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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20230 results in Negative / Null Result Report · page 280 of 675

Negative / Null Result ReportMedicine

Post-AI uterine lavage and PRP infusion reduce some uterine inflammation parameters but do not improve fertility in jennies inseminated with frozen semen.

Sancler-Silva YFR, Albino MV, Freitas MS et al. · 2026 · Journal of equine veterinary science

Background The use of cryopreserved semen in donkey jennies induces an exacerbated post-insemination uterine inflammatory response, resulting in low fertility rates. Aims/objectives This study aimed to investigate the effects of different…

View details →DOI: 10.1016/j.jevs.2026.106061
Negative / Null Result ReportMedicine

Crystalline Lens Shape During Accommodation in Children.

Pradhan A, Hughes RPJ, Woodman-Pieterse EC et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose To determine how accommodation affects lens shape in myopic and non-myopic children. Methods Participants included 76 non-myopic (spherical equivalent refraction (SER): 0.00 to +1.75 D) and 18 myopic children (SER = -3.50 to -0.75…

View details →DOI: 10.1007/s44402-026-00069-5
Negative / Null Result Report

The Utility of MRI for spinal clearance in blunt trauma. A retrospective cohort study of 539 blunt trauma patients in a level one trauma center in Singapore

Cayden L, Chandrasagran RA, Adam C et al. · 2026 · Preprint

Abstract Introduction: The majority of spinal injuries occur secondary to blunt trauma and patients with significant blunt trauma must be assumed to have an unstable spinal injury until complete radiological and clinical assessment. MRI…

View details →DOI: 10.21203/rs.3.rs-9464497/v1
Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

View details →DOI: 10.1113/ep093636
Negative / Null Result ReportMedicine

Voiding Function, Pain Level, and Patient Satisfaction after Gender-Affirming Surgery of Transgender Women: A Prospective Evaluation.

Wenk MJ, Rademacher N, Liedl B et al. · 2026 · Urologia internationalis

Introduction The aim of the study was to prospectively evaluate patient and clinician reported outcomes of voiding function, pain levels and patient satisfaction of transgender women preoperatively (t0), 6 months (t1), and 12 months (t2)…

View details →DOI: 10.1159/000551982
Negative / Null Result ReportMedicine

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt-1 in women with new onset hypertension in pregnancy.

Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…

View details →DOI: 10.1111/aogs.70221
Negative / Null Result ReportMedicine

Self-disclosure to Peers and Changes in Personal Recovery in Community-dwelling People with Mental Disorders: A One-year Longitudinal Study.

Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal

This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…

View details →DOI: 10.1007/s10597-026-01661-2
Negative / Null Result ReportMedicine

Dupilumab in the treatment of severe chronic rhinosinusitis with nasal polyps (CRSwNP) in cystic fibrosis patients.

Di Girolamo A, Cristallo M, Daddato MF et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Chronic rhinosinusitis with nasal polyps (CRSwNP) manifests as either a solitary upper airway involvement or as part of a more intricate clinical picture, such as Cystic Fibrosis (CF). The altered viscoelastic properties of mucus…

View details →DOI: 10.1016/j.jcf.2026.04.003
Negative / Null Result ReportMedicine

Tight stomatal regulation and high intrinsic capacity of carbon assimilation inferred from isotopic composition negatively correlate with drought-driven decline in sclerophyllous species.

Piper FI, Paula S, Urrutia-Jalabert R · 2026 · Annals of botany

Background and aims Long-term droughts reduce the carbon (C) and water pools of trees, causing mortality. However, the underlying physiological mechanisms explaining tree mortality remain unclear, and evidence from mature forests is…

View details →DOI: 10.1093/aob/mcag100
Negative / Null Result ReportMedicine

A Comparison of Recovery Curves in Total Knee Arthroplasty With and Without Soft-Tissue Releases.

Metz AK, Loughmiller SK, Braathen DL et al. · 2026 · The Journal of arthroplasty

Background The use of alternative alignment strategies has become commonplace in performing total knee arthroplasty (TKA). A primary reported benefit of these techniques is a reduction in the need for soft-tissue releases for appropriate…

View details →DOI: 10.1016/j.arth.2026.03.082
Negative / Null Result ReportMedicine

Resting energy expenditure in children with cancer undergoing chemotherapy using indirect calorimetry: A longitudinal study.

Froon-Torenstra D, Renting L, Ijpma I et al. · 2026 · Clinical nutrition ESPEN

Background and aims Malnutrition is common among children with cancer and is related to treatment-related toxicity, mortality and lower quality of life. So far, it remains unknown whether changes in resting energy expenditure (REE)…

View details →DOI: 10.1016/j.clnesp.2026.103331
Negative / Null Result Report

Changes in species composition of sessile communities on subtidal rock walls in the southern Gulf of Maine during four decades of warming

McCollum BA, Byrnes JEK, Sebens KP · 2026 · Preprint

Climate change is driving species range shifts and population change in density and location globally. Two theories behind these shifts, that species in the ocean are largely tracking climate velocities, and the concept of long-term…

View details →DOI: 10.64898/2026.03.01.708879
Negative / Null Result ReportMedicine

Evolution of the rate, molecular spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans.

Saber S, Rifat MMI, Rahimi F et al. · 2026 · Genetics

The rate, molecular spectrum, and fitness effects of mutations vary at all levels of the biological hierarchy, from within individual genomes to among taxonomic domains. Understanding the evolutionary factors underpinning that variation is…

View details →DOI: 10.1093/genetics/iyag085
Negative / Null Result ReportOpen accessMedicine

Short communication: performance of beef cows fed Kernza intermediate wheatgrass straw mixed with alfalfa haylage.

Pizarro DM, Crooks A, Wattiaux MA et al. · 2026 · Translational animal science

Kernza intermediate wheatgrass ( Thinopyrum intermedium [Host] Barkworth & D.R. Dewey) is a novel dual-use perennial grain and forage crop with environmental and economic benefits for farmers. Perennial crop byproducts, such as Kernza…

View details →DOI: 10.1093/tas/txaf131
Negative / Null Result ReportMedicine

Attentional lapses and mind wandering during the maintenance of visual attention over varying durations.

Zanesco AP, Spivey DJ, Horn LF et al. · 2026 · Attention, perception & psychophysics

Sustaining the focus of our attention is effortful and cannot be maintained indefinitely. Our minds naturally wander, necessitating effortful control of attention to maintain focus and resist distraction from external events or internally…

View details →DOI: 10.3758/s13414-026-03229-4
Negative / Null Result ReportMedicine

How lability impacts the biological activity of polynuclear μ-oxo bridged ruthenium acetates.

Nazar PHO, Reis FCC, Barbosa HE et al. · 2026 · Journal of inorganic biochemistry

Complexes of the μ-oxo-bis(μ-acetate)diruthenium class exhibit ligand lability at the positions trans to the μ-oxo bridge. Lability is an important property for numerous drugs, such as cis-[Pt(NH 3 ) 2 Cl 2 ], given that its biological…

View details →DOI: 10.1016/j.jinorgbio.2026.113390
Negative / Null Result ReportMedicine

Position of Swing-Phase Foot Relative to Stance-Phase Foot at Minimum Toe Clearance: The Effect of Walking Speed.

Gomez NG, Gomez MA, MacWilliams BA et al. · 2026 · Journal of applied biomechanics

Minimum toe clearance (MTC) location relative to the stance-phase foot, as well as how this location changes with walking speed, helps in better understanding the circumstances when MTC is most relevant. This study helps define where MTC…

View details →DOI: 10.1123/jab.2025-0327
Negative / Null Result Report

Very short-term monitoring of Romosozumab longitudinal effects in a cohort of postmenopausal women by means of Radiofrequency Echographic Multi-Spectrometry (REMS) technology

Semeraro A, Chialà A, Carafa A et al. · 2026 · Preprint

Abstract Background Romosozumab/AMG785 (Evenity®, Amgen and UCB pharma, RMZ) is a sclerostin-neutralizing antibody that rapidly increases BMD, but very short-term monitoring in clinical routine is limited by specific issues of available…

View details →DOI: 10.21203/rs.3.rs-9116907/v1
Negative / Null Result ReportMedicine

Minimally invasive evacuation for intracerebral hemorrhage: current practice and perspectives after ENRICH.

Incontri D, Kellner CP, Polymeris A et al. · 2026 · Journal of neurointerventional surgery

Background The results of the Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH) trial have renewed interest in minimally invasive hematoma evacuation (MIE) as a treatment option for intracerebral hemorrhage (ICH).…

View details →DOI: 10.1136/jnis-2025-023804
Negative / Null Result ReportMedicine

From Referral to Service: Initial Outcomes of a Mental Health Outreach Program for Sexual Assault Survivors.

Mai K, Salim SR, Tilstra-Ferrell E et al. · 2026 · Journal of forensic nursing

Aims To examine data from an early intervention program for mental health following recent sexual assault (SA) to compare referral and service utilization rates before and after a community-based outreach model was implemented. Methods In…

View details →DOI: 10.1097/jfn.0000000000000598
Negative / Null Result ReportMedicine

Linezolid-Induced Serotonin Release from QGP-1 Cells.

Tsutsumi T, Kashiwagi H, Imai S et al. · 2026 · Drug research

Background Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting…

View details →DOI: 10.1055/a-2815-4097
Negative / Null Result ReportMedicine

Octa evaluation of macular and optic disc vascular changes after PRP.

Karabacak DD, Doğruya S, Altınışık M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This study aimed to evaluate the impact of panretinal photocoagulation (PRP) on macular and optic nerve head microvascular parameters using optical coherence tomography angiography (OCTA) in eyes with proliferative diabetic…

View details →DOI: 10.1007/s00417-026-07220-5
Negative / Null Result ReportMedicine

Interaction of ambient temperature and conditioning temperatures on moisture addition throughout pelleting, the pelleting process, and enzyme activity

Renner A, Estanich EB, Lynch EA et al. · 2026 · Journal of Applied Poultry Research.

Thermal processes during steam conditioning and pellet die extrusion aid in pelleting but may degrade exogenous feed enzymes. This study determined how ambient temperature interacts with varying steam conditioning temperatures to influence…

Negative / Null Result ReportMedicine

Mindful Self-Compassion for Infertility-Related Distress: A Single-Group Intervention Study.

Halleran M, Balsom AA, Gordon JL · 2026 · Journal of integrative and complementary medicine

Objectives Women experiencing infertility report heightened levels of anxiety, depression, and distress. However, access to affordable mental health care is limited in most areas of the world. Self-directed interventions, including…

View details →DOI: 10.1177/27683605261427699
Negative / Null Result ReportOpen accessMedicine

Postoperative Reduction in Postvoid Residual Urine Volume May Be Associated With Bladder Capacity Decrease Rather Than an Increase in Tidal Voided Urine Volume in Patients With Pelvic Organ Prolapse.

Kuroda K, Miyoshi H, Hamamoto K et al. · 2026 · The journal of obstetrics and gynaecology research

Aim More than half of patients with pelvic organ prolapse (POP) complain of lower urinary tract symptoms (LUTS), especially voiding difficulty. Surgical approaches such as laparoscopic sacrocolpopexy (LSC) and transvaginal mesh surgery…

View details →DOI: 10.1111/jog.70358