid bone loss. This modified Delphi study aimed to assess expert consensus on RSA planning processes and…
Iwagami S, Miyai H, Nishihata M · 2026 · Research and reports in urology
Purpose Transperineal prostate biopsy is essential for diagnosing prostate cancer; however, infection remains a clinically significant issue. We evaluated the safety and outcome of a single, prophylactic oral dose of cefaclor 500mg during…
Ashaibi NA, Mason AG, Hector MP et al. · 2025 · Clinical and experimental dental research
Objectives Dental pain of odontogenic origin can be difficult to accurately locate to a specific tooth. This study aimed to determine how effectively volunteers could locate electrical stimuli applied to teeth in both the anterior and…
Glanzer BM, Ladki MS, Chea M et al. · 2023 · Preprint
This study tests the utilization of Bluetooth noise-canceling headphones in improving the quality of eye exams in patients with hearing loss. University of Texas Medical Branch patients above 55 years of age were screened for hearing loss…
Schlötelburg W, Hartrampf PE, Kosmala A et al. · 2024 · Endocrine
Purpose We aimed to evaluate the prognostic potential of baseline [ 18 F]FDG PET/CT for overall survival (OS) in patients with adrenocortical carcinoma (ACC). Methods We performed a retrospective analysis of 67 treatment-naïve ACC patients…
von Gönner J, Gröning J, Grescho V et al. · 2023 · Preprint
Agricultural pesticides, nutrients, and habitat degradation are major causes of insect declines in lowland streams. To effectively conserve and restore stream habitats, standardized stream monitoring data and societal support for…
Byington CG, Goodman AM, Allendorfer JB et al. · 2024 · Epilepsia
Objective The uncinate fasciculus (UF) has been implicated previously in contributing to the pathophysiology of functional (nonepileptic) seizures (FS). FS are frequently preceded by adverse life events (ALEs) and present with comorbid…
Mohammadzadeh M, Abdi F, Hadi S et al. · 2026 · BMC nutrition
Background A high-quality diet is an important strategy for preventing chronic diseases, including cancer. The Nutrient Rich Food Score (NRFS) is a very useful index that can compare the value of key micronutrients and macronutrients per…
Soufi R, Salamzadeh J, Alavi Darazam I et al. · 2025 · Iranian journal of pharmaceutical research : IJPR
Background Vancomycin is commonly used in intensive care units (ICUs), but its optimal dosage in patients with acute kidney injury (AKI) remains uncertain. This study aimed to evaluate vancomycin's pharmacokinetic and pharmacodynamic…
Ullal SD, Thomas AG, Acharya SD et al. · 2026 · Pharmacology research & perspectives
Epilepsy is a common neurologic disorder; its incidence in childhood is 2.5 per 1000 children. Levetiracetam (LEV) is an antiepileptic drug with a broad spectrum of action used in localized and generalized epilepsies in both adults and…
Hawkey AB, Fan R, Nwachukwu K et al. · 2025 · Neurotoxicology and teratology
Neurotoxic risks in the environment come from many toxicants, which are often found together in complex mixtures. However, nearly all experimental studies evaluate one chemical at a time. Neurobehavioral effects of developmental exposure…
Jacover A, Beller T, Mahamid N et al. · 2025 · Annals of surgical oncology
Introduction Neoadjuvant therapy (NT) is generally preferred over upfront surgery for borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC), but many patients fail to reach surgical resection. This study evaluates real-world…
Tanisaka Y, Ryozawa S, Mizuide M et al. · 2025 · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Endoscopic sphincterotomy (EST) is challenging for patients with surgically altered anatomy (SAA). The blades of conventional sphincterotomes designed for SAA do not always face the correct direction of EST. We aimed to evaluate the…
Sandby K, Magkos F, Chabanova E et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)
Background & aims In recent years, epidemiological studies have reported links between the consumption of fermented dairy products, such as yogurt, and health; however, evidence from human intervention trials is scarce and inconsistent. We…
Buck AN, Fleiner T, Rosskothen-Kuhl N et al. · 2026 · Trends in hearing
It is widely known that users of cochlear implants (CIs) often show deficits in binaural hearing. In particular, interaural time difference (ITD) discrimination tends to be substantially worse in CI users. However, only very few studies…
Chen Y, Gao J, Wang X et al. · 2024 · Frontiers in nutrition
Background Evidence from observational studies on the association between folate and metabolic dysfunction-associated steatotic liver disease (MASLD) is conflicting. Aims This study aimed to investigate the association between serum folate…
Castillo L, Berrozpe-Villabona C, Miserachs-García S et al. · 2024 · Acta ophthalmologica
Purpose The role of the choroid in Leber hereditary optic neuropathy (LHON) remains unclear. The literature is scarce, with conflicting results and lacks axial length measurements. Therefore, we aimed to analyse the choriocapillaris (CC)…
Ding L, Reiher M · 2026 · Journal of chemical theory and computation
Neural quantum states (NQS) are a promising ansatz for solving many-body quantum problems due to their inherent expressiveness. Yet this expressiveness can only be harnessed efficiently for treating identical particles if the suitable…
Brunekreef J · 2024 · Journal of imaging informatics in medicine
The cited article reports on a convolutional neural network trained to predict response to neoadjuvant chemotherapy from pre-treatment breast MRI scans. The proposed algorithm attains impressive performance on the test dataset with a mean…
Loos E, Van Stiphout L, Lucieer F et al. · 2025 · Scientific reports
Little is known about the evolution of vestibular dysfunction and health-related quality of life in bilateral vestibulopathy patients over time. Furthermore, it is unknown whether etiology influences the evolution. A retrospective study…
Ahmadi Somaghian S, Pajouhi N, Dezfoulian O et al. · 2024 · Archives of physiology and biochemistry
Objective Improvement of cell survival is essential for achieving better clinical outcomes in stem cell therapy. We investigated the effects of hyperoxic pre-treatment (HP) on the viability of human adipose stromal stem cells (ASCs).…
Liao C, Nie J, Xu XJ et al. · 2024 · Leukemia & lymphoma
Two hundred and thirty-one acute lymphoblastic leukemia (ALL) children with 1376 high-dose methotrexate (HD-MTX) courses (3-5 g/m 2 ) were enrolled to analyze the influence of the plasma MTX concentration ( C MTX ) in ALL. The 24-h target…
Chen W, Yoshida S, Fujii Y · 2026 · Cancer reports (Hoboken, N.J.)
Background Androgen receptor signaling inhibitors (ARSI) combined with androgen deprivation therapy (ADT) have demonstrated significant survival benefits in metastatic hormone-sensitive prostate cancer (mHSPC) in several clinical trials.…
Findlay MC, Tenhoeve S, Alt J et al. · 2024 · Neurosurgery
Background and objective Cushing disease (CD) affects mortality and quality of life along with limited long-term remission, underscoring the need to better identify recurrence risk. The identification of surgical or imaging predictors for…