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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 268 of 662

Negative / Null Result ReportOpen accessMedicine

Pulmonary Hypertension Associated with Interstitial Lung Disease (PH-ILD): Back to the Future.

Fiorentù G, Bernardinello N, Giulianelli G et al. · 2025 · Advances in therapy

Pulmonary hypertension (PH) is a progressive syndrome characterized by increased pulmonary artery pressure. PH often complicates chronic lung diseases, thus contributing to a substantial disease burden and poor prognosis. The WHO Group 3…

View details →DOI: 10.1007/s12325-025-03129-3
Negative / Null Result ReportMedicine

Stereotactic radiosurgery versus whole-brain radiotherapy in patients with 4-10 brain metastases: A nonrandomized controlled trial.

Bodensohn R, Kaempfel AL, Boulesteix AL et al. · 2023 · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Background and purpose There is no randomized evidence comparing whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) in the treatment of multiple brain metastases. This prospective nonrandomized controlled single arm trial…

View details →DOI: 10.1016/j.radonc.2023.109744
Negative / Null Result ReportOpen accessMedicine

The role of bronchoscopic cryoimmunotherapy in non-small cell lung cancer: current evidence and future perspectives.

Perez PN, Smesseim I, Sterman DH · 2026 · Immunotherapy

Lung cancer is the leading cause of cancer deaths, and despite therapeutic advances, recurrence and resistance persist. Local tumor ablation can function as an in situ vaccine, but thermal techniques may disrupt antigen and extracellular…

View details →DOI: 10.1080/1750743x.2026.2651072
Negative / Null Result ReportMedicine

Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003.

Gondi V, Pugh SL, Mehta MP et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Hippocampal avoidance (HA) during therapeutic whole-brain radiotherapy reduces the risk of neurocognitive function (NCF) toxicity in patients with brain metastasis. This trial hypothesized that HA during prophylactic cranial…

View details →DOI: 10.1200/jco-25-00221
Negative / Null Result ReportMedicine

Ruminal degradation kinetics of mombasa and elephant grass silages as affected by fibrolyitc enzymes and regrowth ages.

de Lima Cruz GF, Pereira OG, Alves WS et al. · 2025 · Tropical animal health and production

Tropical grasses are widely used for silage, but their high fiber content and variable quality often limit ruminal degradation and animal performance. Strategies such as optimizing regrowth age (RA) and applying fibrolytic enzymes may help…

View details →DOI: 10.1007/s11250-025-04765-1
Negative / Null Result ReportOpen accessMedicine

Investigating the effect of Ranolazine drug on the pathophysiology of asthma in a rat model.

Sadeghi M, Shahrooz S, Aghamohammadi M et al. · 2025 · BMC research notes

Objective Asthma is a common multifactorial inflammatory disease affecting both children and adults. Various cells and cytokines contribute to this inflammatory process. Smooth muscle contraction, vascular congestion, and airway edema lead…

View details →DOI: 10.1186/s13104-025-07455-1
Negative / Null Result ReportOpen accessMedicine

Education and Provision of a Pest Management Tool Kit to Residents in Low-Income Housing: Effect on Cockroach Reduction.

Pan X, Sarker S, Yu JJ et al. · 2026 · Insects

High rates of pest infestations are frequently reported in low-income homes in the U.S. However, even with access to effective insecticides, most residents are unaware of how to properly control indoor pests. We designed and evaluated the…

View details →DOI: 10.3390/insects17050483
Negative / Null Result ReportMedicine

De novo donor specific antibody (dnDSA) development with tacrolimus versus Belatacept based regimens in kidney transplant recipients.

Kass C, Katz-Greenberg G, Bodner J et al. · 2025 · Transplant immunology

Purpose Belatacept has been associated with less de novo specific antibody (dnDSA) development, but few publications have compared the incidence of dnDSA development between tacrolimus and belatacept-based immunosuppression regimens. The…

View details →DOI: 10.1016/j.trim.2025.102297
Negative / Null Result Report

“Inhaled Nitric Oxide in Neonates with Pulmonary Hypertension in Amazonas, Brazil: Physiological Improvement Versus Impact on Relevant Clinical Outcomes”

Ferreira RD, Faleiros Ferreira CH, Gonçalves-Ferri WA · 2025 · Preprint

Background Inhaled nitric oxide (iNO) is a standard treatment for neonatal pulmonary hypertension in high-resource settings. Yet, its efficacy and cost-effectiveness in low- and middle-income countries (LMICs) remain underexplored. This…

View details →DOI: 10.1101/2025.08.19.25333602
Negative / Null Result ReportOpen accessMedicine

Biallelic variants in DNAH11 cause male infertility with asthenozoospermia in a Chinese non-consanguineous family: A case report.

Zhang Y, Pan J, Hou J et al. · 2025 · Medicine

Rationale Asthenozoospermia (AZS), a leading cause of male infertility, frequently results from genetic defects that disrupt flagellar assembly. Mutations in the DNAH11 gene can cause abnormal dynein arm structures, leading to AZS and…

View details →DOI: 10.1097/md.0000000000046556
Negative / Null Result ReportMedicine

A Comparison of Intravenous and Oral Transmucosal Administration of Pentobarbital Sodium for Humane Euthanasia in White Leghorn Chickens (<i>Gallus gallus domesticus</i>).

Masri A, Tully TN, Como K et al. · 2025 · Journal of avian medicine and surgery

Euthanasia is a common veterinary medical procedure performed on terminally ill backyard chickens ( Gallus gallus domesticus ). To reduce stress for these animals, it is important to develop a euthanasia protocol that provides a rapid and…

View details →DOI: 10.1647/avianms-d-24-00022
Negative / Null Result ReportOpen accessMedicine

Effect of Human-Derived Collagen Injection on Clinical and Structural Outcomes after Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Trial.

Lee JH, Hwang K, Jeong WK · 2026 · Clinics in orthopedic surgery

Background Arthroscopic rotator cuff repair is widely performed; yet tendon healing failure still occurs in some cases and remains a challenge. To address this issue, several studies have investigated intraoperative injection or patch…

View details →DOI: 10.4055/cios25235
Negative / Null Result ReportMedicine

Antibody Responses Elicited by Vaccination with Recombinant LaSota Virus Expressing IBV Spike in Chickens with Maternal Antibodies.

Cuadrado C, Breedlove C, Toro H · 2025 · Avian diseases

Vaccination with a recombinant Newcastle disease virus (NDV) LaSota (LS) strain expressing Arkansas (Ark) -type infectious bronchitis virus (IBV) spike ectodomain (Se) protein and granulocyte-macrophage colony-stimulating factor (GMCSF)…

View details →DOI: 10.1637/aviandiseases-d-25-00035
Negative / Null Result ReportMedicine

Stem migration and bone density at ten years : a randomized radiostereometry and dual-energy X-ray absorptiometry study on a short uncemented hip stem with and without a collar.

Daudi S, Zampelis V, Belfrage O et al. · 2025 · The bone & joint journal

Aims Short, uncemented hip stems might provide a favourable alternative in total hip arthroplasty (THA) by preserving proximal bone mass through reduced strain-adaptive remodelling. We evaluated and compared the migration and…

View details →DOI: 10.1302/0301-620x.107b9.bjj-2024-1720.r1
Negative / Null Result ReportMedicine

Short-term effects of group-based nutritional education on nutritional adherence and glycaemic control in outpatients with type 2 diabetes: a randomised clinical trial.

Busanello A, Koller OG, Menezes VM et al. · 2025 · The British journal of nutrition

The objective of this study was to evaluate the impact of incorporating group-based nutritional education into usual care on adherence to nutritional counselling among outpatients with type 2 diabetes (T2DM). This parallel-group,…

View details →DOI: 10.1017/s0007114525105485
Negative / Null Result ReportMedicine

Arthroscopic partial meniscectomy outcomes are comparable in patients with synovitis treated by synovectomy and those without synovitis.

Williams KG, Constantine EP, Whitney KE et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To determine whether patients undergoing arthroscopic partial meniscectomy (APM) with synovitis treated by synovectomy exhibit similar outcomes to those without synovitis after 24-month follow-up. Methods A total of 181 patients…

View details →DOI: 10.1002/ksa.70202
Negative / Null Result ReportMedicine

The Effects of a Bacopa monnieri Extract (Bacumen<sup>®</sup>) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lopresti AL, Smith SJ · 2025 · Clinical drug investigation

Background and objectives Bacopa monnieri is a plant used in Ayurvedic medicine with traditional uses for memory and cognitive function. The objective of this study was to examine the effects of supplementation with a Bacopa monnieri…

View details →DOI: 10.1007/s40261-025-01492-1
Negative / Null Result ReportMedicine

Evaluation of soft palate thickness in brachycephalic dogs 3 months after folded flap palatoplasty versus standard staphylectomy.

Timmermans J, Van Goethem B, Stock E et al. · 2026 · Veterinary surgery : VS

Objective To evaluate the soft palate thickness in brachycephalic dogs 3 months after performing folded flap palatoplasty (FFP) or standard staphylectomy (STS). Study design Prospective, observational study. Animals Twenty client-owned…

View details →DOI: 10.1111/vsu.70006
Negative / Null Result ReportMedicine

Response of Atlantic salmon to long-term sustained aerobic training at suboptimum elevated temperature: Cardiac anatomy, aerobic performance, and growth implications

Foddai M, Carter CG, Wood AT et al. · 2025 · Comparative Biochemistry and Physiology, Part A

Sustained aerobic training is suggested to enhance cardiac performance and growth in farmed salmonids, but its effects under suboptimum elevated temperatures remain unclear. This study examined whether continuous training at different…

Negative / Null Result Report

A Comprehensive Toxicological Safety Evaluation of Anaerostipes caccae

Modica V, Glávits R, Clewell A et al. · 2025 · Preprint

Anaerostipes caccae CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple…

View details →DOI: 10.1101/2025.07.08.663675
Negative / Null Result ReportMedicine

Synergistic interaction between nitrifying bacteria and Enterobacter ludwigii enhances PAHs biodegradation in coal mine dump soils.

Pulikova EP, Kotsarev VI, Demin KA et al. · 2025 · Journal of environmental management

Polycyclic aromatic hydrocarbons (PAHs) are one of the most widespread organic pollutants. The methods to restore the natural environments contaminated with these substances include bioremediation based on PAH-degrading microorganisms. In…

View details →DOI: 10.1016/j.jenvman.2025.127601
Negative / Null Result ReportMedicine

Smartphone-based approach-avoidance bias modification training for anorexia nervosa - A randomized clinical trial.

Blomberg M, Schaper R, Bonabi A et al. · 2025 · Behaviour research and therapy

Background Effective treatments for anorexia nervosa (AN) are available, yet many patients do not respond to treatment or experience relapse. Cognitive bias modification aims to ameliorate cognitive biases that are assumed to contribute to…

View details →DOI: 10.1016/j.brat.2025.104900
Negative / Null Result ReportMedicine

The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): A randomized open-label phase 2 study.

Lorigan P, Medina TM, Nyakas M et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Purpose Immune checkpoint inhibitor (ICI) combinations have improved outcomes in patients with advanced melanoma; however, long term survival remains poor. The addition of therapeutic cancer vaccines to ICI combinations represents a…

View details →DOI: 10.1016/j.ejca.2025.116162
Negative / Null Result ReportMedicine

The Impact of Intermaxillary Fixation Screws on Long-Term Dental Complications in Pediatric Facial Fractures.

Gündüz N, Duran M, Erdal AI et al. · 2026 · The Journal of craniofacial surgery

Facial fractures are a significant aspect of pediatric trauma cases. The impact of intermaxillary fixation (IMF) using screws on dental development, particularly in pediatric patients undergoing primary and mixed dentition, remains a…

View details →DOI: 10.1097/scs.0000000000011750
Negative / Null Result ReportMedicine

Clinical outcomes according to the location of graft retear after arthroscopy-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears.

Baek CH, Lim C, Kim JG et al. · 2025 · The bone & joint journal

Aims This study aimed to compare clinical outcomes according to the location of transferred graft retear in arthroscopy-assisted lower trapezius tendon transfer (aLTT) for posterosuperior irreparable rotator cuff tears (PSIRCTs). Methods…

View details →DOI: 10.1302/0301-620x.107b10.bjj-2024-1573.r2
Negative / Null Result Report

Sulfadoxine-Pyrimethamine Dosing and Malaria Parasitemia Among Pregnant Women at Lira Regional Referral Hospital, Northern Uganda: A Cross-Sectional Study

Ogwang R, Benyumiza D, Mwandah DC et al. · 2025 · Preprint

Abstract Background : Malaria in pregnancy poses severe adverse effects to both the mother and fetus and the newborn. There is limited literature on the effectiveness of sulfadoxine/pyrimethamine as a malaria preventive measure across…

View details →DOI: 10.21203/rs.3.rs-8133778/v1
Negative / Null Result ReportMedicine

Length of maxillomandibular discrepancy may not predict tongue base airway obstruction severity among infants with Robin Sequence.

Bryton CA, Tingen JN, Scott AR · 2026 · International journal of pediatric otorhinolaryngology

Objective To evaluate the relationship between severity of micrognathia and mandibular distraction distance required to alleviate symptoms among neonates with isolated Robin Sequence (iRS), as measured by frontal nasomental (FNM) angle…

View details →DOI: 10.1016/j.ijporl.2026.112886
Negative / Null Result Report

Influence of Sociodemographic Variables and the Approach to Incontinence on the Appearance of Incontinence-Associated Dermatitis

García-Ruiz MP, Torres-Bautista RM, López-Franco MD et al. · 2026 · Preprint

Objectives: The general objective of the study was to analyze the influence of sociodemographic factors and care and hygiene practices on the appearance of Incontinence-Associated Dermatitis (IAD). The specific objectives sought to…

View details →DOI: 10.20944/preprints202601.1868.v1
Negative / Null Result ReportMedicine

The association between preoperative serum transferrin and occult metastasis in early T classification oral squamous cell carcinoma.

Tan L, Jiang TC, Gong ZJ · 2026 · BMC oral health

Background This study aimed to investigate the potential of preoperative serum transferrin levels as a biomarker for predicting occult metastasis in patients with clinically node-negative (cN0), early T-classification (T1-T2) oral squamous…

View details →DOI: 10.1186/s12903-026-08895-2