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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20230 results in Negative / Null Result Report · page 273 of 675

Negative / Null Result ReportMedicine

Hormonal mechanism and pathogenetic therapy of citalopram-induced infertility in female rats.

Delibasi IB, Gumusburun N, Bulut S et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)

Citalopram is a selective serotonin reuptake inhibitor (SSRI) and has been associated with reproductive dysfunction in women. In this study, the effects of citalopram on reproductive health in female rats were investigated. Albino Wistar…

View details →DOI: 10.1016/j.reprotox.2025.108859
Negative / Null Result ReportOpen accessMedicine

Persistent Hyperparathyroidism in Vitamin D-Dependent Rickets Type 2A Does Not Prevent Normalization of Hypophosphatemia or Healing of the Rickets.

Lodefalk M, Nilsson O · 2025 · Hormone research in paediatrics

Introduction Vitamin D-dependent rickets type 2A (VDDR2A) is a rare, autosomal recessive disorder caused by pathogenic variants of the VDR gene encoding the vitamin D receptor. It has been proposed to be a form of parathyroid hormone…

View details →DOI: 10.1159/000546444
Negative / Null Result ReportOpen accessMedicine

A Nonrandomized Clinical Trial Investigating Keratinocyte Growth Factor-Hair Serum for the Prevention of Chemotherapy-Induced Alopecia.

Mann K, Potluri P, Paul EE et al. · 2026 · Journal of cosmetic dermatology

Introduction Chemotherapy-induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations are barriers for…

View details →DOI: 10.1111/jocd.70797
Negative / Null Result ReportOpen accessMedicine

Germination control by a hard seed coat: insights from a tropical legume.

Pereira GF, Sanches MC, De-Paula OC et al. · 2025 · Scientific reports

Classifying seed dormancy is an essential task for plant propagation; however, several plant species lack information about the kind of dormancy the seeds have or inaccurate reports are passed on without an in-depth investigation. We…

View details →DOI: 10.1038/s41598-025-27823-y
Negative / Null Result ReportMedicine

The tail segments are required by the performance but not the accomplishment of various modes of Drosophila larval locomotion.

He Y, Ding Y, Gong C et al. · 2024 · Behavioural brain research

The tail plays important roles in locomotion control in many animals. But in animals with multiple body segments, the roles of the hind body segments and corresponding innervating neurons in locomotion control are not clear. Here, using…

View details →DOI: 10.1016/j.bbr.2024.115074
Negative / Null Result ReportMedicine

Effects of Double J Stent (DJS) Placement Before Pediatric ESWL on Complications and Stone-free Rates.

Bosnali E, Mutlu N, Cakmak K et al. · 2025 · Journal of pediatric surgery

Background Pediatric urolithiasis remains a significant health problem in certain regions worldwide. Extracorporeal shock wave lithotripsy (ESWL) is the preferred treatment for upper urinary tract stones smaller than 20 mm in children due…

View details →DOI: 10.1016/j.jpedsurg.2025.162274
Negative / Null Result ReportOpen accessMedicine

Effect of N-Acetylcysteine, Ascorbic Acid, and a Vitamin E Analog on Oxidative and Storage Lesions in Canine Packed Red Blood Cells.

Roque-Torres JL, Woolcock AD, Santos A et al. · 2025 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objective To describe storage and oxidative lesions in canine packed red blood cells (pRBCs) during routine storage with additives, including saline, N-acetylcysteine (NAC), ascorbic acid (AA), and vitamin E analog (VE). Design…

View details →DOI: 10.1111/vec.70002
Negative / Null Result ReportOpen accessMedicine

Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy.

Battaglia-Vieni A, Marchant V, Tejedor-Santamaria L et al. · 2025 · Pharmaceuticals (Basel, Switzerland)

Background/Objectives : Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the…

View details →DOI: 10.3390/ph18060822
Negative / Null Result ReportMedicine

Electrical Muscle Stimulation With or Without Blood Flow Restriction Does Not Prevent the Impairment in Glycemic Control After 1 Week of Physical Inactivity.

Pignanelli C, Robertson AA, Handy RM et al. · 2025 · Scandinavian journal of medicine & science in sports

Physical inactivity depresses glycemic control, an impairment that can be prevented with exercise. We investigated whether electrical muscle stimulation (EMS) with blood flow restriction (BFR) could similarly prevent the impairments in…

View details →DOI: 10.1111/sms.70056
Negative / Null Result ReportOpen accessMedicine

Effects of Ovariectomy and Sex Steroids on Prolactin Synthesis.

Cairang Z, Kanasaki H, Tumurbaatar T et al. · 2025 · International journal of endocrinology

Prolactin (PRL) plays a variety of roles to maintain female reproductive functions. In female rats, Prl mRNA expression in the anterior pituitary was significantly suppressed by OVX. The OVX-induced inhibition of PRL expression was…

View details →DOI: 10.1155/ije/8883536
Negative / Null Result ReportOpen accessMedicine

Multiple myeloma extramedullary relapse at the sellar and suprasellar region after autologous stem cell transplantation.

De Jesus O · 2024 · Surgical neurology international

Background The effectiveness of autologous stem cell transplantation (ASCT) in preventing the development of central nervous system (CNS) plasmacytomas in multiple myeloma (MM) patients is not well understood. An ASCT patient who developed…

View details →DOI: 10.25259/sni_964_2023
Negative / Null Result ReportMedicine

Effects of Grazing by Native and Non-Native Terrestrial Vertebrates on the Growth of Tecticornia arbuscula in Australian Temperate Saltmarshes

Prahalad V, Aalders J, Kirkpatrick JB · 2024 · Wetlands.

The effects of grazing and browsing by terrestrial vertebrates are poorly understood for southern hemisphere saltmarshes, many of which are recovering from stock grazing. We investigated whether the native late-successional shrub,…

View details →DOI: 10.1007/s13157-024-01859-8
Negative / Null Result ReportMedicine

Association of the addition of a multicomponent additive to the human milk provided to preterm newborns with outcomes: A prospective cohort.

Mendes TGM, Nunes ACP, Dantas de Carvalho AV et al. · 2025 · Clinical nutrition ESPEN

Background The nutritional needs of preterm newborns (PTNB) are increased and enhancing nutritional management is essential to meet them. The addition of multicomponent additive (MA) to human milk (HM) is used as a treatment strategy. The…

View details →DOI: 10.1016/j.clnesp.2025.03.032
Negative / Null Result ReportMedicine

Arrhythmic Risk and Clinical Features in Catecholaminergic Polymorphic Ventricular Tachycardia: Results From a Multicenter Study in Korea.

Cho MJ, Song MK, Jun SY et al. · 2025 · The American journal of cardiology

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but life-threatening inherited arrhythmia in children, often associated with sudden cardiac death (SCD). Risk stratification remains challenging. This study aimed to…

View details →DOI: 10.1016/j.amjcard.2025.08.008
Negative / Null Result ReportOpen accessMedicine

Diverticular perforation with exclusive local invasion in cytomegalovirus infection during ganciclovir treatment: an autopsy case report.

Ishiguro Y, Kuriyama A, Ishiguro S · 2025 · Annals of medicine and surgery (2012)

Introduction and importance Cytomegalovirus (CMV) can cause severe colitis in immunocompromised patients. While its morphological manifestations vary, diverticular perforation is rare, with most lesions remaining intact. We report a rare…

View details →DOI: 10.1097/ms9.0000000000003573
Negative / Null Result ReportMedicine

Is Liver Transplantation Alone an Effective Treatment for Homozygotic Familial Hypercholesterolemia in Children?

Yılmaz Dağlı H, Artan R, Civan DD et al. · 2024 · Pediatric transplantation

Aim To examine the long-term results and treatment effectiveness of liver transplantation (LT) in the treatment of homozygous familial hypercholesterolemia (HoFH) in children and adolescents. Method Patients who underwent LT due to HoFH…

View details →DOI: 10.1111/petr.14853
Negative / Null Result ReportOpen accessMedicine

Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy.

Zierke L, Gischke M, Sendler M et al. · 2026 · Molecular biomedicine

Acute pancreatitis is caused by a premature activation of digestive proteases. One hypothesis is based on the proteolytic activation of the serine protease trypsinogen by the lysosomal enzyme cathepsin B (CTSB) after co-localization in the…

View details →DOI: 10.1186/s43556-026-00479-4
Negative / Null Result ReportOpen accessMedicine

Oxidative stress impairs processive motility of the axonal transport motor KIF1A.

Chen AP, Pandey H, Hancock WO · 2026 · The Journal of biological chemistry

The kinesin-3 family member, KIF1A is an essential motor protein that carries out intracellular transport in neurons. Previous work has established that: (1) intracellular transport can be impaired in neurodegenerative diseases such as…

View details →DOI: 10.1016/j.jbc.2026.111471
Negative / Null Result ReportMedicine

Peripherally administered TNF inhibitor is not protective against α-synuclein-induced dopaminergic neuronal death in rats.

Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2025 · Neurobiology of disease

The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an important…

View details →DOI: 10.1016/j.nbd.2025.106803
Negative / Null Result ReportOpen accessMedicine

Occupational Transmission of Measles Despite COVID-19 Precautions.

De Carli G, Giombini E, Colosi A et al. · 2025 · Pathogens (Basel, Switzerland)

To determine whether patient-to-doctor transmission of measles occurred in an emergency department (ED) despite isolation precautions and full personal protective equipment (PPE) during the COVID-19 pandemic, an epidemiological and…

View details →DOI: 10.3390/pathogens14060519
Negative / Null Result ReportOpen accessMedicine

GalNAc Carbohydrate Prevents the Formation of Neutrophil Extracellular Traps and Increase Myeloperoxidase Enzyme Activity in Interactions of Neutrophils and Entamoeba histolytica Preincubated With GalNAc.

Levaro-Loquio D, Cruz-Baquero A, Higuera-Martínez G et al. · 2026 · BioMed research international

During amoebic infection, neutrophils are the first cells of the immune system to interact with trophozoites of Entamoeba histolytica, initiating amoebicidal activity. Different lectins and carbohydrates can participate in the mechanism of…

View details →DOI: 10.1155/bmri/8280585
Negative / Null Result ReportOpen accessMedicine

Impact of age on the reliability of GE Entropy™ module indices for guidance of maintenance of anaesthesia in adult patients: a single-centre retrospective analysis.

Ebensperger M, Kreuzer M, Kratzer S et al. · 2025 · British journal of anaesthesia

Background The GE Entropy™ module uses frontal EEG to compute the processed indices state entropy (SE), response entropy (RE), and burst suppression ratio (BSR) to guide maintenance of anaesthesia by supposedly minimising overly 'deep' or…

View details →DOI: 10.1016/j.bja.2024.11.050
Negative / Null Result Report

Peripherally administered TNF inhibitor is not protective against α-synuclein-induced dopaminergic neuronal death in rats

Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2024 · Preprint

ABSTRACT The underlying cause of neuronal loss in Parkinson’s disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an…

View details →DOI: 10.1101/2024.10.11.617361
Negative / Null Result ReportMedicine

Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells.

Henriksen K, Jørgensen A, Kaur S et al. · 2025 · Molecular and cellular endocrinology

Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…

View details →DOI: 10.1016/j.mce.2025.112522
Negative / Null Result ReportMedicine

Subthreshold Micropulse Laser for Eyes: With Center Involving Diabetic Macular Edema With Good Visual Acuity: The PULSE Study, a Randomized Clinical Trial.

Feldman S, Basra J, Lawani A et al. · 2025 · Ophthalmic surgery, lasers & imaging retina

Background and objective To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA). Patients and methods Prospective, single-masked,…

View details →DOI: 10.3928/23258160-20240924-03