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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19843 results in Negative / Null Result Report · page 287 of 662

Negative / Null Result ReportMedicine

Safety and outcome of transscleral fine-needle aspiration biopsy in uveal melanoma: 10-year experience in 347 cases.

Bourdin A, Dureau S, Algret N et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To report safety outcomes of transscleral fine-needle aspiration biopsy (FNAB) followed by irradiation for uveal melanoma (UM) in a tertiary ocular oncology center over 10 years, and assess whether FNAB modified the overall…

View details →DOI: 10.1097/iae.0000000000004906
Negative / Null Result ReportMedicine

Mortality Risk Prediction from Dense PICU Data from Patients with Suspected Infection: Data-Derived Physiological Trajectories Outperform Expert Assessments When Temporal Resolution Is High.

Velez T, Badaki-Makun O, Hirsch D et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objective Early identification of mortality risk in critically ill children with suspected infection remains challenging. Whether severity scores (SIRS, pSOFA, Phoenix) add incremental value beyond data-derived physiologic features in…

View details →DOI: 10.1016/j.ijid.2026.108899
Negative / Null Result ReportMedicine

Is There an Added Value of Dual-Time-Point [<sup>68</sup>Ga]Ga-Fibroblast Activation Protein Inhibitor (FAPI) PET/CT in Differentiating Malignant and Benign Uptake Findings?

Al-Ibraheem A, Moghrabi S, Alsyouf B et al. · 2026 · Cancers

Background : [ 68 Ga]Ga-FAPI PET/CT demonstrates high sensitivity for tumor detection but limited specificity because benign fibro-inflammatory conditions may also show tracer uptake. Dual-time-point imaging has been proposed to improve…

View details →DOI: 10.3390/cancers18121963
Negative / Null Result ReportMedicine

Beyond microprocessor knees: exploring the potential of fully powered prosthetic legs.

Embry KR, Jayaraman C, Yang C et al. · 2026 · Journal of neuroengineering and rehabilitation

Background Powered knee and ankle prostheses generate mechanical energy to replicate biological leg function, yet direct comparisons with more commonly prescribed microprocessor-controlled knee prostheses are limited by methodological…

View details →DOI: 10.1186/s12984-026-02042-2
Negative / Null Result ReportMedicine

High-dose metoclopramide versus placebo for gastroduodenal visualization during endoscopy in patients with acute upper gastrointestinal bleeding. A triple-blind, randomized clinical trial.

Herrera-Elizondo JL, Jiménez-Castillo RA, García-Compeán D et al. · 2026 · Revista de gastroenterologia de Mexico (English)

Introduction and aims The usefulness of metoclopramide for improving endoscopic visualization in upper gastrointestinal bleeding (UGIB) is controversial. Our primary aim was to evaluate the utility of metoclopramide 20 mg/IV for endoscopic…

View details →DOI: 10.1016/j.rgmxen.2026.05.005
Negative / Null Result ReportMedicine

Striatal DAT-SPECT texture beyond mean binding in major depressive disorder.

Tamura T, Abe S, Matsui H et al. · 2026 · Journal of affective disorders

Background Dopaminergic dysfunction has been implicated in major depressive disorder (MDD), but dopamine transporter (DAT) imaging studies using conventional mean binding have yielded inconsistent findings. One possible contributor is that…

View details →DOI: 10.1016/j.jad.2026.122099
Negative / Null Result ReportMedicine

Platelet-rich plasma versus plasma gel for fat graft survival under cigarette smoke exposure: An experimental study.

Naghizade B, Özyazgan İ, Bozkurt F et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation,…

View details →DOI: 10.1016/j.bjps.2026.05.060
Negative / Null Result ReportMedicine

Is Inflammatory Arthritis an Absolute Indication for Patellar Resurfacing in Total Knee Arthroplasty?

Song BM, Ford CA, Schneider AM et al. · 2026 · The Journal of arthroplasty

Background Inflammatory arthritis (IA) has been considered an absolute indication for patellar resurfacing (PR) in total knee arthroplasty (TKA), yet limited data supports this. The purpose of this study was (1) to compare outcomes of TKA…

View details →DOI: 10.1016/j.arth.2026.04.094
Negative / Null Result Report

Effects of Cognitive Demand Reduction on Choice Overload

Seo S, Lee S, Lee N et al. · 2026 · Preprint

Choice overload occurs when an ever-growing number of options impairs decision quality, because evaluating options taxes cognitive resources. We investigated whether reducing cognitive demand could mitigate overload by encouraging greater…

View details →DOI: 10.64898/2026.02.19.706731
Negative / Null Result ReportMedicine

Effect of prolonged interval between neoadjuvant chemoradiotherapy and surgery on pathological and oncological outcomes in locally advanced rectal cancer: a randomized controlled trial.

Sileika E, Cerkauskaite D, Bausys A et al. · 2026 · International journal of colorectal disease

Background The optimal interval between neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) in locally advanced rectal cancer (LARC) remains controversial. This randomized controlled trial evaluated whether prolonging…

View details →DOI: 10.1007/s00384-026-05144-4
Negative / Null Result ReportMedicine

How DISCERNing is ChatGPT? An Evaluation of Models and Prompt Engineering in Assessing Patient Education Materials.

Blackman J, Friesen D, Sikkel MB et al. · 2026 · Applied clinical informatics

Objectives The objective of this study is to evaluate whether ChatGPT models can reliably apply the DISCERN instrument, a 16-question human-scored rubric developed in 1999 to evaluate consumer health information, and assess the impact of…

View details →DOI: 10.1055/a-2853-8892
Negative / Null Result ReportMedicine

Paretic limb biomechanical response to hip exoskeleton limb assistance strategies during walking for individuals post-stroke.

Stewart KM, Sawicki GS, Young AJ et al. · 2026 · Journal of biomechanics

Individuals post-stroke with hemiparetic gait often experience impaired mobility, which can be restored using powered exoskeletons. Specifically, hip exoskeletons can deliver positive work to the leg to help initiate leg swing; however, it…

View details →DOI: 10.1016/j.jbiomech.2026.113259
Negative / Null Result ReportMedicine

Digital Phenotyping and Lifestyle Intervention in Patients With Myasthenia Gravis (DIG-MG): A Randomized Controlled Trial of Feasibility, Adherence, and Effects on Fatigue.

Norling M, Eriksson N, Westerberg E et al. · 2026 · Muscle & nerve

Introduction/aims Physical activity and sleep influence fatigue in myasthenia gravis (MG), and digital health technologies (DHT) enable objective monitoring of these behaviors in daily life. Using this approach, we evaluated whether a…

View details →DOI: 10.1002/mus.70234
Negative / Null Result Report

Compared effects on Metrosideros laurifolia of arbuscular mycorrhizal fungal communities from restored lateritic subsoil and reference ultramafic soil.

Amir H, Martini A, Médevielle V et al. · 2026 · Preprint

The rehabilitation of mine-impacted areas through ecological restoration can ensure long-term ecosystem resilience by reestablishing at least part of the original biodiversity. In New Caledonia, large surfaces of mined land need to be…

View details →DOI: 10.22541/au.176826796.62402425/v1
Negative / Null Result ReportMedicine

A randomised controlled trial of defibrillation with manual pressure augmentation during out-of-hospital cardiac arrest.

Nehme Z, Mahony E, Nehme E et al. · 2026 · Resuscitation

Aim To determine whether defibrillation with manual pressure augmentation (MPA) reduces transthoracic impedance and improves cardioversion and survival from initially shockable out-of-hospital cardiac arrest (OHCA) compared with standard…

View details →DOI: 10.1016/j.resuscitation.2026.111121
Negative / Null Result ReportMedicine

Does hypercholesterolemia worsen cognitive decline in arterial hypertension? Insights from clinical and experimental studies.

Betat A, Santos VD, Oliveira CGA et al. · 2026 · Journal of hypertension

Background Arterial hypertension has been linked to cognitive decline, potentially through cerebrovascular alterations and associations with Alzheimer's disease. A positive correlation between elevated serum cholesterol levels and…

View details →DOI: 10.1097/hjh.0000000000004277
Negative / Null Result ReportMedicine

Health-Related Quality of Life in People Living with HIV andHypertension: Effects of a Short Message Service-Based Mobile HealthIntervention (MOPHADHIV Trial).

Hongoro DJ, Kengne AP, Peer N et al. · 2026 · AIDS and behavior

Mobile health (mHealth) interventions offer scalable support for adherence and self-management, yet their effects on health-related quality of life (HRQoL) among people living with HIV (PLWH) and comorbid hypertension remain unclear. We…

View details →DOI: 10.1007/s10461-026-05128-z
Negative / Null Result ReportMedicine

Exercise-nutrition prehabilitation attenuates lean body mass loss before gastrectomy: a randomized controlled trial.

Yamamoto K, Shinno N, Omori T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Background Older patients undergoing gastrectomy frequently exhibit sarcopenia and reduced physiologic reserve, increasing vulnerability to perioperative muscle loss. However, randomized evidence supporting multimodal exercise-nutrition…

View details →DOI: 10.1007/s10120-026-01747-6
Negative / Null Result ReportMedicine

Impact of fludarabine dosage on outcomes in large B-cell lymphoma patients treated with CAR T-cell therapy: a retrospective study of the CTIWP of the EBMT.

Dachy G, Mooyaart JE, Gabellier L et al. · 2026 · Bone marrow transplantation

Lymphodepleting conditioning (LD) with fludarabine and cyclophosphamide is critical to ensure optimal expansion and persistence of CD19 CAR T-cells. We conducted a retrospective EBMT registry study to assess the impact of fludarabine…

View details →DOI: 10.1038/s41409-026-02925-x
Negative / Null Result ReportMedicine

High-dose Vitamin D<sub>3</sub> supplementation and glycaemic control in adult males with Type 2 diabetes: a randomised placebo-controlled trial.

Nasr MH, Abdulrasool Hassan B, Othman N et al. · 2026 · Journal of pharmaceutical policy and practice

Background Vitamin D deficiency is common among individuals with type 2 diabetes mellitus (T2DM) and has been linked to insulin resistance and poor glycaemic control. However, findings from randomised controlled trials remain inconsistent.…

View details →DOI: 10.1080/20523211.2026.2680824
Negative / Null Result ReportMedicine

Flash glucose monitoring addition to self-monitoring of blood glucose and perinatal outcomes in gestational diabetes: a randomized controlled trial.

Zorko K, Munda A, Janež A et al. · 2026 · American journal of obstetrics and gynecology

Background Self-monitoring of blood glucose represents the standard for glycemic monitoring in gestational diabetes mellitus, while the role of continuous glucose monitoring remains uncertain. Objective To assess whether adjunctive flash…

View details →DOI: 10.1016/j.ajog.2026.03.030
Negative / Null Result ReportMedicine

Durability and mechanistic performance of aztreonam/avibactam versus aztreonam plus ceftazidime/avibactam against Stenotrophomonas maltophilia complex.

Kunz Coyne AJ, Gray R, Gonnabathula P et al. · 2026 · The Journal of antimicrobial chemotherapy

Background Stenotrophomonas maltophilia complex infections are difficult to treat because of intrinsic resistance mediated by the L1 metallo-β-lactamase and L2 serine β-lactamase. Although aztreonam/avibactam is clinically available,…

View details →DOI: 10.1093/jac/dkag177
Negative / Null Result ReportMedicine

Switching anti-VEGF agents does not improve visual outcomes in branch retinal vein occlusion-related macular edema.

Peretz-Kahlon M, Wood K, Harris A et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

BACKGROUND: Branch retinal vein occlusion (BRVO) frequently results in macular edema (ME), impairing visual acuity (VA). Intravitreal anti-vascular endothelial growth factor (VEGF) injections are standard first-line therapy but the benefit…

View details →DOI: 10.1007/s00417-026-07227-y