e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21277 results · page 237 of 710

Negative / Null Result ReportMedicine

Genetic profile of Lepr<sup>+</sup> skeletal stem/progenitor cells in the periodontal ligament and functional compensation during aging and bone repair.

Shidara S, Ito S, Desai K et al. · 2026 · Bone

Skeletal stem/progenitor cells (SSPCs) play a fundamental role in maintaining skeletal homeostasis throughout life. Leptin receptor (Lepr)-positive cells were initially identified as SSPCs in the long bone marrow and later in the…

View details →DOI: 10.1016/j.bone.2026.117833
Negative / Null Result ReportOpen accessMedicine

Intraoperative hypotension after remimazolam or propofol induction with sevoflurane maintenance in angiotensin II receptor blockers-treated patients: a randomized controlled trial.

Kim HJ, Kim N, Kim J et al. · 2025 · Scientific reports

Robot-assisted laparoscopic prostatectomy (RALP) is associated with hemodynamic shifts; patients on angiotensin receptor blockers (ARBs) are especially susceptible to intraoperative hypotension. We investigated whether induction with…

View details →DOI: 10.1038/s41598-025-23469-y
Negative / Null Result ReportMedicine

Increase in Diaphragm and Expiratory respiratory muscles thickness is not associated with postoperative pulmonary complications after thoracic surgery: A prospective ultrasound cohort study.

Berthoud V, Nguyen M, Vinay J et al. · 2026 · Anaesthesia, critical care & pain medicine

Introduction In thoracic surgery, all respiratory muscles have a significant increase in workload, and recruitment of these muscles may be important, especially in the presence of diaphragmatic dysfunction. Evaluating diaphragmatic and…

View details →DOI: 10.1016/j.accpm.2025.101683
Negative / Null Result ReportMedicine

A clinical shift toward personalized cochlear implantation: Using preoperative planning to optimize insertion depth.

Bircher B, Aebischer P, Wimmer W et al. · 2026 · American journal of otolaryngology

Objective To evaluate the clinical implementation of preoperative, anatomy-tailored planning for electrode selection in cochlear implantation, quantify planning accuracy under routine conditions, and identify factors associated with…

View details →DOI: 10.1016/j.amjoto.2025.104777
Negative / Null Result ReportMedicine

Effect of intraoperative dexmedetomidine on postoperative mental health in cardiac surgery: a randomized controlled trial.

Hao X, Zhang Z, Cai C et al. · 2026 · International journal of surgery (London, England)

Background Dexmedetomidine was widely used in anesthesia management during cardiac surgery. The purpose was to evaluate the safety and efficacy of intraoperative dexmedetomidine in the treatment of postoperative depression in adult…

View details →DOI: 10.1097/js9.0000000000003906
Negative / Null Result ReportMedicine

The Effect of a Water, Sanitation, and Hygiene Intervention on Clinical Trachoma: A Cluster-Randomised Trial.

Wittberg DM, Admassu F, Aragie S et al. · 2026 · Tropical medicine & international health : TM & IH

Objectives Few randomised trials have been done to assess the impact of hygiene interventions on trachoma even though hygiene improvements feature prominently in the strategy for global elimination of trachoma. This study's aim was to…

View details →DOI: 10.1111/tmi.70086
Negative / Null Result ReportMedicine

Efficacy and safety of heparin in preventing embolic events during transradial cerebral angiography: a randomised controlled trial.

Liu C, Deng G, Wang Y et al. · 2026 · Stroke and vascular neurology

Background Transradial access has become an increasingly preferred approach for cerebral angiography. However, embolic events, often clinically silent, remain a frequent concern. Despite routine use, the efficacy and safety of heparin…

View details →DOI: 10.1136/svn-2025-004887
Negative / Null Result ReportOpen accessMedicine

Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial.

Jiang C, Zhao Z, Yang Z et al. · 2026 · Circulation

Background Observational studies have suggested that SGLT2 (sodium-glucose cotransporter 2) inhibitors are associated with a lower risk of atrial fibrillation (AF) recurrence after catheter ablation in patients with AF with concomitant…

View details →DOI: 10.1161/circulationaha.125.077447
Negative / Null Result ReportMedicine

Safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide versus continuing dolutegravir/lamivudine in people living with HIV with neuropsychiatric comorbidities: Week 24 and 48 results from the Management of INSTI-associated Neuropsychiatric Disorders (MIND) clinical trial.

Perez-Valero I, Corona Mata D, Crussells Canales MJ et al. · 2026 · International journal of antimicrobial agents

Objective To evaluate if switching from dolutegravir/lamivudine (DTG/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) improves neuropsychiatric tolerability in suppressed adults with stable neuropsychiatric…

View details →DOI: 10.1016/j.ijantimicag.2026.107825
Negative / Null Result ReportMedicine

Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.

Zhang F, Zhong Y, Li Q et al. · 2025 · High altitude medicine & biology

Zhang, Fengying, Yang Zhong, Qiuyue Li, Doudou Hao, Zhiyou Shi, Suying Zhu, Qian Zhang, and Yunhong Wu. Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.…

View details →DOI: 10.1177/15578682251401137
Negative / Null Result ReportMedicine

Prophylactic Subcutaneous Heparin Is Not Associated With Increased Rates of Hematoma, Pulmonary Embolism, or Deep Vein Thrombosis Following Lumbar Fusion: A Multi-Institutional, Propensity Score-Matched Analysis of 3106 Patients.

Crawford AM, Striano BM, Schoenfeld AJ et al. · 2026 · Spine

Study design Retrospective multicenter cohort study. Objective To compare the safety and efficacy of venous thromboembolism prophylaxis (VTE) strategies between two high-volume spine centers with distinct protocols. Summary of background…

View details →DOI: 10.1097/brs.0000000000005607
Negative / Null Result ReportMedicine

Ambulatory care by on-call teams in an Emergency Department.

Kinsella A, Gilligan P · 2025 · Irish medical journal

Aim Admission rate is a key performance indicator for Emergency Departments (EDs). Senior hospital management advised that, if discharge by on-call teams was possible within 24 hours, a patient should be termed 'ambulatory' and remain in…

Negative / Null Result ReportMedicine

Efficacy of topical hydrophilic gel of paromomycin combined with systemic or locally administered leishmanicidal drugs for treatment of experimental leishmaniasis caused by Leishmania (Viannia) braziliensis.

Alves LL, Pinheiro Rosa DC, Freire ML et al. · 2025 · The Journal of antimicrobial chemotherapy

Objective This study aimed at evaluating the combination of a topical hydrophilic gel of paromomycin (PA) with intralesion meglumine antimoniate (Glu IL) or systemic administration of liposomal amphotericin B (AmphLipo) for the treatment…

View details →DOI: 10.1093/jac/dkaf362
Negative / Null Result ReportOpen accessMedicine

Diaryl-Aminoindazole with Extensive In Vitro Mycobactericidal Activity Dependent on Exposure to Reactive Nitrogen Species.

Warrier T, Martínez-Hoyos M, Porras De Francisco E et al. · 2026 · ACS infectious diseases

A bromoindazole was reported with the ability to rapidly and extensively kill Mycobacterium tuberculosis (Mtb) in vitro, but only in the presence of sublethal levels of reactive nitrogen species (RNS) (Warrier et al., ACS Infectious…

View details →DOI: 10.1021/acsinfecdis.5c00879
Negative / Null Result ReportMedicine

Impact of daily adaptive head and neck radiotherapy on toxicity and quality of life: results of the DARTBOARD phase II randomized trial.

Sher DJ, Avkshtol V, Lin MH et al. · 2025 · Journal of the National Cancer Institute

Background The utility of adaptive radiotherapy (ART) for head and neck squamous cell carcinoma (HNSCC) remains poorly defined. Daily ART (DART) promises both anatomic adaptation and planning target volume (PTV) reduction. In this…

View details →DOI: 10.1093/jnci/djaf232
Negative / Null Result ReportMedicine

The Moderating Effect of Social Skills and Social Support on the Association Between Poverty Ratio and Health Promotion Behaviors in Adolescence.

Furman CR, Worth IA, Zhang JD et al. · 2025 · Behavioral medicine (Washington, D.C.)

Eating and exercise habits established in adolescence are associated with immediate and long-term health outcomes. These habits may be influenced by adolescents' socioeconomic status (SES), such that low SES households often experience…

View details →DOI: 10.1080/08964289.2025.2471875
Negative / Null Result ReportOpen accessMedicine

Rapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial.

Hay AD, Abbs S, Ridd M et al. · 2026 · JAMA internal medicine

Importance Most antibiotic prescribing takes place in primary care, driving antimicrobial resistance, a top-10 threat to global public health. There is considerable international interest in whether rapid multiplex microbiological…

View details →DOI: 10.1001/jamainternmed.2026.1426
Negative / Null Result Report

Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk

Le Sage V, Vu MN, Maltepes MA et al. · 2025 · Preprint

In China, low pathogenic avian influenza (LPAI) H3N8 virus is widespread among chickens and has recently caused three zoonotic infections, with the last one in 2023 being fatal. Here we evaluated the relative pandemic risk of this 2023…

View details →DOI: 10.1101/2025.10.02.679960
Negative / Null Result ReportMedicine

Aortic Arch Morphology and Cerebrovascular Accidents After Transfemoral Transcatheter Aortic Valve Implantation.

Baltruskeviciute L, Moccetti F, Wolfrum M et al. · 2026 · The American journal of cardiology

Cerebrovascular accidents (CVA) after transcatheter aortic valve implantation (TAVI) remain a major concern. However, the impact of aortic arch morphology has not been investigated in this context. To address this gap, consecutive patients…

View details →DOI: 10.1016/j.amjcard.2025.09.066
Negative / Null Result ReportMedicine

The Effects of Acarbose on the Postprandial Hypotensive Response in Older Adults.

Madden KM, Feldman B, Meneilly GS · 2025 · Canadian journal on aging = La revue canadienne du vieillissement

Postprandial hypotension (PPH) is defined as a postprandial decline in systolic blood pressure (SBP) of 20 mm of Hg. Some have recommended the use of acarbose (an alpha-glucosidase inhibitor) as a potential therapy for PPH based…

View details →DOI: 10.1017/s0714980825100056
Negative / Null Result ReportOpen accessMedicine

Impact of an Educational Programme in Primary Care for mothers With Infant Colic Babies: Quasi-Experimental Study.

Martínez-Lentisco MDM, Carreño-Segura S, León-Morillas F et al. · 2026 · Clinical pediatrics

This quasi-experimental study assessed the impact of a postpartum educational programme on health care utilization and maternal stress in mothers of infants with colic. A total of 84 mothers took part in 2 individual sessions, 15 days…

View details →DOI: 10.1177/00099228261423662
Negative / Null Result ReportMedicine

Prophylactic norepinephrine infusion to reduce severe hypotension during induction of anaesthesia in patients undergoing cardiac surgery: a randomised controlled single-centre clinical trial.

Gaillard C, Breul L, Foucher A et al. · 2026 · British journal of anaesthesia

Background The EPITUBE trial aimed to determine whether a prophylactic infusion of norepinephrine reduced severe hypotension after induction of general anaesthesia and tracheal intubation in patients undergoing cardiac surgery. Methods We…

View details →DOI: 10.1016/j.bja.2025.10.055
Negative / Null Result ReportMedicine

Behavioral Economics and Medication Adherence for Hypertension: A Randomized Clinical Trial.

Dodson JA, Adhikari S, Schoenthaler AM et al. · 2026 · Journal of the American College of Cardiology

Background Nonadherence to antihypertensive medications is common. Mobile health (mHealth)-based behavioral economic interventions may improve adherence, but remain largely untested, especially in vulnerable populations. Objective The…

View details →DOI: 10.1016/j.jacc.2025.10.062
Negative / Null Result ReportMedicine

Aerobic training conducted at different times of day in elderly patients with hypertension: a controlled trial.

Azevêdo LM, da Silva Junior ND, de Oliveira GF et al. · 2025 · GeroScience

Previous data showed greater blood pressure (BP) reduction after aerobic training performed in the evening than in the morning in middle-aged hypertensive men. This study investigated whether the time of day in which aerobic training is…

View details →DOI: 10.1007/s11357-025-02000-1
Negative / Null Result ReportMedicine

Low dose of landiolol does not prevent postoperative atrial fibrillation after cardiac surgery in non-Asian patients: a multicentre randomised study.

Amour J, Naudin C, Besnard A et al. · 2026 · British journal of anaesthesia

Background Postoperative atrial fibrillation (POAF) affects 30% of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Beta-blockers are the first-line agents recommended for POAF prevention. Landiolol, an…

View details →DOI: 10.1016/j.bja.2025.09.019
Negative / Null Result ReportMedicine

Efficacy of Erector Spinae Plane Block in Preventing Chronic Pain After Breast Cancer Surgery: A Randomized Controlled Trial.

Lin W, Zhang X, Zhuo Y et al. · 2026 · Anaesthesia, critical care & pain medicine

Background Chronic postsurgical pain (CPSP) affects up to 60% of breast cancer surgery patients, substantially impairing quality of life. Although erector spinae plane block (ESPB) provides effective acute analgesia with superior safety…

View details →DOI: 10.1016/j.accpm.2025.101676