A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19847 results in Negative / Null Result Report · page 312 of 662
Smith AA, Jeon D, Rudy K et al. · 2025 · Scientific reports
To characterize the potential long-term impact of intrauterine growth restriction (IUGR), we assessed the endocrine and hematological consequences of IUGR at birth and in the early postnatal period. Piglets (n = 911) were collected…
Steffens NA, Petreceli RR, Azevedo VC et al. · 2025 · Clinical biochemistry
Introduction Healthcare systems face several challenges, with microbial infections being one of the main concerns. Therapeutic drug monitoring (TDM) is a strategy that has been encouraged to optimize antimicrobial regimens, particularly…
Yamasoba T, Uranaka T, Koyama H et al. · 2025 · Journal of clinical medicine
Background/Objectives : Since we started endoscopic stapes surgery, we have frequently noticed a white spot (WS) with a clear boundary on the bone surface around the fissula ante fenestrum (FAF) in otosclerosis cases. We investigated the…
Boktor J, Jayaraju U, Joseph V et al. · 2024 · Cureus
Background In the UK, the vast majority of bilateral total knee replacements (BTKRs) are performed as staged procedures. Historically, the second-operated knee, in patients undergoing staged BTKRs, has poorer outcomes compared with the…
Zhang B, Du X, Luo C et al. · 2026 · Clinical cardiology
Background and aims Vasovagal syncope (VVS) poses challenges despite therapy, and optimal cardioneuroablation (CNA) targeting ganglionated plexi (GPs) remains debated. This study compared long-term efficacy and safety between empirical…
Sorenson S, Flyger SSB, Pingel L et al. · 2025 · British journal of anaesthesia
Background Peripheral and truncal nerve blocks provide effective analgesia facilitating perioperative care. However, thresholds for clinically relevant effects remain undetermined and are left for clinicians to choose. These choices are…
Li X, Liu X, Mao J et al. · 2024 · Preprint
Not occasional phamracokinetic variability and suboptimal exposure have been reported for micafungin in the intensive-care-unit (ICU) patients. This study aims to evaluate the quality of population pharmacokinetic models and provide…
McNamara DM, Cooper LT, Friedrich MG et al. · 2026 · ESC heart failure
Introduction Cannabidiol has been shown to exert significant anti-inflammatory effects and has demonstrated efficacy in murine models of autoimmune myocarditis, pericarditis, and heart failure. The ARCHER Study assessed whether a…
Lau J, Wong GJ, Wan SW et al. · 2026 · Family practice
Background Colorectal cancer screening is an evidence-based preventive approach. Singapore has a national screening programme, but local studies suggest poor uptake. Gender differences in screening uptake exist in the literature, and women…
Moffack Djuloun C, Al-Nosairy KO, Beyer R et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
Purpose This study aimed to investigate the effects of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma (GLA)…
Brown HS, Wall B, Mears SC et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation
Introduction 1 mm cerclage cables have been introduced that can be placed under plates and hold reduction of periprosthetic femur fractures (PPFFx) around total hip arthroplasty (THA). Their utilization remains controversial due to the…
Lima MR, Paiva MS, Maltês S et al. · 2025 · Current problems in cardiology
Background Atrial septal defects (ASD) often go unrecognized until very late in life. The impact of ASD closure on life expectancy in elderly patients remains unclear. This study compares the survival of patients≥65-years who underwent ASD…
Nishikimi M, Ohshimo S, Nobayashi K et al. · 2026 · Critical care (London, England)
Background Neither the magnitude nor the timing of mean arterial pressure (MAP) increase after norepinephrine (NE) initiation is well defined, leaving clinicians without clear criteria for adequate starting doses. This study aimed to…
Hviid CVB, Rasmussen NH, Røikjer J · 2025 · Acta diabetologica
Background Objective and easily applicable biomarkers for diabetic polyneuropathy (DPN) are warranted. Circulating nerve-specific proteins have emerged as valuable biomarkers for central nervous system disease but few of these have been…
Zhao P, Zhao S, Huang C et al. · 2025 · Hematological oncology
Polatuzumab vedotin plus R-CHP (Pola-R-CHP) is approved as a new standard first-line therapy for diffuse large B-cell lymphoma (DLBCL) based on the POLARIX trial. However, real-world data on its efficacy and safety in unselected patients…
Reindl N, Seitz S, Schleier M et al. · 2025 · Pediatric surgery international
Purpose Postoperative scarring remains a major concern for patients and parents following repair of congenital abdominal wall defects. This study evaluated perceptions of postoperative scars in children after omphalocele or gastroschisis…
Thomas P, Kerrey B, Edmunds K et al. · 2024 · Pediatric emergency care
Background The lower clinical exposure of Pediatric Emergency Medicine (PEM) fellows to critical procedures may impede skill acquisition. We sought to determine the tracheal intubation learning curve of PEM fellows during training and…
Pelzer F, Leisge K, Kaczmarek C et al. · 2025 · Scientific reports
We often perform motor tasks in front of other people, and this may help or hinder our performances. Previous research mainly focused on changes in motor performance, and less is known about spectator influences on performance predictions.…
Moore E, Webb E, Sasaki R et al. · 2025 · Preprint
Numerous studies highlight alterations in motor cortical neurophysiology after mild traumatic brain injury (mTBI). In contrast, understanding of effects in cognitive brain areas, which potentially underpin more impactful effects of injury,…
Panzer S, Hofstetter N, Schreiber M et al. · 2026 · Experimental brain research
The present study examined if a daytime nap of 90 min can further improve skill memory afforded by observation and physical practice. Moreover, we determined if a 'nap' benefit was restricted to a particular representational form (spatial…
McNaughton DT, Mara P, Jones MP · 2024 · Australian health review : a publication of the Australian Hospital Association
Objective There is a need to undertake more proactive and in-depth analyses of general practice accreditation processes. Two areas that have been highlighted as areas of potential inconsistency are the self-assessment and surveyor…
Fowler TE, Bloomquist RF, James JN · 2025 · BMC oral health
Background The incidence of fascial space infections of the head and neck has long been suggested to correlate with weather patterns, though objective evidence is inconsistent, and a causative effect is difficult to prove. One issue in the…
Viskupič F, Wiltse DL · 2025 · PLOS global public health
It is possible that the negative attitudes toward COVID-19 vaccination developed by some people, such as self-identified Republicans, might spill over toward other vaccines. We conducted a survey experiment to investigate if mentioning…
Meade MJ, Jensen S, Ju X et al. · 2024 · International orthodontics
Objective The aim of the present study was to evaluate the quality and readability of content contained within clear aligner therapy (CAT) informed consent forms. Methods CAT informed consent forms were identified via an online search. The…
Chhaya D, Gress M, Raja A et al. · 2024 · International journal of environmental research and public health
The objective of this study is to investigate the potential mutagenic effects of the exposure of mice to aerosols produced from the component liquids of an electronic nicotine delivery system (ENDS). The use of electronic cigarettes…
Xu L, Yu D, Li F et al. · 2024 · Preprint
Abstract Objective To determine the efficacy and tolerability of Anlotinib plus temozolomide (TMZ) as a first-line treatment for recurrent malignant glioma (rMG). Methods A total of 30 eligible patients who relapsed from the standard…
Maier F, Luttenberger I, Dreisoerner A et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress
Chronic stress has well-documented adverse effects on physical and psychological health. Beyond contributing to the development of fatigue, its impact is intensified by social stressors such as loneliness, making the development of…
Turner TJ, Brun P, Gruber R et al. · 2024 · Preprint
Tolebrutinib is a covalent BTK inhibitor designed and selected for potency and CNS exposure to optimize impact on BTK-dependent signaling in CNS-resident cells. We applied a translational approach to evaluate three BTK inhibitors in Phase…
Al-Khalaifah H, Al-Nasser A, Al-Surrayai T · 2025 · Life (Basel, Switzerland)
There is growing interest in adding marine algae to poultry feed rations. The aim of the present study is to examine the effect of various inclusions of Sargassum sp., Gracilaria sp., and Spirulina sp. on productive performance, serum…
Zamora Veliz HY, Paredes Cabanillas RY, Gomez Trejo JE et al. · 2025 · Cureus
Introduction Intestinal anastomotic leakage is a serious postoperative complication associated with high morbidity and mortality. Although acute-phase reactants such as procalcitonin (PCT) and CRP have been proposed as early biomarkers,…