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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19735 results in Negative / Null Result Report · page 22 of 658

Negative / Null Result ReportOpen accessMedicine

Micro-Loans, Insecticide-Treated Bednets, and Malaria: Evidence from a Randomized Controlled Trial in Orissa, India

Alessandro Tarozzi, Aprajit Mahajan, Brian G. Blackburn et al. · 2014 · American Economic Review

We describe findings from the first large-scale cluster randomized controlled trial in a developing country that evaluates the uptake of a health-protecting technology, insecticide-treated bednets (ITNs), through micro-consumer loans, as…

View details →DOI: 10.1257/aer.104.7.1909Cited by 246
Negative / Null Result ReportOpen accessMedicine

Surgery With or Without Preoperative Paclitaxel and Carboplatin in Early-Stage Non–Small-Cell Lung Cancer: Southwest Oncology Group Trial S9900, an Intergroup, Randomized, Phase III Trial

Katherine M.W. Pisters, Eric Vallières, John J. Crowley et al. · 2010 · Journal of Clinical Oncology

PURPOSE Patients with early-stage non-small-cell lung cancer (NSCLC) have a poor prognosis even after complete resection. Earlier studies of preoperative (induction) chemotherapy in resectable NSCLC demonstrated feasibility and encouraging…

View details →DOI: 10.1200/jco.2009.26.1685Cited by 246
Negative / Null Result ReportOpen accessMedicine

Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo

Michael A. Yassa, L. Tugan Muftuler, Craig E.L. Stark · 2010 · Proceedings of the National Academy of Sciences

The perforant path (PP) undergoes synaptic changes in the course of aging and dementia. Previous studies attempting to assess the integrity of the PP in humans using diffusion tensor imaging (DTI) were limited by low resolution and the…

View details →DOI: 10.1073/pnas.1002113107Cited by 246
Negative / Null Result ReportSocial Sciences

Intersectionality of Race, Ethnicity, Gender, and Age on Criminal Punishment

Darrell Steffensmeier, Noah Painter‐Davis, Jeffery T. Ulmer · 2016 · Sociological Perspectives

Race, ethnicity, gender, and age are core foci within sociology and law/criminology. Also prominent is how these statuses intersect to affect behavioral outcomes, but statistical studies of intersectionality are rare. In the area of…

View details →DOI: 10.1177/0731121416679371Cited by 246
Negative / Null Result ReportOpen accessNeuroscience

A multimodal approach to emotion recognition ability in autism spectrum disorders

Catherine R. G. Jones, Andrew Pickles, Milena Falcaro et al. · 2010 · Journal of Child Psychology and Psychiatry

BACKGROUND: Autism spectrum disorders (ASD) are characterised by social and communication difficulties in day-to-day life, including problems in recognising emotions. However, experimental investigations of emotion recognition ability in…

View details →DOI: 10.1111/j.1469-7610.2010.02328.xCited by 246
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Migration and Wage Effects of Taxing Top Earners: Evidence from the Foreigners’ Tax Scheme in Denmark*

Henrik Kleven, Camille Landais, Emmanuel Saez et al. · 2013 · The Quarterly Journal of Economics

Abstract This article analyzes the effects of income taxation on the international migration and earnings of top earners using a Danish preferential foreigner tax scheme and population-wide Danish administrative data. This scheme,…

View details →DOI: 10.1093/qje/qjt033Cited by 245
Negative / Null Result ReportOpen accessPhysics and Astronomy

Galaxy And Mass Assembly (GAMA): improved cosmic growth measurements using multiple tracers of large-scale structure

Chris Blake, I. K. Baldry, Joss Bland‐Hawthorn et al. · 2013 · Monthly Notices of the Royal Astronomical Society

We present the first application of a ‘multiple-tracer’ redshift-space distortion (RSD) analysis to an observational galaxy sample, using data from the Galaxy and Mass Assembly (GAMA) survey. Our data set is an r < 19.8 magnitude-limited…

View details →DOI: 10.1093/mnras/stt1791Cited by 245
Negative / Null Result ReportOpen accessMedicine

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

Brian A. Walker, Christopher P. Wardell, Lorenzo Melchor et al. · 2012 · Blood

We have used whole exome sequencing to compare a group of presentation t(4;14) with t(11;14) cases of myeloma to define the mutational landscape. Each case was characterized by a median of 24.5 exonic nonsynonymous single-nucleotide…

View details →DOI: 10.1182/blood-2012-03-412981Cited by 245
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Sources of persistence in regional start-up rates--evidence from Sweden

Martin Andersson, Sierdjan Koster · 2010 · Journal of Economic Geography

This article assesses the spatial–temporal persistence of a dynamic phenomenon: start-ups. Two mechanisms that explain persistence in start-up rates are distinguished: (i) determinants of start-ups that are spatially ‘sticky’ and durable…

View details →DOI: 10.1093/jeg/lbp069Cited by 245
Negative / Null Result ReportPsychology

Physical and Psychological Morbidity in Adolescents With Atypical Anorexia Nervosa

Susan M. Sawyer, Melissa Whitelaw, Daniel Le Grange et al. · 2016 · PEDIATRICS

BACKGROUND AND OBJECTIVE: Adolescents with atypical anorexia nervosa (AN) have lost significant weight but are not underweight. This study aimed to describe the physical and psychological morbidity of adolescents diagnosed with atypical…

View details →DOI: 10.1542/peds.2015-4080Cited by 244
Negative / Null Result ReportBusiness, Management and Accounting

An Examination of Reputational Costs and Tax Avoidance: Evidence from Firms with Valuable Consumer Brands

Chelsea Rae Austin, Ryan J. Wilson · 2016 · Journal of the American Taxation Association

ABSTRACT We expect firms with the greatest exposure to reputational damage among consumers will engage in lower levels of tax avoidance to minimize unwanted scrutiny that could impair the firms' reputation. We identify a set of firms with…

View details →DOI: 10.2308/atax-51634Cited by 244
Negative / Null Result ReportOpen accessDentistry

Exploring the genetic basis of chronic periodontitis: a genome-wide association study

Kimon Divaris, K. L. Monda, K. E. North et al. · 2013 · Human Molecular Genetics

Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a major cause of tooth loss. Here, we present the results of a genome-wide association study of CP that was…

View details →DOI: 10.1093/hmg/ddt065Cited by 244
Negative / Null Result ReportMedicine

Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

Leonard B. Saltz, Stephen Clarke, Eduardo Díaz‐Rubio et al. · 2023 · Journal of Clinical Oncology

Purpose To evaluate the efficacy and safety of bevacizumab when added to first-line oxaliplatin-based chemotherapy (either capecitabine plus oxaliplatin [XELOX] or fluorouracil/folinic acid plus oxaliplatin [FOLFOX-4]) in patients with…

View details →DOI: 10.1200/jco.22.02760Cited by 243
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Temporal Stability of Time Preferences

Stephan Meier, Charles Sprenger · 2014 · The Review of Economics and Statistics

The preferences assumed to govern intertemporal trade-offs are generally considered to be stable economic primitives, though evidence on this stability is notably lacking. We present evidence from a large field study conducted over two…

View details →DOI: 10.1162/rest_a_00433Cited by 243
Negative / Null Result ReportOpen accessNeuroscience

The Role of Microglia and Astrocytes in Huntington’s Disease

Thulani H. Palpagama, Henry J. Waldvogel, Richard L. M. Faull et al. · 2019 · Frontiers in Molecular Neuroscience

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. HD patients present with movement disorders, behavioral and psychiatric symptoms and cognitive decline. This review summarizes the contribution of microglia and astrocytes to HD pathophysiology. Neuroinflammation in the HD brain is characterized by a reactive morphology in these glial cells. Microglia and astrocytes are critical in regulating neuronal activity and maintaining an optimal milieu for neuronal function. Previous studies provide evidence that activated microglia and reactive astrocytes contribute to HD pa

View details →DOI: 10.3389/fnmol.2019.00258Cited by 242
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants

Urko M. Marigorta, Arcadi Navarro · 2013 · PLoS Genetics

Genome-wide association studies (GWAS) have detected many disease associations. However, the reported variants tend to explain small fractions of risk, and there are doubts about issues such as the portability of findings over different ethnic groups or the relative roles of rare versus common variants in the genetic architecture of complex disease. Studying the degree of sharing of disease-associated variants across populations can help in solving these issues. We present a comprehensive survey of GWAS replicability across 28 diseases. Most loci and SNPs discovered in Europeans for these cond

View details →DOI: 10.1371/journal.pgen.1003566Cited by 241
Negative / Null Result ReportOpen accessMedicine

Ebola Virus Enters Host Cells by Macropinocytosis and Clathrin-Mediated Endocytosis

Paulina Aleksandrowicz, Andrea Marzi, Nadine Biedenkopf et al. · 2011 · The Journal of Infectious Diseases

Virus entry into host cells is the first step of infection and a crucial determinant of pathogenicity. Here we show that Ebola virus-like particles (EBOV-VLPs) composed of the glycoprotein GP(1,2) and the matrix protein VP40 use…

View details →DOI: 10.1093/infdis/jir326Cited by 241
Negative / Null Result ReportSocial Sciences

The Rise of the Nation-State across the World, 1816 to 2001

Andreas Wimmer, Yuval Feinstein · 2010 · American Sociological Review

Why did the nation-state proliferate across the world over the past 200 years, replacing empires, kingdoms, city-states, and the like? Using a new dataset with information on 145 of today’s states from 1816 to the year they achieved…

View details →DOI: 10.1177/0003122410382639Cited by 241
Negative / Null Result ReportEconomics, Econometrics and Finance

EFFECTS OF INDEX‐FUND INVESTING ON COMMODITY FUTURES PRICES

James D. Hamilton, Jing Cynthia Wu · 2015 · International Economic Review

We develop a simple model of futures arbitrage that implies that if purchases by commodity index funds influence futures prices, then the notional positions of the index investors should help predict excess returns in these contracts. We…

View details →DOI: 10.1111/iere.12099Cited by 241
Negative / Null Result ReportOpen accessPsychology

Common stressful life events and difficulties are associated with mental health symptoms and substance use in young adolescents

Nancy Chooi Ping Low, Erika N. Dugas, Erin K. O’Loughlin et al. · 2012 · BMC Psychiatry

BACKGROUND: Stressful life events are associated with mood disorders in adults in clinical settings. Less described in the literature is the association between common life stressors and a wide range of psychopathology in young adolescents. This study uses a large non-clinical sample of young adolescents to describe the associations among worry or stress about common life events/difficulties, mental health and substance use. METHODS: Data on lifetime stress or worry about common life events/difficulties (i.e., romantic breakups, family disruption, interpersonal difficulties, and personal stres

View details →DOI: 10.1186/1471-244x-12-116Cited by 240
Negative / Null Result ReportOpen accessImmunology and Microbiology

Incidence, prevalence and mortality of patients with psoriasis: a U.K. population-based cohort study

David A. Springate, Rosa Parisi, Evangelos Kontopantelis et al. · 2016 · British Journal of Dermatology

BACKGROUND: The burden of psoriasis across many world regions is high and there is a recognized need to better understand the epidemiology of this common skin disorder. OBJECTIVES: To examine changes in the prevalence and incidence of psoriasis, and mortality rates over a 15-year period. METHODS: Cohort study involving analysis of longitudinal electronic health records between 1999 and 2013 using the U.K. Clinical Practice Research Datalink (CPRD). RESULTS: The prevalence of psoriasis increased steadily from 2·3% (2297 cases per 100 000) in 1999 to 2·8% (2815 per 100 000) in 2013, which does n

View details →DOI: 10.1111/bjd.15021Cited by 240
Negative / Null Result ReportOpen accessSocial Sciences

Poverty and Support for Militant Politics: Evidence from Pakistan

Graeme Blair, C. Christine Fair, Neil Malhotra et al. · 2012 · American Journal of Political Science

Policy debates on strategies to end extremist violence frequently cite poverty as a root cause of support for the perpetrating groups. There is little evidence to support this contention, particularly in the Pakistani case. Pakistan's…

View details →DOI: 10.1111/j.1540-5907.2012.00604.xCited by 240
Negative / Null Result ReportOpen accessEnvironmental Science

Oral ingestion of hexavalent chromium through drinking water and cancer mortality in an industrial area of Greece - An ecological study

Athena Linos, Athanassios Petralias, Costas A. Christophi et al. · 2011 · Environmental Health

BACKGROUND: Hexavalent chromium is a known carcinogen when inhaled, but its carcinogenic potential when orally ingested remains controversial. Water contaminated with hexavalent chromium is a worldwide problem, making this a question of significant public health importance. METHODS: We conducted an ecological mortality study within the Oinofita region of Greece, where water has been contaminated with hexavalent chromium. We calculated gender, age, and period standardized mortality ratios (SMRs) for all deaths, cancer deaths, and specific cancer types of Oinofita residents over an 11-year perio

View details →DOI: 10.1186/1476-069x-10-50Cited by 240
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Assessing the Value Relevance of Accounting Data After the Introduction of IFRS in Europe

Alain Devalle, Enrico Onali, Riccardo Magarini · 2010 · Journal of International Financial Management and Accounting

Abstract Since 2005, European‐listed companies have been required to prepare their consolidated financial statements in accordance with the International Financial Reporting Standards (IFRS). We examine whether value relevance increased…

View details →DOI: 10.1111/j.1467-646x.2010.01037.xCited by 240
Negative / Null Result ReportOpen accessMedicine

High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery

Frederic T. Billings, Patricia A. Hendricks, Jonathan S. Schildcrout et al. · 2016 · JAMA

IMPORTANCE: Statins affect several mechanisms underlying acute kidney injury (AKI). OBJECTIVE: To test the hypothesis that short-term high-dose perioperative atorvastatin would reduce AKI following cardiac surgery. DESIGN, SETTING, AND…

View details →DOI: 10.1001/jama.2016.0548Cited by 239
Negative / Null Result ReportOpen accessComputer Science

Time-based Fairness Improves Performance in Multi-rate WLANs

Godfrey Tan, John V. Guttag · 2026 · arXiv (Cornell University)

The performance seen by individual clients on a wireless local area network (WLAN) is heavily influenced by the manner in which wireless channel capacity is allocated. The popular MAC protocol DCF (Distributed Coordination Function) used…

View details →DOI: 10.48550/arxiv.2603.08623Cited by 239
Negative / Null Result ReportOpen accessMedicine

Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study

Gillian C. Barnett, Charlotte E. Coles, Rebecca Elliott et al. · 2011 · The Lancet Oncology

BACKGROUND: Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few associations have been tested in independent validation studies. This prospective study aimed to validate reported associations between genotype and radiation toxicity in a large independent dataset. METHODS: 92 (of 98 attempted) SNPs in 46 genes were successfully genotyped in 1613 patients: 976 received adjuvant breast radiotherapy in the Cambridge breast IMRT trial (ISRCTN21474421, n=942) or in a prospective study of breast toxicity at the Chris

View details →DOI: 10.1016/s1470-2045(11)70302-3Cited by 239
Negative / Null Result ReportOpen accessNeuroscience

Correspondence between hair cortisol concentrations and 30-day integrated daily salivary and weekly urinary cortisol measures

Sarah J. Short, Tobias Stalder, Kristine Marceau et al. · 2016 · Psychoneuroendocrinology

Characterization of cortisol production, regulation and function is of considerable interest and relevance given its ubiquitous role in virtually all aspects of physiology, health and disease risk. The quantification of cortisol concentration in hair has been proposed as a promising approach for the retrospective assessment of integrated, long-term cortisol production. However, human research is still needed to directly test and validate current assumptions about which aspects of cortisol production and regulation are reflected in hair cortisol concentrations (HCC). Here, we report findings fr

View details →DOI: 10.1016/j.psyneuen.2016.05.007Cited by 238
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Allopolyploidy, diversification, and the Miocene grassland expansion

Matt C. Estep, Michael R. McKain, Dilys M. Vela Díaz et al. · 2014 · Proceedings of the National Academy of Sciences

The role of polyploidy, particularly allopolyploidy, in plant diversification is a subject of debate. Whole-genome duplications precede the origins of many major clades (e.g., angiosperms, Brassicaceae, Poaceae), suggesting that polyploidy…

View details →DOI: 10.1073/pnas.1404177111Cited by 238
Negative / Null Result ReportOpen accessMedicine

Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial

Noémie Travier, Miranda J. Velthuis, Charlotte N. Steins Bisschop et al. · 2015 · BMC Medicine

BACKGROUND: Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue. METHODS: This multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic and resistance exercise (n = 102). By design, all patients received chemotherapy

View details →DOI: 10.1186/s12916-015-0362-zCited by 237