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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20230 results in Negative / Null Result Report · page 282 of 675

Negative / Null Result ReportMedicine

Integrating morphology, vascularity, and elasticity: diagnostic role of multiparametric quantitative ultrasound in breast lesions.

Sabharwal P, Kaur N, Kaur R et al. · 2026 · Journal of ultrasound

Objectives To determine the incremental diagnostic value of multiparametric quantitative ultrasound-integrating B-mode, Color Doppler, Strain, and Shear Wave Elastography (SWE)-in differentiating benign and malignant breast lesions, using…

View details →DOI: 10.1007/s40477-026-01116-0
Negative / Null Result ReportMedicine

Assessing the Clinical Performance of a Presymptomatic Acute Graft-Versus-Host Disease Biomarker Test in Hematopoietic Stem Cell Transplant Recipients.

Wang L, Pulgrossi RC, Anderson J et al. · 2026 · The journal of applied laboratory medicine

Background Acute graft-versus-host disease (aGVHD) is a common complication of allogenic hematopoietic cell transplantation (HCT). The aGVHD presymptomatic algorithm is comprised of 2 serum biomarkers, suppression of tumorigenicity 2 and…

View details →DOI: 10.1093/jalm/jfaf193
Negative / Null Result ReportMedicine

Combined therapy with nebulized and intravenous colistin for the treatment of multidrug resistance pneumonia in burn patients: experience from a third referral burn care center in Mexico City.

Delaye-Martínez MA, Aguilar-Rodea BP, Cardona-Ortiz AF et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Purpose Nebulized colistin has shown promise in treating ventilator-associated pneumonia (VAP) due to carbapenem-resistant strains; evidence in burn patients is limited. This study evaluated the efficacy of nebulized colistin as an adjunct…

View details →DOI: 10.1007/s10096-026-05550-0
Negative / Null Result ReportMedicine

Leading large language models on a periodontology knowledge test.

Rusa AM, Schmidlin PR, Sarkar P et al. · 2026 · Swiss dental journal

Large language models (LLMs) are increasingly used in clinical and educational settings. However, there is a paucity of data on LLMs' performance in specialized dental domains. This study assessed the performance of four LLMs, including…

View details →DOI: 10.61872/sdj-2025-04-04
Negative / Null Result ReportMedicine

PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone for ARPI-pretreated and chemotherapy-naive metastatic castration-resistant prostate cancer: a pooled analysis of KEYNOTE-921 and CheckMate 7DX trials.

Zou Q, Huang Q, Li J et al. · 2026 · International urology and nephrology

Background The optimal treatment strategy for androgen receptor pathway inhibitor (ARPI)-pretreated and chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) remains unclear. Chemotherapy has limited efficacy as a…

View details →DOI: 10.1007/s11255-026-05064-w
Negative / Null Result ReportMedicine

The Value of Oxygenation Vital Signs in Machine Learning Prediction of Neurodevelopmental Outcomes in Preterm Infants.

van Boven M, Bennis F, Onland W et al. · 2025 · IEEE journal of biomedical and health informatics

Machine learning models predicting neurodevelopmental outcome in preterm infants have great potential, but have often relied on inaccessible brain magnetic resonance imaging measurements. This study aimed to build models using readily…

View details →DOI: 10.1109/jbhi.2025.3559793
Negative / Null Result ReportMedicine

Effect of a Drug Dosing Safety Bundle Initiative to Improve Pediatric Drug Dosing by Paramedics. Results of the Michigan Pediatric EMS Error Reduction Study (MI-PEERS).

Hoyle JD Jr, Ekblad G, Dunwoody S et al. · 2026 · Prehospital emergency care

Objectives We sought to decrease pediatric prehospital dosing errors by implementing a bundled drug dosing safety system (DDSS). Multiple studies have demonstrated that pediatric prehospital drug-dosing errors occur at rates of > 30% for…

View details →DOI: 10.1080/10903127.2025.2609784
Negative / Null Result ReportMedicine

[Mandibular donor site healing after bone graft harvesting in cleft patients: a comparative study of rotary bur and piezoelectric osteotomy techniques].

Ivanov AL, Reshetnyak EI, Sukacheva SA · 2026 · Stomatologiia

Objective To evaluate mandibular donor site healing after cortical bone graft harvesting in cleft patients, comparing outcomes of osteotomies performed with rotary burs and piezosurgery. Material and methods Fifty-three patients (64 bone…

View details →DOI: 10.17116/stomat202610501137
Negative / Null Result ReportMedicine

Motivational Interviewing and Cognitive Behavioural Therapy in the Auckland Cardiac Rehabilitation Programme: A Propensity Score-Matched Study.

Marshall PW, Benatar JR, O'Halloran P et al. · 2026 · Heart, lung & circulation

Aim Suboptimal enrolment and engagement in cardiac rehabilitation remains a persistent issue worldwide. This study evaluated the impact of a nurse-specialist-delivered motivational interviewing (MI) and cognitive behavioural therapy (CBT)…

View details →DOI: 10.1016/j.hlc.2025.10.006
Negative / Null Result ReportMedicine

Attention Networks and Speech Disfluencies among Monolingual Dutch and Bilingual Dutch-Turkish Speaking Children: A Pilot Study.

Aslan G, Eggers K · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction This pilot study investigated whether attention skills influence speech disfluencies in school-aged children, comparing monolingual Dutch (MONO) speakers and bilingual Dutch-Turkish speakers (BIL). Disfluencies frequently…

View details →DOI: 10.1159/000551501
Negative / Null Result ReportMedicine

Influence of the correct placement of external ventricular drainage on puncture channel bleeding in patients with aneurysmal subarachnoid hemorrhage.

Marschal V, Ziebart A, Abdoullahi M et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

While ventriculostomy-associated hemorrhages are well-documented in spontaneous subarachnoid hemorrhage (SAH), the impact of external ventricular drainage (EVD) placement accuracy on puncture channel bleeding (PCB) remains underexplored.…

View details →DOI: 10.1016/j.jocn.2026.112077
Negative / Null Result Report

Relative Hemodynamic Timing in Human White Matter

Li M, Ding Z, Gore JC · 2026 · Preprint

ABSTRACT Hemodynamic lag in white matter (WM) remains poorly understood despite its relevance to neurovascular health. We developed Local Propagation Mapping to quantify the spatiotemporal architecture of relative hemodynamic timing within…

View details →DOI: 10.64898/2026.05.29.728865
Negative / Null Result ReportMedicine

Effects of glucose ingestion on blood flow in the small intestine and exercising limbs during endurance exercise.

Endo MY, Kashima H, Miura A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Performance during endurance exercise depends on the balance between the blood flow (BF) to active muscles and their energy use. We compared the acute cardiovascular regulation after the ingestion of a 300-mL drink containing 50 g glucose…

View details →DOI: 10.1152/japplphysiol.00954.2025
Negative / Null Result ReportMedicine

Clinical Characteristics and Management for Flares in Patients With Rheumatoid Arthritis Treated With Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs.

Kim YE, Ahn SM, Oh JS et al. · 2026 · International journal of rheumatic diseases

Objective To evaluate the frequency and management of flares in rheumatoid arthritis (RA) patients treated with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). Methods Data were analyzed from the KOrean…

View details →DOI: 10.1111/1756-185x.70631
Negative / Null Result ReportOpen accessMedicine

[Corrigendum] Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway.

Niu P, Sun Y, Wang S et al. · 2026 · Molecular medicine reports

Following the publication of the above article, an interested reader drew to the authors' attention that, concerning the TUNEL assay data shown in Fig. 5A on p. 6, the images shown for the H 2 O 2 and PU+H 2 O 2 groups were remarkably…

View details →DOI: 10.3892/mmr.2026.13849
Negative / Null Result ReportMedicine

A polymorphism and expression levels of SCD and their relationships to production traits in a Japanese farmed emu population.

Koshiishi Y, Moriya S, Ishida Y et al. · 2026 · PloS one

The emu is a novel poultry species producing meat, eggs, and fat. In particular, emu oil derived from the fat is considered the most important product of the emu owing to its anti-inflammatory and anti-melanin production. Meanwhile, there…

View details →DOI: 10.1371/journal.pone.0352695
Negative / Null Result ReportMedicine

Factors influencing time to speech processor upgrades.

Hung C, Spitzer ER, Waltzman SB · 2026 · Cochlear implants international

Objective Cochlear implant (CI) speech processors have undergone technological advancements. Therefore, patients upgrade speech processors when new features are available or when their previous device becomes broken and is no longer…

View details →DOI: 10.1080/14670100.2026.2635191
Negative / Null Result ReportMedicine

Non-alcoholic beverage provision reduces alcohol consumption and improves health-related outcomes, with no effect on presenteeism: a randomized controlled trial.

Dobashi S, Hotoge S, Kikuchi A et al. · 2026 · Scientific reports

Excessive alcohol consumption contributes to mortality and productivity losses, yet evidence for workplace-based substitution interventions remains limited. This randomized controlled trial examined whether providing non-alcoholic…

View details →DOI: 10.1038/s41598-026-58855-7
Negative / Null Result ReportMedicine

Pharmacokinetics of polyethylene glycol (PEG)-capped gold nanoparticles in rats: impact of free PEG pre-administration.

Darweesh RS, Alnuaimi TM, Zayed AL et al. · 2026 · Nanotechnology

Polyethylene glycol (PEG)-capped gold nanoparticles (PEG-AuNPs) are of great interest for targeted drug delivery and targeted delivery of chemotherapy due to their biocompatibility and ability to evade detection by the immune system.…

View details →DOI: 10.1088/1361-6528/ae4fc9
Negative / Null Result ReportMedicine

Early visual processing in adults with ADHD: evidence from contrast sensitivity, spatial integration, and external noise.

Ifrah-Tsruya H, Lev M, Polat U · 2026 · Vision research

Attention-Deficit/Hyperactivity Disorder (ADHD) is typically conceptualized as a disorder of executive control; however, accumulating evidence suggests that early sensory processing may also be atypical. The present study examined contrast…

View details →DOI: 10.1016/j.visres.2026.108867
Negative / Null Result ReportMedicine

Reliability of Noninvasive Blood Pressure Monitoring During Atrial Fibrillation Ablation Under General Anesthesia.

Schwartz J, Al-Sadawi M, Mattimore D et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives To evaluate the accuracy and reliability of noninvasive blood pressure (NIBP) monitoring compared to invasive blood pressure (IBP) measurements during atrial fibrillation (AF) ablation under general anesthesia, and to determine…

View details →DOI: 10.1053/j.jvca.2026.03.003
Negative / Null Result ReportMedicine

Concomitant cholecystectomy did not significantly reduce the risk of subsequent biliary events and malignancy in treating gallstone ileus.

Su YS, Liu HY, Chen CY et al. · 2026 · Surgical endoscopy

Background This nationwide cohort study compared long-term subsequent benign biliary events and biliary tract malignancy in patients with gallstone ileus treated with or without concomitant cholecystectomy. Methods This retrospective…

View details →DOI: 10.1007/s00464-025-12536-0
Negative / Null Result ReportMedicine

Management of the Condyle in Posterior Mandibular Reconstruction: Major Clinical and Patient-Reported Outcomes.

Coleman-Belin JC, Zhang KK, Cohen Z et al. · 2026 · Journal of surgical oncology

Background and objectives Tumor involvement of the posterior mandible often requires resection of the mandibular condyle and associated soft tissue. This study explores clinical and patient-reported outcomes (PROs) associated with condyle…

View details →DOI: 10.1002/jso.70182