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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19830 results in Negative / Null Result Report · page 250 of 661

Negative / Null Result ReportMedicine

Effect of duration of feeding a sorghum silage-based backgrounding diet in an intense postweaning production system for Nellore bulls on growth performance

Pucetti P, Silva JT, Alves JB et al. · 2026 · Animal Feed Science and Technology.

The objective of this study was to evaluate the effects of different backgrounding durations in an intense postweaning production system for Nellore bulls, as compared with immediate adaptation to a corn-based finishing diet. Forty bulls…

Negative / Null Result ReportMedicine

Influence of accent and learning styles on online animation learning.

Zhang Y, Zhang H, Wang Y et al. · 2026 · Cognitive processing

The influence of the interaction between accent and learning styles on learners' learning is an important issue to be considered in online animation design and application. The objective of this study is to reveal the effects of accent and…

View details →DOI: 10.1007/s10339-026-01356-2
Negative / Null Result ReportMedicine

Inclusion of rapeseed cake or oil in the diet of beef cattle reduces enteric methane emissions without affecting animal performance.

Folliard NT, Waters SM, Roskam E et al. · 2026 · Animal : an international journal of animal bioscience

The global methane (CH 4 ) pledge aims to reduce anthropogenic CH 4 emissions by 30% by 2030. Oilseed rape (Brassica napus L), a break crop with 40 million ha cultivated globally in 2022, produces fatty acid-rich by-products that could…

View details →DOI: 10.1016/j.animal.2026.101780
Negative / Null Result ReportMedicine

Outcomes and Complications After LUMiC<sup>®</sup> Endoprosthetic Reconstruction of Periacetabular Defects-A Retrospective Cohort Analysis.

Niemann AS, Ramon R, Mayor J et al. · 2026 · Life (Basel, Switzerland)

(1) Background: The reconstruction of periacetabular defects after tumor resection remains one of the most challenging procedures in orthopaedic oncology. The modular LUMiC ® system was designed to improve fixation stability and reduce…

View details →DOI: 10.3390/life16060955
Negative / Null Result Report

Depth effects of long-term Piliostigma reticulatum residue management under varying planting densities on SOC stocks and pools using DRIFTS

Koomson E, Nkwain Y, Lutz N et al. · 2026 · Preprint

Abstract Background and aims: The West African Sahel faces severe soil degradation and declining productivity due to climate variability and unsustainable land use. Integrating the native shrub Piliostigma reticulatum into cereal-based…

View details →DOI: 10.21203/rs.3.rs-9721145/v1
Negative / Null Result ReportMedicine

Sex, Race, and Ethnicity in National Institutes of Health Career Development Award Submissions and Success: A 20-Year Retrospective Cohort Study.

Koumpias AM, Kirch M, Steppe E et al. · 2026 · Journal of women's health (2002)

Background Obtaining a National Institutes of Health (NIH) career development (K) award is a pivotal milestone for early-career faculty, contributing not only to individual career progression but also to the diversity of the biomedical…

View details →DOI: 10.1177/15409996261454981
Negative / Null Result ReportMedicine

Comparison of explosive power, balance and muscle morphology in female volleyball players with and without chronic ankle instability.

Comlekci M, Yıldız AE, Demirel A · 2026 · BMC sports science, medicine & rehabilitation

Background Ankle sprains are among the most common injuries in athletes, accounting for approximately 80% of all athletic injuries. Recurrent ankle sprains often progress to chronic ankle instability (CAI), which can impair athletic…

View details →DOI: 10.1186/s13102-026-01783-w
Negative / Null Result Report

Intact learning and memory in mice incapable of de novo myelination

Swire M, Nayar SG, Jiang Y et al. · 2026 · Preprint

Summary Motor skill learning stimulates and requires generation of oligodendrocytes (OLs) from their precursors (OLPs) in the adult mouse brain, but the functional role(s) of the newly formed OLs is not known. We asked whether new compact…

View details →DOI: 10.64898/2026.06.12.730403
Negative / Null Result ReportMedicine

The Impacts of Mitoquinone Supplementation on Oxidative Status and Cryo-Survival of Cryopreserved Male Donkey (<i>Equus asinus</i>) Semen.

Abdelnaby EA, Alhaider AK, Emam IA · 2026 · Veterinary sciences

This current study aimed to determine the impact of Mitoquinone (MitoQ) on the quality of frozen-thawed donkey semen. Ejaculates were collected from six male donkeys ( Equus asinus ), and ejaculates were polled and aliquoted into 12…

View details →DOI: 10.3390/vetsci13060510
Negative / Null Result ReportMedicine

Efficacy and safety of morning or evening antihypertensive drug administration on albuminuria in hypertensive patients: an open-label pilot randomized controlled trial.

Trakarnvanich T, Nochaiwong S, Ruengorn C et al. · 2026 · Scientific reports

To date, little is known regarding the treatment effects of different timed-dosing antihypertensive medications among hypertensive patients with albuminuria. We aimed to investigate whether morning or evening dosing of antihypertensive…

View details →DOI: 10.1038/s41598-026-54798-1
Negative / Null Result Report

The flip side of multisensory integration: Sensory processing sensitivity and metacognitive monitoring in the Sound-induced Flash Illusion

Azizi Z, Chan J, Ward T et al. · 2026 · Preprint

Multisensory integration (MSI)–the brain’s ability to combine information from different senses–is crucial for coherent perception and adaptive behavior. While often viewed as a bottom-up process, emerging research shows internal states…

View details →DOI: 10.31234/osf.io/vwg7r_v3
Negative / Null Result ReportMedicine

Human Steering Control Under Unpredictable Disturbances.

Liu JY, Cooke JRH, Selen LPJ et al. · 2026 · The European journal of neuroscience

There are multiple methods for controlling dynamical systems under external disturbances, with some emphasizing robust performance and others prioritizing efficiency. Here, we characterized the control strategies of human steering behavior…

View details →DOI: 10.1111/ejn.70605
Negative / Null Result ReportOpen accessMedicine

Effects of homeopathic remedy supplementation on performance, blood parameters, and behavior of pigs under vaccination and regrouping stress conditions.

Lee H, Sung JY, Son J et al. · 2026 · Journal of animal science and technology

In the modern swine production systems, pigs are often challenged with regrouping and vaccination, which may negatively affect growth performance and behavior of pigs. The objective was to test the hypothesis that a supplemental…

View details →DOI: 10.5187/jast.2025.e28
Negative / Null Result ReportMedicine

Therapeutic targeting of bleomycin-induced pulmonary fibrosis by human bone marrow mesenchymal stem cell-derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice.

Charoenphannathon JS, Royce SG, Higham Y et al. · 2026 · British journal of pharmacology

Background and purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell-derived extracellular vesicles…

View details →DOI: 10.1111/bph.70539
Negative / Null Result ReportMedicine

Effects of Synbiotic Supplementation on Blood and Urinary Concentrations of Factors Related to Kidney Stone Formation in Overweight or Obese Patients with Hyperoxaluria: A Randomized Controlled Trial.

Maddahi N, Zamani B, Nadjarzadeh A et al. · 2026 · Urology journal

Purpose This study investigated the impact of synbiotics on blood and urinary concentrations of factors related to kidney stone formation in overweight or obese patients with hyperoxaluria. Materials and methods A randomized double-blind…

View details →DOI: 10.22037/uj.v22i.8740
Negative / Null Result ReportMedicine

Simultaneous Assessment of Calcium Signaling and Mitochondria Activity in Human Platelets Using Continuous Flow Cytometry.

Mishukov AA, Ignatova AA, Ogneva AL et al. · 2026 · Cytometry. Part A : the journal of the International Society for Analytical Cytology

Increasing evidence suggests connection between mitochondrial dysfunction and platelet-related disorders, necessitating developing of a high throughput method for assessing the functioning of mitochondria in platelets. Here we develop an…

View details →DOI: 10.1002/cyto.a.70038
Negative / Null Result ReportOpen accessMedicine

Effects of tocilizumab on neutrophil gelatinase-associated lipocalin following out-of-hospital cardiac arrest, and its prognostic value.

Alaoui-Ismaili Z, Grand J, Frydland M et al. · 2026 · Resuscitation plus

Background Early risk assessment is crucial in comatose survivors of out-of-hospital cardiac arrest (OHCA) for timely resource allocation and initiation of interventions. Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory…

View details →DOI: 10.1016/j.resplu.2026.101372
Negative / Null Result Report

Intermittent exposure to high ambient heat during the second half of gestation in mice causes mild alterations of reproductive endpoints in male embryos

Abt K, Amato CM, Kitakule A et al. · 2026 · Preprint

Periods of elevated ambient temperature challenge the body’s ability to maintain internal homeostasis, and heat stress poses particular risks during pregnancy. Epidemiological studies associate gestational heat exposure with higher rates…

View details →DOI: 10.64898/2026.05.22.727256
Negative / Null Result ReportMedicine

Supplementation of betaine and creatine to neonatal parenteral nutrition lowers telemetric blood pressure in adult Yucatan miniature pigs.

Randunu RS, Huber LA, Van Vliet BN et al. · 2026 · The Journal of nutrition

Background Developmental programming is a key determinant of adult hypertension. Total parenteral nutrition (TPN) can exert nutritional stress during development and cause irreversible programming of metabolism via epigenetic…

View details →DOI: 10.1016/j.tjnut.2026.101686
Negative / Null Result ReportMedicine

Metabolic and endocrinological effects of weekly growth hormone replacement therapy with somapacitan in patients with adult growth hormone deficiency after switching from daily growth hormone replacement therapy: A real-world exploratory cohort study.

Abe I, Kubo K, Fujita Y et al. · 2026 · Drug discoveries & therapeutics

The metabolic and endocrinological effects in patients with adult growth hormone deficiency (AGHD) who switched from daily growth hormone (GH) replacement therapy to weekly GH replacement therapy with somapacitan were evaluated and…

View details →DOI: 10.5582/ddt.2026.01003
Negative / Null Result Report

Comparative evaluation of Dual Gracey™ curettes and sonic instruments for deposit removal in molar furcations: an in vitro study

Bittarello F, Girardello MdM, Santos ALR et al. · 2026 · Preprint

Objective: To evaluate the removal of simulated deposits in molar furcations using Dual Gracey™ curettes and sonic instruments. Material and method: Sixteen molars (80 tooth surfaces) were divided into maxillary (n=8) and mandibular (n=8)…

View details →DOI: 10.1590/scielopreprints.16134