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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 255 of 662

Negative / Null Result ReportMedicine

Effects of zinc supplementation forms (ZnO, Zn-Lysine, Nano-ZnO) on growth performance and metabolic health in pre-weaned Holstein calves.

Alipour A, Ganjkhanlou M, Zali A et al. · 2026 · Scientific reports

The pre-weaning period is critical because early-life nutrition and management influence growth, metabolic function and Rumen development, thereby affecting subsequent productivity in dairy calves. Zinc (Zn) supplementation plays a key…

View details →DOI: 10.1038/s41598-026-51255-x
Negative / Null Result ReportMedicine

Effect of dietary phosphorus and calcium depletion-repletion on pig performance and bone quality.

Palacios-Duchicela R, Létourneau-Montminy MP, Lizardo R et al. · 2026 · Animal : an international journal of animal bioscience

Feeding strategies such as P and Ca depletion and repletion have been proposed to reduce the use of phosphate or improve P utilisation efficiency in pig diets, thereby contributing to the sustainability of the sector. A total of 48 entire…

View details →DOI: 10.1016/j.animal.2026.101865
Negative / Null Result ReportMedicine

How does prescribed burning in grasslands of coastal southern Texas, USA, impact butterfly populations?

Zerlin RR, Elissetche JC, Avila-Sanchez JS et al. · 2025 · Journal of environmental management

Butterflies are important pollinators worldwide and are often sensitive indicators of ecosystem health. Prescribed fire is used in grassland to mimic historic wildfires, improve forage nutritional value, and increased forb production and…

View details →DOI: 10.1016/j.jenvman.2025.128034
Negative / Null Result ReportMedicine

Cynandione A improves white adipose tissue homeostasis in high-fat diet-fed mice.

Sawamoto A, Shiba M, Okuyama S et al. · 2026 · The Journal of pharmacy and pharmacology

Objectives Cynandione A (CA), a major bioactive compound isolated from Cynanchum wilfordii Radix, is a crude drug traditionally used in East Asia. We have previously demonstrated that CA induces a beige adipocyte-like phenotype in vitro.…

View details →DOI: 10.1093/jpp/rgag038
Negative / Null Result ReportMedicine

Effect of Procedure Setting on Urinary Retention After Bulkamid Injection.

Stock A, Adaniya C, Gaines M et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Urethral Bulkamid is a U.S. Food and Drug Administration-approved nonsurgical treatment for stress urinary incontinence and stress-predominant mixed urinary incontinence due to intrinsic sphincter deficiency. This procedure is…

View details →DOI: 10.1097/spv.0000000000001828
Negative / Null Result ReportMedicine

ARHGAP39 plays an essential role in anxiety-like behavior and stress response.

Deng SM, Chen YJ, Hung WC et al. · 2026 · Translational psychiatry

Anxiety is a common mental health disorder marked by heightened stress responses and impaired emotional regulation. While the hippocampus and the hypothalamic-pituitary-adrenal (HPA) axis play key roles in regulating anxiety, the molecular…

View details →DOI: 10.1038/s41398-026-04088-1
Negative / Null Result ReportMedicine

Acute Effects of Accentuated Eccentric Loading in Comparison to Traditional Resistance Loading on Velocity and Other Parameters in Concentric and Eccentric Phases in Barbell Back Squat.

Najafi A, Nosaka K, Javidi M et al. · 2026 · Journal of strength and conditioning research

Abstract Najafi, A, Nosaka, K, Javidi, M, Naddafha, S, Kumagawa, D, Bertochi, GFA, and Latella, C. Acute effects of accentuated eccentric loading in comparison to traditional resistance loading on velocity and other parameters in…

View details →DOI: 10.1519/jsc.0000000000005396
Negative / Null Result ReportMedicine

Effects of Sacubitril/Valsartan vs Irbesartan on Urine Tubular Biomarkers in CKD: Findings from the UK HARP-III Trial.

Goonasekera MA, Malijan GB, Sardell RJ et al. · 2026 · American journal of nephrology

Introduction Sacubitril/valsartan shows benefits in heart failure and may have kidney protective effects. Its impact on kidney tubular health in chronic kidney disease (CKD) remains unclear. We evaluated the effects of sacubitril/valsartan…

View details →DOI: 10.1159/000552348
Negative / Null Result ReportMedicine

Effects of emamectin benzoate spiked sediment on adult, larval and post-larval stages of the American lobster (Homarus americanus).

Asnicar D, Jonah L, Kingsbury M et al. · 2026 · The Science of the total environment

Salmon farming represents a significant economic sector on both Canada's Atlantic and Pacific coasts. To manage sea lice outbreaks, medicated feeds containing emamectin benzoate (EMB) are commonly applied. Because EMB is poorly soluble and…

View details →DOI: 10.1016/j.scitotenv.2026.181799
Negative / Null Result ReportMedicine

Primary and steroid-induced antibody deficiency in severe asthma: a real-life analysis of a well-defined biologic-treated cohort.

Yegin Katran Z, Argın Ö, Bulut İ · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma

Background Severe asthma is frequently associated with recurrent exacerbations and prolonged systemic corticosteroid use, which may lead to secondary immunodeficiency (SID). In addition, unrecognized primary immunodeficiencies (PIDs) may…

View details →DOI: 10.1080/02770903.2026.2644881
Negative / Null Result ReportMedicine

The effects of imidacloprid exposure on the mouse ovary in vivo.

Mourikes VE, Lee C, Oladosu JI et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)

Imidacloprid (IMI) is an insect-selective synthetic nicotine derivative used in commercial agricultural systems, home gardening, and veterinary pharmaceuticals. People are exposed to IMI through consumption of contaminated food and water…

View details →DOI: 10.1016/j.reprotox.2025.109045
Negative / Null Result ReportMedicine

Co-administration of digoxin and trans-2-decenoic acid ethyl ester improves motor learning performance in mice.

Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research

Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…

View details →DOI: 10.1016/j.bbr.2026.116225
Negative / Null Result ReportMedicine

Post-COVID-19 diabetes outcomes.

Lin CJ, Bosco AA, Alves LI et al. · 2026 · Scientific reports

Long-COVID-19 presentation has not been evaluated with proper depth in patients with diabetes (DM). This retrospective study evaluated 870 patients (320 DM, 550 non-DM) followed for up to 7.1 months post-hospitalization. Acute myocardial…

View details →DOI: 10.1038/s41598-026-42284-7
Negative / Null Result ReportMedicine

Physicochemical, rheological, textural, tribological, and sensory insights into the role of citrus fiber in quark cheese spreads with varying fat content.

Vincová A, Šantová K, Jaššo M et al. · 2026 · Journal of dairy science

The objective of this study was to evaluate the effect of citrus fiber (1% wt/wt) on the physicochemical, rheological, textural, tribological, and sensory properties of quark cheese spreads with different fat content (10%, 15%, and 20%…

View details →DOI: 10.3168/jds.2025-27829
Negative / Null Result Report

Novel recombinant bovine papular stomatitis virus expressing foot and mouth disease virus-like particles elicits protective levels of neutralizing antibodies in cattle

Chambaro HM, Delhon G, Miraglia MC et al. · 2026 · Preprint

Foot-and-mouth disease (FMD) remains a major burden in endemic regions, where inactivated vaccines are constrained by cost, short duration of immunity, cold-chain dependence, and high-containment manufacturing. Here, we engineered a…

View details →DOI: 10.64898/2026.06.01.729332
Negative / Null Result ReportMedicine

Impact of formaldehyde application in commercial hatchers on chick intestinal microbiota.

Meisinger BD, Coufal CD, Olson EG et al. · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

Reducing microbial contamination during late-stage incubation is important for hatchery sanitation and early chick microbial exposure. Formaldehyde is commonly applied in commercial hatchers to reduce airborne and eggshell-associated…

View details →DOI: 10.1080/03601234.2026.2677407
Negative / Null Result ReportMedicine

Nasal shedding of bovine coronavirus during commingling is associated with reduced average daily gain and lung lesions in weaned seropositive calves.

Urbaniec J, Anagnostopoulos A, Davies P et al. · 2026 · Journal of dairy science

Bovine coronavirus (BCV) is a common calf pathogen and has been proposed as a potential contributor to bovine respiratory disease (BRD); however, little is known about its epidemiology and genetic diversity on UK farms. The aim of this…

View details →DOI: 10.3168/jds.2026-28706
Negative / Null Result Report

Temporary deterioration of health and behavior during pexidartinib-mediated microglia depletion and repopulation in progranulin-deficient mice

Weyer M, Hahnefeld L, Franck L et al. · 2026 · Preprint

Progranulin (PGRN) is a neurotrophic and anti-inflammatory factor produced mainly by neurons and microglia in the central nervous system. Progranulin haploinsufficiency causes frontotemporal dementia (FTD). In a previous study we showed…

View details →DOI: 10.64898/2026.04.20.719642
Negative / Null Result Report

Crosstalk Between Calcium Dynamics and ROS Levels in U87 Glioblastoma Cells Exposed to Extremely low frequency pulsed electromagnetic fields

Hadichgeni S, Shariatpanahi SP, Goliaei B et al. · 2026 · Preprint

Extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) have been proposed to modulate intracellular signaling in cancer cells, however, the primary mediators and their temporal sequence remain incompletely understood. In this…

View details →DOI: 10.64898/2026.04.15.718611
Negative / Null Result ReportMedicine

Differential Antioxidant Capacities of Human Endometriotic and Endometrial Cell Models Under H<sub>2</sub>O<sub>2</sub> Exposure.

Coelho JA, Gomes KS, Cerchiaro G · 2026 · International journal of molecular sciences

Endometriosis is associated with oxidative stress and debilitating symptoms, yet its pathophysiology remains incompletely understood, and current treatments are still limited. In this study, oxidative stress responses were compared in 2D…

View details →DOI: 10.3390/ijms27094131
Negative / Null Result ReportMedicine

Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration after Axotomy.

Pottorf TS, Lane EL, Haley-Johnson Z et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience

Spinal cord ventral horn microglia proliferate after nerve injuries and migrate toward cell bodies of injured motoneurons (MNs) enwrapping them. The significance of this microglia reaction has remained unclear. Moreover, some injured MNs…

View details →DOI: 10.1523/jneurosci.0112-26.2026
Negative / Null Result ReportMedicine

Persistence of Campylobacter fetus subsp. venerealis in the reproductive tract of vaccinated heifers after experimental infection: Insights into vaginal mucosal immunity in heifers.

Scioli MV, Sosa E, Barale J et al. · 2026 · Veterinary immunology and immunopathology

Bovine genital campylobacteriosis (BGC) remains a major cause of reproductive failure in beef cattle systems. This study evaluated the persistence of Campylobacter fetus subsp. venerealis (Cfv) and associated lesions in the reproductive…

View details →DOI: 10.1016/j.vetimm.2026.111131
Negative / Null Result ReportMedicine

Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling.

Ormes JA, Smrcka AV, Jutkiewicz EM · 2026 · Molecular pharmacology

The clinical utility of μ-opioid receptor (MOR) agonists is limited by side effects and tolerance. G protein βγ subunits (Gβγ) are critical mediators of MOR signaling that not only drive anticonception but also regulate phospholipase C and…

View details →DOI: 10.1016/j.molpha.2026.100123
Negative / Null Result ReportMedicine

Using Telehealth in End-of-Life Palliative Care: A Multimethod Randomized Controlled Trial.

Sigaard JVA, Spindler H, Joensen EDR et al. · 2026 · Journal of palliative medicine

Background An estimated 4.4 million people in Europe require palliative care annually, a number expected to rise with population aging. Telepalliative care (TPC) has been practiced in various settings over the past two decades. The Telepal…

View details →DOI: 10.1177/10966218261444643