Negative / Null Result ReportMedicine
Simeonova L, Leseva M, Stoyanov K et al. · 2025 · Biochimica et biophysica acta. Molecular basis of disease
Sirtuin 1 (Sirt1), a class III histone deacetylase, is a key regulator of gene expression in various immune cell types, including neutrophils, during infection and acute inflammation. Herein, we studied the effect of the Sirt1 activator…
View details →DOI: 10.1016/j.bbadis.2025.167915 Negative / Null Result ReportMedicine
Jackson CB, Xue W, Gupta AA et al. · 2025 · International journal of radiation oncology, biology, physics
Purpose To evaluate local failure (LF) rates for patients with intermediate-risk rhabdomyosarcoma treated on the Children's Oncology Group ARST1431 clinical trial, the first and largest international, phase 3 randomized study to use FOXO1…
View details →DOI: 10.1016/j.ijrobp.2025.03.038 Negative / Null Result ReportOpen accessMedicine
Chow WD, Spinner RJ, Amrami KK et al. · 2026 · Journal of neurosurgery. Case lessons
Background Bertolotti syndrome is an underrecognized cause of chronic low back pain. Back pain generated from Bertolotti syndrome is believed to result from altered weight dissipation mechanics and/or instability of the pseudoarticulation,…
View details →DOI: 10.3171/case25948 Negative / Null Result Report
Boda A, Bandey IN, Chowdhury S et al. · 2025 · Preprint
Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate and limited treatments. Agonistic CD40 antibodies are promising, but clinical trials have shown only modest efficacy and significant hepatotoxicity. We previously reported…
View details →DOI: 10.1101/2025.02.23.639774 Negative / Null Result ReportMedicine
Vicenti C, Cercone M, Nieman G et al. · 2025 · Veterinary anaesthesia and analgesia
Objective To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. Study design A crossover,…
View details →DOI: 10.1016/j.vaa.2025.06.007 Negative / Null Result ReportMedicine
Jacob A, He J, Peck A et al. · 2025 · Heliyon
Sjögren's (SS) involves salivary and lacrimal gland dysfunction. These studies examined metabolic profiles in the B6. Il14α transgene mouse model of SS and a cohort of human SS patients at different stages of disease. In B6. Il14α mice,…
Replication FailureOpen accessMedicine
Döhner H, Späth D, Saadati M et al. · 2026 · Blood
Abstract Core-binding factor acute myeloid leukemia (CBF-AML) is associated with KIT mutations and deregulated expression of KIT. We report results from the randomized, open-label, phase 3 trial of intensive chemotherapy with or without…
View details →DOI: 10.1182/blood.2025030722 Negative / Null Result Report
Pae Y, Park H, Lee H et al. · 2024 · Preprint
Abstract Background Hyperhidrosis is the secretion of excess sweat beyond what the body needs for homeostatic regulation. Secondary hyperhidrosis is usually related to an underlying cause, mostly a medical condition, or extrinsic factors…
View details →DOI: 10.21203/rs.3.rs-5279798/v1 Negative / Null Result ReportOpen accessMedicine
Bertsias A, Flouri I, Emmanouilidou E et al. · 2026 · Arthritis research & therapy
Background Difficult to manage (D2M) axial spondyloarthritis (axSpA) is an evolving clinical concept. We aimed to assess the prevalence, predictors and long-term outcomes of D2M axSpA. Methods Prospective single center cohort study of…
View details →DOI: 10.1186/s13075-026-03732-x Negative / Null Result ReportOpen accessMedicine
Bošnjak K, Vengust R · 2025 · Journal of clinical medicine
Background : We aimed to analyze radiographic sagittal balance parameters in patients who underwent a TLIF procedure for single-level degenerative spondylolisthesis with a mean follow-up of 8.6 years and to determine whether lumbar…
View details →DOI: 10.3390/jcm14155457 Negative / Null Result Report
Ribic A, McCoy E, Pendala V et al. · 2024 · Preprint
Abstract Preterm birth is a leading risk factor for atypicalities in cognitive and sensory processing, but it is unclear how prematurity impacts circuits that support these functions. To address this, we trained adult mice born a day early…
View details →DOI: 10.21203/rs.3.rs-5529783/v1 Negative / Null Result ReportOpen accessMedicine
Ikegishi Y, Abe R, Maehata A et al. · 2026 · Internal medicine (Tokyo, Japan)
Copper deficiency is a rare but critical cause of anemia and neurological impairment. We herein report a hemodialysis patient who developed acute-onset copper deficiency after spinal surgery with zinc supplementation, despite no…
View details →DOI: 10.2169/internalmedicine.5960-25 Negative / Null Result ReportOpen accessMedicine
Umer A, Nafis S, Karimi M · 2026 · Cureus
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited bone marrow failure disorder characterized by severe thrombocytopenia due to absent or markedly decreased megakaryocytes. It typically presents in infancy and may…
View details →DOI: 10.7759/cureus.102147 Failed Experiment Report
Fina A, Àvila Cabré S, Vázquez Pereira E et al. · 2024 · Preprint
The introduction of heterologous pathways into microbial cell compartments offers several potential advantages, including increasing enzyme concentrations and reducing competition with native pathways, making this approach attractive to…
View details →DOI: 10.20944/preprints202412.0269.v1 Methods Dead-EndMedicine
Artal JM, Randall L, Rubeck S et al. · 2025 · American journal of medical genetics. Part A
Parents of children with Down syndrome have historically reported poor experiences receiving a prenatal diagnosis. In a 2003 survey, mothers reported that their physicians pitied them, emphasized negative aspects of Down syndrome, and…
View details →DOI: 10.1002/ajmg.a.63981 Failed Experiment ReportMedicine
Grant Owens R, Lockwood G, Storm D · 2025 · Urology
Prenatal diagnosis of left multicystic dysplastic kidney (MCDK) and ureterocele was made in a male fetus at 24-week gestation. The initial postnatal course was uneventful. At 4 weeks of age, he developed urosepsis and respiratory distress.…
View details →DOI: 10.1016/j.urology.2024.10.060 Negative / Null Result ReportMedicine
Pisljar Z, Markelc B, Brezar SK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Radiotherapy is a standard therapy for oral squamous cell carcinoma (OSCC) with immunomodulatory potential. Due to high lymphocyte radiosensitivity, partial tumor-volume irradiation (pIR), targeting only part of the tumor, is being…
View details →DOI: 10.1016/j.biopha.2025.118107 Failed Experiment ReportOpen accessMedicine
Davis MP, Ulrich A, Segal R et al. · 2024 · Cancers
Background: Chemotherapy-induced peripheral neuropathy (CIPN) from oxaliplatin and taxane drugs is a bothersome toxicity. Palmitoylethanolamide (PEA) has been reported to improve myelinated nerve fiber function in patients experiencing…
View details →DOI: 10.3390/cancers16244244 Negative / Null Result ReportMedicine
Paul N, Weiss B · 2025 · Die Anaesthesiologie
With a decrease in mortality of critically ill patients in recent years, intensive care medicine research has shifted its focus on functional impairments of intensive care units (ICU) survivors. ICU survivorship is characterized by…
View details →DOI: 10.1007/s00101-024-01483-5 Negative / Null Result ReportOpen accessMedicine
Aguila L, Castillo R, Pérez-García F et al. · 2026 · Animals : an open access journal from MDPI
Haploid embryos constitute a valuable model for genetic and epigenetic studies; however, their developmental competence is reduced compared with diploid counterparts. This study evaluated whether supplementation of the culture medium with…
View details →DOI: 10.3390/ani16101517 Replication FailureMedicine
Bi X, Yu Y, Zhou S et al. · 2024 · Nephron
Introduction The renoprotective benefits of adding immunosuppressant therapy to corticosteroid (CS) treatment for immunoglobulin A nephropathy (IgAN) patients with less than 25% crescent formation (C1) remain uncertain, warranting further…
View details →DOI: 10.1159/000534788 Negative / Null Result ReportMedicine
Vicenti C, Cercone M, Nieman G et al. · 2025 · Veterinary Anaesthesia and Analgesia
To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses. A crossover, nonrandomized, experimental…
Negative / Null Result ReportOpen accessMedicine
Kaplan A, Malik S, Persaud NA et al. · 2025 · Cureus
Fragile X syndrome (FXS) is classified as a genetic disorder located in the fragile X messenger ribonucleoprotein-1 (FMR1) gene on the X chromosome. FXS is considered the most prevalent single-gene cause of intellectual disability and…
View details →DOI: 10.7759/cureus.88159 Negative / Null Result ReportMedicine
Calvani R, Giampaoli O, Marini F et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)
Background & aims Long-term effects of coronavirus disease 2019 (long COVID) develop in a substantial number of people following an acute COVID-19 episode. Red beetroot juice may have positive effects on multiple pathways involved in long…
View details →DOI: 10.1016/j.clnu.2024.11.023 Negative / Null Result ReportOpen accessMedicine
Tardif A, Boulay ME, Côté A et al. · 2026 · Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
BACKGROUND: Tezepelumab is the most recent human monoclonal antibody in the therapeutic arsenal of patients with severe uncontrolled asthma. It neutralizes thymic stromal lymphopoietin (TSLP). Phase 2 and phase 3 studies showed a…
View details →DOI: 10.1186/s13223-026-01037-x Negative / Null Result ReportOpen accessMedicine
Fu Y, Zhang Y, Deng Q et al. · 2025 · BMC psychiatry
Background Post-stroke depression (PSD) constitutes an important complication of stroke, affecting approximately one-third of stroke patients. PSD decreases rehabilitation motivation, delays function recovery, and increases the family and…
View details →DOI: 10.1186/s12888-025-06673-y Negative / Null Result ReportMedicine
Kateh Shamshiri M, Vakili-Ghartavol R, Aiyelabegan HT et al. · 2025 · Cytokine
While liposomes enhance the safety and pharmacokinetic profile of free drugs, they have not significantly improved therapeutic efficacy. To overcome this challenge, targeted depletion of tumor-associated macrophages (TAMs) shows…
View details →DOI: 10.1016/j.cyto.2025.156860 Negative / Null Result ReportMedicine
Lamboley Q, Fourcade Y · 2024 · Journal of biogeography
AIM: The continuous development of statistical tools applied to ecology has contributed to great advances for modelling species' niches and distributions from opportunistic observations. However, as these observations are subject to biases…
Negative / Null Result ReportMedicine
Alghizzi TM, Alshahrani TM · 2024 · Heliyon
Despite considerable evidence that supports the use of grading rubrics (GRs) as tools for written corrective feedback, there is a paucity of research that investigates which of the different types of GRs best develops learners'…
Negative / Null Result Report
Siegrist H, Spieler A, Peters AS et al. · 2024 · Preprint
There is currently no clinically valid biomarker for predicting the growth and prognosis of abdominal aortic aneurysms (AAA). The most promising candidates with highest diagnostic values are plasma D-dimers and markers of activated…
View details →DOI: 10.20944/preprints202410.2260.v1 