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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19843 results in Negative / Null Result Report · page 298 of 662

Negative / Null Result ReportMedicine

The association between residential natural vegetation exposure at diagnosis and colorectal cancer-specific mortality among colorectal cancer cases in Kentucky.

Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research

Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…

View details →DOI: 10.1016/j.envres.2025.123574
Negative / Null Result ReportOpen accessMedicine

The Effect of Myo-Inositol Supplementation During Pregnancy on Fetal and Maternal Outcomes: Results of the Myo-Inositol for the Prevention of Gestational Diabetes Mellitus (MiGDM) Randomized Double-Blind, Placebo-Controlled Pilot Trial.

Okunoye G, George Samuel C, Abdullahi H et al. · 2026 · Cureus

Gestational diabetes mellitus (GDM) is a common pregnancy complication with significant maternal and neonatal risks, and its prevalence is particularly high in Qatar. Myo-inositol has been proposed as an insulin-sensitizing supplement that…

View details →DOI: 10.7759/cureus.102259
Negative / Null Result ReportOpen accessMedicine

No Support for White Matter Alterations in Adults With Dyslexia: A Fixel-Based Diffusion MRI Study.

Verhelst H, Gerrits R, Karlsson EM · 2025 · Neurobiology of language (Cambridge, Mass.)

Developmental dyslexia is a common learning disability marked by reading and spelling difficulties. While previous imaging studies aiming to elucidate the neurobiological mechanisms of this disorder have reported white matter alterations,…

View details →DOI: 10.1162/nol.a.17
Negative / Null Result ReportMedicine

Effect of different durations of treatment with antihypertensive drugs with anticholinergic effects on the risk of dementia: a target trial emulation study.

Aguado J, Gutierrez L, Forns J et al. · 2025 · American journal of epidemiology

Studying the effect of duration of treatment on prognostic outcomes using real-world data is challenging because only people who survive for a long time can receive a treatment for a long time. Specifying a target trial helps overcome such…

View details →DOI: 10.1093/aje/kwae263
Negative / Null Result ReportMedicine

Losing sleep? The effects of exposure to shootings near one's residence on self-reported sleep quantity in Chicago, 2020-2021.

McLone SG, Coleman CM, Matzke HJ et al. · 2026 · American journal of epidemiology

Firearm violence is a public health crisis in the United States and negatively impacts individuals and communities. We used data from The Healthy Chicago Survey, a citywide survey of 8754 respondents from 2020 to 2021, and police-reported…

View details →DOI: 10.1093/aje/kwaf031
Negative / Null Result ReportOpen accessMedicine

Negative news exposure does not affect risk or ambiguity aversion.

Garcia Campos LS, Lempert KM · 2025 · Frontiers in psychology

Introduction Uncertain decisions can be risky (with known probabilities) or ambiguous (with unknown probabilities). Previous studies have found that negative affect can increase risk aversion and ambiguity aversion, but it is unknown if…

View details →DOI: 10.3389/fpsyg.2025.1485346
Negative / Null Result ReportOpen accessMedicine

Elusive effects of legalized wolf hunting on human-wolf interactions.

Merz LM, von Hohenberg BC, Bergmann NT et al. · 2025 · Science advances

Expanding gray wolf ( Canis lupus ) populations in Europe and North America contribute to increased risks of livestock predation, which can threaten human livelihoods and lead government agencies to target wolves for lethal removal. Public…

View details →DOI: 10.1126/sciadv.adu8945
Negative / Null Result ReportOpen accessMedicine

Psychotherapy Process Dynamics and Their Relation to Treatment Success Do Not Differ Across Diagnoses.

Seizer L, Kratzer L, Löchner J et al. · 2026 · Clinical psychology & psychotherapy

Psychotherapy process research increasingly uses intensive longitudinal monitoring to capture dynamic patterns of change in patients. In this study, 283 psychiatric inpatients diagnosed with depression (n = 70), PTSD (n = 148),…

View details →DOI: 10.1002/cpp.70222
Negative / Null Result ReportMedicine

Speech sounds in larger inventories are not (necessarily) less variable.

Hauser I · 2022 · The Journal of the Acoustical Society of America

This paper reconsiders a classic claim about phonetic variability-that speech sounds in larger phonemic inventories should exhibit less within-category variability in production. Although this hypothesis is intuitive, existing literature…

View details →DOI: 10.1121/10.0014912
Negative / Null Result ReportMedicine

Maternal Mediterranean Diet during Pregnancy and Adiposity from Early Childhood through Preadolescence.

Gonzalez-Nahm S, Griffith E, Maguire RL et al. · 2026 · Childhood obesity (Print)

Objective To assess the longitudinal associations between maternal diet during pregnancy and child adiposity between ages 2 and 12 years. Methods Repeated measures linear regression models with autoregressive covariance were used to assess…

View details →DOI: 10.1177/21532176261420979
Negative / Null Result ReportOpen accessMedicine

Examining valproate's potential anticancer effect among patients with bipolar disorder: a territory-wide active-comparator new user study spanning two decades.

Wei C, Ng VWS, Wei Y et al. · 2025 · BMC psychiatry

AIMS: Preclinical studies have suggested potential anticancer effects of valproate, but clinical evidence is limited and inconclusive. This study aims to reexamine the relationship between valproate use and cancer incidence, using lithium…

View details →DOI: 10.1186/s12888-025-07622-5
Negative / Null Result ReportOpen accessMedicine

Glucagon-like Peptide-1 Receptor Agonists and Colorectal Cancer Risk.

Winkelman JW, Levine MJ · 2026 · AACE endocrinology and diabetes

Type 2 diabetes mellitus is a highly prevalent metabolic disorder and a well-established risk factor for colorectal cancer (CRC), mediated by hyperglycemia, hyperinsulinemia, chronic inflammation, and obesity-related metabolic dysfunction.…

View details →DOI: 10.1016/j.aed.2026.02.013
Negative / Null Result ReportOpen accessMedicine

Conformity to social norm interventions is not amplified in tighter nations.

Acierno J, Tedaldi E, Ginn J et al. · 2026 · Communications psychology

Social norms have a reliable and oftentimes strong influence on individual attitudes and behaviors across environmental and other domains. This influence has been theorized to differ by cultural tightness-the extent to which people adhere…

View details →DOI: 10.1038/s44271-026-00429-4
Negative / Null Result ReportMedicine

Transcutaneous Auricular Vagus Nerve Stimulation Does Not Accelerate Fear Extinction: A Randomized, Sham-Controlled Study.

D'Agostini M, Vanden Bossche L, Burger AM et al. · 2025 · Psychophysiology

Transcutaneous auricular vagus nerve stimulation (taVNS) has been tested as a strategy to facilitate fear extinction learning based on the hypothesis that taVNS increases central noradrenergic activity. Four studies out of six found taVNS…

View details →DOI: 10.1111/psyp.14754
Negative / Null Result ReportOpen accessMedicine

Sterile-neutrino search based on 259 days of KATRIN data.

· 2025 · Nature

Neutrinos are the most abundant fundamental matter particles in the Universe and play a crucial part in particle physics and cosmology. Neutrino oscillation, discovered about 25 years ago, shows that the three known species mix with each…

View details →DOI: 10.1038/s41586-025-09739-9
Negative / Null Result ReportMedicine

A Comprehensive Assessment of the Causal Relationship between Atopic Conditions and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomization Study.

He J, Sabroso-Lasa S, Coscia C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Observational studies consistently report reduced pancreatic ductal adenocarcinoma (PDAC) risk among individuals with atopic conditions (asthma and rhinitis); however, the underlying biological mechanism remains unclear. This…

View details →DOI: 10.1158/1055-9965.epi-25-1601
Negative / Null Result ReportOpen accessMedicine

State Point-of-Sale Comprehensive Background Check Policies and County Firearm Homicide Rates.

Schleimer JP, Rencken CA, Wagenaar BH et al. · 2026 · JAMA network open

Importance Background checks aim to prevent illegal firearm transfers. Existing research has shown little evidence for the effect of point-of-sale comprehensive background check (CBC) policies on firearm-related violence at the state…

View details →DOI: 10.1001/jamanetworkopen.2026.18188
Negative / Null Result Report

Foetal Exposure to Phthalates and Endocrine effects on the Leydig cell

Nielsen SP, Mathiesen L, Moller P · 2024 · Preprint

not-yet-known not-yet-known not-yet-known unknown Abstract This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and…

View details →DOI: 10.22541/au.172521306.69719621/v1
Negative / Null Result ReportMedicine

Working memory training in students with dyslexia: Additional effects to reading and spelling remediation not likely.

Walda SAE, van Weerdenburg M, Bosman AMT · 2024 · Research in developmental disabilities

Background Poor decoding and spelling (literacy) skills have been associated with weak working memory. Aims The aim of this study was to elucidate the contribution of working memory to literacy progress in students with dyslexia. It has…

View details →DOI: 10.1016/j.ridd.2024.104865
Negative / Null Result ReportMedicine

Does antimicrobial use during pregnancy impact excess weight in early childhood? Findings from the 2015 Pelotas (Brazil) Birth Cohort Study.

Bertoldi AD, Flores TR, Silveira MPT et al. · 2026 · Ciencia & saude coletiva

This study aimed to investigate the association between the use of antimicrobials during pregnancy and excess weight in children at ages three, 12, 24 and 48 months. Data of participants from the 2015 Pelotas (Brazil) Birth Cohort study…

View details →DOI: 10.1590/1413-81232026313.10692024
Negative / Null Result ReportOpen accessMedicine

Complications Following Aseptic Knee Revision Based on Tourniquet Use.

Pater WJ, Buller LT, Ziemba-Davis M et al. · 2026 · Arthroplasty today

Background Tourniquet use in revision total knee arthroplasty (rTKA) enhances visualization and improves cement penetration. However, concerns exist about muscle injury, pain, wound complications, and venous thromboembolism (VTE). This…

View details →DOI: 10.1016/j.artd.2026.102028
Negative / Null Result ReportMedicine

Cash transfers and mental health in Egypt.

El-Enbaby H, Hollingsworth B, Maystadt JF et al. · 2024 · Economics and human biology

The relationship between poverty and mental health is complex. Conditional cash transfers are seen as an important policy tool in reducing poverty and fostering social protection. Evidence on the impact of cash transfers on mental health…

View details →DOI: 10.1016/j.ehb.2024.101396
Negative / Null Result ReportOpen accessMedicine

Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study.

Kransberg J, Sjøli Bråthen AC, Falch ES et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer's disease. This pre-registered functional magnetic resonance…

View details →DOI: 10.1162/imag.a.1196