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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 232 of 661

Negative / Null Result Report

Longitudinal Interaction Between Frailty and Postoperative Symptom Burden in Elderly Patients Undergoing Colorectal Cancer Surgery: A Random Intercept Cross-Lagged Panel Model Study

Li P, Ge L, Liu Y et al. · 2026 · Preprint

Background: /Objectives: Frailty and postoperative symptom burden are prevalent in older adults undergoing colorectal cancer (CRC) surgery, but their temporal, within-person interplay remains unclear. We aimed to investigate this…

View details →DOI: 10.20944/preprints202606.0136.v1
Negative / Null Result ReportMedicine

Tibial-Sided Suspension Fixation increases Risk of Cyclops Lesion following Anterior Cruciate Ligament Reconstruction.

Hansen BK, Sandefur EP, Garcia AR et al. · 2026 · The journal of knee surgery

Abstract Cyclops lesions are a common postoperative complication that occurs in up to 47% of patients after anterior cruciate ligament reconstruction (ACLR), often resulting in painful extension loss. While risk factors for cyclops lesions…

View details →DOI: 10.1055/a-2886-8022
Negative / Null Result ReportMedicine

Independent and joint associations of chronotype and sleep quality with psychoactive substance use in adolescents.

Espinoza-Abad R, Gogeascoechea-Trejo MDC, García-García F · 2026 · Sleep medicine

Objective To examine the associations of chronotype and sleep quality with psychoactive substance use among adolescents attending schools with different schedules and patterns associated with chronotype-school schedule combinations.…

View details →DOI: 10.1016/j.sleep.2026.109095
Negative / Null Result ReportMedicine

A randomized controlled trial to evaluate the efficacy and safety of a double-walled incubator compared to a radiant warmer in the care of extremely low-birth-weight infants.

Kabra NS, Umate SS, Halder P et al. · 2026 · Journal of tropical pediatrics

This study compared the safety and efficacy of double-walled incubators versus radiant warmers in extremely low-birth weight (ELBW: birth weight < 1000 g) preterm infants, hypothesizing that incubator care would reduce the time to regain…

View details →DOI: 10.1093/tropej/fmag040
Negative / Null Result ReportMedicine

Macromolecular crowding and ionic strength diminish the energetic severity of the Arrhenius break point of thermolysin: Implications for biological significance.

Miller JJ, Duggal M, Bahnson BJ · 2026 · Protein science : a publication of the Protein Society

A growing number of enzymes demonstrate deviations from typical linear kinetic temperature dependencies as modeled by the Arrhenius and Eyring equations. These deviations may manifest as biphasic temperature dependencies consisting of two…

View details →DOI: 10.1002/pro.70632
Negative / Null Result ReportMedicine

Perioperative Outcomes of Robot-Assisted Partial Nephrectomy Using Hinotori Compared With da Vinci Xi: A Propensity Score-matched Analysis.

Kanehira M, Nozaki Y, Ogasawara K et al. · 2026 · The international journal of medical robotics + computer assisted surgery : MRCAS

Introduction Robot-assisted partial nephrectomy (RAPN) using the da Vinci Surgical System (DVSS) is broadly performed globally. In Japan, the Hinotori Surgical Robot System (HSRS) has recently been developed. However, few studies have…

View details →DOI: 10.1002/rcs.70173
Negative / Null Result ReportMedicine

Species-level reporting of Coagulase-negative staphylococci with MALDI-TOF does not impact clinical outcomes.

Cebulla C, Hamdan A, Poonawala H et al. · 2026 · Diagnostic microbiology and infectious disease

Background Coagulase-negative Staphylococci (CoNS) are common blood culture contaminants, yet distinguishing true infection from contamination remains challenging. In January 2023, we implemented routine species-level CoNS reporting. This…

View details →DOI: 10.1016/j.diagmicrobio.2026.117479
Negative / Null Result ReportMedicine

Early, frequent, yet reversible: acute kidney injury after hematopoietic stem cell transplantation in pediatric Fanconi anemia and long-term renal outcomes.

Askarian F, Karimizadeh Z, Kalantari A et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Acute kidney injury (AKI) is an understudied complication in pediatric Fanconi anemia (FA) patients undergoing hematopoietic stem cell transplantation (HSCT). This study evaluates AKI incidence, risk factors, renal trajectories,…

View details →DOI: 10.1007/s00467-026-07390-8
Negative / Null Result ReportMedicine

Should nintedanib be continued after acute exacerbation of idiopathic pulmonary fibrosis? A retrospective observational study using a nationwide database in Japan.

Shuto H, Hagiwara A, Kudoh R et al. · 2026 · Respiratory medicine and research

Background Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) carries a high risk of short-term mortality, and optimal management strategies remain unclear. Although recent studies have suggested that antifibrotic therapy…

View details →DOI: 10.1016/j.resmer.2026.101293
Negative / Null Result ReportMedicine

<i>Staphylococcus aureus</i> inhibits the NLRP3 inflammasome in macrophages to varying degrees during early and late stages of infection.

Bhagat S, Kaur K, Petronglo JR et al. · 2026 · Infection and immunity

Staphylococcus aureus ( S. aureus ) is a highly virulent pathogen responsible for chronic infections such as osteomyelitis. Although its interaction with the host immune system has been widely studied, the specific role of inflammasomes in…

View details →DOI: 10.1128/iai.00200-26
Negative / Null Result ReportMedicine

Combining structural and microvascular parameters via machine learning for enhanced diagnosis of normal-tension glaucoma among highly myopic eyes: a prospective cross-sectional diagnostic accuracy study.

He CZ, Qiu Q, Lai H et al. · 2026 · BMC ophthalmology

This study aimed to evaluate whether a combination of optical coherence tomography (OCT) and OCT angiography (OCTA) parameters could improve the discrimination between clinically diagnosed normal-tension glaucoma (NTG) and non-glaucomatous…

View details →DOI: 10.1186/s12886-026-05065-4
Negative / Null Result ReportMedicine

Long-term outcomes of tacrolimus conversion to sirolimus in kidney transplant recipients: an eight-year follow-up.

Tawhari I, Park S, Yamani F et al. · 2026 · Frontiers in nephrology

Objective Calcineurin inhibitors, such as tacrolimus, are associated with long-term nephrotoxicity and renal allograft dysfunction despite evidence of improved kidney transplantation outcomes. Consequently, minimizing calcineurin inhibitor…

View details →DOI: 10.3389/fneph.2026.1813146
Negative / Null Result ReportMedicine

Chronic Mild Unpredictable Stress Selectively Downregulates Exon I Bdnf mRNA in the Rat Frontal Cortex Independently of Anhedonia.

Stepanichev M, Peregud D, Manolova A et al. · 2026 · Cell biochemistry and function

Chronic stress is often a precursor to depression. Multiple brain mechanisms underlying the development of depression involve alterations in neurotrophin signaling. In the present study, male Wistar rats were exposed to chronic mild…

View details →DOI: 10.1002/cbf.70225
Negative / Null Result ReportMedicine

The Use of Non-Contrast Abbreviated MRI for the Detection of Recurrent Hepatocellular Carcinoma in Postoperative Surveillance.

Chen J, Zhu Y, Zheng D et al. · 2026 · Journal of magnetic resonance imaging : JMRI

Background MRI is sensitive for detecting hepatocellular carcinoma (HCC), but its routine use is hindered by low accessibility. Purpose To evaluate the performance of non-contrast abbreviated MRI (NC-AMRI) alone and in combination with…

View details →DOI: 10.1002/jmri.70356
Negative / Null Result ReportMedicine

Achilles tendon rupture does not significantly reduce career longevity in professional soccer players compared with matched controls.

Khan HA, Khan A, Rosenberg A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To compare the career longevity of professional soccer players after achilles tendon rupture (ATR) with that of an uninjured matched control cohort. Methods A retrospective analysis of ATR cases in professional male athletes from…

View details →DOI: 10.1002/ksa.70420
Negative / Null Result ReportMedicine

Does a Brochure Reduce Dental Anxiety in Patients Undergoing Third Molar Extraction? A Randomized Clinical Trial.

Schemel-Suarez M, Egido-Moreno S, Martínez-Lizan I et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Dental anxiety frequently compromises patient cooperation and outcomes during third molar (3M) extraction prompting the use of nonpharmacological strategies such as detailed written information. Evidence on reducing preoperative…

View details →DOI: 10.1016/j.joms.2026.05.063
Negative / Null Result ReportMedicine

Supervised Machine Learning Models for Ocular Sagittal Height Prediction Incorporating Corneoscleral Profile Data.

González-Cruces T, Carrillo-Pulido M, Aguilar-Salazar FJ et al. · 2026 · Eye & contact lens

Objective This study aimed to develop supervised machine learning (ML) models to predict ocular sagittal height (OC-SAG), using anterior eye data derived from topography and tomography. Method ology: A retrospective cohort of 100 eyes…

View details →DOI: 10.1097/icl.0000000000001277
Negative / Null Result ReportMedicine

Effect of additive manufacturing technology and print orientation on the accuracy of static guided implant surgery: An in vitro study.

Amini S, Alshammari M, Abdulhameed N et al. · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

Purpose The aim of this in vitro study was to investigate the effect of print orientation and printing technology on the accuracy of static computer-aided implant surgery (s-CAIS). Materials and methods A cone beam computed tomography…

View details →DOI: 10.1111/jopr.70152
Negative / Null Result ReportMedicine

Exploring a Single Music Therapy Session to Reduce 22q11.2 Deletion Syndrome Child and Adolescent's Outpatient Clinic-Related Anxiety.

Broughton MC, Bunzli E, Pagel S et al. · 2026 · Journal of paediatrics and child health

Aim This study explored whether a single music therapy session could reduce 22q11.2 deletion syndrome (DS) children and adolescents' clinic-related anxiety when visiting the hospital outpatient clinic for health appointments. Methods The…

View details →DOI: 10.1111/jpc.70397
Negative / Null Result ReportMedicine

Mediating effects of depression, stigma, and self-efficacy on self-management improvement in an evidence-based epilepsy self-management program.

Armah L, Tan L, Branning R et al. · 2026 · Epilepsy & behavior : E&B

Aims To evaluate whether improvements in depressive symptoms, epilepsy self-efficacy, and perceived stigma mediate the association between the SMART intervention and epilepsy self-management. Methods 160 people with epilepsy were enrolled…

View details →DOI: 10.1016/j.yebeh.2026.111117
Negative / Null Result Report

Comparative chemical characterisation of chitosans and their impact on growth, faecal consistency and microbiota composition in weaned piglets

Blasio SD, Middelkoop A, Molist F et al. · 2026 · Preprint

Managing post-weaning diarrhoea (PWD) in piglets is difficult due to limits on antibiotics and zinc. Chitosan is emerging as a potential feed additive. We analysed a chito-oligosaccharide hydrochloride (COS-HCl), a low molecular weight…

View details →DOI: 10.64898/2026.03.26.714014
Negative / Null Result ReportMedicine

Relationship Between Mental Health and Protective Health Behaviors in Adolescents: A Secondary Data Analysis.

Mahat G, Zha P · 2026 · Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

Evidence highlights rising mental health concerns among youth. This study investigated the relationship between protective behaviors, including physical activity, regular breakfast, sleep, and parental monitoring, and adolescent mental…

View details →DOI: 10.1016/j.pedhc.2026.05.012
Negative / Null Result ReportMedicine

Impact of oral glucocorticoids on the effectiveness of romosozumab: the multicenter OASIS cohort study.

Yukishima T, Kobayakawa T, Hirano Y et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

This multicenter retrospective cohort compared romosozumab outcomes between oral glucocorticoid users and non-users. Bone turnover marker responses and lumbar spine bone mineral density gains were similar, whereas total hip bone mineral…

View details →DOI: 10.1007/s00198-026-08051-0
Negative / Null Result ReportMedicine

Attention Networks and Speech Disfluencies among Monolingual Dutch and Bilingual Dutch-Turkish Speaking Children: A Pilot Study.

Aslan G, Eggers K · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction This pilot study investigated whether attention skills influence speech disfluencies in school-aged children, comparing monolingual Dutch (MONO) speakers and bilingual Dutch-Turkish speakers (BIL). Disfluencies frequently…

View details →DOI: 10.1159/000551501
Negative / Null Result ReportMedicine

Influence of the correct placement of external ventricular drainage on puncture channel bleeding in patients with aneurysmal subarachnoid hemorrhage.

Marschal V, Ziebart A, Abdoullahi M et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

While ventriculostomy-associated hemorrhages are well-documented in spontaneous subarachnoid hemorrhage (SAH), the impact of external ventricular drainage (EVD) placement accuracy on puncture channel bleeding (PCB) remains underexplored.…

View details →DOI: 10.1016/j.jocn.2026.112077
Negative / Null Result Report

Relative Hemodynamic Timing in Human White Matter

Li M, Ding Z, Gore JC · 2026 · Preprint

ABSTRACT Hemodynamic lag in white matter (WM) remains poorly understood despite its relevance to neurovascular health. We developed Local Propagation Mapping to quantify the spatiotemporal architecture of relative hemodynamic timing within…

View details →DOI: 10.64898/2026.05.29.728865