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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21173 results · page 27 of 706

Negative / Null Result ReportOpen accessNeuroscience

Brain-derived neurotrophic factor (BDNF) as a potential mechanism of the effects of acute exercise on cognitive performance

Aaron T. Piepmeier, Jennifer L. Etnier · 2014 · Journal of sport and health science/Journal of Sport and Health Science

The literature shows that improvements in cognitive performance may be observed following an acute bout of exercise. However, evidence in support of the biological mechanisms of this effect is still limited. Findings from both rodent and…

View details →DOI: 10.1016/j.jshs.2014.11.001Cited by 212
Negative / Null Result ReportOpen accessSocial Sciences

The Effect of Education on Criminal Convictions and Incarceration: Causal Evidence from Micro-data

Randi Hjalmarsson, Helena Holmlund, Matthew J. Lindquist · 2014 · The Economic Journal

This article studies the causal effect of educational attainment on conviction and incarceration using Sweden's compulsory schooling reform as an instrument for years of schooling and a 70% sample from Sweden's Multigenerational Register…

View details →DOI: 10.1111/ecoj.12204Cited by 211
Negative / Null Result ReportOpen accessMedicine

Associations of specific types of sports and exercise with all-cause and cardiovascular-disease mortality: a cohort study of 80 306 British adults

Pekka Oja, Paul Kelly, Željko Pedišić et al. · 2016 · British Journal of Sports Medicine

BACKGROUND/AIM: Evidence for the long-term health effects of specific sport disciplines is scarce. Therefore, we examined the associations of six different types of sport/exercise with all-cause and cardiovascular disease (CVD) mortality…

View details →DOI: 10.1136/bjsports-2016-096822Cited by 211
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Women’s empowerment in agriculture and agricultural productivity: Evidence from rural maize farmer households in western Kenya

Gracious Diiro, Greg Seymour, Menale Kassie et al. · 2018 · PLoS ONE

This paper documents a positive relationship between maize productivity in western Kenya and women's empowerment in agriculture, measured using indicators derived from the abbreviated version of the Women's Empowerment in Agriculture Index. Applying a cross-sectional instrumental-variable regression method to a data set of 707 maize farm households from western Kenya, we find that women's empowerment in agriculture significantly increases maize productivity. Although all indicators of women's empowerment significantly increase productivity, there is no significant association between the women

View details →DOI: 10.1371/journal.pone.0197995Cited by 211
Negative / Null Result ReportSocial Sciences

Does Ethnic Diversity Erode Trust? Putnam’s ‘Hunkering Down’ Thesis Reconsidered

Patrick Sturgis, Ian Brunton‐Smith, Sanna Read et al. · 2010 · British Journal of Political Science

We use a multi-level modelling approach to estimate the effect of ethnic diversity on measures of generalized and strategic trust using data from a new survey in Britain with a sample size approaching 25,000 individuals. In addition to the…

View details →DOI: 10.1017/s0007123410000281Cited by 211
Negative / Null Result ReportOpen accessComputer Science

Relevance of deep learning to facilitate the diagnosis of HER2 status in breast cancer

Michel E. Vandenberghe, Marietta Scott, Paul W. Scorer et al. · 2017 · Scientific Reports

Tissue biomarker scoring by pathologists is central to defining the appropriate therapy for patients with cancer. Yet, inter-pathologist variability in the interpretation of ambiguous cases can affect diagnostic accuracy. Modern artificial intelligence methods such as deep learning have the potential to supplement pathologist expertise to ensure constant diagnostic accuracy. We developed a computational approach based on deep learning that automatically scores HER2, a biomarker that defines patient eligibility for anti-HER2 targeted therapies in breast cancer. In a cohort of 71 breast tumour r

View details →DOI: 10.1038/srep45938Cited by 211
Negative / Null Result ReportOpen accessChemistry

MoMo: discovery of statistically significant post-translational modification motifs

Alice Cheng, Charles E. Grant, William Stafford Noble et al. · 2018 · Bioinformatics

MOTIVATION: Post-translational modifications (PTMs) of proteins are associated with many significant biological functions and can be identified in high throughput using tandem mass spectrometry. Many PTMs are associated with short sequence…

View details →DOI: 10.1093/bioinformatics/bty1058Cited by 211
Negative / Null Result ReportEconomics, Econometrics and Finance

Aggregate Idiosyncratic Volatility

Geert Bekaert, Robert J. Hodrick, Xiaoyan Zhang · 2012 · Journal of Financial and Quantitative Analysis

Abstract We examine aggregate idiosyncratic volatility in 23 developed equity markets, measured using various methodologies. We find no evidence of upward trends after extending the sample to 2008. Instead, idiosyncratic volatility is well…

View details →DOI: 10.1017/s0022109012000543Cited by 211
Negative / Null Result ReportSocial Sciences

Family policies and single parent poverty in 18 OECD countries, 1978–2008

Laurie C. Maldonado, Rense Nieuwenhuis · 2015 · Community Work & Family

This study examined to what extent family policies differently affect poverty among single-parent households and two-parent households. We distinguished between reconciliation policies (tested with parental leave and the proportion of…

View details →DOI: 10.1080/13668803.2015.1080661Cited by 211
Negative / Null Result ReportSocial Sciences

Why Do Countries Adopt Constitutional Review?

T. Ginsburg, Mila Versteeg · 2013 · The Journal of Law Economics and Organization

In recent decades, there has been a wide-ranging global movement towards constitutional review. This development poses important puzzles of political economy: Why would self-interested governments willingly constrain themselves by…

View details →DOI: 10.1093/jleo/ewt008Cited by 210
Negative / Null Result ReportOpen accessEnvironmental Science

Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study

Eva Cecilie Bonefeld‐Jørgensen, Manhai Long, Rossana Bossi et al. · 2011 · Environmental Health

BACKGROUND: Breast cancer (BC) is the most common cancer for women in the western world. From very few cases an extraordinary increase in BC was observed in the Inuit population of Greenland and Canada although still lower than in western populations. Previous data suggest that exposure to persistent organic pollutants (POPs) might contribute to the risk of BC. Rat studies showed that perfluorinated compounds (PFCs) cause significantly increase in mammary fibroadenomas. This study aimed at evaluating the association between serum levels of POPs/PFCs in Greenlandic Inuit BC cases and their cont

View details →DOI: 10.1186/1476-069x-10-88Cited by 210
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

CEO equity risk bearing and strategic risk taking: The moderating effect of CEO personality

Mirko H. Benischke, Geoffrey Martin, Lotte Glaser · 2018 · Strategic Management Journal

Research Summary We draw upon applied psychology literature to explore interagent differences in perceived risk to their equity when making strategic risk decisions. Our theory suggests behavioral agency's predicted negative relationship between equity risk bearing and strategic risk taking is contingent upon four personality traits. Our empirical analyses, based on personality profiles of 158 Chief Executive Officers (CEOs) of S&P 1,500 firms in manufacturing industries, indicate the relationship between executive risk bearing and strategic risk taking crosses from negative to positive fo

View details →DOI: 10.1002/smj.2974Cited by 210
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

Federico Innocenti, Gregory M. Cooper, Ian B. Stanaway et al. · 2011 · PLoS Genetics

The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two independent collections of primary tissue profiled with Agilent (n = 206) and Illumina (n = 60) expression arrays and Illumina SNP genotyping (550K), and we also incorporated data from a published study (n = 266). We found that ∼30% of SNP-expression correlations in one study failed to replicate in either of the others, even at thresholds yielding high reproducibility in simulations, and

View details →DOI: 10.1371/journal.pgen.1002078Cited by 210
Negative / Null Result ReportOpen accessComputer Science

Insights Into LSTM Fully Convolutional Networks for Time Series Classification

Fazle Karim, Somshubra Majumdar, Houshang Darabi · 2019 · IEEE Access

Long short-term memory fully convolutional neural networks (LSTM-FCNs) and Attention LSTM-FCN (ALSTM-FCN) have shown to achieve the state-of-the-art performance on the task of classifying time series signals on the old University of…

View details →DOI: 10.1109/access.2019.2916828Cited by 210
Negative / Null Result ReportOpen accessNeuroscience

Human observers have optimal introspective access to perceptual processes even for visually masked stimuli

Megan A. K. Peters, Hakwan Lau · 2015 · eLife

Many believe that humans can 'perceive unconsciously' - that for weak stimuli, briefly presented and masked, above-chance discrimination is possible without awareness. Interestingly, an online survey reveals that most experts in the field recognize the lack of convincing evidence for this phenomenon, and yet they persist in this belief. Using a recently developed bias-free experimental procedure for measuring subjective introspection (confidence), we found no evidence for unconscious perception; participants' behavior matched that of a Bayesian ideal observer, even though the stimuli were visu

View details →DOI: 10.7554/elife.09651Cited by 210
Negative / Null Result ReportBusiness, Management and Accounting

The Adoption and Design of Enterprise Risk Management Practices: An Empirical Study

Leen Paape, Roland F. Speklé · 2012 · European Accounting Review

We examine (1) the extent of enterprise risk management (ERM) implementation and the factors that are associated with cross-sectional differences in the level of ERM adoption, and (2) specific risk management design choices and their…

View details →DOI: 10.1080/09638180.2012.661937Cited by 209
Negative / Null Result ReportOpen accessPhysics and Astronomy

STAR FORMATION AT 4 < z < 6 FROM THE SPITZER LARGE AREA SURVEY WITH HYPER-SUPRIME-CAM (SPLASH)

Charles L. Steinhardt, Joshua S. Speagle, P. Capak et al. · 2014 · The Astrophysical Journal Letters

Using the first 50% of data collected for the Spitzer Large Area Survey with Hyper-Suprime-Cam observations on the 1.8 deg^2 Cosmological Evolution Survey we estimate the masses and star formation rates of 3398 M_* > 10^(10) M_☉…

View details →DOI: 10.1088/2041-8205/791/2/l25Cited by 209
Negative / Null Result ReportSocial Sciences

Facebook news and (de)polarization: reinforcing spirals in the 2016 US election

Michael A. Beam, Myiah J. Hutchens, Jay D. Hmielowski · 2018 · Information Communication & Society

The rise of social media, and specifically Facebook, as a dominant force in the flow of news in the United States has led to concern that people incur greater isolation from diverse perspectives through filter bubbles (from algorithmic…

View details →DOI: 10.1080/1369118x.2018.1444783Cited by 209
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Sexual selection accelerates signal evolution during speciation in birds

Nathalie Seddon, Carlos A. Botero, Joseph A. Tobias et al. · 2013 · Proceedings of the Royal Society B Biological Sciences

Sexual selection is proposed to be an important driver of diversification in animal systems, yet previous tests of this hypothesis have produced mixed results and the mechanisms involved remain unclear. Here, we use a novel phylogenetic approach to assess the influence of sexual selection on patterns of evolutionary change during 84 recent speciation events across 23 passerine bird families. We show that elevated levels of sexual selection are associated with more rapid phenotypic divergence between related lineages, and that this effect is restricted to male plumage traits proposed to functio

View details →DOI: 10.1098/rspb.2013.1065Cited by 209
Negative / Null Result ReportOpen accessMedicine

Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor

Christoph Garbers, Wolfgang Thaiss, Gareth W. Jones et al. · 2011 · Journal of Biological Chemistry

IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling but was described to not interfere with classic signaling via the membrane-bound IL-6R. Physiological and most pathophysiological conditions are characterized by a molar excess of serum sIL-6R over IL-6 characterized by free IL-6 and IL-6 found in IL-6·sIL-6R complexes allowing both classic and trans-signaling. Surprisingly, under these conditions, sgp130 was able to trap all free IL-6 molecules in IL-6·sIL-6R·sg

View details →DOI: 10.1074/jbc.m111.295758Cited by 208
Negative / Null Result ReportOpen accessMedicine

The Alpha Defensin-1 Biomarker Assay can be Used to Evaluate the Potentially Infected Total Joint Arthroplasty

Joshua S. Bingham, Henry D. Clarke, Mark J. Spangehl et al. · 2014 · Clinical Orthopaedics and Related Research

BACKGROUND: Diagnosing a periprosthetic joint infection (PJI) requires a complex approach using various laboratory and clinical criteria. A novel approach to diagnosing these infections uses synovial fluid biomarkers. Alpha defensin-1…

View details →DOI: 10.1007/s11999-014-3900-7Cited by 208
Negative / Null Result ReportOpen accessMedicine

Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors

US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2018 · JAMA

Importance: Cardiovascular disease (CVD) is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk Score, the Pooled Cohort Equations, or similar CVD risk assessment models. If current CVD risk assessment models could be improved by adding more risk factors, treatment might be better targeted, thereby maximizing the benefits and minimizing the harms. Objective: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on using nontraditional risk factors in coron

View details →DOI: 10.1001/jama.2018.8359Cited by 207
Negative / Null Result ReportOpen accessMedicine

Neurofilament as a potential biomarker for spinal muscular atrophy

Basil T. Darras, Thomas O. Crawford, Richard S. Finkel et al. · 2019 · Annals of Clinical and Translational Neurology

Abstract Objective To evaluate plasma phosphorylated neurofilament heavy chain ( pNF ‐H) as a biomarker in spinal muscular atrophy ( SMA ). Methods Levels of pNF ‐H were measured using the ProteinSimple ® platform in plasma samples from…

View details →DOI: 10.1002/acn3.779Cited by 207
Negative / Null Result ReportOpen accessEnvironmental Science

LED lighting increases the ecological impact of light pollution irrespective of color temperature

Stephen M. Pawson, Martin Karl‐Friedrich Bader · 2014 · Ecological Applications

Recognition of the extent and magnitude of night-time light pollution impacts on natural ecosystems is increasing, with pervasive effects observed in both nocturnal and diurnal species. Municipal and industrial lighting is on the cusp of a…

View details →DOI: 10.1890/14-0468.1Cited by 207
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Trust, social capital, and the bond market benefits of ESG performance

Hami Amiraslani, Karl V. Lins, Henri Servaes et al. · 2022 · Review of Accounting Studies

Abstract We investigate whether a firm’s social capital and the trust that it engenders are viewed favorably by bondholders. Using firms’ environmental and social (E&S) performance to proxy for social capital, we find no relation between social capital and bond spreads over the period 2006–2019. However, during the 2008–2009 financial crisis, which represents a shock to trust and default risk, high-social-capital firms benefited from lower bond spreads. These effects are stronger for firms with higher expected agency costs of debt and firms whose E&S efforts are more salient. During th

View details →DOI: 10.1007/s11142-021-09646-0Cited by 207
Negative / Null Result ReportOpen accessMedicine

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure

James J. McNamee, Michael Gillies, Nicholas Barrett et al. · 2021 · JAMA

Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. Objective: To determine…

View details →DOI: 10.1001/jama.2021.13374Cited by 207
Negative / Null Result ReportOpen accessMedicine

Injury to the Premature Cerebellum: Outcome is Related to Remote Cortical Development

Catherine Limperopoulos, Gevorg Chilingaryan, Nancy Sullivan et al. · 2012 · Cerebral Cortex

Cerebellar injury is an important complication of preterm birth with far-reaching neuropsychiatric sequelae. We have previously shown a significant association between isolated injury to the premature cerebellum and subsequent impairment…

View details →DOI: 10.1093/cercor/bhs354Cited by 206
Negative / Null Result ReportOpen accessSocial Sciences

Auditing Partisan Audience Bias within Google Search

Ronald E. Robertson, Shan Jiang, Kenneth Joseph et al. · 2018 · Proceedings of the ACM on Human-Computer Interaction

There is a growing consensus that online platforms have a systematic influence on the democratic process. However, research beyond social media is limited. In this paper, we report the results of a mixed-methods algorithm audit of partisan…

View details →DOI: 10.1145/3274417Cited by 206
Negative / Null Result ReportDentistry

In Vitro Biofilm Formation on Titanium and Zirconia Implant Surfaces

Stefan Roehling, Monika Astasov‐Frauenhoffer, Irmgard Hauser‐Gerspach et al. · 2016 · Journal of Periodontology

Background: It has been hypothesized that zirconia might have a reduced bacterial adhesion compared with titanium; however, results from experimental studies are rather controversial. The aim of the present study is to compare biofilm…

View details →DOI: 10.1902/jop.2016.160245Cited by 206
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The Global Distribution of Biological Nitrogen Fixation in Terrestrial Natural Ecosystems

Taraka Davies‐Barnard, Pierre Friedlingstein · 2020 · Global Biogeochemical Cycles

Abstract Biological nitrogen fixation is a key contributor to sustaining the terrestrial carbon cycle, providing nitrogen input that plants require. However, the amount and global distribution of this fixation is highly disputed. Using a…

View details →DOI: 10.1029/2019gb006387Cited by 206