Extracellular methylglyoxal; the passage across brain endothelial cells and the effect on barrier function
Berends E; Guimbal S; Zhang X; Frijns I; van de Waarenburg MP; Scheijen JL; Wouters K; van Oostenbrugge RJ · 2026 · Preprint
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Methylglyoxal (MGO), a highly reactive by-product of glycolysis, has been associated with cognitive decline and Alzheimer’s disease, though the mechanistic role of MGO remains unclear. Moreover, conflicting findings exist…
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Metadata source: Europe PMC · DOI 10.64898/2026.02.20.706964