Why Standard LP-Based Flux Balance Analysis Cannot Detect Synergy for Essential Gene Pairs in ESKAPE Pathogens: A Systematic Evaluation and Proof-of-Concept Feature-Based ML Alternative
Byeongsoo · 2026 · Preprint
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Abstract Background. Flux balance analysis (FBA) is widely used to simulate gene essentiality in genome-scale metabolic models (GEMs), and several studies have proposed using FBA-based combination simulations to predict antibiotic synergy.…
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Metadata source: Europe PMC · DOI 10.21203/rs.3.rs-9398278/v1