A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19743 results in Negative / Null Result Report · page 25 of 659
Jessica E. Atwell, Josh Van Otterloo, Jennifer Zipprich et al. · 2013 · PEDIATRICS
BACKGROUND: In 2010, 9120 cases of pertussis were reported in California, more than any year since 1947. Although this resurgence has been widely attributed to waning immunity of the acellular vaccine, the role of vaccine refusal has not…
Allen S. Liu, Huang‐Kai Kao, Richard G. Reish et al. · 2011 · Plastic & Reconstructive Surgery
BACKGROUND: Acellular dermal matrix has become a common adjunct in prosthesis-based breast reconstruction. The authors' aim was to determine whether acellular dermal matrix use in immediate prosthesis-based breast reconstruction is…
Yoshiya Yamada, Evangelia Katsoulakis, Ilya Laufer et al. · 2017 · Neurosurgical FOCUS
OBJECTIVE An analysis of factors contributing to durable radiographic control of spinal metastases was undertaken, drawing from a large single-institution database in an attempt to elucidate indications and dose requirements for successful…
Carlos Celis‐Morales, Donald M. Lyall, Jana Anderson et al. · 2016 · European Heart Journal
Aims: It is unclear whether the potential benefits of physical activity differ according to level of cardiorespiratory fitness (CRF) or strength. The aim of this study was to determine whether the association between physical activity and…
Daniel Memmert, Joseph Baker, Claudia Bertsch · 2010 · High Ability Studies
Current theoretical approaches regarding the development of creativity support the view that gathering diversified experience over years is an ideal medium for creative thinking. This study examined the role of practice conditions in the…
Kiwoong Nam, Carina F. Mugal, Benoît Nabholz et al. · 2010 · Genome biology
BACKGROUND: Obtaining a draft genome sequence of the zebra finch (Taeniopygia guttata), the second bird genome to be sequenced, provides the necessary resource for whole-genome comparative analysis of gene sequence evolution in a non-mammalian vertebrate lineage. To analyze basic molecular evolutionary processes during avian evolution, and to contrast these with the situation in mammals, we aligned the protein-coding sequences of 8,384 1:1 orthologs of chicken, zebra finch, a lizard and three mammalian species. RESULTS: We found clear differences in the substitution rate at fourfold degenerate
David Berger, Ian Dew-Becker, Stefano Giglio · 2019 · The Review of Economic Studies
Abstract We provide evidence on the relationship between aggregate uncertainty and the macroeconomy. Identifying uncertainty shocks using methods from the news shocks literature, the analysis finds that innovations in realized stock market…
Rebecca Thornton, Laurel Hatt, Erica M. Field et al. · 2010 · Health Economics
This article presents the results from an experimental evaluation of a voluntary health insurance program for informal sector workers in Nicaragua. Costs of the premiums as well as enrollment location were randomly allocated. Overall,…
Simone Dietrich, Joseph Wright · 2015 · The Journal of Politics
Over the past two decades, donors increasingly link foreign aid to democracy objectives in Africa. This study investigates whether and how foreign aid influences specific outcomes associated with democratic transition and consolidation.…
Seong-Yeol Kim, Sung-Ja Koo · 2016 · Journal of Physical Therapy Science
[Purpose] The effect of duration of smartphone use on neck and shoulder muscle fatigue and pain was investigated in adults with forward head posture. [Subjects and Methods] Thirty-four adults with forward head posture were classified into…
Gavin Churchyard, Wendy Stevens, L D Mametja et al. · 2015 · The Lancet Global Health
BACKGROUND: In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme…
Alyson K. Zalta, Seth J. Gillihan, Aaron J. Fisher et al. · 2013 · Journal of Consulting and Clinical Psychology
OBJECTIVE: The goal of the current study was to examine mechanisms of change in prolonged exposure (PE) therapy for posttraumatic stress disorder (PTSD). Emotional processing theory of PTSD proposes that disconfirmation of erroneous…
Yen‐Wei Li, Tung‐Wei Kao, Pi-Kai Chang et al. · 2021 · Scientific Reports
Deeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) has been well established. We conducted a 9-year longitudinal study to identify the association between easily measured lipid parameters, future MetS, hypertension and T2DM by gender and age distribution. Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medi
Christine Kaufmann, Martin Weber, Emily Haisley · 2012 · Management Science
Financial professionals have a great deal of discretion concerning how to relay information about the risk of financial products to their clients. This paper introduces a new risk tool to communicate the risk of investment products, and it…
Per Carlbring, Maria Apelstrand, Helena Sehlin et al. · 2012 · BMC Psychiatry
BACKGROUND: Computerized cognitive bias modification for social anxiety disorder has in several well conducted trials shown great promise with as many as 72% no longer fulfilling diagnostic criteria after a 4 week training program. To test if the same program can be transferred from a clinical setting to an internet delivered home based treatment the authors conducted a randomized, double-blind placebo-controlled trial. METHODS: After a diagnostic interview 79 participants were randomized to one of two attention training programs using a probe detection task. In the active condition the partic
Brandon De La Cuesta, Kosuke Imai · 2016 · Annual Review of Political Science
Recently, the regression discontinuity (RD) design has become increasingly popular among social scientists. One prominent application is the study of close elections. We explicate several methodological misunderstandings widespread across…
Carlos Ferrando, Ricard Mellado Artigas, Alfredo Gea et al. · 2020 · Critical Care
BACKGROUND: Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone. METHODS: Prospective, multicenter, adjusted observational cohort study in consecutive COVID-19 patients with acute respiratory failure (ARF) receiving respiratory support with HFNO from 12 March to 9 June 2020. Patients were cla
Jimme K. Wiggers, Bas Groot Koerkamp, Kasia P. Cieslak et al. · 2016 · Journal of the American College of Surgeons
BACKGROUND: Liver surgery for perihilar cholangiocarcinoma (PHC) is associated with postoperative mortality ranging from 5% to 18%. The aim of this study was to develop a preoperative risk score for postoperative mortality after liver…
Giuseppina Laganà, Nicolò Venza, Ali Borzabadi‐Farahani et al. · 2017 · BMC Oral Health
BACKGROUND: To analyze the prevalence and associations between dental anomalies detectable on panoramic radiographs in a sample of non-orthodontic growing subjects. METHODS: For this cross-sectional study, digital panoramic radiographs of 5005 subjects were initially screened from a single radiographic center in Rome. Inclusion criteria were: subjects who were aged 8-12 years, Caucasian, and had good diagnostic quality radiographs. Syndromic subjects, those with craniofacial malformation, or orthodontic patients were excluded and this led to a sample of 4706 subjects [mean (SD) age = 9.6 (1.2)
Chris Twelves, Javier Cortés, Linda T. Vahdat et al. · 2014 · Breast Cancer Research and Treatment
Data from two phase 3 studies of eribulin were pooled in analyses initially requested by the European Medicines Agency to assess whether specific patient subgroups, previously treated with an anthracycline and a taxane, benefited from…
Zhen Chen, Yongzi Chen, Xiao Feng Wang et al. · 2011 · PLoS ONE
As one of the most important reversible protein post-translation modifications, ubiquitination has been reported to be involved in lots of biological processes and closely implicated with various diseases. To fully decipher the molecular mechanisms of ubiquitination-related biological processes, an initial but crucial step is the recognition of ubiquitylated substrates and the corresponding ubiquitination sites. Here, a new bioinformatics tool named CKSAAP_UbSite was developed to predict ubiquitination sites from protein sequences. With the assistance of Support Vector Machine (SVM), the highl
Jennifer E. Smith, R Horn, Katherine S. Powning et al. · 2010 · Behavioral Ecology
Coalitionary support in agonistic interactions represents cooperation because intervening in a fight is potentially costly to the donor of support but benefits the recipient. Here, we first review the characteristics of, and evolutionary…
Nathan Danneman, Emily Hencken Ritter · 2013 · Journal of Conflict Resolution
Civil conflict appears to be contagious—scholars have shown that civil wars in a state’s neighborhood make citizens more likely to rebel at home. However, war occurs when both rebels and the state engage in conflict. How do state…
Mi-Yeon Cho, Eun Sil Min, Myung‐Haeng Hur et al. · 2013 · Evidence-based Complementary and Alternative Medicine
The purpose of this study was to investigate the effects of aromatherapy on the anxiety, sleep, and blood pressure (BP) of percutaneous coronary intervention (PCI) patients in an intensive care unit (ICU). Fifty-six patients with PCI in ICU were evenly allocated to either the aromatherapy or conventional nursing care. Aromatherapy essential oils were blended with lavender, roman chamomile, and neroli with a 6 : 2 : 0.5 ratio. Participants received 10 times treatment before PCI, and the same essential oils were inhaled another 10 times after PCI. Outcome measures patients' state anxiety, sleepi
Brendan O’Fallon, Lars Fehren‐Schmitz · 2011 · Proceedings of the National Academy of Sciences
The genetic and demographic impact of European contact with Native Americans has remained unclear despite recent interest. Whereas archeological and historical records indicate that European contact resulted in widespread mortality from…
Giuseppe Boriani, Antoine Da Costa, Aurelio Quesada et al. · 2016 · European Journal of Heart Failure
AIMS: The aim of this study was to evaluate the clinical efficacy and safety of remote monitoring in patients with heart failure implanted with a biventricular defibrillator (CRT-D) with advanced diagnostics. METHODS AND RESULTS: The…
Helen G. Jing, Kevin P. Madore, Daniel L. Schacter · 2016 · Journal of Experimental Psychology General
Previous research has demonstrated that an episodic specificity induction--brief training in recollecting details of a recent experience--enhances performance on various subsequent tasks thought to draw upon episodic memory processes.…
Marieke M. Lansbergen, Martine van Dongen‐Boomsma, Jan K. Buitelaar et al. · 2010 · Journal of Neural Transmission
Electroencephalography (EEG)-neurofeedback has been shown to offer therapeutic benefits to patients with attention-deficit/hyperactivity disorder (ADHD) in several, mostly uncontrolled studies. This pilot study is designed to test the…
Lydiane Agier, Lützen Portengen, Marc Chadeau‐Hyam et al. · 2016 · Environmental Health Perspectives
BACKGROUND: The exposome constitutes a promising framework to improve understanding of the effects of environmental exposures on health by explicitly considering multiple testing and avoiding selective reporting. However, exposome studies…
Florian Gnad, Albion Baucom, Kiran Mukhyala et al. · 2013 · BMC Genomics
BACKGROUND: Recent advances in sequencing technologies have greatly increased the identification of mutations in cancer genomes. However, it remains a significant challenge to identify cancer-driving mutations, since most observed missense changes are neutral passenger mutations. Various computational methods have been developed to predict the effects of amino acid substitutions on protein function and classify mutations as deleterious or benign. These include approaches that rely on evolutionary conservation, structural constraints, or physicochemical attributes of amino acid substitutions. H