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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 238 of 675

Negative / Null Result ReportMedicine

Comparison of mechanical complications between metal-ceramic and monolithic zirconia implant-supported prostheses: A retrospective split-mouth study.

Park JO, Park YB, Yoon JH et al. · 2026 · The Journal of prosthetic dentistry

Statement of problem Comparative studies assessing monolithic zirconia and metal-ceramic for implant-supported fixed prostheses remain limited. Purpose This retrospective study aimed to compare the survival and success of metal-ceramic and…

View details →DOI: 10.1016/j.prosdent.2026.02.024
Negative / Null Result ReportMedicine

Age-stratified clinical outcomes and adverse events in patients with metastatic castration-sensitive prostate cancer receiving triplet therapy with darolutamide, androgen deprivation therapy, and docetaxel.

Uchimoto T, Hirosuna K, Niigawa H et al. · 2026 · Japanese journal of clinical oncology

Background Triplet therapy with darolutamide, androgen deprivation therapy, and docetaxel (DOC) has emerged as an intensified treatment option for metastatic castration-sensitive prostate cancer (mCSPC). This study evaluated real-world…

View details →DOI: 10.1093/jjco/hyag011
Negative / Null Result Report

Association of second-trimester APRI and FIB-4 scores with intrahepatic cholestasis of pregnancy: a retrospective case–control study

Özceyran C, Sonu NC, Öcal FD et al. · 2026 · Preprint

Abstract Background: To evaluate whether second-trimester aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) scores can predict subsequent development of intrahepatic cholestasis of pregnancy (ICP). Methods:…

View details →DOI: 10.21203/rs.3.rs-9702763/v1
Negative / Null Result ReportMedicine

Effect of postural conditions on pinch strength and manual dexterity in young adults: a cross-sectional study.

Büğüşan Oruç S, Akdağ Mirzaoğlu N, Yakut Y · 2026 · International journal of occupational safety and ergonomics : JOSE

Objectives . This study aimed to investigate pinch strength and manual dexterity in different postures among young adults. Methods . A total of 200 individuals aged 18-45 years participated. Key, tip and palmar pinch strengths were…

View details →DOI: 10.1080/10803548.2026.2679347
Negative / Null Result ReportOpen accessMedicine

A comparative evaluation of ChatGPT and Gemini for stroke caregiver support: accuracy, safety, and response characteristics.

Karaca O, Torlak MS, Tekin AN · 2026 · Revista da Associacao Medica Brasileira (1992)

Objective The use of large language models is increasing in healthcare. The aim of this study was to evaluate and compare the responses provided by ChatGPT (OpenAI) and Gemini (Google) to frequently asked questions about stroke and its…

View details →DOI: 10.1590/1806-9282.20251488
Negative / Null Result ReportMedicine

Comparative evaluation of root dentin thickness following hand and rotary instrumentation of primary molar root canals using cone-beam computed tomography - an invitro study.

Thomas RM, Nayak R, Madi M et al. · 2026 · BMC oral health

Remaining Root Dentin Thickness (RRDT) after root canal instrumentation is an important parameter to be assessed with newer file systems. This study aimed to evaluate the root dentin thickness following instrumentation of primary molar…

View details →DOI: 10.1186/s12903-026-09005-y
Negative / Null Result ReportMedicine

Age-stratified comparison of visual function between eyes with an enhanced monofocal intraocular lens and phakic eyes.

Hayashi K, Yoshida M, Hayashi S et al. · 2026 · Japanese journal of ophthalmology

Purpose To compare visual function between pseudophakic eyes with enhanced monofocal intraocular lenses (IOLs) and phakic eyes with clear lenses among patients in their 50s, 60s, and 70s. Study design Prospective comparative study. Methods…

View details →DOI: 10.1007/s10384-025-01321-0
Negative / Null Result ReportMedicine

Comparative study of prosthesis implantation, latissimus dorsi flap, and combined reconstruction immediately after breast cancer surgery: A retrospective, single-center, observational cohort study.

Zhang Y, Yu W, Shen W · 2026 · Medicine

This study aimed to explore the effects of 3 immediate reconstruction methods - prosthesis implantation, latissimus dorsi flap (LDF), or their combination - on postoperative outcomes following breast cancer (BC) surgery. A retrospective,…

View details →DOI: 10.1097/md.0000000000049090
Negative / Null Result Report

Immersive Virtual Reality in Undergraduate Critical Care Nursing Education: A Pragmatic Three-Cohort Quasi-Experimental Evaluation of Perceived Simulation Effectiveness and Clinical Learning Needs

Ismaile S, Alhosban F, Shajrawi A et al. · 2026 · Preprint

Abstract Background Preparing undergraduate nurses for high-acuity practice requires educational approaches that allow safe rehearsal of complex clinical situations, yet evidence from routine programme delivery remains mixed when immersive…

View details →DOI: 10.21203/rs.3.rs-9187827/v1
Negative / Null Result ReportMedicine

Effect of Remimazolam or Propofol Combined With Esketamine on Anesthesia and Early Perioperative Neurocognitive Disorders in Patients Undergoing Thoracoscopic Partial Lung Resection: A Randomized Clinical Trial.

Yuan W, Liang X, Zhang R et al. · 2026 · Clinical therapeutics

Purpose This study aimed to evaluate the effects of remimazolam in conjunction with esketamine on anesthesia and the incidence of early perioperative neurocognitive disorders (PNDs) in patients undergoing thoracoscopic partial lung…

View details →DOI: 10.1016/j.clinthera.2026.02.015
Negative / Null Result Report

Safety and short-term outcomes during the introduction of retroperitoneal single-port robot-assisted radical prostatectomy: a single-surgeon comparison with transperitoneal multiport radical prostatectomy in a Japanese population

Hattori S, Shimizu K, Kotorii R et al. · 2026 · Preprint

Abstract Purpose. To evaluate the safety and feasibility of introducing retroperitoneal single-port robot-assisted radical prostatectomy (SP-RARP) by comparing a single surgeon’s initial 50 cases with 50 recent transperitoneal multiport…

View details →DOI: 10.21203/rs.3.rs-9990410/v1
Negative / Null Result ReportMedicine

Challenge Under Pressure Contextual Interference or Differential Learning.

Taghizadeh H, Parvizi MJ, Roostaei A et al. · 2026 · Research quarterly for exercise and sport

This study compared the effects of blocked practice, random practice (contextual interference), and differential learning on acquisition, retention, and performance under psychological pressure of a basketball jump shot in novice…

View details →DOI: 10.1080/02701367.2026.2686249
Negative / Null Result Report

Evaluating the sensitivity of heart rate variability fractal correlation properties to training load variations: Implications for monitoring training readiness and durability

van Rassel CR, Rummel M, MacInnis MJ · 2026 · Preprint

This study examined the utility of HRV detrended fluctuation analysis alpha-1 (DFAα1) to assess readiness-to-train and exercise durability under varying acute training loads. Nineteen trained cyclists completed two 20-minute time-trials…

View details →DOI: 10.64898/2026.05.27.26354281
Negative / Null Result Report

The KangDuo Robotic System, Da Vinci Robotic System, and Laparoscopic Surgery for Endometrial Cancer: A Retrospective Study Based on Real-World Data

Huang W, Jiang L, Wang H et al. · 2026 · Preprint

Abstract Background With advances in minimally invasive surgery, endometrial cancer treatment has evolved from laparotomy to laparoscopic (LS) and robotic techniques. However, outcomes such as surgical trauma, recovery, and cost vary…

View details →DOI: 10.21203/rs.3.rs-9654946/v1
Negative / Null Result ReportMedicine

Evaluation of Osteomeatal Complex Anatomical Variations, Pathologies and Nasal Cavity Volume in Patients with Cleft Lip and Palate.

Cebeci T, Polat Akmansoy B · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo compare osteomeatal complex (OMC) anatomical variations and nasal cavity airway volume between individuals with cleft lip and palate (CLP) and healthy controls using cone beam computed tomography (CBCT).DesignRetrospective,…

View details →DOI: 10.1177/10556656261458450
Negative / Null Result ReportMedicine

The use of partially slatted floor designs as an alternative to littered systems in broiler chickens. II. The effects on welfare and behavioral traits.

Çavdarcı H, Sarıca M, Erensoy K et al. · 2026 · Tropical animal health and production

This study investigated the effects of different flooring designs on the welfare and behavioral traits in fast-growing broilers. A total of 600 day-old Ross-308 chickens were randomly allocated to five treatment groups: fully littered…

View details →DOI: 10.1007/s11250-026-05149-9
Negative / Null Result ReportMedicine

Sublethal effects and bioaccumulation of "smart" anti-corrosion nanoadditives spiked in sediment in the ragworm Hediste diversicolor.

Bruni M, Perina F, Figueiredo J et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)

Metallic corrosion poses an economic problem worldwide and is often mitigated by adding corrosion inhibitors (CIs) to protective coatings. Conventional CIs, such as 2-mercaptobenzothiazole (MBT) and benzotriazole (BTA), exhibit toxicity to…

View details →DOI: 10.1016/j.aquatox.2026.107912
Negative / Null Result ReportMedicine

The Effect of Concomitant Hysterectomy Route on Robotic Sacrocolpopexy Outcomes.

Swallow C, Imamoglu M, Imamoglu AG et al. · 2025 · Urogynecology (Philadelphia, Pa.)

Importance Sacrocolpopexy is essential in the surgical management of advanced pelvic organ prolapse, and selecting the appropriate route for concomitant hysterectomy is critical. Objectives The aim of this study was to evaluate the effect…

View details →DOI: 10.1097/spv.0000000000001659
Negative / Null Result ReportOpen accessMedicine

Ductus Arteriosus Morphology in Pulmonary Atresia With Ventricular Septal Defect: A Retrospective Case Series Comparing Echocardiography and Digital Subtraction Angiography.

Quan TT, Nguyen HM, Nguyen HT et al. · 2026 · Cureus

Objective This study aims to describe ductus arteriosus (DA) morphology in patients with pulmonary atresia with ventricular septal defect (PA-VSD) and to assess exploratory paired differences between echocardiography and digital…

View details →DOI: 10.7759/cureus.108765
Negative / Null Result ReportMedicine

Embryo Euploidy Rates and Reproductive Outcomes Following Ethanol Sclerotherapy, Laparoscopic Cystectomy, or No Intervention for Ovarian Endometriomas Prior to IVF with PGT-A: A Retrospective Cohort Study.

Goc G, Sukur YE · 2026 · Journal of minimally invasive gynecology

Study objective To compare embryo euploidy rates and reproductive outcomes among women with ovarian endometriomas who underwent ethanol sclerotherapy (EST), laparoscopic cystectomy, or expectant management prior to in vitro fertilization…

View details →DOI: 10.1016/j.jmig.2026.06.010