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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20230 results in Negative / Null Result Report · page 267 of 675

Negative / Null Result ReportMedicine

Effects of warming on leaf litter decomposition and soil organic carbon stability in alpine shrubs.

Wang NN, Luo CJ, Liu LG et al. · 2026 · Ying yong sheng tai xue bao = The journal of applied ecology

Litter decomposition is a core process regulating the formation and stability of soil organic carbon. Under the background of climate warming, the intrinsic mechanisms by which the expansion of alpine shrubs affects carbon balance of…

View details →DOI: 10.13287/j.1001-9332.202606.011
Negative / Null Result Report

Effect of social media on patient’s awareness of orthodontic treatment

Sanei A, Asgarian FS, Ebrahiminezhad M · 2026 · Preprint

Abstract Background The lack of studies and sometimes conflicting results in this field, has required that this study be conducted with the aim of improving treatment results in dental health care system. Methods The present study was…

View details →DOI: 10.21203/rs.3.rs-8080200/v1
Negative / Null Result Report

Ethanol drinking involves astrocytes in male Wistar rats

Tan X, Ding Z · 2026 · Preprint

Astrocytes are the most abundant glial cells in the brain and an integrative component of the neural network. Studies have shown that ethanol altered expression of an astrocyte marker, i.e., glial fibrillary acidic protein (GFAP), in two…

View details →DOI: 10.64898/2026.03.10.710881
Negative / Null Result ReportMedicine

Relationship between acute coronary syndrome and coronavirus disease 2019 infection and vaccination type: a retrospective observational study.

Gokdemir MT, Gokdemir GS · 2026 · BMC infectious diseases

Background Studies have reported that the Coronavirus Disease 2019 (COVID-19) vaccine causes other serious health problems, including myocarditis, pericarditis, neurological problems, and problems resulting from the reactivation of chronic…

View details →DOI: 10.1186/s12879-026-13542-w
Negative / Null Result ReportMedicine

Evaluating the need for omentectomy during laparoscopic placement of tunneled peritoneal dialysis catheters in pediatrics: a multicenter comparative study.

Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international

Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…

View details →DOI: 10.1007/s00383-026-06464-w
Negative / Null Result ReportOpen accessMedicine

Mechanistic investigation of flavonoid-mediated inhibition of N-methyl-N-nitrosourea-induced mutagenicity via noncovalent DNA binding.

Matsuoka C, Takatama N, Muraoka T et al. · 2026 · Genes and environment : the official journal of the Japanese Environmental Mutagen Society

Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to…

View details →DOI: 10.1186/s41021-026-00361-3
Negative / Null Result ReportOpen accessMedicine

Neuro-behavioral Impact of Tourette-Related Striatal Disinhibition in Rats.

Loayza J, Taylor CJL, Renstrom JG et al. · 2026 · eNeuro

Tourette syndrome (TS) has been linked to reduced GABAergic inhibition, the so-called neural disinhibition, in the dorsal striatum. Dorsal striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A receptor…

View details →DOI: 10.1523/eneuro.0068-26.2026
Negative / Null Result ReportMedicine

Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility.

Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…

View details →DOI: 10.1016/j.cgh.2024.05.017
Negative / Null Result ReportOpen accessMedicine

Real-world outcomes in patients with brain metastases secondary to HR+/HER2- MBC treated with abemaciclib and local intracranial therapy.

Gathirua-Mwangi W, Martin H, He D et al. · 2025 · The oncologist

Background Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients…

View details →DOI: 10.1093/oncolo/oyae274
Negative / Null Result ReportMedicine

Clinical significance of TP53 mutations in patients with acute myeloid leukemia: the HM-SCREEN-JAPAN 01/02 study.

Ogasawara F, Minami Y, Chi S et al. · 2026 · International journal of hematology

Mutant TP53 (mTP53) variants are diverse, and residual wild-type p53 function (functional, non-functional), gain-of-function (GOF) mTP53, and the number of mTP53 (single-hit, multi-hit) can affect prognosis. We used next-generation…

View details →DOI: 10.1007/s12185-026-04192-4
Negative / Null Result Report

Adrβ2 in skeletal muscle cells is required for exercise-induced Pgc1α but not for metabolic benefits of exercise on diet-induced obesity

Galvan M, Fujitani M, Dushime J et al. · 2026 · Preprint

β2-Adrenergic receptor ( Adrβ2 ) is the most abundant form of adrenergic receptors in skeletal muscle. Our previous studies have shown that the ventromedial hypothalamic nucleus (VMH) regulates metabolic benefits of exercise, potentially…

View details →DOI: 10.64898/2026.03.27.714812
Negative / Null Result ReportMedicine

The Association of Persistent Fecal White Blood Cell Excretion with Impaired Weight Gain and Food Allergy Among Children with Allergic Proctocolitis.

Fattahi Z, Talakesh T, Kheiri S et al. · 2026 · Recent advances in inflammation & allergy drug discovery

Introduction/objective In children affected by allergic proctocolitis, impaired weight gain and developmental failure to thrive can be a prominent manifestation. However, it remains unclear whether the association between White Blood Cell…

View details →DOI: 10.2174/0127722708469650260417115846
Negative / Null Result ReportMedicine

Hypothetical Bias in the SG and TTO.

Baillon A, Bleichrodt H, Granic GD · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundHealth state utility measurements are central in health policy and medical decision making. Common methods are the standard gamble (SG) and the time tradeoff (TTO). They typically use hypothetical questions. It is unknown whether…

View details →DOI: 10.1177/0272989x261423884
Negative / Null Result Report

A ‘capture-handling-restraint protocol’ elicits short-term stress responses in wild great tits ( Parus major ) but has little impact on reproductive success

Fröhlich F, Mentesana L, Deimel C et al. · 2026 · Preprint

Capturing and handling wild animals is essential for ecological and evolutionary research, yet their effects on physiology, behaviour, and reproductive success remain poorly understood. We investigated short-and longer-term consequences of…

View details →DOI: 10.64898/2026.03.17.712382
Negative / Null Result ReportMedicine

Risk factors of biliary cast syndrome among liver transplant recipients.

Nakamura M, Nishioka Y, Akamatsu N et al. · 2026 · Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Biliary cast syndrome (BCS) remains a significant concern that can lead to graft failure and mortality. Data on the etiology and outcomes are limited, particularly with regard to the differences in the risk of occurrence of BCS between…

View details →DOI: 10.1097/lvt.0000000000000872
Negative / Null Result ReportMedicine

The influence of galanin receptor agonist during the seasonal recrudescence and nonbreeding phases of the ovarian cycle in the gekkonid lizard Hemidactylus frenatus.

Ganeyan A, Ganesh CB · 2026 · Neuropeptides

Galanin (GAL), a neuropeptide produced in both the central and peripheral nervous systems, is implicated in various physiological processes, including reproduction in vertebrates. Yet, the role of GAL is not understood in reptilian…

View details →DOI: 10.1016/j.npep.2026.102614
Negative / Null Result ReportMedicine

Differential effects of hypothalamic ET<sub>B</sub> receptor blockade in fever, hypolocomotion and serotonin release during systemic inflammation in male and female rats.

Alencar TS, Santos MO, Schneider VMM et al. · 2026 · Brain research

Systemic inflammation triggers a set of physiological and behavioral changes known as sickness behavior, including fever and hypolocomotion. Previous studies demonstrated that lipopolysaccharide (LPS) induces these responses in both sexes,…

View details →DOI: 10.1016/j.brainres.2026.150417
Negative / Null Result ReportOpen accessMedicine

Exhausted olive pomace as a replacement for soybean hulls in corn silage-based diets for late-lactating Holstein cows: Insights from sustainable dairy farming.

Fonseca AJM, Cabrita ARJ · 2026 · JDS communications

This study evaluated the effects of replacing soybean hulls with exhausted olive pomace (EOP) on feed intake, milk production and composition, and rumen fermentation parameters. A cyclical changeover design experiment was used with 4…

View details →DOI: 10.3168/jdsc.2025-0932
Negative / Null Result ReportMedicine

Interactions among progesterone, estradiol, and γ-aminobutyric acid in rat spermatozoal hyperactivation.

Muroi M, Fukuda S, Takahashi M et al. · 2026 · The Journal of reproduction and development

Our previous study in hamsters indicated that progesterone (P) induces enhancement of spermatozoal hyperactivation, while 17β-estradiol (Eβ) and γ-aminobutyric acid (GABA) suppress this enhancement. Since P has also been shown to enhance…

View details →DOI: 10.1262/jrd.2025-106
Negative / Null Result ReportMedicine

Revisiting hypocholesterolemia during prolonged sepsis: From targeted cholesterol repletion to unresolved adrenal and muscle dysfunction.

De Bruyn L, Van Beek F, Vander Perre S et al. · 2026 · Molecular and cellular endocrinology

Background Sepsis HDL- and LDL-hypocholesterolemia associate with adverse outcomes, but whether this necessitates supplementation or merely reflects disease severity remains unclear. We hypothesize that sustained hypocholesterolemia can…

View details →DOI: 10.1016/j.mce.2026.112848
Negative / Null Result ReportMedicine

Effect of different vaccination schedules and administration of a nonsteroidal anti-inflammatory drug around dry-off on inflammation, immunity, and performance of dairy cows.

Gao J, Savegnago CG, Marins TN et al. · 2026 · Journal of dairy science

This study evaluated the effects of different vaccination schedule and oral administrating a nonsteroidal anti-inflammatory drug (NSAID) around dry-off on systemic inflammation, immune responses, behaviors during the early dry period, and…

View details →DOI: 10.3168/jds.2026-28261
Negative / Null Result ReportMedicine

A Performance Evaluation of Bayesian Forecasting for Serum Linezolid Concentrations: Impact of Clinical Factors on Prediction Accuracy.

Hashimoto N, Wakimoto Y, Kusama T et al. · 2026 · Therapeutic drug monitoring

Background Pycsim, a dosing software for linezolid (LZD) based on Bayesian estimation, predicts dosing in the therapeutic drug monitoring (TDM) of LZD. However, its predictive performance, examined using an independent data set with a…

View details →DOI: 10.1097/ftd.0000000000001468
Negative / Null Result ReportMedicine

Copper regulates the synthesis of steroid hormones through CCS and ATOX1 dependent MEK1-ERK1/2 pathway in follicular granulosa cells of yak (Bos grunniens).

Lou Y, Yang T, Xia C et al. · 2026 · Molecular and cellular endocrinology

Steroid hormone synthesis in granulosa cells (GCs) is crucial for normal follicular development and ovulation. Emerging evidence suggests that copper (Cu), a trace element, influences hormone secretion in yak granulosa cells (YGCs);…

View details →DOI: 10.1016/j.mce.2026.112812