e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 228 of 661

Negative / Null Result ReportMedicine

Auditory mismatch-negativity predicts response to dorsomedial prefrontal intermittent theta-burst stimulation in major depressive disorder.

Anderson M, Bodén R, Wass CE et al. · 2026 · Journal of affective disorders

Background Impaired plasticity has been implicated in major depressive disorder (MDD), which is reflected in impaired automatic sensory detection as measured using mismatch negativity (MMN). Intermittent theta-burst stimulation (iTBS) is…

View details →DOI: 10.1016/j.jad.2026.121908
Negative / Null Result ReportOpen accessMedicine

Increased cytokine production capacity and persistent inflammation after achieving remission of Cushing's syndrome.

van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology

Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…

View details →DOI: 10.1016/j.jcte.2026.100443
Negative / Null Result ReportMedicine

The Utility of Comprehensive Sampling in Cervical Lymph Node Dissection for Head and Neck Squamous Cell Carcinoma: Is More Better?

Ould Ismail AA, Pettus JR, Tafe LJ et al. · 2026 · Head & neck

Purpose To evaluate whether comprehensive sampling of cervical lymphadenectomy tissue increases lymph node yield (LNY) and improves staging adequacy beyond standard grossing practice. Methods At a single academic center, a comprehensive…

View details →DOI: 10.1002/hed.70288
Negative / Null Result ReportMedicine

Chronic atorvastatin treatment weakens procontractile influence of NADPH oxidase derived ROS in systemic murine arteries.

Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology

The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…

View details →DOI: 10.1007/s00424-026-03181-0
Negative / Null Result Report

The Utility of MRI for spinal clearance in blunt trauma. A retrospective cohort study of 539 blunt trauma patients in a level one trauma center in Singapore

Cayden L, Chandrasagran RA, Adam C et al. · 2026 · Preprint

Abstract Introduction: The majority of spinal injuries occur secondary to blunt trauma and patients with significant blunt trauma must be assumed to have an unstable spinal injury until complete radiological and clinical assessment. MRI…

View details →DOI: 10.21203/rs.3.rs-9464497/v1
Negative / Null Result ReportMedicine

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury - a pilot study.

Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology

Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…

View details →DOI: 10.1113/ep093636
Negative / Null Result ReportMedicine

Voiding Function, Pain Level, and Patient Satisfaction after Gender-Affirming Surgery of Transgender Women: A Prospective Evaluation.

Wenk MJ, Rademacher N, Liedl B et al. · 2026 · Urologia internationalis

Introduction The aim of the study was to prospectively evaluate patient and clinician reported outcomes of voiding function, pain levels and patient satisfaction of transgender women preoperatively (t0), 6 months (t1), and 12 months (t2)…

View details →DOI: 10.1159/000551982
Negative / Null Result ReportMedicine

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt-1 in women with new onset hypertension in pregnancy.

Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…

View details →DOI: 10.1111/aogs.70221
Negative / Null Result ReportMedicine

Self-disclosure to Peers and Changes in Personal Recovery in Community-dwelling People with Mental Disorders: A One-year Longitudinal Study.

Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal

This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…

View details →DOI: 10.1007/s10597-026-01661-2
Negative / Null Result ReportMedicine

Dupilumab in the treatment of severe chronic rhinosinusitis with nasal polyps (CRSwNP) in cystic fibrosis patients.

Di Girolamo A, Cristallo M, Daddato MF et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Chronic rhinosinusitis with nasal polyps (CRSwNP) manifests as either a solitary upper airway involvement or as part of a more intricate clinical picture, such as Cystic Fibrosis (CF). The altered viscoelastic properties of mucus…

View details →DOI: 10.1016/j.jcf.2026.04.003
Negative / Null Result ReportMedicine

Tight stomatal regulation and high intrinsic capacity of carbon assimilation inferred from isotopic composition negatively correlate with drought-driven decline in sclerophyllous species.

Piper FI, Paula S, Urrutia-Jalabert R · 2026 · Annals of botany

Background and aims Long-term droughts reduce the carbon (C) and water pools of trees, causing mortality. However, the underlying physiological mechanisms explaining tree mortality remain unclear, and evidence from mature forests is…

View details →DOI: 10.1093/aob/mcag100
Negative / Null Result ReportMedicine

A Comparison of Recovery Curves in Total Knee Arthroplasty With and Without Soft-Tissue Releases.

Metz AK, Loughmiller SK, Braathen DL et al. · 2026 · The Journal of arthroplasty

Background The use of alternative alignment strategies has become commonplace in performing total knee arthroplasty (TKA). A primary reported benefit of these techniques is a reduction in the need for soft-tissue releases for appropriate…

View details →DOI: 10.1016/j.arth.2026.03.082
Negative / Null Result ReportMedicine

Resting energy expenditure in children with cancer undergoing chemotherapy using indirect calorimetry: A longitudinal study.

Froon-Torenstra D, Renting L, Ijpma I et al. · 2026 · Clinical nutrition ESPEN

Background and aims Malnutrition is common among children with cancer and is related to treatment-related toxicity, mortality and lower quality of life. So far, it remains unknown whether changes in resting energy expenditure (REE)…

View details →DOI: 10.1016/j.clnesp.2026.103331
Negative / Null Result ReportMedicine

From Referral to Service: Initial Outcomes of a Mental Health Outreach Program for Sexual Assault Survivors.

Mai K, Salim SR, Tilstra-Ferrell E et al. · 2026 · Journal of forensic nursing

Aims To examine data from an early intervention program for mental health following recent sexual assault (SA) to compare referral and service utilization rates before and after a community-based outreach model was implemented. Methods In…

View details →DOI: 10.1097/jfn.0000000000000598
Negative / Null Result ReportMedicine

Linezolid-Induced Serotonin Release from QGP-1 Cells.

Tsutsumi T, Kashiwagi H, Imai S et al. · 2026 · Drug research

Background Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting…

View details →DOI: 10.1055/a-2815-4097
Negative / Null Result ReportMedicine

Octa evaluation of macular and optic disc vascular changes after PRP.

Karabacak DD, Doğruya S, Altınışık M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This study aimed to evaluate the impact of panretinal photocoagulation (PRP) on macular and optic nerve head microvascular parameters using optical coherence tomography angiography (OCTA) in eyes with proliferative diabetic…

View details →DOI: 10.1007/s00417-026-07220-5
Negative / Null Result ReportMedicine

Interaction of ambient temperature and conditioning temperatures on moisture addition throughout pelleting, the pelleting process, and enzyme activity

Renner A, Estanich EB, Lynch EA et al. · 2026 · Journal of Applied Poultry Research.

Thermal processes during steam conditioning and pellet die extrusion aid in pelleting but may degrade exogenous feed enzymes. This study determined how ambient temperature interacts with varying steam conditioning temperatures to influence…

Negative / Null Result ReportMedicine

Mindful Self-Compassion for Infertility-Related Distress: A Single-Group Intervention Study.

Halleran M, Balsom AA, Gordon JL · 2026 · Journal of integrative and complementary medicine

Objectives Women experiencing infertility report heightened levels of anxiety, depression, and distress. However, access to affordable mental health care is limited in most areas of the world. Self-directed interventions, including…

View details →DOI: 10.1177/27683605261427699
Negative / Null Result ReportMedicine

Beyond traditional sets: A longitudinal comparison of cluster and superset strength training in male basketball players.

Janicijevic D, Cuevas-Aburto J, Zhang X et al. · 2026 · Journal of sports sciences

This randomised study compared mid-term effects of supersets (SS) and cluster sets (CL) on neuromuscular performance in amateur male basketball players. Thirty participants were allocated to SS (n = 15) or CL (n = 15) and completed a…

View details →DOI: 10.1080/02640414.2026.2637204
Negative / Null Result ReportMedicine

Effect of Three Types of Specially-Designed Myopia Control Spectacle Lenses on Astigmatism: A Two-Year Result.

Wen K, Yang B, Liu L et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose This study sought to determine whether specially-designed myopia control spectacle lenses had any effect on astigmatism in clinical practice. Methods Medical records of 74 patients (age: 6 to 12 years old) involving the use of…

View details →DOI: 10.1007/s44402-026-00077-5
Negative / Null Result ReportMedicine

Age and sex differences in longitudinal CPAP adherence patterns.

Vodapally M, Chan-Golston AM, Sandhu J et al. · 2026 · Respiratory medicine

Study objective This study investigated long-term adherence to continuous positive airway pressure (CPAP) therapy among adult patients with obstructive sleep apnea (OSA), with a focus on identifying associations between age, sex, residual…

View details →DOI: 10.1016/j.rmed.2026.108755
Negative / Null Result ReportMedicine

Inflammation may explain part of atherosclerotic cardiovascular disease risk conferred by elevated remnant lipoproteins: a cohort and Mendelian randomization study.

Wadström BN, Wulff AB, Pedersen KM et al. · 2026 · Atherosclerosis

Background and aims Elevated remnant lipoproteins are a causal risk factor for atherosclerotic cardiovascular disease. We tested the hypothesis that low-grade inflammation can explain part of the increased risk of peripheral artery disease…

View details →DOI: 10.1016/j.atherosclerosis.2026.120772
Negative / Null Result ReportOpen accessMedicine

Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort.

Talathi R, Juhasz V, Delgado M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Data on the metabolic effects of contemporaneous gender-affirming hormone therapy (GAHT) are limited. Objective To characterize the metabolic effects of GAHT ie, estradiol with anti-androgen therapy. Design Prospective…

View details →DOI: 10.1210/clinem/dgaf665
Negative / Null Result ReportMedicine

Active Aging: Learning English and Developing Fine Psychomotor Abilities.

Baranowska K, Dylewski R, Fugiel J et al. · 2026 · Experimental aging research

Background Recent studies highlight that cognitive processes involved in learning share neural pathways with those controlling fine motor skills. Building on this insight, the mini-EDUball method was developed to integrate cognitive and…

View details →DOI: 10.1080/0361073x.2026.2635284