A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20227 results in Negative / Null Result Report · page 230 of 675
Turan G, Spiertz V, Bein O et al. · 2023 · Preprint
The human brain is postulated to function as a prediction machine, constantly comparing incoming sensory input to predictions based on past experiences. When an event contradicts these predictions, it results in a prediction error (PE),…
Agir M, Sahin K, Pulatkan A et al. · 2026 · JSES international
Background Rotator cuff tears are a leading cause of shoulder pain, with high rerupture rates despite advancements in surgical techniques. Tendon-to-bone healing failure is often attributed to insufficient fibrocartilage regeneration at…
Meier K, van Hoeken D, Kager CCM et al. · 2025 · The International journal of eating disorders
Objective This study examined the impact of the COVID-19 pandemic on incidence rates of anorexia nervosa (AN) and bulimia nervosa (BN) in Dutch primary care by comparing pre-pandemic (2015-2019) and in-pandemic (2020-2022) periods. We…
Haucke M, Heinz A, Heinzel S et al. · 2025 · European archives of psychiatry and clinical neuroscience
Adverse alcohol consumption is a major public health concern, which might have been further increased by the COVID-19 pandemic. In this study we investigated the impact of a lockdown stage on the association between alcohol consumption,…
Hascher K, Brown R, Janulis P et al. · 2026 · Biopsychosocial science and medicine
Objective Sexual minority (SM) populations experience worse cardiovascular health than heterosexual populations. One potential pathway is the effects of disclosure (sharing) or concealment (withholding) of SM identity due to anticipated…
Kweon J, Ganesh P, Brown JC · 2025 · Transcranial magnetic stimulation (2024)
Health and behavioral factors likely influence repetitive transcranial magnetic stimulation (rTMS) effectiveness, though clear support is lacking. Since habitual caffeine use has been found to impair corticomotor plasticity, we…
Chung YH, Williams LH, Brady TF et al. · 2025 · Journal of experimental psychology. General
Across many studies, verbal labels have been shown to significantly affect perceptual and cognitive processes. Here, we ask whether verbal labels can also improve visual working memory performance by making objects more recognizable. In a…
Popovic D, Reddy YNV, Omar M et al. · 2025 · Mayo Clinic proceedings
Objective Myeloperoxidase (MPO) is a heme peroxidase that scavenges nitric oxide and contributes to microvascular dysfunction. Patients with heart failure and preserved ejection fraction (HFpEF) have microvascular dysfunction that leads to…
Cohen M, Orgel E, Nevarez-Mejia J et al. · 2025 · EJHaem
Introduction Obesity contributes to poorer clinical outcomes in patients with acute lymphoblastic leukemia. We have shown that adipocytes cause anthracycline resistance by absorbing and metabolizing them into less-active alcohol…
Więcławski W, Smus A, Binder M · 2025 · Vision research
Pupillary light response (PLR) is modulated by the allocation of spatial attention. Larger pupil constrictions for bright stimuli presented on the left side are considered indicative of pseudoneglect, a subtle attentional bias observed in…
Mielniczek M, Lunde P, Grzyb W et al. · 2025 · Journal of functional morphology and kinesiology
Objective: The aim of the study was to investigate the effect of eight weeks of in-season training with wearable resistance attached to the forearm on spike velocity in female volleyball players. Methods: A total of 13 senior female…
Müller A, Zethof JHT, Pirani C et al. · 2025 · Rhizosphere
Biofilm formation on plant roots is traditionally assumed an important trait for plant growth promoting rhizobacteria, but its importance in the interplay between soil, plant roots and the rhizosphere bacterial and archaeal community is…
Sasaki AE, Benites NM, Rodrigues B et al. · 2025 · Hearing research
Rodent auditory brainstem neurons undergo substantial electrophysiological maturation during the postnatal period, spanning both pre- and post-hearing phases. These developmental adaptations support high-frequency, temporally precise…
Duong LHK, Lam NV, Tran VT · 2025 · Life (Basel, Switzerland)
Background: Atrial high-rate episodes (AHREs) detected by pacemakers are linked to increased stroke risk. The predictive value of high-sensitivity cardiac troponin I (hs-cTnI) for AHREs in pacemaker patients remains uncertain. This study…
Kim SH, Heo JH, Cunanan K et al. · 2026 · Journal of the Endocrine Society
Context While popular weight-loss medications have raised concerns about lean mass loss, the normative effects of nonpharmacologic weight loss on body composition remain unclear. Objective We assessed how the extent of weight loss from…
Parsowith EJ, Herring E, Cohen B et al. · 2025 · Experimental gerontology
Background Over 25% of U.S. older adults experience chronic knee pain, which worsens with inactivity, creating a cycle of pain, disability, and sedentary behavior. However, a limited understanding of the underlying mechanisms hinders the…
Rubino M, Fan R', Kulesz PA et al. · 2026 · The Laryngoscope
Objectives Complete or relative voice rest is recommended following phonomicrosurgery. Primarily, adherence to rest has been measured using patient reports, but their validity is unknown. Instrumental measures of rest adherence are…
Bertram AM, Lalot F, van der Werff L et al. · 2025 · Frontiers in psychology
Introduction Many daily situations require rapid judgments about whether information is true or false based on limited information. Prior research has predominantly examined how statement and source characteristics influence these…
Alharbi BM, Williams HE, Parr T et al. · 2025 · Mathematical biosciences
We propose a mathematical model based on coupled ordinary differential equations (ODEs) for metabolite concentrations with the aim of investigating how modifications to the rates affects outputs from a regulatory network. Our aim is to…
Poller A, Jha S, Molander L et al. · 2025 · International journal of cardiology
Background It is incompletely understood why patients with takotsubo syndrome (TS) have milder symptoms and a better hemodynamic profile than patients with ST-elevation myocardial infarction (STEMI) despite similar or more extensive…
López-Moraga A, De Ceuninck M, Van der Heyden Y et al. · 2025 · Preprint
Although avoidance can serve an adaptive function in daily life, excessive or persistent avoidance can form a debilitating symptom of anxiety-related disorders. The transition from adaptive to maladaptive avoidance remains poorly…
Maier LE, Vanden Berg ER, Simpson L et al. · 2026 · Physiological reports
This study examined how sex influences blood flow during exercise at altitude and relative contributions of adrenergic mechanisms. Thirteen participants (8 M/5F) were tested at low and high altitude (days 3-11). Participants performed…
Rikken RM, Yaqub M, Coomans EM et al. · 2025 · Alzheimer's research & therapy
Background Neuroinflammation plays a key role in Alzheimer's disease (AD) pathophysiology, but it is not clear how neuroinflammation contributes to disease progression. We aim to investigate the role of neuroinflammation on longitudinal…
Chamoux M, Rakobowchuk M, Gaston AF et al. · 2025 · Journal of sport and health science
Background Interest in clothing that reflects far infrared (FIR) radiation naturally emitted by the body during and after exercise has increased based on the assumption that this can increase arterial and venous blood flow. Indeed, in…
DiSilvestro AN, Wesolowski LT, Williams BD et al. · 2025 · Journal of equine veterinary science
In humans, intestinal microbiota are recognized to play key regulatory roles in inflammation. In horses, addition of dietary starch is known to alter the intestinal microbiome, but the relationship between diet and inflammation in horses…
Nelson TB, Stutts KJ, Nair SS et al. · 2025 · Journal of equine veterinary science
Repetitive concussive forces on joints during exercise may lead to increased inflammation and gait asymmetry. While used to reduce inflammation and symptoms related to joint disease, intra-articular corticosteroids have not been…
Liu Z, Chitoran I, Turco G · 2025 · Language and speech
The present study examines the perceptual salience of tonal speech errors compared with segmental errors (consonant and vowel). Tonal errors are observed less often than segmental errors. We thus hypothesize that tone errors are more…
Munroe S, O'Mara K, Kenyon R et al. · 2025 · Marine environmental research
Wet season freshwater flows deliver catchment nutrients (terrestrial and freshwater) to tropical estuaries that stimulate productivity and support consumers. However, the impact of flows on species in the adjacent nearshore is unclear. We…
Skau S, Karlsson J, Åsberg Johnels J et al. · 2026 · Frontiers in psychology
This study investigates whether visual aids increase or decrease cognitive load during arithmetic tasks in 9-year-old children, using behavioral measures and functional near-infrared spectroscopy (fNIRS). Previous research suggests mixed…
Goodwin I, Larsen KM, Sangchooli A et al. · 2025 · Preprint
Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non-clinical psychotic-like experiences, predating illness onset.…