A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20227 results in Negative / Null Result Report · page 232 of 675
Bliesner RK, Stevens AA, Holling L et al. · 2026 · Cureus
Background Being in the large majority, right-handed people are not required to use their nondominant hands throughout their daily lives, resulting in a loss of motor dexterity. As technology continues to advance, improving motor dexterity…
Oscorbin IP, Smertina MA, Kunova MS et al. · 2025 · Preprint
The metal-binding periplasmic protein CusF has been proposed as a bifunctional tag enhancing solubility of recombinant proteins and enabling purification using Cu affinity chromatography. However, evidence for its performance remains…
Nascimento GO, Otávio KS, Ferreira J et al. · 2026 · Tropical animal health and production
Bioactive peptides (BP) have been investigated as potential functional feed additives due to their reported immunomodulatory and metabolic properties. This study evaluated the effects of dietary BP supplementation on growth performance,…
Tortajada M, Rodríguez-Larios J, Martínez-Pérez V et al. · 2026 · Journal of cognitive neuroscience
Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in working memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…
Kim SB, Lopez A, Gu X et al. · 2026 · Journal of vitreoretinal diseases
Purpose: To evaluate real-world differences in treatment frequency, appointment compliance, and visual outcomes among patients with DME or RVO whose eyes either remained on antivascular endothelial growth factor (anti-VEGF) therapy or were…
Sobel Misieczko M, Barber SJ · 2026 · Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Affective forecasting, the process of predicting future feelings, is key for decision-making, but prone to errors. Prior research suggests that age differences in forecasting accuracy vary by event valence such that older adults tend to be…
Wu Y, Feng K, Liu L et al. · 2026 · Preprint
Abstract Background Acute profound thrombocytopenia is an infrequent, but potentially serious, even fatal complication associated with intravenous glycoprotein IIb/IIIa receptor inhibitors (GPI), which are widely used in acute coronary…
Alberts KO, Espiritu IJ, Castel AD · 2026 · Experimental aging research
Background Young and older adults are often victimized by various forms of scams and fraud. However, little research has been conducted on how a scam prevention intervention may impact young and older adults' accuracy and confidence in…
Brisola GMP, da Cruz AL, Belorio LGDS et al. · 2026 · Journal of strength and conditioning research
Abstract Brisola, GMP, da Cruz, AL, Belorio, LGdS, Grossi, JP, De Poli, RAB, Zagatto, AM, Esco, MR, and Mendes, OdC. Effects of dry-land versus in-water resistance priming exercise on performance parameters of young female water polo…
Arraes Rocha Felix V, Rohani P, Drake JM · 2026 · Journal of the Royal Society, Interface
Infectious disease forecasting is important to public health decision-making, particularly for mitigating the burden of seasonal influenza. We propose and evaluate comprehensive autoregressive modelling approaches (autoregressive…
Hill CR, Balmer L, Abbiss H et al. · 2026 · Food & function
S -Methyl cysteine sulfoxide (SMCSO) is an organosulfur compound with demonstrated hypocholesterolemic, anti-diabetic, and antioxidant benefits in rodents. However, the doses used have limited translatability for humans. We explored…
Vargas Ribera PR, Nogales A, Calvet C et al. · 2026 · Applied Soil Ecology.
Crop rotation enhances agroecosystem sustainability by reducing nutrient loss, improving soil fertility, and decreasing crop evapotranspiration. Arbuscular mycorrhizal fungi (AMF) inoculation further supports enhanced nutrient and water…
Di Cesare B, Mancini GF, Parente M et al. · 2026 · Life sciences
Aims Metabolic syndrome (MetS) is characterized by several metabolic alterations that may increase the risk of memory alterations. While metabolic consequences of MetS are well documented, its memory impact remains underexplored. This…
Leal RMS, Campos MCBP, Copelli FA et al. · 2026 · International endodontic journal
Aim To evaluate the endodontic retreatment of S-shaped mesial root canals of mandibular molars using the Reciproc Blue R25 and R40 instruments, with or without the use of an orange oil solvent, and to assess the effect of additional apical…
Ko E, Kim YH, Lee S et al. · 2025 · The Journal of surgical research
Introduction Sepsis is a severe pathological crisis marked by infection and systemic inflammation with high mortality rates. Sepsis induces microcirculatory dysfunction and oxidative stress, which share pathophysiological features with…
Dong Z, Wu L, Du H et al. · 2026 · Gastroenterology
Background & aims Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lacking. We aimed to explore whether AI can enhance gastric neoplasm detection. Methods…
Greistofer E, Taher F, Assadian A et al. · 2026 · Annals of vascular surgery
Background The objective of this study was to evaluate the prognostic value of routine postoperative laboratory parameters including renal function, inflammatory markers, and hematologic indices in patients undergoing fenestrated…
Lee TY, Hunter DA, Perez R et al. · 2026 · The Journal of hand surgery
Purpose Polyethylene glycol (PEG) fusion has been reported to restore axonal continuity after nerve repair if initiated before Wallerian degeneration (WD). Sterile α and Toll/Interleukin-1 Receptor motif-containing 1 (SARM1) inhibition can…
Umbricht D, Abt M, Derks M et al. · 2026 · The Journal of clinical psychiatry
Objective: Cognitive impairment associated with schizophrenia (CIAS) is a key driver of functional deficits in patients with this disorder. CIAS may involve deficient NMDA receptor-dependent neurotransmission. Negative allosteric…
Toprak HB, Erdemir M, Bilgiç E et al. · 2026 · Preprint
Abstract Background The C-reactive protein–to–albumin ratio has been proposed as a composite inflammatory biomarker associated with adverse outcomes in critically ill patients. However, whether the C-reactive protein–to–albumin ratio…
Liu Y, Wang X, Qian P et al. · 2026 · Preprint
Abstract Background Patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing surgery after neoadjuvant chemotherapy (NCT) or neoadjuvant chemoimmunotherapy (NICT) remain at risk of disease progression. Currently,…
Kitowski A, Heise C, Sperling S et al. · 2026 · British journal of pharmacology
Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to…
Grossmann I, Rudnev M, Clark CJ et al. · 2026 · Preprint
Experts and pundits routinely forecast societal trends, yet these predictions often fall short, leading to poor policy decisions. What distinguishes accurate forecasters? In a three-year longitudinal tournament (N = 520), we tested whether…
Talathi R, Hubbard RA, Somasundar P et al. · 2026 · Surgery
Background The Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (STRASS 2) trial is evaluating the impact of neoadjuvant chemotherapy versus surgery in patients with high-risk, resectable…
Zhao A, Chen W, Liang Y et al. · 2026 · Cancer treatment and research communications
Objective To compare and analyze the efficacy and safety of an overall strategy of immunotherapy combined with chemoradiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC)-including induction immunotherapy plus…
Sarica C, Darmani G, Ramezanpour H et al. · 2026 · Science translational medicine
Transcranial ultrasound stimulation (TUS) is a promising noninvasive technique for modulating deep brain targets and circuits with high spatial precision. For its successful clinical translation, confirmation of target engagement, together…
Riestra JM, Levin-Carrion Y, Sutar R et al. · 2026 · Human psychopharmacology
Treatment-resistant depression (TRD) remains a formidable challenge in psychiatry, with nearly one-third of patients with major depressive disorder (MDD) failing to respond adequately to first-line pharmacological treatments.…
Nandi D, Gajarski RJ, Zhao H et al. · 2026 · Pediatric transplantation
Purpose Human Leukocyte Antigen (HLA) sensitization can adversely impact heart transplant (HTx) outcomes. We evaluated the effect of panel-reactive antibody (PRA) and desensitization (DS) strategies on outcomes of pediatric HTx recipients…
Silva-García J, Eurolo I, Fuentes-Flores R et al. · 2026 · Brain research
Ischemic stroke is a leading cause of death and disability worldwide. Among survivors, one-third live with permanent impairments, and two-thirds experience upper limb dysfunction. Despite advances in acute care, no universally effective…
Hayashi T, Go M, Kawasumi K et al. · 2026 · Preprint
Abstract Introduction Maintaining dose intensity is essential for the efficacy of adjuvant S-1 chemotherapy in gastric cancer. Although pharmacist interventions can reduce toxicity and improve adherence, multicenter evidence regarding…