A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20233 results in Negative / Null Result Report · page 298 of 675
Cairang Z, Kanasaki H, Tumurbaatar T et al. · 2025 · International journal of endocrinology
Prolactin (PRL) plays a variety of roles to maintain female reproductive functions. In female rats, Prl mRNA expression in the anterior pituitary was significantly suppressed by OVX. The OVX-induced inhibition of PRL expression was…
De Jesus O · 2024 · Surgical neurology international
Background The effectiveness of autologous stem cell transplantation (ASCT) in preventing the development of central nervous system (CNS) plasmacytomas in multiple myeloma (MM) patients is not well understood. An ASCT patient who developed…
Prahalad V, Aalders J, Kirkpatrick JB · 2024 · Wetlands.
The effects of grazing and browsing by terrestrial vertebrates are poorly understood for southern hemisphere saltmarshes, many of which are recovering from stock grazing. We investigated whether the native late-successional shrub,…
Mendes TGM, Nunes ACP, Dantas de Carvalho AV et al. · 2025 · Clinical nutrition ESPEN
Background The nutritional needs of preterm newborns (PTNB) are increased and enhancing nutritional management is essential to meet them. The addition of multicomponent additive (MA) to human milk (HM) is used as a treatment strategy. The…
Cho MJ, Song MK, Jun SY et al. · 2025 · The American journal of cardiology
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but life-threatening inherited arrhythmia in children, often associated with sudden cardiac death (SCD). Risk stratification remains challenging. This study aimed to…
Ishiguro Y, Kuriyama A, Ishiguro S · 2025 · Annals of medicine and surgery (2012)
Introduction and importance Cytomegalovirus (CMV) can cause severe colitis in immunocompromised patients. While its morphological manifestations vary, diverticular perforation is rare, with most lesions remaining intact. We report a rare…
Yılmaz Dağlı H, Artan R, Civan DD et al. · 2024 · Pediatric transplantation
Aim To examine the long-term results and treatment effectiveness of liver transplantation (LT) in the treatment of homozygous familial hypercholesterolemia (HoFH) in children and adolescents. Method Patients who underwent LT due to HoFH…
Zierke L, John D, Gischke M et al. · 2024 · Cell. Mol. Life Sci
The co-localization of the lysosomal protease cathepsin B (CTSB) and the digestive zymogen trypsinogen is a prerequisite for the initiation of acute pancreatitis. However, the exact molecular mechanisms of co-localization are not fully…
Wang F, Gao T, Yang X et al. · 2025 · Aquaculture.
The significance of DNA methylation in fish sex determination and differentiation is increasingly being recognized. Exploring the role of DNA methylation in sex determination and differentiation is advantageous for the advancement of sex…
Zierke L, Gischke M, Sendler M et al. · 2026 · Molecular biomedicine
Acute pancreatitis is caused by a premature activation of digestive proteases. One hypothesis is based on the proteolytic activation of the serine protease trypsinogen by the lysosomal enzyme cathepsin B (CTSB) after co-localization in the…
Chen AP, Pandey H, Hancock WO · 2026 · The Journal of biological chemistry
The kinesin-3 family member, KIF1A is an essential motor protein that carries out intracellular transport in neurons. Previous work has established that: (1) intracellular transport can be impaired in neurodegenerative diseases such as…
Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2025 · Neurobiology of disease
The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an important…
Kang JI, Choi YK, Han SC et al. · 2025 · Chemico-biological interactions
Chemotherapy-induced alopecia (CIA) is a side effect of the anticancer drug 5-fluorouracil (5-FU). However, the mechanism of action in hair follicle cells is unclear. This study investigated the mechanism of action of 5-FU on the hair…
De Carli G, Giombini E, Colosi A et al. · 2025 · Pathogens (Basel, Switzerland)
To determine whether patient-to-doctor transmission of measles occurred in an emergency department (ED) despite isolation precautions and full personal protective equipment (PPE) during the COVID-19 pandemic, an epidemiological and…
Levaro-Loquio D, Cruz-Baquero A, Higuera-Martínez G et al. · 2026 · BioMed research international
During amoebic infection, neutrophils are the first cells of the immune system to interact with trophozoites of Entamoeba histolytica, initiating amoebicidal activity. Different lectins and carbohydrates can participate in the mechanism of…
Ebensperger M, Kreuzer M, Kratzer S et al. · 2025 · British journal of anaesthesia
Background The GE Entropy™ module uses frontal EEG to compute the processed indices state entropy (SE), response entropy (RE), and burst suppression ratio (BSR) to guide maintenance of anaesthesia by supposedly minimising overly 'deep' or…
Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2024 · Preprint
ABSTRACT The underlying cause of neuronal loss in Parkinson’s disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an…
Gudziol H, Hummel T, Guntinas-Lichius O · 2025 · HNO
Background There are various views in the literature regarding the influence of chronic rhinosinusitis (CRS) as a comorbidity on the occurrence of COVID-19 disease. Objective Did CRS prevent or promote infection with severe acute…
Henriksen K, Jørgensen A, Kaur S et al. · 2025 · Molecular and cellular endocrinology
Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…
Feldman S, Basra J, Lawani A et al. · 2025 · Ophthalmic surgery, lasers & imaging retina
Background and objective To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA). Patients and methods Prospective, single-masked,…
Chen H, Huang X, Wang C et al. · 2025 · The Journal of infectious diseases
Assessing the time-varying effectiveness of coronavirus disease 2019 (COVID-19) vaccines is critical to guiding vaccine strategies and public health policies. We developed a Bayesian framework to estimate the waning vaccine effectiveness…
Horizono J, Mizumoto K, Suico MA et al. · 2025 · Biological & pharmaceutical bulletin
Cyclodextrins (CDs) are cyclic oligosaccharides that encapsulate hydrophobic molecules such as cholesterol. Hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic heptasaccharide, has gained attention as a protective agent for chronic kidney…
Hojo FR, Martins TC, Vieira-Junior WF et al. · 2025 · Operative dentistry
This study evaluated the influence of six resin composite coating agents on color stability and surface roughness after toothbrushing abrasion. Discs (Ø6 mm x 2 mm) of nanofilled resin composite (Filtek Z350XT) were prepared for…
Chen A, Chou TY, Chen Y et al. · 2024 · Preprint
Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major disease affecting banana production around the globe. To study the movement of Foc in planta and investigate potential physical mechanisms of deterrence, the roots…
Giles C, Lee J · 2024 · Preprint
Abstract Nearly 90% of cancer deaths are due to metastasis. Conventional cancer therapeutics including chemotherapy, surgery, and radiotherapy, are effective in treating primary tumors, but may aggravate disseminated tumor cells (DTCs)…
Beningaza AM, Di Benedetto IMD, Babino L et al. · 2025 · Acta tropica
Chagas disease, vectored by kissing bugs, poses a public health problem across the Americas. The best way for reducing disease transmission is through vector control, which is currently based on the use of insecticides. However,…
Asadikorayem M, Weber P, Zhang S et al. · 2025 · Biomaterials advances
Osteoarthritis (OA) is one of the most common degenerative joint diseases, with no effective therapeutic options available. In this study, we aimed to develop an interpenetrating, in-situ-forming hydrogel based on biocompatible and…
Baudat M, Joosten EAJ, Simons SHP · 2025 · Pediatric research
Background While the incidence of neonatal intensive care unit (NICU) admission steadily increases, neonatology lacks evidence of a safe, effective, and preventive analgesic for treating procedural pain. Given its role in nociception and…
Moksi L, Sissala N, Ojala R et al. · 2026 · Journal of orthopaedic surgery and research
Background Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger…
Shimada T, Iwahashi T, Suzuki K et al. · 2025 · Journal of pharmacological sciences
Chronic nerve compression disorders, such as carpal tunnel syndrome, are common and can significantly impair daily activities due to motor and sensory dysfunctions. Currently, no systemic pharmacotherapy exists for preventing or treating…