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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 262 of 662

Negative / Null Result ReportOpen accessMedicine

Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.

Rasmussen MIS, Hansen ML, Pellicer A et al. · 2026 · JAMA pediatrics

Importance Cerebral oximetry monitoring in the first 72 hours after birth has not been shown to reduce death or severe brain injury at 36 weeks' postmenstrual age in extremely preterm infants. The long-term effects remain uncertain.…

View details →DOI: 10.1001/jamapediatrics.2026.1066
Negative / Null Result ReportOpen accessMedicine

Effect of Local Administration of Vancomycin to the Wound on Renal and Hepatic Function After Cardiac Surgery in Neonates.

Suvorov VV, Sayitkuliev DB · 2026 · Diseases (Basel, Switzerland)

The development of sternal infection in neonates after cardiac defect correction using median sternotomy is a serious complication, increasing the length of hospital stay, mortality, and treatment costs. One effective method for preventing…

View details →DOI: 10.3390/diseases14030093
Negative / Null Result ReportMedicine

Short-term effects of group-based nutritional education on nutritional adherence and glycaemic control in outpatients with type 2 diabetes: a randomised clinical trial.

Busanello A, Koller OG, Menezes VM et al. · 2025 · The British journal of nutrition

The objective of this study was to evaluate the impact of incorporating group-based nutritional education into usual care on adherence to nutritional counselling among outpatients with type 2 diabetes (T2DM). This parallel-group,…

View details →DOI: 10.1017/s0007114525105485
Negative / Null Result ReportMedicine

Arthroscopic partial meniscectomy outcomes are comparable in patients with synovitis treated by synovectomy and those without synovitis.

Williams KG, Constantine EP, Whitney KE et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To determine whether patients undergoing arthroscopic partial meniscectomy (APM) with synovitis treated by synovectomy exhibit similar outcomes to those without synovitis after 24-month follow-up. Methods A total of 181 patients…

View details →DOI: 10.1002/ksa.70202
Negative / Null Result ReportMedicine

The Effects of a Bacopa monnieri Extract (Bacumen<sup>®</sup>) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lopresti AL, Smith SJ · 2025 · Clinical drug investigation

Background and objectives Bacopa monnieri is a plant used in Ayurvedic medicine with traditional uses for memory and cognitive function. The objective of this study was to examine the effects of supplementation with a Bacopa monnieri…

View details →DOI: 10.1007/s40261-025-01492-1
Negative / Null Result ReportMedicine

Evaluation of soft palate thickness in brachycephalic dogs 3 months after folded flap palatoplasty versus standard staphylectomy.

Timmermans J, Van Goethem B, Stock E et al. · 2026 · Veterinary surgery : VS

Objective To evaluate the soft palate thickness in brachycephalic dogs 3 months after performing folded flap palatoplasty (FFP) or standard staphylectomy (STS). Study design Prospective, observational study. Animals Twenty client-owned…

View details →DOI: 10.1111/vsu.70006
Negative / Null Result ReportMedicine

Response of Atlantic salmon to long-term sustained aerobic training at suboptimum elevated temperature: Cardiac anatomy, aerobic performance, and growth implications

Foddai M, Carter CG, Wood AT et al. · 2025 · Comparative Biochemistry and Physiology, Part A

Sustained aerobic training is suggested to enhance cardiac performance and growth in farmed salmonids, but its effects under suboptimum elevated temperatures remain unclear. This study examined whether continuous training at different…

Negative / Null Result Report

A Comprehensive Toxicological Safety Evaluation of Anaerostipes caccae

Modica V, Glávits R, Clewell A et al. · 2025 · Preprint

Anaerostipes caccae CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple…

View details →DOI: 10.1101/2025.07.08.663675
Negative / Null Result ReportMedicine

Synergistic interaction between nitrifying bacteria and Enterobacter ludwigii enhances PAHs biodegradation in coal mine dump soils.

Pulikova EP, Kotsarev VI, Demin KA et al. · 2025 · Journal of environmental management

Polycyclic aromatic hydrocarbons (PAHs) are one of the most widespread organic pollutants. The methods to restore the natural environments contaminated with these substances include bioremediation based on PAH-degrading microorganisms. In…

View details →DOI: 10.1016/j.jenvman.2025.127601
Negative / Null Result ReportMedicine

Smartphone-based approach-avoidance bias modification training for anorexia nervosa - A randomized clinical trial.

Blomberg M, Schaper R, Bonabi A et al. · 2025 · Behaviour research and therapy

Background Effective treatments for anorexia nervosa (AN) are available, yet many patients do not respond to treatment or experience relapse. Cognitive bias modification aims to ameliorate cognitive biases that are assumed to contribute to…

View details →DOI: 10.1016/j.brat.2025.104900
Negative / Null Result ReportMedicine

The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): A randomized open-label phase 2 study.

Lorigan P, Medina TM, Nyakas M et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Purpose Immune checkpoint inhibitor (ICI) combinations have improved outcomes in patients with advanced melanoma; however, long term survival remains poor. The addition of therapeutic cancer vaccines to ICI combinations represents a…

View details →DOI: 10.1016/j.ejca.2025.116162
Negative / Null Result ReportMedicine

The Impact of Intermaxillary Fixation Screws on Long-Term Dental Complications in Pediatric Facial Fractures.

Gündüz N, Duran M, Erdal AI et al. · 2026 · The Journal of craniofacial surgery

Facial fractures are a significant aspect of pediatric trauma cases. The impact of intermaxillary fixation (IMF) using screws on dental development, particularly in pediatric patients undergoing primary and mixed dentition, remains a…

View details →DOI: 10.1097/scs.0000000000011750
Negative / Null Result ReportMedicine

Clinical outcomes according to the location of graft retear after arthroscopy-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears.

Baek CH, Lim C, Kim JG et al. · 2025 · The bone & joint journal

Aims This study aimed to compare clinical outcomes according to the location of transferred graft retear in arthroscopy-assisted lower trapezius tendon transfer (aLTT) for posterosuperior irreparable rotator cuff tears (PSIRCTs). Methods…

View details →DOI: 10.1302/0301-620x.107b10.bjj-2024-1573.r2
Negative / Null Result ReportMedicine

Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial.

Pirracchio R, Fong N, Legrand M · 2025 · Intensive care medicine

Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arterial pressure targets (65-70 mmHg vs 80-85 mmHg) in septic shock and…

View details →DOI: 10.1007/s00134-025-08104-8
Negative / Null Result ReportMedicine

Rabies immunoglobulin overdose in post-exposure prophylaxis.

Łukasik AJ, Podlasin RB · 2025 · Przeglad epidemiologiczny

Rabies is a zoonotic viral infection caused by an RNA virus from the Rhabdoviridae family, a Lyssavirus species with the highest mortality rate among all infectious diseases. Post-exposure propylahis (PEP) should be applied as soon as…

View details →DOI: 10.32394/pe/205745
Negative / Null Result ReportOpen accessMedicine

Simulated brushing effects on surface roughness and color stability of coated additively manufactured dental resin: an in vitro study.

Alsalem Z, Alothemeen M, Alshehri D et al. · 2026 · Journal of medicine and life

This study aimed to evaluate the effect of a glaze coating on the surface roughness and color stability of 3D-printed temporary crown resin materials before and after simulated toothbrushing. Nano-filled ceramic resin specimens were…

View details →DOI: 10.25122/jml-2025-0181
Negative / Null Result ReportMedicine

Prediction of the digestibility and digestible energy content of hay for horses using an enzymatic degradability method.

Andueza D, Martin-Rosset W · 2025 · Animal : an international journal of animal bioscience

The nutritive value of forage for horses is closely dependent on the digestibility of organic matter (OMD), which is typically measured in vivo. Researchers have developed a variety of prediction methods to estimate the digestibility value…

View details →DOI: 10.1016/j.animal.2025.101597
Negative / Null Result ReportOpen accessMedicine

Variations in cow milk and teat skin microbiota across the lactation cycle with intramammary cephalosporin use at dry-off.

Van Beeck W, Lemos MLP, Niesen AM et al. · 2026 · Applied and environmental microbiology

Cephalosporins and other broad-spectrum antibiotics are frequently administered prophylactically into the udder when dairy cows end their lactation cycle, termed dry-off, to reduce mastitis risk. However, the use of antibiotics on cows…

View details →DOI: 10.1128/aem.02312-25
Negative / Null Result ReportOpen accessMedicine

Improving Diagnostic Quality of Anogenital Photodocumentation in Emergency Department Evaluations for Acute Child Sexual Assault.

Miller ZE, Digirolamo SJ, Molnar J et al. · 2026 · Pediatric quality & safety

Introduction Emergency department evaluations for acute child sexual assault include anogenital photodocumentation as a standard of care, which has implications for accurate clinical care and forensic significance. If photodocumentation…

View details →DOI: 10.1097/pq9.0000000000000876
Negative / Null Result ReportMedicine

Alignment and early clinical outcomes following total knee arthroplasty using a handheld navigation system compared to conventional instruments.

Nishida C, Shimoda B, Weldon RH et al. · 2025 · Archives of orthopaedic and trauma surgery

Introduction Proper lower extremity alignment is important for success and longevity of total knee arthroplasty (TKA). Conventional instrumentation has demonstrated higher rates of mechanical axis (MA) malalignment compared to robotic or…

View details →DOI: 10.1007/s00402-025-05998-3
Negative / Null Result ReportOpen accessMedicine

The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

Fenerich BA, Fernandes JC, Silva CLA et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Insulin Receptor Substrate 1 (IRS1) is differentially expressed in hematological neoplasms suggesting a role in hematopoiesis and neoplastic transformation. Irs1 knockout mice represent a tool to investigate IRS1 function.…

View details →DOI: 10.1016/j.htct.2026.106465
Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

View details →DOI: 10.1021/acsnano.5c04610
Negative / Null Result ReportMedicine

Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.

Yoshiura K, Murata M, Hamasuna M et al. · 2025 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD…

View details →DOI: 10.1111/psyg.70085