A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20227 results in Negative / Null Result Report · page 250 of 675
Miño V, Bacigalupo F, Quezada-Scholz VE et al. · 2026 · Acta psychologica
The present study investigated whether cognitive reappraisal modulates conditioned responding during extinction in a socially relevant fear-conditioning paradigm and whether these effects vary as a function of 5-HTTLPR genotype and…
Gajula SNR, Kallam JS, Kanukolanu A et al. · 2026 · Biopharmaceutics & drug disposition
Echinacea is a widely used herbal supplement and is frequently co-administered with antiviral drugs, raising concerns regarding potential herb-drug interactions. This study evaluated the effect of repeated Echinacea administration on the…
Zhang P, Iskandarani ME, Riggs S · 2026 · IEEE transactions on visualization and computer graphics
Optical see-through head-mounted displays (OST-HMDs) allow users to interact with both physical and virtual displays overlaid in the real world within augmented reality (AR) environments. When arranging these displays in space, spatial…
Liu W, Tang Y, Ding W et al. · 2026 · Preprint
Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances. Ergothioneine (EGT) is a diet-derived thiol/thione antioxidant, yet its effects on the…
Hoshiyama K, Hirano T, Sekiya E et al. · 2026 · Scientific reports
This prospective observational study evaluated short-term intraocular pressure (IOP) changes and safety following intravitreal injection of aflibercept 8 mg versus 2 mg in diabetic macular edema (DME). We included 40 eyes from 36 patients…
Bektaş B, Ulusoy CO, Uslu H et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective In the present study, we aimed to evaluate the impact of vaginal birth after cesarean (VBAC) on quality of life, sexual function, sleep quality, and urinary incontinence and compare the results with those of vaginal birth (VB)…
Avalos MA, Shah S, Rosenblatt NJ · 2026 · Experimental brain research
Following a loss of balance, proper reactive responses are needed to avoid a fall. Efforts have focused on how physiological factors affect these responses, but few have addressed psychological states. One psychological factor of…
Burgazli AY, Avuloglu Yilmaz E, Mamur S et al. · 2026 · Toxicology mechanisms and methods
Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach.…
Wu Y, Zhu L, Lin G et al. · 2026 · Bioresource technology
Antibiotic resistance genes (ARGs) are an increasing environmental and public health concern in wastewater treatment systems due to their persistence, mobility, and links to human bacterial pathogens (HBPs). In this study, aerobic…
Li H, Zhao B, Wang J et al. · 2026 · Theriogenology
Ovum pick-up and in vitro embryo production (OPU-IVP) in Holstein cows is influenced by donor characteristics, yet quantitative selection criteria for optimizing oocyte developmental competence remain limited. In this study, data from 600…
Vukovic V, Karan-Djurasevic T, Antic D et al. · 2026 · Biomolecules & biomedicine
Fludarabine treatment in patients with chronic lymphocytic leukemia (CLL) has been associated with immune dysregulation and the development of autoimmune hemolytic anemia (AIHA). Prior research indicates a potential correlation between the…
Gutierrez AM, Robinson JO, Allen-Rhoades WA et al. · 2026 · Pediatric blood & cancer
Background Decision-making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and…
Barros C, Fernandes C, Baylina P · 2026 · Preprint
In the healthcare sector, burnout has become a critical concern due to the combination of high job demands and sustained emotional strain. The present study aims to analyze whether emotional intelligence moderates the relationship between…
Halawi H, Matar A, Wang I et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology
Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of…
Wan L, Xie B, Shuda M et al. · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy
CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…
Obaji D, Kim J, Olagbegi Y et al. · 2026 · Preprint
Transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that recruits RNA polymerase III (Pol III) to the majority of its target genes. Evolutionarily conserved overlap between TFIIIC binding sites and the structural…
Abbasi D, Schall M, Acosta-Sojo Y et al. · 2026 · Applied ergonomics
Shoulder disorders have been associated with repetitive overhead work and manual lifting. Passive exoskeletons may reduce exposure to physical risk factors associated with shoulder injuries. This repeated-measures study evaluated the…
Ma Z, Cao W, Zhang J et al. · 2026 · Neuroreport
Background γ-Aminobutyric acid (GABA) is essential for the central sedative/hypnotic actions of ethanol. The tuberomammillary nucleus (TMN), the exclusive source of forebrain histaminergic innervation, functions as the principal arousal…
Sugawara K, Yagi K, Yajima S et al. · 2026 · International journal of clinical oncology
Purpose We aimed to evaluate the outcomes of transmediastinal esophagectomy (TME) for esophagogastric junction cancer (EGJC) patients. Methods We retrospectively reviewed patients who underwent TME for EGJC (Siewert Type II) between 2018…
Li Y, Chen W, Hill R et al. · 2026 · European clinical respiratory journal
Asthma is a chronic respiratory condition that can be managed using Single Maintenance and Reliever Therapy (SMART) or traditional therapy with inhaled corticosteroid (ICS)-long-acting beta-agonist (LABA) for maintenance and short-acting…
Cosenza M, Fabbri M, Pizzini B et al. · 2026 · Journal of gambling studies
Adolescence represents a critical developmental period for the emergence of maladaptive gambling behaviors, including loss chasing, a key marker of gambling-related harm. The present study provides the first behavioral examination of the…
Vidon M, Wang X, Costes L et al. · 2026 · Clinics and research in hepatology and gastroenterology
Background and study aims Educational interventions have been proposed to improve adherence to bowel preparation instructions. We evaluated whether adding a short instructional video to standard written and oral information improves bowel…
Ahmed ME, Mahjoub SMAH, Adam SIY · 2026 · Tropical animal health and production
This study evaluated the effects of partially replacing groundnut cake with soaked chickpea (Cicer arietinum L.) seeds, with or without enzyme supplementation, on growth performance, carcass traits, serum biochemical indices, and…
Ren X, Wu Q, Zhao M et al. · 2026 · Preprint
This research aimed to determine the effects of replacing ryegrass (Lolium perenne L.) with licorice residue (LR) on growth performance, slaughtering performance, meat quality, serum biochemistry and cecal flora. Five pelleted rations were…
Uğurlu T, Sağlam BC, Koçak S et al. · 2026 · Preprint
Abstract Background The aim of this in vitro study was to examine the effects of different glide path files on root canal transportation and centering in curved root canals. Methods In this study, 33 mandibular first molars with a 10 mm…
Alqantash AH, Alshehri SM, Almalki AA et al. · 2026 · Preprint
Abstract Background Medical students, as future healthcare providers, must possess a comprehensive understanding of medication safety during pregnancy to prevent teratogenic risks and ensure maternal health. Knowledge gaps in this area can…
Thapa K, R Iyer A, A Cruz-Gonzalez M et al. · 2026 · Journal of racial and ethnic health disparities
Background Refugees often experience disruptions in social networks after resettlement. This study examined associations between bonding (within-group) and bridging (across-group) social capital and self-rated health among resettled U.S.…
Kozakoğlu F, Gürses M · 2026 · Preprint
Abstract Objectives: This study aimed to evaluate the 1-year clinical performance of Ribbond-reinforced direct composite restorations placed in different orientations in endodontically treated posterior teeth. Materials and Methods: This…
Mathiesen KK, Rasmussen JH, Channir H et al. · 2026 · Acta oto-laryngologica
Background Cancer of unknown primary (CUP) is diagnostically challenging. Diagnostic strategy remains controversial. Aim The aim of this retrospective study was to evaluate the diagnostic value of FDG-PET/CT and MRI in detecting primary…
Vega MM, Roberts MD, Goble DJ et al. · 2026 · Preprint
Abstract Background Aging is associated with increases in fat mass (FM) and decreases in fat-free mass (FFM), yet whether these indices independently predict force plate-derived postural sway and low-frequency postural oscillations remains…