Negative / Null Result ReportMedicine
Karajannis MA, Onar-Thomas A, Lin T et al. · 2025 · Neuro-oncology
Background The outcome for pediatric patients with high-grade glioma (HGG) remains poor. Veliparib, a potent oral poly(adenosine diphosphate-ribose) polymerase (PARP) 1/2 inhibitor, enhances the activity of radiotherapy and DNA-damaging…
View details →DOI: 10.1093/neuonc/noae247 Replication FailureOpen accessMedicine
Pickard S, Speach D, Hauber K et al. · 2026 · Interventional pain medicine
Background Low back injury is one of the leading causes of work-related injuries, disability, and lost productivity. Patients with lumbar radiculopathy are a subgroup of patients within work related low back injury. To our knowledge, there…
View details →DOI: 10.1016/j.inpm.2026.100736 Negative / Null Result ReportOpen accessMedicine
Luo JY, Xiang J, Hong XL et al. · 2026 · The American journal of case reports
BACKGROUND Epidermal growth factor receptor (EGFR) is a key driver gene in non-small-cell lung cancer (NSCLC), and EGFR tyrosine kinase inhibitors (TKIs) are the standard treatment for classical mutations, including exon 19 deletion and…
View details →DOI: 10.12659/ajcr.949630 Negative / Null Result ReportMedicine
Raj AK, Pedersen SJ, Mainsbridge C et al. · 2024 · Ergonomics
Prolonged sitting is postulated to influence musculoskeletal performance (cervical flexor endurance, balance, and agility), discomfort and alter cervical spine angles during work-based computer use. Stair climbing breaks may be a great…
View details →DOI: 10.1080/00140139.2024.2335551 Negative / Null Result ReportOpen accessMedicine
Li N, Wu C, Cao P et al. · 2024 · Access microbiology
Background Rhodococcus equi is one of the most important causes of zoonotic infections from grazing animals. It poses a particular risk to immunocompromised individuals, including those who are undergoing long-term immunosuppressive…
View details →DOI: 10.1099/acmi.0.000600.v4 Negative / Null Result Report
Zhang Q, Yan Y, Li J et al. · 2023 · Preprint
Objectives: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) can improve pregnancy and neonatal outcomes for patients with limited good-quality embryos. Design: Retrospective cohort study. Setting: University…
View details →DOI: 10.22541/au.167358786.60569205/v1 Negative / Null Result ReportOpen accessMedicine
Liu H, Hu Z, Song Q et al. · 2025 · JAMA network open
Importance Evidence from everyday dining situations regarding the effects of traffic light labels (TLLs) on dietary improvement remains inconsistent. Objective To evaluate the effects of TLLs on dietary consumption and choices in cafeteria…
View details →DOI: 10.1001/jamanetworkopen.2025.10894 Failed Experiment ReportOpen accessMedicine
Awawdeh MS · 2024 · Journal of advanced veterinary and animal research
Objective The current study investigated the effects of supplying ruminally protected amino acids (AA) (lysine, L; and methionine, M) and dietary protein levels on the performance of late-nursing ewes. Materials and methods Thirty-one…
View details →DOI: 10.5455/javar.2024.k821 Failed Experiment ReportMedicine
Remaks JD, Vientos-Plotts AI, Rindt H et al. · 2024 · American journal of veterinary research
Objective To determine if multistrain probiotics administered to asthmatic cats treated with anti-inflammatory glucocorticoids would attenuate the asthmatic phenotype and beneficially alter respiratory, blood, and oropharyngeal (OP)…
View details →DOI: 10.2460/ajvr.23.12.0271 Negative / Null Result ReportMedicine
Cearns K, Lazarus ER, Wahid R · 2026 · The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres
BackgroundMental health nurses represent only 1.03% of the global nursing workforce, contributing to persistent workforce shortages. Undergraduate nursing students demonstrate limited interest in mental health nursing (MHN), often…
View details →DOI: 10.1177/08445621261447369 Negative / Null Result Report
Zhao Y, Zhang H, Gao J et al. · 2026 · Preprint
Abstract Background Venetoclax (VEN)-based regimens are increasingly used in frontline treatment for acute myeloid leukaemia (AML), resulting in a growing number of patients who develop relapsed or refractory disease after prior VEN…
View details →DOI: 10.21203/rs.3.rs-9496750/v1 Negative / Null Result ReportMedicine
S YK, Dwibedi B, Das RR · 2026 · European journal of pediatrics
Because of the excessive endogenous inflammatory mediators, acute encephalitis syndrome (AES) results in death, or sequelae in survivors. Pentoxifylline, a modulator of inflammation, can have beneficial role in AES. The primary objective…
View details →DOI: 10.1007/s00431-026-07097-w Negative / Null Result ReportMedicine
Ansaloni LS, Domingues CEC, Gregori M et al. · 2026 · Insects
Given the current global agricultural system, honey bees are exposed to a complex network of stressors that can act simultaneously, making it challenging to maintain healthy colonies. Therefore, studies on natural products to improve…
View details →DOI: 10.3390/insects17060594 Negative / Null Result Report
Li J, Lu X, Yue S et al. · 2026 · Preprint
Abstract Non-small cell lung cancer (NSCLC) patients carrying HER2 20ins exon 20 insertion (HER2 20ins) are poorly respond to conventional therapies and pan HER inhibitors. Trastuzumab Deruxtecan (T-DXd) has been approved in second line…
View details →DOI: 10.21203/rs.3.rs-8854444/v1 Negative / Null Result ReportMedicine
Schmid SR, Blume C, Ell J et al. · 2026 · Journal of sleep research
Cognitive behavioural therapy for insomnia (CBT-I) is recommended as first-line treatment for insomnia disorder. However, around 25% of the patients do not respond to the treatment, and only 40% achieve full remission. The current study…
View details →DOI: 10.1111/jsr.70357 Negative / Null Result Report
Goričan I, Šorgo A, Strnad M · 2026 · Preprint
Background: and Objectives: Slovenia, as many other European nations, have introduced voluntary first responders to enhance survival rates in out-of-hospital cardiac arrests. In currently published research exists no conclusive data on the…
View details →DOI: 10.20944/preprints202604.0841.v1 Null DatasetMedicine
Motta‐Romero HA, Guha S, Seravalli J et al. · 2024 · Cereal chemistry
BACKGROUND AND OBJECTIVES: Wheat porridge contributes to the intake of micronutrients but can also be a route of the toxic heavy metal, cadmium. This study aimed to determine the effect of processing on micronutrients, cadmium…
View details →DOI: 10.1002/cche.10778 Failed Experiment ReportMedicine
Li W, Shi M, Zhou P et al. · 2024 · Pediatric blood & cancer
Background The outcome of extramedullary infiltration (EMI) in pediatric acute myeloid leukemia (AML) is controversial, and little is known about the implications of stem cell transplantation (SCT) and gemtuzumab ozogamicin (GO) treatment…
View details →DOI: 10.1002/pbc.31014 Methods Dead-EndMedicine
Sun X, Yan T, Li Z et al. · 2023 · Nutrients
(1) Background: We investigated the effects of a 12-week exercise intervention with or without vitamin D supplementation on insulin resistance and the plasma lipidome of participants with type 2 diabetes. We further explored whether the…
View details →DOI: 10.3390/nu15133027 Failed Experiment ReportOpen accessMedicine
Liu X, Ma Y, Cui H et al. · 2026 · Frontiers in pediatrics
Background Extrauterine growth restriction (EUGR) critically impacts preterm infants, often due to nutritional deficiency. Lactational protein restriction can disrupt offspring glucose/lipid metabolism by altering gene expression and…
View details →DOI: 10.3389/fped.2026.1829936 Replication FailureOpen accessMedicine
Ward E, Hanbury G, Possamai L et al. · 2025 · BMJ open quality
Background End-stage liver disease (ESLD) is a terminal diagnosis with a poor prognosis and an accelerating mortality rate in the UK. Limited research suggests that patients with ESLD have unmet palliative care (PC) needs, likely due to…
View details →DOI: 10.1136/bmjoq-2025-003521 Negative / Null Result Report
Li N, Wu C, Cao P et al. · 2023 · Preprint
Abstract Background: Rhodococcus equi is one of the most important causes of zoonotic infections from grazing animals. It poses a particular risk to immunocompromised individuals, including those who are undergoing long-term…
View details →DOI: 10.1099/acmi.0.000600.v3 Negative / Null Result ReportOpen accessMedicine
Akbarzadeh G, Abedi P, Jahanfar S et al. · 2024 · Frontiers in medicine
Background Sexual dysfunction is prevalent among breastfeeding women. Objective This study was designed to evaluate the effect of Rose damascene extract on sexual function and anxiety of breastfeeding women. Materials and methods This was…
View details →DOI: 10.3389/fmed.2024.1466341 Negative / Null Result ReportMedicine
Nishiofuku H, Mori M, Yokomichi N et al. · 2024 · Journal of palliative medicine
Delirium is a distressing condition in terminally ill cancer patients, often treated with antipsychotics. Administering them orally, subcutaneously, or intravenously can be challenging in severely agitated patients. Transdermal…
View details →DOI: 10.1089/jpm.2023.0584 Negative / Null Result ReportMedicine
Oliver-Pons C, Sala-Vila A, Cofán M et al. · 2024 · Journal of the American Geriatrics Society
Background Nutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha-linolenic (the vegetable n-3 fatty acid) and polyphenols, their…
View details →DOI: 10.1111/jgs.19007 Failed Experiment ReportOpen accessMedicine
Wang Y, Wang C, Yin S et al. · 2025 · CNS neuroscience & therapeutics
Background Systemic therapeutic options for meningiomas remain limited. Emerging evidence indicates meningiomas harbor an immunosuppressive microenvironment and programmed cell death ligand 1 (PD-L1) expression is significantly upregulated…
View details →DOI: 10.1111/cns.70659 Replication FailureOpen access
Panca M, Serfaty M, Satchell J et al. · 2025 · Preprint
Abstract Background : Crime has significant impact on older victims. High rates of anxiety and depression may be associated with crimes. Aims: This paper aims to evaluate the cost-effectiveness of a Victim Improvement Package (VIP) for the…
View details →DOI: 10.21203/rs.3.rs-7256160/v1 Negative / Null Result ReportMedicine
Polauke E, Stage Sø J, Carl H et al. · 2024 · Journal of environmental management
Ambitious to fulfill the European Water Framework Directive obligations, the European governments support projects to rehabilitate lakes with poor water quality. However, most lake restorations having relied on biomanipulation by fish…
View details →DOI: 10.1016/j.jenvman.2024.120570 Negative / Null Result ReportOpen accessMedicine
Li J, Zhou J, Ha Q et al. · 2026 · Frontiers in cardiovascular medicine
Objective Obesity is an independent risk factor for cardiovascular diseases and elevated mortality, yet the underlying mechanisms remain incompletely understood. Impaired endothelium-dependent relaxation is an early manifestation of…
View details →DOI: 10.3389/fcvm.2026.1797300 Replication FailureMedicine
Shankie-Williams K, Day M, Dowland S · 2026 · Biology open
There is a critical need for novel non-hormonal contraceptives. Zinc-based intrauterine devices (IUDs) demonstrate 100% efficacy in rats, yet the mechanism remains unclear. We investigated whether zinc targets sperm, embryos, or the…
View details →DOI: 10.1242/bio.062546 