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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 257 of 675

Negative / Null Result ReportMedicine

Increasing Buprenorphine and Naloxone Access in Texas Community Pharmacies Through an Academic Detailing Intervention.

Torrez SB, Evoy KE, Reveles KR et al. · 2026 · Substance use & addiction journal

Background Patients with opioid use disorder need prompt buprenorphine/naloxone (BUP/NX) and naloxone nasal spray (NNS) access from pharmacies, but audit studies report substantial availability deficits. No specific intervention has…

View details →DOI: 10.1177/29767342261422061
Negative / Null Result ReportMedicine

Marine heatwaves have no impact on fertilization, early development and sensitivity to metal toxicity in the sea urchin Paracentrotus lividus.

Gambardella C, Soro P, Miroglio R et al. · 2026 · Marine environmental research

Marine Heatwaves (MHWs) have become more severe and frequent worldwide under global warming. They are projected to intensify under different climate scenarios, with unknown consequences for the marine biota. In this study we assess the…

View details →DOI: 10.1016/j.marenvres.2026.107983
Negative / Null Result ReportMedicine

Nocturnal Sleep Breathing Patterns in Healthy Adolescents Residing at Very High Altitudes in Bolivia.

Patterson K, Rodríguez SU, Arancibia-Levit EN et al. · 2026 · Journal of sleep research

Data on sleep and respiratory patterns among adolescents residing at very high altitude (> 3500 m) remain scarce, and altitude-related physiological differences may influence these parameters. Studying adolescents at different very high…

View details →DOI: 10.1111/jsr.70326
Negative / Null Result ReportMedicine

Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.

De La Garza-Ramos C, Silver C, Islam F et al. · 2026 · Cardiovascular and interventional radiology

Purpose Describe the incidence and severity of gastrointestinal tract-related adverse events (GIAE) following radiation segmentectomy (RS) for hepatocellular carcinoma (HCC) in the left hepatic lobe. Materials and methods A single-center…

View details →DOI: 10.1007/s00270-026-04376-9
Negative / Null Result ReportMedicine

Evaluation of squid shiokara products marketed in Japan using sensory tests, amino acid and organic acid profiles, and analysis of bacterial communities

Mizusawa N, Nishimura K, Ouchi D et al. · 2026 · Fish Sci

Shiokara is a traditional Japanese salted and fermented seafood product. The aim of this study was to compare various commercially available squid shiokara products in Japan by examining their NaCl content, free amino acid content (all…

Negative / Null Result ReportMedicine

Preliminary evaluation of a developmentally centred approach to optimise comfort in neonates following cardiac surgery.

Jones MB, Caprarola SD, Gordish H et al. · 2026 · Cardiology in the young

Introduction Children with CHD are at risk for neurodevelopmental impairments, and though these are often mild, some children face severe developmental challenges. Both unalleviated pain and exposure to opioids in the neonatal period have…

View details →DOI: 10.1017/s1047951125110949
Negative / Null Result ReportMedicine

Dung beetles do not profit from enhanced spatial heterogeneity in temperate production forests: A forest manipulation experiment

Asch J, Scherer‐Lorenzen M, Pierick K et al. · 2026 · Journal of Applied Ecology.

Central European forest management strategies promoting structurally homogeneous closed‐canopy forests have led to landscape‐level declines in biodiversity and ecosystem multifunctionality. Conservation‐targeted management programs aim at…

Negative / Null Result ReportMedicine

Exopolysaccharide biosynthesis and regulation in Leuconostoc mesenteroides influences water holding capacity of fermented plant-based milks.

Sukarno AS, Dong A, Gumulya Y et al. · 2026 · International journal of food microbiology

Physical instability remains a major challenge in fermented plant-based yoghurts in the absence of added texturizing agents. Cultures can improve water holding capacity (WHC) through production of exopolysaccharide (EPS). This study…

View details →DOI: 10.1016/j.ijfoodmicro.2026.111797
Negative / Null Result ReportMedicine

The influence of adolescent idiopathic scoliosis on hip joint development: a two-year longitudinal evaluation of the hip center-edge angle.

Matsumoto T, Yokoe T, Takahashi T et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

PURPOSE: Several studies have reported an association between adolescent idiopathic scoliosis (AIS) and hip decentration (HD). However, these previous studies evaluated the hip center-edge (CE) angle at only a single time point. This study…

View details →DOI: 10.1007/s00586-026-09787-3
Negative / Null Result ReportMedicine

Non-modifiable cardiovascular risk factors and coronary plaque characteristics in patients with acute coronary syndromes.

Scalamera R, Covani M, Andreaggi S et al. · 2026 · European heart journal. Cardiovascular Imaging

Aims Cardiovascular risk factors predict adverse clinical outcomes, including acute coronary syndromes (ACS). A recent study showed a close correlation between the number of modifiable risk factors and plaque vulnerability. However, the…

View details →DOI: 10.1093/ehjci/jeag023
Negative / Null Result ReportMedicine

Bark beetles as ecosystem engineers: triggered tree mortality rearranges the assemblage of Tree-related Microhabitats in old-growth coniferous forest

Przepióra F, Ciach M · 2025 · Forest Ecology and Management.

Although species with ecosystem engineering capabilities like woodpeckers, ungulates or saproxylic insects may initiate the formation of Tree-related Microhabitats (TreMs), their overall impact on TreM assemblages remains unexplored. Bark…

Negative / Null Result ReportMedicine

Heat-Killed <i>Enterococcus faecalis</i> EF-2001 Promotes Systemic Th1-Skewed Immune Activation Without Detectable Reduction of Influenza Viral Load in Mice.

Ohashi T, Hagihara M, Asai N et al. · 2026 · Microorganisms

Heat-killed Enterococcus faecalis EF-2001 (EF-2001) is a postbiotic preparation reported to modulate host immunity. However, its specific impact on host immune responses and virological outcomes during the early phase of influenza…

View details →DOI: 10.3390/microorganisms14020316
Negative / Null Result Report

Assessment of Heavy Metals in Organic and Non-Organic Vegetables Post Severe Tropical Cyclone Gabrielle: A cross-sectional comparative analysis.

Dearing C, Ye Z, Robertshaw G · 2025 · Preprint

Abstract* Background Heavy metals such as cadmium, lead, and mercury are ubiquitous in the environment, accumulating in plants, animals, water and human food. Human exposure through the consumption of vegetable crops is a global concern…

View details →DOI: 10.12688/f1000research.175538.1
Negative / Null Result ReportMedicine

Impact of neoadjuvant immunotherapy on postoperative cardiac adverse events in NSCLC: insights from a bidirectional cohort.

Yan C, Zhang X, Hu S et al. · 2026 · International journal of surgery (London, England)

The impact of neoadjuvant chemo-immunotherapy (nCIT) on perioperative cardiac safety in patients undergoing lung cancer resection remains unclear. This study aimed to evaluate the incidence and risk factors of postoperative cardiac adverse…

View details →DOI: 10.1097/js9.0000000000004846
Negative / Null Result ReportMedicine

Effect of acute intraperitoneal injection of methylglyoxal on organ injury and oxidative stress in chicks (Gallus gallus domestics).

Okino M, Makino R, Aoki M et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Methylglyoxal (MGO) is an α-dicarbonyl compound and produced from several metabolic pathways, including glucose metabolism. This compound induces oxidative stress and organ damage in mammals and is associated with various diseases,…

View details →DOI: 10.1016/j.cbpa.2026.111975
Negative / Null Result Report

Glucose coating tunes the catalytic reactivity of FeO@Fe 3 O 4 for biomedical applications: safety assessment using a 3D hepatic in vitro model

Ovalle MAM, Rozman I, Winkler EL et al. · 2026 · Preprint

Abstract Iron-oxide magnetic nanoparticles (MNPs) have been extensively investigated as magnetically actuable nanocatalysts for diagnostic and therapeutic applications. However, because wüstite/magnetite/maghemite phases can interconvert,…

View details →DOI: 10.21203/rs.3.rs-8474662/v1
Negative / Null Result Report

The Safety of Low-Molecular-Weight Heparin Bridging Therapy in Patients Receiving Preoperative Oral Antithrombotic Drugs During Spinal Fusion Surgery

Yan W, Che Z, Deng H et al. · 2026 · Preprint

Abstract 【Purpose】 To evaluate whether preoperative oral antithrombotic drugs increase perioperative bleeding risk in spinal fusion patients receiving low-molecular-weight-heparin (LMWH) bridging therapy, and compare bleeding risk with…

View details →DOI: 10.21203/rs.3.rs-8344022/v1
Negative / Null Result ReportMedicine

Shortening the perioperative prophylactic antimicrobial duration in pediatric ventriculoperitoneal (VP) shunt insertion.

Tada A, Ihara S, Suwa J et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

Background Perioperative antimicrobial therapy is important to prevent central nervous system (CNS) infections following cerebrospinal fluid (CSF) shunt insertion, but the optimal duration remains unclear. This study aimed to evaluate the…

View details →DOI: 10.1111/ped.70372
Negative / Null Result ReportOpen accessMedicine

Impact of offset polyethylene liners on acetabular component loosening : an Australian Orthopaedic Association National Joint Replacement Registry-based analysis.

Shafiei SH, Latorre MR, Shimmin A · 2026 · Bone & joint open

Aims Restoring native hip biomechanics is essential for the long-term success of total hip arthroplasty (THA). Lateralized (offset) acetabular liners were developed to increase global offset and improve soft-tissue tension, but their…

View details →DOI: 10.1302/2633-1462.76.bjo-2026-0033.r1
Negative / Null Result ReportMedicine

Effectiveness of a Remote Physical Activity Intervention in Individuals with Alzheimer's Disease and their Caregivers: Results from a Randomized Trial.

Ptomey LT, Helsel BC, Montgomery RN et al. · 2026 · Medicine and science in sports and exercise

Purpose Individuals with Alzheimer's disease and related dementias (ADRD) and their caregivers often experience reduced physical activity (PA), diminished functional fitness, and heightened health risks. Remotely delivered PA interventions…

View details →DOI: 10.1249/mss.0000000000003974
Negative / Null Result ReportMedicine

Atherosclerotic Cardiovascular Risk in Patients with Chronic Hepatitis B: Tenofovir Disoproxil Fumarate Vs. Tenofovir Alafenamide: A Korean Nationwide Study.

Yang J, Lim J, Kim YJ et al. · 2026 · Journal of medical virology

Tenofovir alafenamide (TAF) exhibits antiviral efficacy comparable to tenofovir disoproxil fumarate (TDF). Nonetheless, concerns persist regarding TAF's impact on the lipid profile and potential atherosclerotic cardiovascular disease…

View details →DOI: 10.1002/jmv.70829
Negative / Null Result ReportMedicine

The Effect of High-Intensity Interval Training on Neuroplasticity-Related Proteins in the Cerebrum of Postnatally Growth-Restricted Mice.

Kim SH, Quinn MA, Ananyev J et al. · 2026 · Medicine and science in sports and exercise

Introduction Childhood growth restriction can lead to lasting developmental changes, increasing susceptibility to chronic diseases and neurodegenerative conditions in adulthood. High-intensity interval training (HIIT) elevates…

View details →DOI: 10.1249/mss.0000000000003964
Negative / Null Result ReportMedicine

A randomized trial of I-SLEEP: A patient education and empowerment intervention on inpatient sleep duration and medical sleep disruptions.

Sunderrajan A, Cursio J, Mason N et al. · 2026 · Journal of hospital medicine

Background Sleep is essential for recovery in hospitalized patients, yet frequent disruptions from medical care make rest difficult. Most prior efforts have focused on environmental modifications, often overlooking patients' role in…

View details →DOI: 10.1002/jhm.70273
Negative / Null Result ReportOpen accessMedicine

Effect of ruminally protected lysine on growth and nitrogen balance of grain-finished beef cattle fed diets of decreasing protein concentration.

Herzog DS, Jo J, Nakajima D et al. · 2026 · Translational animal science

Two experiments were conducted to determine the effect of ruminally protected lysine (AjiPro-L) supplementation on performance and nitrogen (N) balance of feedlot cattle fed decreasing concentrations of dietary protein. Diets contained (DM…

View details →DOI: 10.1093/tas/txag076
Negative / Null Result ReportMedicine

Nirsevimab Implementation and Primary Management of Lower Respiratory Tract Infections in Infants in Spain: A Quasi-Experimental Study.

Medina Muñoz M, Gallego Campillo S, Martín Peinador Y et al. · 2026 · Indian pediatrics

Objective Lower respiratory tract infections (LRTIs) are a common cause of primary care visits in infants. This study was done to evaluate the course of LRTIs before-and-after the introduction of nirsevimab and to identify the associated…

View details →DOI: 10.1007/s13312-026-00385-6
Negative / Null Result ReportMedicine

The association between skin-suturing technique, prolonged healing and recurrence after Bascom's Cleft lift surgery.

Larsen MB, Faurschou IK, Haas S · 2026 · Techniques in coloproctology

Background The optimal treatment for complex Pilonidal Sinus Disease (PSD) is still debated. Despite great advances with the introduction of off-midline closure techniques, healing problems and recurrence remain challenges. We aimed to…

View details →DOI: 10.1007/s10151-026-03377-7