A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19735 results in Negative / Null Result Report · page 23 of 658
David T. Levy, Kenneth E. Warner, K. Michael Cummings et al. · 2018 · Tobacco Control
BACKGROUND: The 2018 National Academies of Sciences, Engineering, and Medicine Report found substantial evidence that electronic cigarette use (vaping) by youth is strongly associated with an increased risk of ever using cigarettes…
Noémie Travier, Miranda J. Velthuis, Charlotte N. Steins Bisschop et al. · 2015 · BMC Medicine
BACKGROUND: Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue. METHODS: This multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic and resistance exercise (n = 102). By design, all patients received chemotherapy
Ann Huff Stevens, Douglas L. Miller, Marianne Page et al. · 2015 · American Economic Journal Economic Policy
It is well known that mortality rates are pro-cyclical. In this paper, we attempt to understand why. We find little evidence that cyclical changes in individuals' own employment-related behavior drives the relationship; own-group…
Rainer Meierhenrich, Elisa Steinhilber, Christian Eggermann et al. · 2010 · Critical Care
INTRODUCTION: Since data regarding new-onset atrial fibrillation (AF) in septic shock patients are scarce, the purpose of the present study was to evaluate the incidence and prognostic impact of new-onset AF in this patient group. METHODS: We prospectively studied all patients with new-onset AF and all patients suffering from septic shock in a non-cardiac surgical intensive care unit (ICU) during a 13 month period. RESULTS: During the study period, 687 patients were admitted to the ICU, of which 58 patients were excluded from further analysis due to pre-existing chronic or intermittent AF. In
A. Mina, Henry Lahr, Alan Hughes · 2013 · Industrial and Corporate Change
Access to finance has figured prominently in the debate on barriers to firm growth, even though existing empirical research has not found conclusive evidence of a "finance gap." Moreover, it is not clear to what extent innovation…
Weimin Cai, Jun Xu, Xiao Wu et al. · 2023 · Cardiovascular Diabetology
Abstract Background The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG index in patients with severe stroke requiring ICU admission remains unclear. The aim of this study was to investigate the association between the TyG index and clinical prognosis of critically ill patients with ischemic stroke (IS). Methods This study identified patients with severe IS requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-IV)
David Larson, Chung-Hsien Sung · 2019 · Online Learning
The purpose of this research was to perform a three way comparison of delivery modes for an introductory Management Information Systems course to determine if there existed a difference in student success among the delivery modes. The research compares student exam and final grade results in this class that was taught by the same instructor using face-to-face, blended and online delivery modes. An Analysis of Variance test was used on the exam and final grade data to determine if a significant difference existed. Additionally, a discussion of this class in relation to student satisfaction, lea
Gabrielle Campbell, Wayne Hall, Amy Peacock et al. · 2018 · The Lancet Public Health
BACKGROUND: Interest in the use of cannabis and cannabinoids to treat chronic non-cancer pain is increasing, because of their potential to reduce opioid dose requirements. We aimed to investigate cannabis use in people living with chronic…
Vera Warmuth, Anders Eriksson, Mim A. Bower et al. · 2012 · Proceedings of the National Academy of Sciences
Despite decades of research across multiple disciplines, the early history of horse domestication remains poorly understood. On the basis of current evidence from archaeology, mitochondrial DNA, and Y-chromosomal sequencing, a number of…
Run Zheng, Zhuyuan Li, Sang-Gyun Na · 2022 · Journal of Retailing and Consumer Services
In the emerging retail market, e-tailers operating in developing economies have to cope with the rapid use of the Internet, new electronic purchasing methods and online selling platforms. However, e-tailers do not understand the effect…
Kelly Wrighton, J. Cameron Thrash, Ryan A. Melnyk et al. · 2011 · Applied and Environmental Microbiology
Despite their importance in iron redox cycles and bioenergy production, the underlying physiological, genetic, and biochemical mechanisms of extracellular electron transfer by Gram-positive bacteria remain insufficiently understood. In…
Silvia Place, Erika Hoff · 2015 · Bilingualism Language and Cognition
Recent findings suggest some properties of input in dual-language environments that influence its value for bilingual development, but the extant data base is small and sometimes inconclusive. The present study sought additional evidence…
David Card, Francesco Devicienti, Agata Maida · 2013 · The Review of Economic Studies
Rent-sharing by workers can reduce the incentives for investment if some of the returns to sunk capital are captured in higher wages. We propose a simple measure of this "holdup" effect based on the size of the wage offset for…
Suzanne Todd, F. Scott Dahlgren, Marc Traeger et al. · 2015 · The Journal of Pediatrics
ObjectiveTo evaluate whether cosmetically relevant dental effects occurred among children who had received doxycycline for treatment of suspected Rocky Mountain spotted fever (RMSF).Study designChildren who lived on an American Indian…
María Rosa Borges · 2010 · European Journal of Finance
This paper reports the results of tests on the weak-form market efficiency applied to stock market indexes of UK, France, Germany, Spain, Greece and Portugal, from January 1993 to December 2007. We use a runs test, and joint variance ratio…
Conceição Bettencourt, Davina J. Hensman Moss, Michael Flower et al. · 2016 · Annals of Neurology
OBJECTIVE: The polyglutamine diseases, including Huntington's disease (HD) and multiple spinocerebellar ataxias (SCAs), are among the commonest hereditary neurodegenerative diseases. They are caused by expanded CAG tracts, encoding glutamine, in different genes. Longer CAG repeat tracts are associated with earlier ages at onset, but this does not account for all of the difference, and the existence of additional genetic modifying factors has been suggested in these diseases. A recent genome-wide association study (GWAS) in HD found association between age at onset and genetic variants in DNA r
Mohamed Dawood Shamout, Rabeb Ben-Abdallah, Muhammad Turki Alshurideh et al. · 2022 · Uncertain Supply Chain Management
The arrival of the era of robots and autonomous machines is undisputable. It is anticipated that the future business environment will be characterized by a variety of intelligent systems and autonomous robots. In 2017, the International Federation of Robotics reported that momentum gained by robotic technologies is strong and that the sales volumes of both service and industrial robots is expected to grow. Building on this projection, the present study proposes a set of prerequisites or key determinants for the adoption of autonomous robots in the supply chain and logistics industry: technolog
Steven Boonen, Jan Van Meirhaeghe, L. Bastian et al. · 2011 · Journal of Bone and Mineral Research
Vertebral fractures are often painful and lead to reduced quality of life and disability. We compared the efficacy and safety of balloon kyphoplasty to nonsurgical therapy over 24 months in patients with acute painful fractures. Adults…
Judith T. Moskowitz, Adam W. Carrico, Larissa G. Duncan et al. · 2017 · Journal of Consulting and Clinical Psychology
OBJECTIVE: We conducted a randomized controlled trial to determine whether IRISS (Intervention for those Recently Informed of their Seropositive Status), a positive affect skills intervention, improved positive emotion, psychological…
Azucena Pérez‐Burgos, Bingxian Wang, Yukang Mao et al. · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Mounting evidence supports the influence of the gut microbiome on the local enteric nervous system and its effects on brain chemistry and relevant behavior. Vagal afferents are involved in some of these effects. We previously showed that…
David A. Bradbard, Cara Peters · 2010 · The Journal of Educators Online
This study sought to examine instructor immediacy and presence in an online learning environment in relation to student affective learning, cognition, and motivation. It found a statistically significant positive relationship between…
Zoe Moodie, Leah Price, Cécile Gouttefangeas et al. · 2010 · Cancer Immunology Immunotherapy
No consensus has been reached on how to determine if an immune response has been detected based on raw data from an ELISPOT assay. The goal of this paper is to enable investigators to understand and readily implement currently available…
A. Michael Lincoff, Jean‐Claude Tardif, Gregory G. Schwartz et al. · 2014 · JAMA
IMPORTANCE: No therapy directed against diabetes has been shown to unequivocally reduce the excess risk of cardiovascular complications. Aleglitazar is a dual agonist of peroxisome proliferator-activated receptors with insulin-sensitizing…
Linlin Ma, Yuehua Tang, Juan-Pedro Gómez · 2018 · The Journal of Finance
ABSTRACT We study compensation contracts of individual portfolio managers using hand‐collected data of over 4,500 U.S. mutual funds. Variations in the compensation structures are broadly consistent with an optimal contracting equilibrium.…
Rita Cappariello, Roberta Zizza · 2010 · Labour
Abstract The paper empirically tests the relationship between underground labour and schooling achievement for Italy, a country ranking badly in both respects when compared with other high‐income economies, with a marked duality between…
Qingxin Meng, Wei Yang, Mengqi Men et al. · 2019 · Frontiers in Microbiology
In composting system, the composition of microbial communities is determined by the constant change in the physicochemical parameters. This study explored the dynamics of bacterial and fungal communities during cow manure and corn straw composting using high throughput sequencing technology. The relationships between physicochemical parameters and microbial community composition and abundance were also evaluated. The sequencing results revealed the major phyla included Proteobacteria, Bacteroidetes, Firmicutes, Chloroflexi and Actinobacteria, Ascomycota and Basidiomycota. Linear discriminant a
Hélder Sebastião, Pedro Godinho · 2021 · Financial Innovation
This study examines the predictability of three major cryptocurrencies-bitcoin, ethereum, and litecoin-and the profitability of trading strategies devised upon machine learning techniques (e.g., linear models, random forests, and support vector machines). The models are validated in a period characterized by unprecedented turmoil and tested in a period of bear markets, allowing the assessment of whether the predictions are good even when the market direction changes between the validation and test periods. The classification and regression methods use attributes from trading and network activi
Martin Petr, Svante Pääbo, Janet Kelso et al. · 2019 · Proceedings of the National Academy of Sciences
Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans. A striking observation in support of this is an apparent monotonic decline in Neandertal ancestry observed in modern humans in Europe over the past 45,000 years. Here, we show that this decline is an artifact likely caused by gene flow between modern human populations, which is not taken into account by statistics previously used to estimate Neandertal ancestry. When we apply a statistic that avoids assumptions about modern human demography by taking advantage of two high-cover
Daron Acemoğlu, Pablo Azar · 2020 · Econometrica
We develop a tractable model of endogenous production networks. Each one of a number of products can be produced by combining labor and an endogenous subset of the other products as inputs. Different combinations of inputs generate…
Karen J. Parker, Joseph P. Garner, Robin A. Libove et al. · 2014 · Proceedings of the National Academy of Sciences
The neuropeptide oxytocin (OXT) and its receptor (OXTR) regulate social functioning in animals and humans. Initial clinical research suggests that dysregulated plasma OXT concentrations and/or OXTR SNPs may be biomarkers of social…