e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19830 results in Negative / Null Result Report · page 240 of 661

Negative / Null Result ReportMedicine

Nationwide questionnaire survey on collaboration for the management of chronic kidney disease from the perspective of referrals in Japan.

Hatta T, Kobayashi K, Tatematsu S et al. · 2026 · Clinical and experimental nephrology

Background Preventing end-stage renal failure progression of patients with chronic kidney disease (CKD) requires collaboration between nephrologists and general practitioners. Following the 2013 and 2019 surveys in Japan, a nationwide…

View details →DOI: 10.1007/s10157-026-02878-x
Negative / Null Result ReportMedicine

Effects of reduced metabolizable protein diets supplemented with rumen-protected His under adequate Met and Lys supply on production, nutrient digestibility, N utilization, and manure ammonia emissions in lactating cows.

Park K, Kim J, Hu H et al. · 2026 · Journal of dairy science

Balancing for limiting AA may prevent reduced production when deficient MP is provided. The objective of the study was to determine the effects of rumen-protected (RP) His supplementation at different levels of MP when Lys and Met supplies…

View details →DOI: 10.3168/jds.2025-27548
Negative / Null Result ReportMedicine

Are gaps in the time of submissions and approvals of new drugs between Health Canada and the Food and Drug Administration related to therapeutic value? A cross-sectional study.

Lexchin J · 2026 · Health policy (Amsterdam, Netherlands)

Background Health Canada is proposing to use decisions by foreign regulators in approving new drugs to speed up their marketing. Objectives To investigate the length of gaps in submissions to and approvals by Health Canada compared to the…

View details →DOI: 10.1016/j.healthpol.2026.105631
Negative / Null Result ReportMedicine

Do potentially traumatic events experienced by people in one's social circle affect one's own mental health and emotional support? Findings from a prospective population-based study.

van der Velden PG, Contino C, Kempe S et al. · 2026 · Acta psychologica

Background Adults may have individuals in their social circle who were recently exposed to potentially traumatic events (PTEs). The present study aims to examine if these adults are at increased risk for mental health problems and reduced…

View details →DOI: 10.1016/j.actpsy.2026.107136
Negative / Null Result ReportMedicine

Impact of concomitant cholecystectomy during gastrectomy for gastric cancer on the postoperative quality of life.

Shimonosono M, Arigami T, Okubo K et al. · 2026 · Surgery today

PURPOSE: This study aimed to evaluate the impact of concomitant prophylactic cholecystectomy during gastrectomy for gastric cancer on the postoperative quality of life (QOL) and nutritional outcomes. METHODS: A retrospective analysis was…

View details →DOI: 10.1007/s00595-026-03294-0
Negative / Null Result Report

Similarity of Major Life-Event Perceptions and Relationship Satisfaction among Romantic Couples: The Case of Moving in Together

Fliedner K, Buehler JL, Wrzus C et al. · 2026 · Preprint

This study examined the similarity of partners’ event perceptions of a major life event (i.e., moving in together as couple) and how similarity relates to relationship satisfaction. Considering event perceptions from multiple individuals…

View details →DOI: 10.31234/osf.io/8h6yb_v1
Negative / Null Result ReportMedicine

Optimizing Necrotizing Otitis Externa Management: The Role of PET-CT in Antibiotic Stewardship.

Zammit M, Davies T, Youssef A · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To optimize antibiotic regimens in necrotizing otitis externa (NOE) and skull base osteomyelitis (SBO) and evaluate the role of positron emission tomography-computed tomography (PET-CT) in disease monitoring. Study design A…

View details →DOI: 10.1097/mao.0000000000004777
Negative / Null Result ReportMedicine

Folded-flap palatoplasty performed with a needle-tip monopolar cautery: retrospective cohort of 66 brachycephalic dogs.

Miloro R, Mala B, Ceplecha V et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To evaluate short- and long-term patient outcomes retrospectively, investigate anesthetic and surgical times, and assess clinically relevant surgical wound complications associated with the use of needle-tip monopolar…

View details →DOI: 10.2460/javma.25.11.0713
Negative / Null Result ReportMedicine

Midazolam versus midazolam-promethazine combination for oral sedation in third molar surgery: A randomized split-mouth trial.

Castanha D, Lessa TC, Martins-de-Araújo ES et al. · 2026 · Medicina oral, patologia oral y cirugia bucal

Background Oral sedation is widely utilized in dental surgical practice for anxiety management during third molar extractions. Midazolam is one of the most frequently employed drugs; however, the clinical benefits of its association with…

View details →DOI: 10.4317/medoral.28014
Negative / Null Result ReportMedicine

Comparison of prehospital tidal volume delivery performance between automated transport ventilators and bag-valve devices in out-of-hospital cardiac arrest patients: does the pressure limit matter?

Chen CH, Yu PH, Fan CY et al. · 2026 · Frontiers in medicine

Background Automatic transport ventilators (ATVs) are a potential option for ventilating patients experiencing out-of-hospital cardiac arrest (OHCA); however, their tidal volume delivery performance at different pressure limits compared…

View details →DOI: 10.3389/fmed.2026.1826906
Negative / Null Result ReportMedicine

Analyzing the association between age-related macular degeneration, retinal vascular occlusions, and dementia.

Alshaikhsalama A, Thompson K, Hashim H et al. · 2026 · European journal of ophthalmology

PurposeTo investigate the association between age-related macular degeneration (AMD), retinal artery occlusion (RAO), and retinal vein occlusion (RVO) and the future development of Alzheimer's disease (AD), vascular dementia (VaD), and…

View details →DOI: 10.1177/11206721261438587
Negative / Null Result ReportMedicine

Effects of a home-based exercise and physical activity intervention after inpatient rehabilitation on real-world mobility in older adults with cognitive impairment: a secondary analysis of a randomised controlled trial.

Werner C, Ullrich P, Degli Angeli L et al. · 2026 · Age and ageing

Persistent mobility limitations after inpatient rehabilitation are common in older adults with cognitive impairment (CI). Home-based exercise interventions can improve locomotor capacity during this vulnerable period; however, evidence…

View details →DOI: 10.1093/ageing/afag189
Negative / Null Result ReportMedicine

Transient pH film model for in vitro powder dissolution of weakly basic drugs into buffer and comparison to conventional film model.

Patel RP, Polli JE · 2026 · Journal of pharmaceutical sciences

The dissolution of ionizable drugs is critically influenced by the pH of the microenvironment at the solid-liquid interface, which in part can be impacted by the dissolving drug itself. For weak bases, dissolution may increase surface pH,…

View details →DOI: 10.1016/j.xphs.2026.104265
Negative / Null Result Report

Intensive Versus Standard Statin Therapy in Acute Ischemic Stroke: A Comparative Study on the Risk of Pneumonia and Multidrug-Resistant Bacterial Infections

Wen Z, Yang Z, Cheng J et al. · 2026 · Preprint

Abstract Background The use of intensive statin therapy in acute ischemic stroke (AIS) is common; however, its association with post-stroke pneumonia (PSP) remains uncertain. This study aimed to determine whether intensive-dose…

View details →DOI: 10.21203/rs.3.rs-8842936/v1
Negative / Null Result ReportMedicine

Work-related Well-Being, Turnover Intention, and Completed Turnover in a Cohort of U.S. Patient Care Workers.

Boden LI, Peters SE, McTernan M et al. · 2026 · Journal of occupational and environmental medicine

Objective To determine whether burnout and thriving from work affect turnover intention and actual turnover. Methods This study used multivariable logistic regression to estimate the impact of burnout and thriving from work on turnover…

View details →DOI: 10.1097/jom.0000000000003713
Negative / Null Result ReportMedicine

Tolerability and effectiveness of definitive chemoradiotherapy in locally advanced lung cancer patients with combined pulmonary fibrosis and emphysema.

Fujimoto K, Kogo M, Kobayashi H et al. · 2026 · Cancer treatment and research communications

Background This study evaluated the efficacy and safety of definitive chemoradiotherapy (CRT) for lung cancer in patients with combined pulmonary fibrosis and emphysema (CPFE), focusing on radiation pneumonitis (RP). Materials and methods…

View details →DOI: 10.1016/j.ctarc.2026.101262
Negative / Null Result ReportMedicine

Early Detection of Transient Hypoparathyroidism After Total Thyroidectomy: A Single-Center Preliminary Study.

Marian M, Rosu M, Tarta C et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Post-thyroidectomy hypoparathyroidism (hypoPTH) is the most common complication of total thyroidectomy. Transient hypoPTH was defined as postoperative day 1 (POD1) intact parathyroid hormone (PTH) Materials and…

View details →DOI: 10.3390/medicina62061137
Negative / Null Result ReportMedicine

DNAemia Thresholds to Discontinue Antivirals in Preemptive Management for Cytomegalovirus Seropositive Recipients After Kidney Transplantation.

Miehrig AH, Foresto RD, Tedesco-Silva H et al. · 2026 · Transplantation

Background Treatment of cytomegalovirus (CMV) after kidney transplantation aims to achieve cessation of viral replication; however, the use of highly sensitive DNA assays creates uncertainty regarding the optimal DNAemia threshold for…

View details →DOI: 10.1097/tp.0000000000005695