e-ISSN: Pending
Replication FailureMedicine

The Zinc contraceptive effect: Targets, timing, and quantitative thresholds.

Shankie-Williams K; Day M; Dowland S · 2026 · Biology open

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

Abstract (excerpt)

There is a critical need for novel non-hormonal contraceptives. Zinc-based intrauterine devices (IUDs) demonstrate 100% efficacy in rats, yet the mechanism remains unclear. We investigated whether zinc targets sperm, embryos, or the…

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Metadata source: Europe PMC · DOI 10.1242/bio.062546