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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 259 of 662

Negative / Null Result ReportOpen accessMedicine

A Longitudinal Observational Study on Lactation-Associated Changes in Procalcitonin, Protein Carbonyl Content, Asymmetric Dimethylarginine, and Symmetric Dimethylarginine in Dairy Cattle.

Sala G, Castelli M, Orsetti C et al. · 2025 · Veterinary sciences

Procalcitonin (PCT), protein carbonyl content (PCC), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) have been proposed as promising biomarkers for detecting diseases in cattle. Their concentrations could…

View details →DOI: 10.3390/vetsci12090895
Negative / Null Result ReportOpen accessMedicine

Influence of Coagulation Factor VIII on Ischemic Stroke.

Martínez-Salmerón MDM, Amaya-Pascasio L, Martínez-Sánchez P et al. · 2026 · Revista de neurologia

Background There is considerable interest in the underlying mechanisms of cryptogenic stroke, with hypercoagulable states being widely studied. An elevated level of Factor VIII has been proposed as a potential prothrombotic marker…

View details →DOI: 10.31083/rn44168
Negative / Null Result ReportOpen accessMedicine

Retrospective analysis of Claudin18.2 expression in ethnically diverse patients with gastroesophageal adenocarcinoma.

Wallam S, Park J, Wu LW et al. · 2025 · Journal of gastrointestinal oncology

Background Claudin18.2 (CLDN18.2), a tight junction molecule, is a novel therapeutic target for patients with advanced gastroesophageal adenocarcinoma. Recent phase III trials demonstrated improved survival with the addition of an…

View details →DOI: 10.21037/jgo-2025-111
Negative / Null Result ReportOpen accessMedicine

Influence of Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism in Conditioned Pain Modulation in Women with Migraine.

Cigarán-Méndez M, de-la-Llave-Rincón AI, Pacho-Hernández JC et al. · 2026 · International journal of molecular sciences

The role of the catechol-O-methyltransferase (COMT) Val158Met rs4680 polymorphism in altered pain processing in headaches is controversial. The aim of this study was to investigate the influence of the Val158Met rs4680 polymorphism in…

View details →DOI: 10.3390/ijms27115107
Negative / Null Result ReportOpen accessMedicine

The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke.

Thapa M, Courville J, Leonhard R et al. · 2025 · Frontiers in stroke

Introduction Whole blood viscosity (WBV), reflecting the intrinsic resistance of blood flow, is an established predictor of stroke events in individuals. This study aims to correlate the WBV at different shear rates with the outcome of…

View details →DOI: 10.3389/fstro.2025.1517343
Negative / Null Result ReportMedicine

Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial.

Indraccolo S, Signoriello S, Piga I et al. · 2024 · The International journal of biological markers

Introduction In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic…

View details →DOI: 10.1177/03936155241296164
Negative / Null Result ReportOpen accessMedicine

Performance of Early Therapeutic Paracentesis in Spontaneous Bacterial Peritonitis and Its Effect on Clinical Outcomes.

Wentworth BJ, Shwetar M, Mallawaarachchi I et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background and aims Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary…

View details →DOI: 10.1002/jgh3.70339
Negative / Null Result ReportMedicine

How plant composition in margins influences the assemblage of pests and predators and its effect on biocontrol in melon fields.

Sanchez JA, de Pedro L, López-Gallego E et al. · 2024 · Scientific reports

Many agricultural landscapes offer few resources for maintaining natural enemy populations and floral plantings have frequently been adopted to enhance biological pest control in crops. However, restored margins may harbour both pests and…

View details →DOI: 10.1038/s41598-024-63985-x
Negative / Null Result ReportMedicine

Assessment of the impact of microplastic ingestion in striped red mullets from an Eastern Mediterranean coastal area (Zakynthos Island, Ionian Sea).

Patsiou D, Digka N, Galli M et al. · 2024 · Marine environmental research

Monitoring microplastics (MPs) in the marine environment is an ongoing process, and our understanding of their impact on marine organisms is limited. The present study evaluates the effects of ingested MPs on the marine MP pollution…

View details →DOI: 10.1016/j.marenvres.2024.106438
Negative / Null Result ReportOpen accessMedicine

Parent substance use and child-to-parent violence: A brief report.

Curtis A, Skvarc D, Brittain N et al. · 2025 · Drug and alcohol review

Introduction Substance use has been associated with child-to-parent violence (CPV), yet little is known about the contributing factors. This study investigated the association between parental substance use and substance involved child to…

View details →DOI: 10.1111/dar.14031
Negative / Null Result ReportOpen accessMedicine

Feeding Therapy and its Relationship to Timing of Independent Oral Feeding for Preterm Infants in the Neonatal Intensive Care Unit.

Nguyen TT, Pineda R, Reynolds S et al. · 2026 · Physical & occupational therapy in pediatrics

Aim To examine the relationship between feeding therapy and the timing of independent oral feeding (IOF) in preterm infants in the neonatal intensive care unit (NICU). Study design A retrospective analysis of 536 preterm infants ( Results…

View details →DOI: 10.1080/01942638.2025.2552136
Negative / Null Result ReportOpen accessMedicine

Frailty as Predictor for Early Functional Outcomes After Radical Prostatectomy.

Stankovic M, Weber C, Koser M et al. · 2025 · Journal of frailty, sarcopenia and falls

Objectives While chronological aging does not necessarily impair oncological outcomes after radical prostatectomy, the role of frailty remains less clear. This study aimed to evaluate whether frailty significantly affects early continence…

View details →DOI: 10.22540/jfsf-10-028
Negative / Null Result ReportOpen accessMedicine

The value of transpulmonary thermodilution parameters in predicting hemodynamic instability in intensive care patients undergoing continuous renal replacement therapy.

Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology

Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…

View details →DOI: 10.1186/s12882-025-04712-0
Negative / Null Result ReportOpen accessMedicine

Neighborhood Physical Disinvestment and Incident Diabetes between visits 1 and 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine

Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…

View details →DOI: 10.1007/s11524-026-01061-7
Negative / Null Result ReportOpen accessMedicine

Burden of atherosclerosis, cardiovascular risk factors and atrial fibrillation in individuals with covert brain infarcts in late midlife: the Akershus Cardiac Examination 1950 Study.

Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open

Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…

View details →DOI: 10.1136/bmjopen-2025-114232
Negative / Null Result ReportOpen accessMedicine

Histological signatures of hormone replacement therapy in the endometrium.

Abdalla M · 2026 · Frontiers in medicine

Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…

View details →DOI: 10.3389/fmed.2026.1718508
Negative / Null Result ReportMedicine

Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.

O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…

View details →DOI: 10.1038/s41372-026-02601-4
Negative / Null Result ReportOpen accessMedicine

Stable bloodstream infection rates despite rising colonization: insights from a hospital system using in-house polymerase chain reaction screening for <i>Candidozyma auris</i>.

Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…

View details →DOI: 10.1017/ash.2025.10076
Negative / Null Result ReportOpen accessMedicine

Ki67 and Lymphovascular Invasion as Histopathological Predictors of Residual Cancer Burden After Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study.

Carabas BA, Țǎpoi DA, Costache M · 2026 · Diagnostics (Basel, Switzerland)

Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I-III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers…

View details →DOI: 10.3390/diagnostics16081213
Negative / Null Result ReportOpen accessMedicine

Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation.

Lee CC, Miller AA, Tallman PS et al. · 2025 · American journal of human biology : the official journal of the Human Biology Council

Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological…

View details →DOI: 10.1002/ajhb.70069
Negative / Null Result ReportOpen accessMedicine

Circulating Levels of Soluble α-Klotho and FGF23 in Childhood Cancer Survivors: Lack of Association with Nephro- and Cardiotoxicity-A Preliminary Study.

Kozłowski K, Konończuk K, Muszyńska-Rosłan K et al. · 2024 · Journal of clinical medicine

Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood cancer survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and…

View details →DOI: 10.3390/jcm13102968
Negative / Null Result ReportOpen accessMedicine

Correlation of Mean Platelet Volume With Angiographic Severity in Diabetic Coronary Artery Disease: A Cross-Sectional Study.

Agarwal Y, Metgudmath A, Metgudmath V · 2026 · Cureus

Aim To evaluate the association of mean platelet volume (MPV) and immature platelet fraction (IPF) with coronary angiographic severity, categorised by the number of significantly diseased epicardial vessels (single, double or triple vessel…

View details →DOI: 10.7759/cureus.102326
Negative / Null Result ReportOpen accessMedicine

Dietary Fiber Intake Was Inversely Associated with All-Cause Mortality but Not with Cancer and Cardiovascular Disease Mortalities in the US.

Akbar Z, Fituri S, Shi Z et al. · 2025 · Diseases (Basel, Switzerland)

Background Evidence linking dietary fiber intake with cancer risk and mortality is equivocal. Objective We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US…

View details →DOI: 10.3390/diseases13080272
Negative / Null Result ReportMedicine

PICU Admission of Children for Status Epilepticus: Is There a Different Approach Between Referral and Second-Level Hospitals in an Italian Region?

Bonardi CM, Nosadini M, Lorenzoni G et al. · 2024 · Clinical pediatrics

Appropriate status epilepticus (SE) management is key to minimize admission to the pediatric intensive care unit (PICU). We retrospectively describe 115 children admitted to the PICU of the tertiary-care referral hospital of Padova for…

View details →DOI: 10.1177/00099228231220174