Negative / Null Result ReportOpen accessMedicine
Palepu K, Sadeghi K, Kleinschmidt DF et al. · 2023 · BMC neurology
Background Sleep spindle activity is commonly estimated by measuring sigma power during stage 2 non-rapid eye movement (NREM2) sleep. However, spindles account for little of the total NREM2 interval and therefore sigma power over the…
View details →DOI: 10.1186/s12883-023-03376-3 Negative / Null Result ReportOpen accessMedicine
Trombetta AB, Hanney WJ, Anderson AW et al. · 2026 · Muscles (Basel, Switzerland)
Background Tensiomyography (TMG) offers a noninvasive means of evaluating skeletal muscle contractile properties, including muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts).…
View details →DOI: 10.3390/muscles5020030 Negative / Null Result ReportOpen accessMedicine
Errington TM, Mathur M, Soderberg CK et al. · 2021 · eLife
Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer…
View details →DOI: 10.7554/elife.71601 Negative / Null Result ReportMedicine
Giesen CG, Eder AB · 2022 · Cognition & emotion
The adaptation-by-binding account and the arousal-biased competition model suggest that emotional arousal increases binding effects for transient links between stimuli and responses. Two highly-powered, pre-registered experiments tested…
View details →DOI: 10.1080/02699931.2022.2130180 Negative / Null Result ReportMedicine
Ianni KM, Chernew ME, McWilliams JM · 2026 · Health services research
Objective To examine the effects of offering non-emergency medical transportation (NEMT) on care utilization among low-income and disabled beneficiaries in Medicare Advantage (MA). Study setting and design We leveraged the 2019 expansion…
View details →DOI: 10.1111/1475-6773.70086 Negative / Null Result ReportOpen accessMedicine
Jaeger B, Jones AL, Satchell L et al. · 2026 · International review of social psychology
The role of perceiver differences in impression formation remains relatively poorly understood. One line of research has tried to understand these differences by exploring the role of perceivers' needs and motivations, reasoning that…
View details →DOI: 10.5334/irsp.996 Negative / Null Result Report
Rafiee Y, Jones BC, Shiramizu VKM · 2022 · Preprint
The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone. However, evidence…
View details →DOI: 10.31234/osf.io/9fsgq Negative / Null Result ReportMedicine
Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
View details →DOI: 10.1016/j.semradonc.2025.07.002 Negative / Null Result ReportOpen accessMedicine
Tebib N, Liaudet L, Ltaief Z · 2026 · Journal of intensive care
Background In patients with refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, but optimal strategies to promote myocardial recovery and facilitate ECMO weaning…
View details →DOI: 10.1186/s40560-026-00884-5 Negative / Null Result ReportOpen accessMedicine
Xu H, Yan Y, Niu J et al. · 2026 · BMC cancer
BACKGROUND: Metastatic colorectal cancer (mCRC) patients who progress following the standard chemotherapy have maintained a favourable performance status. Nevertheless, there are limited effective treatment options, particularly for a…
View details →DOI: 10.1186/s12885-026-15705-z Negative / Null Result ReportMedicine
Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology
Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…
View details →DOI: 10.1007/s10147-025-02877-0 Negative / Null Result ReportMedicine
Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…
View details →DOI: 10.1158/1078-0432.ccr-23-3936 Negative / Null Result ReportMedicine
Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports
Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…
View details →DOI: 10.1007/s11910-024-01335-0 Negative / Null Result ReportOpen accessMedicine
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
View details →DOI: 10.1016/j.jbspin.2023.105543 Negative / Null Result ReportMedicine
Asaithambi G, Castro-Pearson S, Meyer MK et al. · 2023 · Nutrition, metabolism, and cardiovascular diseases : NMCD
Background and aims Stroke is a major cause of mortality and disability, highlighting the importance of prevention. Clinical trials play an important role in evaluating interventions that can maximize stroke prevention. Traditional…
View details →DOI: 10.1016/j.numecd.2023.07.028 Negative / Null Result ReportMedicine
Poplin T, Kuplicki R, Walker EA et al. · 2025 · Biological psychiatry. Cognitive neuroscience and neuroimaging
Background Major depressive disorder (MDD) with comorbid anxiety presents significant treatment challenges, with high relapse rates and suboptimal outcomes. Transcranial direct current stimulation (tDCS) offers a scalable, noninvasive…
View details →DOI: 10.1016/j.bpsc.2025.10.020 Negative / Null Result ReportOpen accessMedicine
Webers C, Been M, van Tubergen A · 2023 · Current opinion in rheumatology
Purpose of review For almost a decade, treat-to-target (T2T) has been advocated as a management strategy for axial spondyloarthritis (axSpA), despite a lack of trial evidence. Recently, the first and only published T2T trial in axSpA did…
View details →DOI: 10.1097/bor.0000000000000941 Negative / Null Result ReportOpen accessMedicine
Gatto L, Di Nunno V, Tosoni A et al. · 2023 · Cancers
The lack of significant improvement in the prognosis of patients with GB over the last decades highlights the need for innovative treatments aimed at fighting this malignancy and increasing survival outcomes. The results of the phase III…
View details →DOI: 10.3390/cancers15123251 Negative / Null Result ReportOpen accessMedicine
Sciscione AC, Booker WA, Clifton RG et al. · 2026 · Obstetrics and gynecology
Objective Activity restriction is commonly recommended in pregnancy despite lacking evidence of benefit. We sought to evaluate the amount of physical activity in patients at high risk for preterm birth and pregnancy latency and preterm…
View details →DOI: 10.1097/aog.0000000000006225 Negative / Null Result ReportOpen accessMedicine
Aparajita, Barmon D, Baruah U et al. · 2025 · World journal of surgical oncology
Background Recent studies have found the presence of post- hysterectomy atypical glandular cells in upper vagina in ~ 30% patients of Endometrial Cancer (EC) with implications of causing isolated vaginal recurrence. The primary objective…
View details →DOI: 10.1186/s12957-025-04121-5 Negative / Null Result ReportOpen accessMedicine
Cai LY, Hoseinyazdi M, Lakhani DA et al. · 2025 · Stroke (Hoboken, N.J.)
Background Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO)…
View details →DOI: 10.1161/svin.125.001900 Negative / Null Result ReportMedicine
Mol F, Scheltinga M, Roumen R et al. · 2023 · Neuromodulation : journal of the International Neuromodulation Society
Objectives Approximately 10% of patients who undergo inguinal hernia repair or Pfannenstiel incision develop chronic (> three months) postsurgical inguinal pain (PSIP). If medication or peripheral nerve blocks fail, a neurectomy is the…
View details →DOI: 10.1016/j.neurom.2022.09.014 Negative / Null Result ReportOpen accessMedicine
Nathan SD, Lacasse V, Bell H et al. · 2024 · Pulmonary circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →DOI: 10.1002/pul2.12430 Negative / Null Result ReportOpen accessMedicine
Ghimouz A, Dureau S, Carton M et al. · 2026 · Scientific reports
The value of music (MUS) and virtual reality (VR) in reducing pain or anxiety during central venous port implantation (CVPI) is controversial. We conducted a randomised multicenter controlled trial in 127 patients who received either MUS…
View details →DOI: 10.1038/s41598-026-42184-w Negative / Null Result ReportMedicine
Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
View details →DOI: 10.1158/1078-0432.ccr-24-2885 Negative / Null Result ReportMedicine
Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine
Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…
View details →DOI: 10.1097/ccm.0000000000006522 Negative / Null Result ReportOpen accessMedicine
Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)
Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…
View details →DOI: 10.1161/svin.125.002175 Negative / Null Result ReportOpen accessMedicine
Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
View details →DOI: 10.1245/s10434-025-18025-x Negative / Null Result ReportOpen accessMedicine
Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)
With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…
View details →DOI: 10.1002/trc2.12485 Negative / Null Result ReportMedicine
Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry
Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…
View details →DOI: 10.1016/j.jaac.2021.11.034 