A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Su M, Saxon-Filipe S, Ahn C et al. · 2025 · Clinical breast cancer
Background Metaplastic breast carcinoma (MpBC) is an aggressive subtype of breast cancer that is usually resistant to chemotherapy. Few studies have analyzed the role of immunotherapy and other treatments in early stage MpBC. We identified…
Narayan P · 2025 · Indian journal of thoracic and cardiovascular surgery
Dual antiplatelet therapy (DAPT) is recommended after acute coronary syndrome (ACS), but evidence in coronary artery bypass graft (CABG) patients is limited. The TACSI (Dual Antiplatelet Therapy with Ticagrelor and Acetylsalicylic Acid…
Marr J, Meyers DJ, Ryan AM · 2026 · Health affairs (Project Hope)
The Centers for Medicare and Medicaid Services (CMS) is increasingly experimenting with prior authorization in traditional Medicare. In 2016, CMS began using pre-claim review, a prior authorization-like system in which claims are reviewed…
Liu S, Song X, Li D et al. · 2025 · Wetlands.
Constructed Wetland (CW) is a low-carbon, sustainable ecological treatment technology widely used for deep treatment of wastewater treatment plant tailwater. However, constrained by the lack of available carbon source in the tailwater, the…
Martínez-Ocón J, Pérez M, Calvo A et al. · 2026 · Journal of clinical anesthesia
Background Sedation during endoscopic retrograde cholangiopancreatography procedures (ERCP) increases the risk of hypoxemia and the need for respiratory support in high-risk patients. High flow nasal cannula (HFNC) provides humidified gas…
Diener J, Krafft J, Rayling S et al. · 2025 · Preprint
The global rise in nursing home (NH) populations presents substantial challenges, as residents frequently experience physical and cognitive decline, low physical activity, and high fall risk. This study evaluated the effectiveness of the…
Linares LAR, Martinez RCR, Carvalho VH et al. · 2026 · Preprint
Abstract Background and Objectives: Pain control after cardiac surgery remains suboptimal, and concerns about neuraxial techniques under anticoagulation limit the use of thoracic epidurals. The erector spinae plane (ESP) block offers a…
Michaan N, Michaan N, Laskov I et al. · 2026 · Journal of lower genital tract disease
Objectives Cervical conization (loop electrosurgical excision procedure) under local anesthesia is often associated with anxiety and procedural pain. Virtual reality (VR) glasses may enhance patient experience and reduce discomfort during…
Butala AD, Nanayakkara S, Johnston R et al. · 2026 · The American journal of cardiology
Stroke is a serious complication following transcatheter aortic valve implantation, associated with increased disability and mortality. Despite this, there is a lack of patient-level data examining stroke in contemporary, lower-risk…
Zhou Y, Dai C, Wu F et al. · 2026 · Pulmonology
Background Low-dose theophylline has anti-inflammatory effects, but its efficacy in mild to moderate COPD remains controversial. Research question Is low dose theophylline effective and safe in patients with mild to moderate COPD? Methods…
Geoffrion D, Mikhail D, Rizk M et al. · 2025 · Ocular immunology and inflammation
Authors reported an 18% rate of endophthalmitis in Boston type 1 keratoprosthesis (KPro) patients, higher than previously reported rates. Most cases occurred during the COVID-19 pandemic, likely due to reduced access to care. Bandage…
Pacini GS, Manfro AG, Schuchmann RA et al. · 2026 · Clinical kidney journal
Background Percutaneous kidney allograft biopsy is essential for evaluating graft dysfunction, but post-procedural bleeding remains the most frequent complication, particularly among recipients with impaired renal function. Desmopressin…
Stelmashook EV, Genrikhs EE, Alexandrova OP et al. · 2025 · Biomeditsinskaia khimiia
Copper ions (Cu2+) at concentrations of 25-50 μM stimulate lipopolysaccharide (LPS)-induced nitric oxide (NO) production in glial cell cultures derived from rat cerebral cortex and containing both astrocytes and microglia. Addition of a…
Hamaya R, Li S, Lau J et al. · 2026 · American journal of hypertension
Background Multivitamin-multimineral (MVM) supplements have been associated with lower blood pressure (BP) in several small trials. We investigated the effects of a MVM on incident hypertension and BP in a secondary analysis of the COcoa…
Li M, Liu L, Qin Y et al. · 2025 · Preprint
Abstract Purpose The relationship between moderate physical activity (MPA) and vigorous physical activity (VPA) concerning the risk of sarcopenia in adolescents remains unclear. We aimed to investigate the association between MPA, VPA, and…
Detelich J, Martin GS · 2025 · Annals of internal medicine
Clinical impact ratings Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text].
Dubrovsky L, Pushkarsky T, Brichacek B et al. · 2026 · Microorganisms
Trained immunity (TRIM) enhances innate immune responses through epigenetic and metabolic reprogramming but may become maladaptive, contributing to chronic inflammation. In people living with HIV (PLWH), maladaptive TRIM has been proposed…
Tamoto M, Kai S, Yoshida H et al. · 2026 · Journal of cardiothoracic and vascular anesthesia
Objectives To compare the real-world effectiveness of combined propofol and dexmedetomidine (PRODEX) sedation with propofol monotherapy on survival and postoperative delirium (POD) in a large nationwide cohort of patients undergoing…
Khun Jush B, Biswas MAAJ, Lim HJJ et al. · 2026 · Pancreas
Background Routine feeding tube (FT) placement during pancreaticoduodenectomy (PD) has not reduced complication rates. Nonetheless, FTs are often selectively placed in patients with poor nutritional status such as those with significant…
Bücken CA, Riesthuis P, Caon G et al. · 2026 · Memory (Hove, England)
False autobiographical memories can have serious implications in legal settings, where the case outcomes may hinge entirely on memory-based eyewitness testimony. This study investigated whether a sensitisation memory training could reduce…
Sato T · 2025 · Preprint
Background: Active-fluidics phacoemulsification can maintain anterior chamber stability at lower intraoperative intraocular pressure (IOP) levels. However, whether reducing IOP alone—without additional stabilizing technologies such as the…
Ruiz-Tagle C, Seguel R, Villarroel L et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce…
Ringer AJ, Hanel RA, Baig AA et al. · 2025 · Journal of neurointerventional surgery
Background The optimal duration for dual antiplatelet therapy (DAPT) after stent-assisted coiling (SAC) of intracranial aneurysms is unclear. Longer-term therapy may reduce thrombotic complications but increase the risk of bleeding…
Bierer JD, Stanzel R, Henderson M et al. · 2026 · The Annals of thoracic surgery
Background Pediatric cardiac surgery with cardiopulmonary bypass (CPB) is associated with systemic inflammation. This trial aimed to determine whether continuous high-exchange ultrafiltration during CPB has a clinical immunomodulatory…
Khueangchiangkhwang S, Oida Y, Taguchi A et al. · 2026 · Parasitology international
Trichinella is a nematode that causes chronic infection via its larvae in muscle cells and remains a global health concern. Drug sensitivity, including to ivermectin (IVM), differs between intestinal adult worms (AW) and muscle larvae…
Dunkel K, Moroz MS, Suares B et al. · 2025 · The Journal of dairy research
This research article aimed to evaluate the effect of a commercial nutraceutical additive in milk replacer on the health and weight gain of dairy calves during the pre-weaning phase. A total of 126 female Holstein calves were randomly…
Meves V, Chamieh A, Mohamed M et al. · 2026 · Endoscopy international open
Background and study aims Previous studies in esophagogastroduodenoscopy or colonoscopy have demonstrated positive effects of music on patient anxiety and comfort. This study prospectively evaluated the effect of functional music on…
Kashtiara A, Pauptit J, Thijs D et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Objectives Enhanced Recovery After Surgery (ERAS) protocols aim to improve surgical outcomes, by mitigating postoperative stress through multimodal perioperative care. In spinal surgery, such protocols may reduce pain, hospital length of…
Sielski W, Osęka T, Antolak A et al. · 2026 · Frontiers in endocrinology
Background Parathyroid preservation during total thyroidectomy with central neck dissection in papillary thyroid carcinoma remains challenging due to the glands' delicate vascular anatomy and risk of inadvertent devascularization or…
Palmier M, Ghorayeb G, Arhant G et al. · 2026 · Annals of vascular surgery
Background Supraceliac aortic cross-clamping can induce remote organ injury, particularly affecting the lungs through ischemia-reperfusion mechanisms. Pulmonary endothelial dysfunction plays a central role in acute lung injury, potentially…