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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19843 results in Negative / Null Result Report · page 282 of 662

Negative / Null Result ReportOpen accessMedicine

Association between the extent of intrapulmonary spread on chest CT and false-negative results of T-SPOT.TB in pulmonary tuberculosis: a retrospective study.

Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases

Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…

View details →DOI: 10.1186/s12879-025-10777-x
Negative / Null Result ReportOpen accessMedicine

Enhanced serodiagnosis of opisthorchiasis using a multi-epitope dot-ELISA: comparative evaluation of visual and imageJ-assisted analysis of IgG and IgM responses.

Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases

Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…

View details →DOI: 10.1186/s12879-026-13445-w
Negative / Null Result ReportOpen accessMedicine

Inconsistent Findings Between Crystal Violet and Congo Red Methods on Biofilms with Comparative Sugar Supplementation.

Unubol N, Ayaş M, Uyar NY et al. · 2025 · Microorganisms

In recent years, the World Health Organization has highlighted biofilm-derived multidrug-resistant bacteria as a critical threat to both global health and the environment. Although various testing methods are available, crystal violet and…

View details →DOI: 10.3390/microorganisms14010021
Negative / Null Result Report

Designing and making an in-house real-time RT qPCR kit for the detection of SARS-CoV- 2 infection at high sensitivity and low cost

AL-Saeedi A, Abdulamir AS, Aufi IM et al. · 2025 · Preprint

Abstract Background The widespread use of accurate real-time RT-PCR tests for community individuals is a critical approach to managing the disease and reducing COVID-19 transmission effectively. In addition, serological ELISA assays are…

View details →DOI: 10.21203/rs.3.rs-8233598/v1
Negative / Null Result ReportOpen accessMedicine

Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study.

Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine

Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…

View details →DOI: 10.1002/cam4.70835
Negative / Null Result ReportMedicine

Sintilimab Plus Modified FOLFIRINOX in Metastatic or Recurrent Pancreatic Cancer: The Randomized Phase II CISPD3 Trial.

Fu Q, Chen Y, Huang D et al. · 2023 · Annals of surgical oncology

Background Folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or modified FOLFIRINOX (mFFX) is the first-line standard of care for metastatic pancreatic adenocarcinoma; effective and safe treatment strategies are needed…

View details →DOI: 10.1245/s10434-023-13383-w
Negative / Null Result ReportMedicine

Phase 2 Single-arm Trial of Primary Retroperitoneal Lymph Node Dissection in Patients with Seminomatous Testicular Germ Cell Tumors with Clinical Stage IIA/B (PRIMETEST).

Hiester A, Che Y, Lusch A et al. · 2023 · European urology

Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…

View details →DOI: 10.1016/j.eururo.2022.10.021
Negative / Null Result ReportMedicine

The field evaluation of the diagnostic performance of a commercial pregnancy-associated glycoprotein-based lateral flow assay for early pregnancy detection in ewes.

Uyanık G, Yüksel M, Abay M et al. · 2026 · Veterinary journal (London, England : 1997)

The present study aimed to determine the diagnostic accuracy of the commercial Alertys OnFarm Pregnancy Test (AOPT) based on pregnancy-associated glycoprotein (PAG) for early pregnancy diagnosis in ewes. A total of 100 multiparous Awassi…

View details →DOI: 10.1016/j.tvjl.2026.106584
Negative / Null Result ReportOpen accessMedicine

Non-Articular Osseous Sarcoidosis: A Rare Case of Active Sarcoidosis with Progressive Lung Lesions and Normal Inflammation Biomarkers.

Zhang J, Hu Y, Dong P et al. · 2025 · Diagnostics (Basel, Switzerland)

Sarcoidosis is a rare multisystem inflammatory disease characterized by non-necrotizing granulomas, typically affecting the lungs, lymph nodes, skin, and bones. Due to its extreme clinical heterogeneity, diagnosis remains challenging.…

View details →DOI: 10.3390/diagnostics15091135
Negative / Null Result ReportOpen accessMedicine

Multiplex qPCR for the early detection of sepsis pathogens and its impact on antimicrobial therapy in critically ill patients.

Pandey P, Bir R, Chatterjee K et al. · 2026 · Iranian journal of microbiology

Background and objectives Sepsis is a life threatening condition caused by a dysregulated host response to infection and is associated with high morbidity and mortality worldwide. Early bacterial detection and therapy with antibiotics…

View details →DOI: 10.18502/ijm.v18i3.21654
Negative / Null Result ReportOpen accessMedicine

Molecular investigation of Neospora caninum in cattle in the Khomas region of Namibia.

Samkange A, Chitanga S, Mbiri P et al. · 2025 · The Onderstepoort journal of veterinary research

Neosporosis is a leading cause of bovine abortions worldwide, with a substantial economic impact because of reproductive losses, costing the cattle industry billions of dollars annually. Despite the global significance of Neospora caninum,…

View details →DOI: 10.4102/ojvr.v92i1.2237
Negative / Null Result ReportMedicine

Evaluation of dried blood spot testing for serological monitoring of epizootic and zoonotic pathogens in domestic pigs.

Steinhauer R, Kübler E, Gaugler S et al. · 2026 · Journal of virological methods

Dried blood spots (DBS) constitute a stable, cost-efficient sampling matrix that can be collected in a minimally invasive manner. Although widely adopted in human medicine, their use in veterinary diagnostics remains limited. This study…

View details →DOI: 10.1016/j.jviromet.2025.115336
Negative / Null Result ReportMedicine

Radiation dosimetry of <sup>15</sup>O-water based on dynamic large axial field of view PET.

Lubberink M, Åhlström A, Tolvanen T et al. · 2026 · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Purpose Previously published effective dose coefficient estimates for 15 O-water are around 1 μSv/MBq, resulting in an effective dose of around 0.4 mSv for a typically injected activity of 400 MBq in clinical cardiac scans. These estimates…

View details →DOI: 10.1016/j.nuclcard.2026.102775
Negative / Null Result ReportMedicine

Application and Evaluation of a Formative Feedback Rubric on Nontechnical Skills Using Retrospective SIMPL App Data in General Surgery Residents.

Cloonan MR, Maginot ER, Tieken KR et al. · 2026 · Journal of surgical education

To determine the frequency of nontechnical skills (NTS) feedback provided by attending surgeons through narrative comments and assess its effectiveness using a validated formative feedback rubric. This retrospective cross-sectional study…

View details →DOI: 10.1016/j.jsurg.2026.104035
Negative / Null Result ReportOpen accessMedicine

Economic evaluation of the second-line regimen of liposome irinotecan (II) combined with 5-FU/LV versus placebo combined with 5-FU/LV for locally advanced or metastatic pancreatic ductal adenocarcinoma in China.

Huang J, Ye H, Lin J et al. · 2026 · PloS one

Background The cost-effectiveness of liposome irinotecan (II) (HR070803) in combination with 5-fluorouracil and leucovorin as a treatment for patients with locally advanced or metastatic pancreatic ductal adenocarcinoma offering a…

View details →DOI: 10.1371/journal.pone.0351853
Negative / Null Result ReportMedicine

Clinical efficacy of portable, cost-effective manual thermal pulsation for obstructive meibomian gland dysfunction and factors associated with therapeutic efficacy.

Cheng X, Huang H, Fan Z et al. · 2026 · BMJ open ophthalmology

Objective To evaluate the efficacy and safety of portable, cost-effective manual thermal pulsation as a single therapy for meibomian gland dysfunction (MGD) and to compare the microbiota and lipid composition in subjects with different…

View details →DOI: 10.1136/bmjophth-2026-002769
Negative / Null Result ReportMedicine

Chronic toxicity and uptake of 10 Per- and Polyfluoroalkyl Acids to marine species Americamysis bahia and Atherinops affinis.

Hayman NT, Pandelides Z, Colvin MA et al. · 2026 · Environmental toxicology and chemistry

A lack of marine specific data results in challenges to assessing site-specific ecological risks and developing marine water quality criteria for per- and polyfluoroalkyl substances (PFAS). Here, the toxicity and bioaccumulation of…

View details →DOI: 10.1093/etojnl/vgag168
Negative / Null Result ReportMedicine

Effective Coverage of Rehabilitation for Adults with Chronic Primary Low Back Pain in Uganda.

De Groote W, Taremwa Y, Duttine A et al. · 2026 · International journal of environmental research and public health

In Uganda, in 2019, 6.8 million people experienced health conditions that are amenable to rehabilitation. This is largely due to musculoskeletal disorders such as low back pain (LBP). Measuring effective coverage of rehabilitation means…

View details →DOI: 10.3390/ijerph23060693
Negative / Null Result ReportMedicine

National medical occupational radiation dose monitoring in Saudi Arabia.

Aljuaid M, Alsiraj K · 2026 · Annals of the ICRP

This is a national study about the occupational Radiation doses for medical workers in the Kingdom of Saudi Arabia which covers the period since the establishment of the Nuclear and Radiological Regulatory Commission (NRRC). The study aims…

View details →DOI: 10.1177/01466453251411988
Negative / Null Result ReportOpen accessMedicine

Awareness of Effective Communication Skills Among Paediatric Dentists in Turkey.

Büyüksefil M, Çimen Ü, Şimşek Derelioğlu S et al. · 2026 · Oral health & preventive dentistry

Purpose Effective communication with paediatric patients is one of the cornerstones of paediatric dentistry. Strong communication skills play a critical role in reducing dental anxiety, enhancing patient satisfaction, and facilitating the…

View details →DOI: 10.3290/j.ohpd.c_2680
Negative / Null Result ReportMedicine

Comparison of effective phacoemulsification times used in cataract surgery between the Veritas Vision System and the Centurion Vision System.

Choi JY, Song WS, Won YK et al. · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the effective phacoemulsification time used in cataract surgery and postoperative outcomes between the Veritas and the Centurion Vision System. Methods A retrospective analysis was conducted on 90 eyes from 82 patients…

View details →DOI: 10.3341/kjo.2025.0196
Negative / Null Result ReportMedicine

Effective population size and N e /N ratio for two populations of Northern chamois (Rupicapra rupicapra) on the edge of the species' distribution range.

Jacobs S, Edelhoff H, Ebert C et al. · 2026 · BMC ecology and evolution

Effective population size (Ne) is a fundamental parameter in conservation genetics, providing relevant information on the adaptability and long-term viability of populations. In contrast, wildlife management strategies, particularly for…

View details →DOI: 10.1186/s12862-026-02543-7
Negative / Null Result ReportMedicine

Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N'Zérékoré, Guinea, 2022.

Cherif IS, Essis EML, Diallo MA et al. · 2026 · Case reports in infectious diseases

Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a…

View details →DOI: 10.1155/crdi/2672939
Negative / Null Result ReportMedicine

Unfolding prion misfolding and the challenge of identifying effective therapeutics: is there hope on the horizon?

Sabzehei S, Innocenti N, Rigoli M et al. · 2026 · Expert opinion on drug discovery

Introduction Prion diseases are rare, fatal neurodegenerative disorders caused by the conformational conversion of cellular prion protein (PrP) into a pathogenic counterpart called PrP Sc , that replicates by templated misfolding. The…

View details →DOI: 10.1080/17460441.2026.2688321
Negative / Null Result ReportOpen accessMedicine

Vessel diameter as a potential predictor of pulsed dye laser response in port wine stain: a retrospective exploratory reflectance confocal microscopy study.

Ran X, Shang Y, Yang X et al. · 2026 · Lasers in medical science

To investigate whether noninvasive reflectance confocal microscopy (RCM)-derived vascular parameters can serve as objective predictors of therapeutic response to pulsed dye laser (PDL) treatment in patients with port wine stain (PWS),…

View details →DOI: 10.1007/s10103-026-04906-4