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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 258 of 662

Negative / Null Result ReportMedicine

Belowground Interactions in a Barley Cultivar Mixture: Root Distribution and Arbuscular Mycorrhizal Contributions to Uptake of Heterogeneous Phosphorus

Siegwart L, Müller‐Stöver D, Dresbøll DB et al. · 2025 · Physiologia Plantarum.

Cultivar mixtures have the potential to mitigate abiotic stress and stabilize crop yields, but their belowground dynamics remain poorly understood. We evaluated phosphorus (P) uptake by two contrasting spring barley (Hordeum vulgare L.)…

Negative / Null Result ReportMedicine

Data-Driven Techniques for Estimating Energy Expenditure in Wheelchair Users.

Doshmanziari R, Strand Aandahl H, Pettersen Reierstad H et al. · 2025 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Providing feedback on energy expenditure (EE) may be an important tool to support obesity prevention among manual wheelchair users (MWU). This paper presents a data-driven approach for estimating EE based on data collected from 40…

View details →DOI: 10.1109/tnsre.2025.3537333
Negative / Null Result ReportMedicine

Responses to Hypoxia and Hyperoxia in Embryonic Tiger Keelbacks (Rhabdophis tigrinus lateralis; Colubridae).

Li XM, Su S, Zhang LW et al. · 2025 · Journal of experimental zoology. Part A, Ecological and integrative physiology

Studies examining the oxygen dependency of embryonic survival, growth, and differentiation have been conducted for decades in a diverse array of animal taxa but including only one oviparous snake, the viperine water snake Natrix maura.…

View details →DOI: 10.1002/jez.2910
Negative / Null Result ReportMedicine

Effect of preharvest boron spraying on the firmness and microstructure of winter-harvested frozen broccoli among maturity types.

Viriyarattanasak C, Takemura Y, Hashimoto T et al. · 2025 · Journal of the science of food and agriculture

Background Softening of winter-harvested frozen broccoli is a challenge. Application of boron (B) can improve fruit texture, but its effects on processed vegetables remain unexplored. This study is the first to investigate the impact of…

View details →DOI: 10.1002/jsfa.14249
Negative / Null Result ReportMedicine

Sigma-1 receptor antagonism as a promising strategy for postoperative pain treatment: A study in laparotomized mice.

Santos-Caballero M, Ruiz-Cantero MC, Mayr HK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Postoperative pain remains a major clinical challenge, as it often persists despite analgesic treatment even with opioids. We studied the effects of sigma-1 receptor antagonists (BD-1063 and S1RA), administered alone or in combination with…

View details →DOI: 10.1016/j.biopha.2025.118298
Negative / Null Result ReportMedicine

Patients Presenting to the Emergency Department with Bleeding in Early Pregnancy: Comparing Different Models to Predict Pregnancy Success.

Essel NOM, Couperthwaite S, Yang EH et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Objectives Bleeding in early pregnancy is a common obstetric presentation in the emergency department (ED), and the outcome is difficult to predict. We developed and compared random forest machine learning (Live Birth Risk Score [LiBRisk])…

View details →DOI: 10.1016/j.jogc.2025.102789
Negative / Null Result ReportMedicine

Evidence for the dependence of visual and kinesthetic motor imagery on isolated visual and motor practice.

Peters CM, Scott MW, Jin R et al. · 2025 · Consciousness and cognition

Motor imagery (MI) is a cognitive process believed to rely on the representation developed through experience. The equivalence between MI and execution has been questioned and the relationship between experience types and MI is unclear. We…

View details →DOI: 10.1016/j.concog.2024.103802
Negative / Null Result ReportMedicine

Validation and Modified Application of the 2023 International Expert Consensus Criteria for Diagnosing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Among Children With Acquired Demyelination in Resource-Limited Regions.

Sondhi V, Desai N, Lingappa L et al. · 2025 · Pediatric neurology

Background This study was undertaken to validate the 2023 myelin oligodendrocyte glycoprotein (MOG) antibody (Ab)-associated disease (MOGAD) diagnostic criteria among children with acquired demyelinating syndromes. Methods In this…

View details →DOI: 10.1016/j.pediatrneurol.2025.08.010
Negative / Null Result ReportMedicine

Variability in adolescent reception of parental support: Testing the domain-matching hypothesis.

Altinoz ZS, Erath SA, Pettit GS et al. · 2024 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

The present study investigated matches and mismatches between adolescent and parent socialization domains (i.e., protection, guidance) as related to adolescent reception of parental support during a laboratory-based social evaluation…

View details →DOI: 10.1037/fam0001225
Negative / Null Result ReportMedicine

Effects of polyphenol-rich extracts and compounds on methane and ammonia emissions from pig slurry during 28-day incubation

Vazifehkhoran AH, Pedersen J, Guldberg LB et al. · 2024 · Biosystems engineering.

Animal manure in livestock production facilities is a major source of methane (CH₄) and ammonia (NH₃) emissions from agriculture. In this study, we investigated different polyphenol-rich extracts and chemicals including commercial chestnut…

View details →DOI: 10.1016/j.biosystemseng.2024.11.002
Negative / Null Result Report

Effect of Short-Term High CO 2 Treatments on Maintaining the Firmness of Highbush and Rabbiteye Blueberries During Cold Storage

Toledo-Guerrero JD, Alvarez MD, Herranz B et al. · 2024 · Preprint

Global demand for blueberries has surged in recent years, primarily due to their health benefits. However, blueberries postharvest losses, particularly firmness loss and decay, remain significant challenges. This study applied high…

View details →DOI: 10.20944/preprints202410.1910.v1
Negative / Null Result ReportMedicine

The Effects of the Nocturnal Sleep on Learning of a Complex Motor Skill in Young and Older Adults.

Leal MG, Dos Martírios Luz JE, Fidelix YL et al. · 2025 · Experimental aging research

Background/study context Research on older adults has shown impairments in nocturnal sleep, impacting motor memory consolidation and learning. However, previous studies primarily focus on simple tasks, limiting generalization to complex…

View details →DOI: 10.1080/0361073x.2024.2439741
Negative / Null Result ReportMedicine

Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms.

Mahmoud M, Richter P, Arnold P et al. · 2025 · Photodiagnosis and photodynamic therapy

Pseudomonas aeruginosa is a hard-to-treat human pathogen for which new antimicrobial agents are urgently needed. P. aeruginosa is known for forming biofilms, a complex aggregate of bacteria embedded in a self-generated protective matrix…

View details →DOI: 10.1016/j.pdpdt.2024.104456
Negative / Null Result ReportOpen accessMedicine

Acute Effects of Commercial Yerba Mate Products on Cardiometabolic Responses during Submaximal Cycling: Brewed to Perform?

Zaki S, Berkachy R, Zein Eddine R et al. · 2026 · Current developments in nutrition

Background Yerba mate ( Ilex paraguariensis ) is an herb native to South America known for its caffeine and polyphenol content, with suggested benefits for fat oxidation and energy metabolism. However, few studies have evaluated its brewed…

View details →DOI: 10.1016/j.cdnut.2026.107637
Negative / Null Result ReportOpen accessMedicine

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.

Mazzini G, Tuerlings M, van der Stap V et al. · 2026 · Cartilage

BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on…

View details →DOI: 10.1177/19476035261458719
Negative / Null Result ReportMedicine

Prior exposure to doxorubicin exacerbates atherosclerotic plaque formation in apolipoprotein-E-deficient mice on a high-fat diet.

Bosman M, Krüger D, Roth L et al. · 2025 · Atherosclerosis

Background and aims Epidemiological data suggest that anthracyclines, such as doxorubicin (DOX), promote atherosclerosis in cancer survivors. However, this has not been established experimentally so far. Here, we investigated whether DOX…

View details →DOI: 10.1016/j.atherosclerosis.2025.119168
Negative / Null Result ReportMedicine

Acute metformin intake on exercise performance in healthy participants during functional fitness training.

Pinheiro AH, Silva LG, Bastos-Silva VJ · 2025 · The Journal of sports medicine and physical fitness

Background The study aimed to assess whether prior intake of metformin enhances performance in the FRAN workout, a popular Functional Fitness Training protocol. Methods Fourteen men (mean±SD: 24.2±3.5 years; height: 173.3±7.8 cm; weight:…

View details →DOI: 10.23736/s0022-4707.24.16591-7
Negative / Null Result ReportMedicine

Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model.

Pereira M, Brandão Ostermann RA, de Fáveri W et al. · 2025 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Aspirin has significant antineoplastic effects on the colon, whereas the outcomes of Vitamin C and D supplementation have been inconsistent. This study addressed the isolated and combined effects of vitamins C and D with aspirin on…

View details →DOI: 10.1016/j.fct.2025.115400
Negative / Null Result Report

The temporal copulatory patterns of female rat sexual behavior

Oyem JC, Heijkoop R, Snoeren EM · 2024 · Preprint

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

View details →DOI: 10.1101/2024.10.07.616964
Negative / Null Result ReportMedicine

Roles of spermary-specific carboxylesterases in Nilaparvata lugens reproduction: Opposite between insecticide-induced upregulation and resistance-associated overexpression.

Zhang H, Yang B, Xu X et al. · 2025 · International journal of biological macromolecules

Seminal fluid proteins (SFPs) in insect males are critical for reproduction, being transported into female ovary. In Nilaparvata lugens, a significant rice pest, seven spermary-specific carboxylesterases (CarEs) were found abundantly in…

View details →DOI: 10.1016/j.ijbiomac.2024.138991
Negative / Null Result ReportOpen accessMedicine

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

Stanfield B, Leroux B, Kaeberlein M et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults…

View details →DOI: 10.1002/jcsm.70274
Negative / Null Result ReportOpen accessMedicine

The Effect of L-Carnitine Supplementation in Culture Medium on the Development and Cryopreservation of in Vitro Produced Bovine Embryos.

Yildiz M, Cetin Y · 2025 · Veterinary medicine and science

Background In vitro culture media play a crucial role in supporting the growth and development of bovine embryos. Despite advancements in media formulations, there is ongoing interest in optimising these media by supplementing them with…

View details →DOI: 10.1002/vms3.70376
Negative / Null Result ReportMedicine

Comparisons of the amylolytic enzymes and malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar developed in Japan) and Kitanohoshi (currently used cultivar for beer production).

Saburi W, Mori H · 2024 · Bioscience, biotechnology, and biochemistry

Starch degradation in malted barley produces yeast-fermentable sugars. In this study, we compared the amylolytic enzymes and composition of the malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar established in…

View details →DOI: 10.1093/bbb/zbae096
Negative / Null Result ReportOpen accessMedicine

In Vitro Evaluation of Olorofim and Amphotericin B Combination Therapy Against <i>Talaromyces marneffei</i>.

Lan LHN, Natesan Sambath H, Brown L et al. · 2026 · Journal of fungi (Basel, Switzerland)

The dimorphic fungus Talaromyces marneffei causes talaromycosis, a life-threatening fungal disease with limited treatment options. Olorofim, a first-in-class orotomide antifungal that targets pyrimidine synthesis essential for fungal…

View details →DOI: 10.3390/jof12060441
Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study.

Ghazzagh A, Naderi A, Agha-Alinejad H et al. · 2025 · International journal of sport nutrition and exercise metabolism

Taurine (TAU) has been shown to improve time to exhaustion (TTE) and fat oxidation during exercise; however, no studies have examined the effect of acute TAU supplementation on maximal fat oxidation (MFO) and related intensity to MFO…

View details →DOI: 10.1123/ijsnem.2024-0076