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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 227 of 661

Negative / Null Result ReportOpen accessMedicine

Assessing the Effectiveness of the Human Immunodeficiency Virus Point-of-Care Proficiency Testing Scheme: Analysis of the Data From 2021 to 2022 in South Africa.

Blasich NP, Adelekan AM · 2026 · Health science reports

Background Point-of-care rapid diagnostic testing plays a critical role in HIV detection and timely linkage to care, particularly in decentralized healthcare settings. To support testing reliability, the National Health Laboratory Service…

View details →DOI: 10.1002/hsr2.71521
Negative / Null Result ReportMedicine

The field evaluation of the diagnostic performance of a commercial pregnancy-associated glycoprotein-based lateral flow assay for early pregnancy detection in ewes.

Uyanık G, Yüksel M, Abay M et al. · 2026 · Veterinary journal (London, England : 1997)

The present study aimed to determine the diagnostic accuracy of the commercial Alertys OnFarm Pregnancy Test (AOPT) based on pregnancy-associated glycoprotein (PAG) for early pregnancy diagnosis in ewes. A total of 100 multiparous Awassi…

View details →DOI: 10.1016/j.tvjl.2026.106584
Negative / Null Result ReportOpen accessMedicine

Non-Articular Osseous Sarcoidosis: A Rare Case of Active Sarcoidosis with Progressive Lung Lesions and Normal Inflammation Biomarkers.

Zhang J, Hu Y, Dong P et al. · 2025 · Diagnostics (Basel, Switzerland)

Sarcoidosis is a rare multisystem inflammatory disease characterized by non-necrotizing granulomas, typically affecting the lungs, lymph nodes, skin, and bones. Due to its extreme clinical heterogeneity, diagnosis remains challenging.…

View details →DOI: 10.3390/diagnostics15091135
Negative / Null Result ReportOpen accessMedicine

Multiplex qPCR for the early detection of sepsis pathogens and its impact on antimicrobial therapy in critically ill patients.

Pandey P, Bir R, Chatterjee K et al. · 2026 · Iranian journal of microbiology

Background and objectives Sepsis is a life threatening condition caused by a dysregulated host response to infection and is associated with high morbidity and mortality worldwide. Early bacterial detection and therapy with antibiotics…

View details →DOI: 10.18502/ijm.v18i3.21654
Negative / Null Result ReportOpen accessMedicine

Molecular investigation of Neospora caninum in cattle in the Khomas region of Namibia.

Samkange A, Chitanga S, Mbiri P et al. · 2025 · The Onderstepoort journal of veterinary research

Neosporosis is a leading cause of bovine abortions worldwide, with a substantial economic impact because of reproductive losses, costing the cattle industry billions of dollars annually. Despite the global significance of Neospora caninum,…

View details →DOI: 10.4102/ojvr.v92i1.2237
Negative / Null Result ReportMedicine

Evaluation of dried blood spot testing for serological monitoring of epizootic and zoonotic pathogens in domestic pigs.

Steinhauer R, Kübler E, Gaugler S et al. · 2026 · Journal of virological methods

Dried blood spots (DBS) constitute a stable, cost-efficient sampling matrix that can be collected in a minimally invasive manner. Although widely adopted in human medicine, their use in veterinary diagnostics remains limited. This study…

View details →DOI: 10.1016/j.jviromet.2025.115336
Negative / Null Result ReportMedicine

Clinical efficacy of portable, cost-effective manual thermal pulsation for obstructive meibomian gland dysfunction and factors associated with therapeutic efficacy.

Cheng X, Huang H, Fan Z et al. · 2026 · BMJ open ophthalmology

Objective To evaluate the efficacy and safety of portable, cost-effective manual thermal pulsation as a single therapy for meibomian gland dysfunction (MGD) and to compare the microbiota and lipid composition in subjects with different…

View details →DOI: 10.1136/bmjophth-2026-002769
Negative / Null Result ReportMedicine

Chronic toxicity and uptake of 10 Per- and Polyfluoroalkyl Acids to marine species Americamysis bahia and Atherinops affinis.

Hayman NT, Pandelides Z, Colvin MA et al. · 2026 · Environmental toxicology and chemistry

A lack of marine specific data results in challenges to assessing site-specific ecological risks and developing marine water quality criteria for per- and polyfluoroalkyl substances (PFAS). Here, the toxicity and bioaccumulation of…

View details →DOI: 10.1093/etojnl/vgag168
Negative / Null Result ReportMedicine

Effective Coverage of Rehabilitation for Adults with Chronic Primary Low Back Pain in Uganda.

De Groote W, Taremwa Y, Duttine A et al. · 2026 · International journal of environmental research and public health

In Uganda, in 2019, 6.8 million people experienced health conditions that are amenable to rehabilitation. This is largely due to musculoskeletal disorders such as low back pain (LBP). Measuring effective coverage of rehabilitation means…

View details →DOI: 10.3390/ijerph23060693
Negative / Null Result ReportMedicine

National medical occupational radiation dose monitoring in Saudi Arabia.

Aljuaid M, Alsiraj K · 2026 · Annals of the ICRP

This is a national study about the occupational Radiation doses for medical workers in the Kingdom of Saudi Arabia which covers the period since the establishment of the Nuclear and Radiological Regulatory Commission (NRRC). The study aims…

View details →DOI: 10.1177/01466453251411988
Negative / Null Result ReportOpen accessMedicine

Awareness of Effective Communication Skills Among Paediatric Dentists in Turkey.

Büyüksefil M, Çimen Ü, Şimşek Derelioğlu S et al. · 2026 · Oral health & preventive dentistry

Purpose Effective communication with paediatric patients is one of the cornerstones of paediatric dentistry. Strong communication skills play a critical role in reducing dental anxiety, enhancing patient satisfaction, and facilitating the…

View details →DOI: 10.3290/j.ohpd.c_2680
Negative / Null Result ReportMedicine

Comparison of effective phacoemulsification times used in cataract surgery between the Veritas Vision System and the Centurion Vision System.

Choi JY, Song WS, Won YK et al. · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the effective phacoemulsification time used in cataract surgery and postoperative outcomes between the Veritas and the Centurion Vision System. Methods A retrospective analysis was conducted on 90 eyes from 82 patients…

View details →DOI: 10.3341/kjo.2025.0196
Negative / Null Result ReportMedicine

Effective population size and N e /N ratio for two populations of Northern chamois (Rupicapra rupicapra) on the edge of the species' distribution range.

Jacobs S, Edelhoff H, Ebert C et al. · 2026 · BMC ecology and evolution

Effective population size (Ne) is a fundamental parameter in conservation genetics, providing relevant information on the adaptability and long-term viability of populations. In contrast, wildlife management strategies, particularly for…

View details →DOI: 10.1186/s12862-026-02543-7
Negative / Null Result ReportMedicine

Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N'Zérékoré, Guinea, 2022.

Cherif IS, Essis EML, Diallo MA et al. · 2026 · Case reports in infectious diseases

Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a…

View details →DOI: 10.1155/crdi/2672939
Negative / Null Result ReportOpen accessMedicine

Cost-Effectiveness of Anticoagulation Treatment for Subclinical Device-Detected Atrial Fibrillation.

Winstén AK, Langén V, Airaksinen KEJ et al. · 2026 · JAMA network open

Importance Anticoagulation for stroke prevention in subclinical, device-detected atrial fibrillation (AF) remains an area of clinical equipoise, and its cost-effectiveness is unknown. Objective To evaluate the cost-effectiveness of direct…

View details →DOI: 10.1001/jamanetworkopen.2026.17213
Negative / Null Result ReportOpen accessMedicine

Pre-TIPS Liver and Spleen Volumetry Are Not Associated With Liver-Related Outcomes After TIPS Placement for Refractory Ascites.

Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…

View details →DOI: 10.1111/liv.70691
Negative / Null Result ReportMedicine

Early Endoscopic Retrograde Cholangiopancreatography is Associated With Improved Health Care Resource Utilization in Acute Biliary Pancreatitis Without Cholangitis.

Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology

Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…

View details →DOI: 10.1097/mcg.0000000000002341
Negative / Null Result ReportMedicine

Extracellular Vesicles Reflect Thrombo-Inflammatory, Endothelial and Tissue-Remodelling Changes in Cirrhosis.

Campello E, Zanetto A, Ferdinande K et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background and aims Cirrhosis is characterized by progressive immune dysregulation, endothelial dysfunction, and haemostatic imbalance. Circulating extracellular vesicles (EVs) have emerged as potential biomarkers reflecting these…

View details →DOI: 10.1111/liv.70723
Negative / Null Result ReportOpen accessMedicine

Characterizing the spiral: potential mechanisms in AI-associated delusions.

Augustin M, Pollak TA, Morrin H · 2026 · NPP - digital psychiatry and neuroscience

AI-associated delusions represent an emerging phenomenon requiring mechanistic understanding. This review, after summarizing key contributions on AI-associated delusions, proposes the "amplification spiral" framework, wherein three…

View details →DOI: 10.1038/s44277-026-00065-0
Negative / Null Result ReportMedicine

Association of IBS-associated E. coli strains with epithelial inflammatory responses and tight junction dysregulation in Caco-2 cells.

Merzaei Z, Kazemian H, Bamzadeh Z et al. · 2026 · BMC research notes

Objective Irritable bowel syndrome (IBS) presents with symptoms of pain, abdominal discomfort, and altered bowel habits. Changes in the intestinal microbiota, including an increase in Enterobacteriaceae like E. coli, have been associated…

View details →DOI: 10.1186/s13104-026-07924-1