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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19843 results in Negative / Null Result Report · page 283 of 662

Negative / Null Result ReportMedicine

Quality assessment of radiographs through AI-driven feedback: A randomized comparative study on radiographer response in lateral knee radiographs.

Lysdahlgaard S, Jensen J, Pedersen MRV et al. · 2026 · Radiography (London, England : 1995)

Introduction High-quality radiographic positioning is essential for accurate diagnosis in knee imaging. Although artificial intelligence (AI) can assess image quality with high accuracy, its influence on radiographers' clinical…

View details →DOI: 10.1016/j.radi.2026.103459
Negative / Null Result ReportMedicine

Retrospective Comparative Analysis of Diffusion Tensor and Constrained Spherical Deconvolution Tractography Models in a Clinical Neurosurgical Navigation Platform.

Watanabe A, Furukawa M, Hiruta R et al. · 2026 · Neurologia medico-chirurgica

Tractography is a technique for visualizing the trajectories of white matter pathways. The most widely used model, the diffusion tensor imaging, assumes a single fiber orientation within each voxel. In contrast, the constrained spherical…

View details →DOI: 10.2176/jns-nmc.2026-0025
Negative / Null Result ReportMedicine

Increasing dose of esketamine for supplemental analgesia after complex spinal fusion surgery: a randomized and double-blind trial.

Guo ZM, Cui F, Zhang Y et al. · 2026 · BMC anesthesiology

Background Complex spinal surgery is associated with significant trauma and pain. Herein we tested the hypothesis that increasing the dose of esketamine, as a supplement to patient-controlled analgesia, might improve pain relief after…

View details →DOI: 10.1186/s12871-026-03962-1
Negative / Null Result ReportMedicine

Low-Temperature Equilibration Impairs Follicular Preservation in Vitrified Domestic Cat Ovarian Tissue.

Rodak O, Alkali IM, Peris-Diaz MD et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

Ovarian tissue vitrification holds great promise as a preservation technique for endangered wild felids; however, the development of an optimal protocol remains desired. One potential factor affecting success is the equilibration…

View details →DOI: 10.1111/rda.70239
Negative / Null Result ReportMedicine

Enzalutamide Plus Metformin Versus Enzalutamide Alone in Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 2 Trial (SAKK 08/14).

Gillessen S, Gobat K, Cathomas R et al. · 2026 · European urology oncology

Background and objective The aim of our study is to determine whether the addition of metformin to enzalutamide can improve the outcomes of men with metastatic castration-resistant prostate cancer (mCRPC). Methods From 2016 to 2021,…

View details →DOI: 10.1016/j.euo.2026.03.001
Negative / Null Result ReportMedicine

Modulation of neuroendocrine and autonomic responses to competitive stress by slow cortical potentials training in golfers: An exploratory randomized controlled trial.

Lizama E, Carcamo-Herrera B, López G et al. · 2026 · Psychoneuroendocrinology

Performance in precision sports such as golf depends on the athlete's ability to regulate psychophysiological responses under competitive pressure. Heart rate variability (HRV), cortisol, and DHEA provide complementary indices of autonomic…

View details →DOI: 10.1016/j.psyneuen.2026.107934
Negative / Null Result ReportOpen accessMedicine

Gene-specific response to muscle specific kinase agonist antibody in the treatment of congenital myasthenic syndromes.

Ho K, Adjei-Afriyie O, Carmona-Martinez R et al. · 2026 · Brain communications

Congenital myasthenic syndromes (CMS) are a group of rare disorders characterized by fatigable muscle weakness and caused by impaired neuromuscular junction (NMJ) function. CMS symptoms are highly variable, but it can be detrimental and…

View details →DOI: 10.1093/braincomms/fcag115
Negative / Null Result ReportMedicine

Losartan shows limited benefit in preclinical models of Geleophysic dysplasia.

Morales AA, Camarena V, Peart L et al. · 2026 · Scientific reports

Geleophysic dysplasia (GD) is a rare genetic disorder characterized by short stature, joint contractures, and cardiopulmonary complications, with early mortality, and linked to mutations in ADAMTSL2 (GD1), FBN1 (GD2), or LTBP3 (GD3) genes.…

View details →DOI: 10.1038/s41598-026-58527-6
Negative / Null Result ReportMedicine

The Effect of PTFE Coating and PTFE Tape Wrapping Abutment Screw After Cyclic Loading: An In Vitro Study.

Kongkhuntian P, Aunmeungtong W, Khongkhunthian P · 2026 · Clinical implant dentistry and related research

Objective This study aimed to compare the effect of PTFE tape wrapping and PTFE-coated titanium alloy screws on the removal torque after cyclic loading and on preload values under repetitive tightening. Methods A total of 60 titanium…

View details →DOI: 10.1111/cid.70162
Negative / Null Result ReportMedicine

Reduction in copper and pesticide levels in grape musts: A new asset for the implementation of bioprotection in oenology.

Tournu E, Tourdot-Maréchal R, Coelho C · 2026 · International journal of food microbiology

Phytosanitary and copper treatments in viticulture are essential to protect vines against biotic and abiotic stresses. However, residues from these treatments can persist in grape musts and wines, potentially raising risks to consumer…

View details →DOI: 10.1016/j.ijfoodmicro.2026.111877
Negative / Null Result ReportMedicine

Personalized Treatment Selection for Digital Eating Disorder Interventions: A Proof-of-Concept for the Personalized Advantage Index.

McClure Z, Fuller-Tyszkiewicz M, Messer M et al. · 2026 · The International journal of eating disorders

Objective Although a range of evidence-based treatments for eating disorders exist, treatment response varies substantially. The ability to match individuals to a treatment which they are most likely to benefit from may help improve…

View details →DOI: 10.1002/eat.70112
Negative / Null Result ReportMedicine

Can biochar and late-season nitrogen fertilization overcome the sulfur-containing amino acid deficiency and improve oil stability in soybean seeds?

Khatri D, Poudel S, Pun Magar L et al. · 2026 · Frontiers in plant science

Soybean meal quality for monogastric animals is limited by low sulfur-containing amino acids, especially methionine and cysteine, while oil oxidative stability is restricted by the high polyunsaturated fatty acid content. This two-year…

View details →DOI: 10.3389/fpls.2026.1849670
Negative / Null Result ReportMedicine

A novel face scale and National Early Warning Score 2 prediction model to assess deteriorating patients in hospital wards: A quick visual early warning score study.

Wall A, Fisher JA, Watkinson EK et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Early warning scores like the National Early Warning Score 2 (NEWS2) identify patient deterioration but do not incorporate clinician-intuitive assessment. Previous research suggests facial expressions can be critical indicators…

View details →DOI: 10.1016/j.aucc.2026.101628
Negative / Null Result ReportMedicine

Assessment of Seed Treatments for Management of Pathogens Causing Seed Rot, Seedling Damping-off, and Seedling Root Rot in Alfalfa ( Medicago sativa ).

Larsen LJ, Dornbusch MR, Hines-Snider C et al. · 2026 · Plant disease

Seed rot and damping-off of alfalfa ( Medicago sativa L.) is caused by a soilborne disease complex resulting in thin initial stands of plants with continuing damage during wet soil conditions decreasing forage yields and winter survival.…

View details →DOI: 10.1094/pdis-05-24-1147-re
Negative / Null Result ReportMedicine

Communicating Time-to-Event Treatment Effects in Randomized Trials: A Randomized Experiment among General Practitioners.

Giese H, Gaissmaier W, Kuss O et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundTime-to-event outcomes from randomized controlled trials (RCTs) are often communicated without clearly conveying how treatment effects evolve over time. This can limit clinicians' ability to interpret results and support patient…

View details →DOI: 10.1177/0272989x261446622
Negative / Null Result ReportMedicine

Joint-specific measures improve risk adjustment in total knee arthroplasty: A machine learning approach.

Müller D, Gillani A, Hirschmann MT et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose Accurate risk adjustment in total knee arthroplasty (TKA) is essential for outcome prediction and quality assessment. Most existing prediction models rely solely on patient demographics and comorbidities and do not account for…

View details →DOI: 10.1002/ksa.70480
Negative / Null Result ReportMedicine

Bovine colostrum as a human milk fortifier for very preterm infants with slow feeding advancement: a randomized controlled trial.

Jiang PP, Huang HY, Zhao L et al. · 2026 · Pediatric research

Background Fortification of human milk for very preterm infants (VPIs) with alternatives to conventional bovine milk-based fortifiers remains minimally studied. This trial tested whether fortification with protein-rich bovine colostrum…

View details →DOI: 10.1038/s41390-026-04768-0
Negative / Null Result ReportMedicine

Safety and outcome of transscleral fine-needle aspiration biopsy in uveal melanoma: 10-year experience in 347 cases.

Bourdin A, Dureau S, Algret N et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To report safety outcomes of transscleral fine-needle aspiration biopsy (FNAB) followed by irradiation for uveal melanoma (UM) in a tertiary ocular oncology center over 10 years, and assess whether FNAB modified the overall…

View details →DOI: 10.1097/iae.0000000000004906
Negative / Null Result ReportMedicine

Acute effects of an individually timed lower-limb post-activation performance enhancement protocol on 50 m front crawl performance and race kinematics in national-level swimmers.

Stanula A, Strzała M, Sadowski W et al. · 2026 · Scientific reports

Post-activation performance enhancement (PAPE) has been proposed as an acute strategy to improve explosive performance, yet its effects on sprint-swimming performance remain unclear, particularly when individualized recovery timing is…

View details →DOI: 10.1038/s41598-026-51746-x
Negative / Null Result Report

Belgian endive-derived biostimulant activity in Arabidopsis, lettuce and sweet pepper at different developmental stages, environmental conditions, and application methods

Ogunsanya HY, Petit C, Audenaert K et al. · 2026 · Preprint

Belgian endive-derived biostimulant (BEE) was previously shown to enhance root and shoot growth of Arabidopsis thaliana and Plectranthus esculentus in in vitro culturing conditions. In this study, we evaluated the effect of BEE on A.…

View details →DOI: 10.64898/2026.04.15.717650
Negative / Null Result ReportMedicine

<i>Enterobacter</i>-based dietary supplements in both larvae and adult diet affect thermal response of sterile males.

Papadogiorgou G, Koskinioti P, Rodovitis V et al. · 2026 · Bulletin of entomological research

Thermal stress can affect the field performance of sterile males used in the sterile insect technique (SIT). We tested whether adding autoclaved Enterobacter as a dietary supplement improves thermal tolerance in sterile Vienna 8 genetic…

View details →DOI: 10.1017/s0007485326101035
Negative / Null Result ReportOpen accessMedicine

Multiple Arterial Grafting in Hemodialysis Patients.

Hachiro K, Takashima N, Kamiya K et al. · 2026 · Circulation reports

Background The effectiveness of multiple arterial grafting (MAG) for hemodialysis (HD) patients is unclear. Methods and results We retrospectively analyzed 149 HD patients who underwent either MAG (n=97) or single arterial grafting (SAG)…

View details →DOI: 10.1253/circrep.cr-25-0302
Negative / Null Result ReportMedicine

Evaluation of postoperative analgesia with perioperative electroacupuncture in clinical dog patients undergoing surgery for cranial cruciate ligament rupture (Tibial Tuberosity Advancement).

Lienert M, Stadler L, Kipfer N et al. · 2026 · Veterinary journal (London, England : 1997)

Objectives To investigate the effect of electroacupuncture on postoperative analgesia in dogs undergoing Tibial Tuberosity Advancement surgery. We hypothesise that acupuncture will reduce pain scores and the need for rescue analgesia…

View details →DOI: 10.1016/j.tvjl.2026.106712
Negative / Null Result ReportMedicine

Correcting photoreceptor diseases at their source: CRISPR strategies for cone-rod dystrophy and achromatopsia.

Zaki HF, Bishri J, Abdul Muqtadir M et al. · 2026 · Experimental eye research

Background Cone-rod dystrophy (CORD) and achromatopsia (ACHM) are inherited retinal dystrophies for which conventional adeno-associated virus (AAV) gene augmentation has important limitations, particularly in autosomal-dominant…

View details →DOI: 10.1016/j.exer.2026.111119
Negative / Null Result ReportMedicine

Responsiveness and Minimal Important Change of the Haemophilia Activities List in Patients With Inherited Bleeding Disorders.

Blokzijl J, Kuijlaars IAR, Pisters MF et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Introduction The Haemophilia Activities List (HAL) is a disease-specific patient-reported outcome measure (PROM) that is widely used in both healthcare and research in people with inherited bleeding disorders (PWBD), but information on…

View details →DOI: 10.1111/hae.70327