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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 219 of 661

Negative / Null Result ReportMedicine

Using Pharmacy technicians to obtain medication histories for emergency department care among older adults.

Qureshi N, Pevnick JM, Torbati SS et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose Obtaining accurate medication histories for older adults in the emergency department (ED) is essential but challenging due to operational barriers and incomplete electronic health records (EHRs). We implemented a…

View details →DOI: 10.1093/ajhp/zxag157
Negative / Null Result ReportMedicine

Cannabis Use Disorder and Suicidal Ideation in the United States: Persistent Risk and Stable Trends, 2014-2023.

Oyetunji TP, Chan-Golston AM, Ha S et al. · 2026 · Journal of studies on alcohol and drugs

Objective Amid rising cannabis use, declining perceived harm, and policy liberalization over the past 15 years, we examined whether the association between cannabis use disorder (CUD) and past-year suicidal ideation among U.S. adults…

View details →DOI: 10.15288/jsad.25-00481
Negative / Null Result ReportMedicine

Bidirectional links between sleep and relationship quality: findings from an 8-year longitudinal study of older couples.

Skoblow HF, Tracy EL, Gilligan M · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The Model of Dynamic Association Between Relationship Functioning and Sleep positions sleep as a fundamentally dyadic and reciprocal process, underscoring the need to study sleep within its relational context and highlighting…

View details →DOI: 10.1093/geronb/gbag067
Negative / Null Result ReportMedicine

Using the biopsychosocial model of challenge and threat to understand stress-induced alcohol consumption.

Petzel ZW, Sowerby L, Crozier C et al. · 2026 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective University students engage in heavy episodic drinking more frequently than nonuniversity peers. While social activities unique to the university experience likely contribute to heavy episodic drinking, drastic lifestyle changes…

View details →DOI: 10.1037/adb0001157
Negative / Null Result ReportMedicine

Emotion regulation in young children of mothers with borderline personality disorder: A transgenerational perspective.

Bunz M, Derhardt R, Seehagen S et al. · 2026 · Development and psychopathology

Emotion regulation (ER) difficulties in early childhood are considered potential predictors of later psychopathology, particularly in children of mothers with Borderline Personality Disorder (BPD). This multicenter study examined ER in…

View details →DOI: 10.1017/s0954579426101345
Negative / Null Result ReportMedicine

A behavioral analysis of reaction time in adolescents.

Buzzelli S, Caprioli L · 2026 · The Journal of sports medicine and physical fitness

Background Fast reaction is critical in sports, and understanding the factors that influence it can be a valuable contribution for coaches and sports scientists. Methods This cross-sectional study presents a descriptive analysis of…

View details →DOI: 10.23736/s0022-4707.26.17414-3
Negative / Null Result ReportMedicine

Comprehensive multimodal prediction of Alzheimer's disease.

Khan F, Pandit D, Lalan S et al. · 2026 · Biomedical physics & engineering express

Alzheimer's disease (AD) classification using machine learning has increasingly relied on multimodal inputs such as Magnetic Resonance Imaging (MRI), cognitive assessments, and biological markers. This study evaluates whether integrating…

View details →DOI: 10.1088/2057-1976/ae4630
Negative / Null Result ReportMedicine

Rehospitalization and the Association of Postoperative Delirium With Cognitive Decline in Older Adults.

Hshieh TT, Kunicki ZJ, Fong TG et al. · 2026 · JAMA internal medicine

Importance Postoperative delirium is associated with long-term cognitive decline in older adults. This might be caused by the delirium itself or because delirium is more common in persons who are ill and frail, and these conditions are…

View details →DOI: 10.1001/jamainternmed.2026.1910
Negative / Null Result ReportMedicine

Metacognitive Beliefs and Symptom Dimensions in OCD: A Network Analysis Identifying Central Nodes and a Severity Predictor.

Anwar S, Younas R, Iqbal M et al. · 2026 · Clinical psychology & psychotherapy

Obsessive-compulsive disorder (OCD) is a heterogeneous condition characterized by a wide range of symptoms and maladaptive beliefs. However, previous research has often studied these symptoms and metacognitive beliefs in isolation,…

View details →DOI: 10.1002/cpp.70287
Negative / Null Result Report

Clinical Trial on the Efficacy and Safety of Sakurajima Radish for Vascular Endothelial Function: A Phase IIb Open-Label, Randomized, Three-Sequence Three-Period Crossover Study with Regular Diet and Aokubi Radish Controls

Tokushige A, Akasaki Y, Shibata K et al. · 2026 · Preprint

Background: /Objectives: We aimed to evaluate the efficacy and safety of trigonelline-rich Sakurajima radish on vascular endothelial function in patients with metabolic syndrome (MetS). Methods: In this multicenter, open-label, randomized,…

View details →DOI: 10.20944/preprints202604.1953.v1
Negative / Null Result ReportMedicine

Horizontal and vertical distributions of microplastics and their water-sediment partitioning in a macrotidal estuarine embayment: Implications for coastal sequestration potential.

Kim SK, Shin JH, Ji YJ et al. · 2026 · Journal of hazardous materials

Estuarine-coastal regimes are critical links between land and the open ocean, yet their role as microplastics (MPs) sinks and the mechanisms governing MP retention remain poorly constrained. We conducted a coupled water-sediment survey in…

View details →DOI: 10.1016/j.jhazmat.2026.142508
Negative / Null Result Report

Urban-Rural Disparities in the Prevalence, Awareness, Treatment, and Control of Hypertension among Adult Diabetic Patients in Northern State, Sudan: A cross sectional Analytical Community-based Study, 2026

Omer AA, Abdelaziz MO, Bashir RE et al. · 2026 · Preprint

Abstract Background Diabetes and hypertension constitute a dual public health burden, particularly in low-income countries. While urban-rural disparities in healthcare access are well documented, this study aims to compare the prevalence,…

View details →DOI: 10.21203/rs.3.rs-9173542/v1
Negative / Null Result ReportMedicine

Showing Behaviour in One Hundred and One Dogs: Gazing, Breed and Cephalic Index.

Commauda S, Maglieri V, Prato-Previde E et al. · 2026 · Animals : an open access journal from MDPI

Dogs exhibit sophisticated interspecific communication skills, including the use of visual signals to indicate the location of inaccessible resources, known as showing behaviour. Previous studies have investigated factors such as age and…

View details →DOI: 10.3390/ani16050760
Negative / Null Result Report

Investigating cross-memory interactions of timing structures

Thong S, Hendrikse J, Chong TT- et al. · 2026 · Preprint

Motor and episodic memories are classically conceptualised as distinct memory domains. However, both memory sequences are characterised by order and timing of their elements. Generalisation has been previously documented between these…

View details →DOI: 10.64898/2026.01.10.698757
Negative / Null Result ReportMedicine

Unraveling PrEP persistence: mental health and substance use among adolescent girls and young women in an implementation program.

Giovenco D, Rousseau E, Wallace M et al. · 2026 · AIDS (London, England)

Objective To examine associations between mental health, substance use, and pre-exposure prophylaxis (PrEP) persistence among South African adolescent girls and young women (AGYW). Design A longitudinal analysis of a decentralized PrEP…

View details →DOI: 10.1097/qad.0000000000004509
Negative / Null Result ReportMedicine

Brief Report: Psychological Flexibility, Perceived Stress and Emotion Regulation in Transitional-Age Youth (TAY) With Autism Spectrum Disorder (ASD).

Visser K, Keulen J, Bodden D et al. · 2026 · Journal of autism and developmental disorders

Purpose In clinical practice and research, there is growing interest in transdiagnostic interventions, such as Acceptance and Commitment Therapy (ACT), for patients with autism spectrum disorder (ASD), due to the pervasive nature of the…

View details →DOI: 10.1007/s10803-026-07234-2
Negative / Null Result ReportOpen accessMathematics

Forecasting Multivariate Time Series under Predictive Heterogeneity: A Validation-Driven Clustering Framework

Ziling Ma, Ángel López Oriona, Hernando Ombao et al. · 2026 · arXiv

We study adaptive pooling under predictive heterogeneity in high-dimensional multivariate time series forecasting, where global models improve statistical efficiency but may fail to capture heterogeneous predictive structure, while naive specialization can induce negative transfer. We formulate adaptive pooling as a statistical decision problem and propose a validation-driven framework that determines when and how specialization should be applied. Rather than grouping series based on representation similarity, we define partitions through out-of-sample predictive performance, thereby aligning

Negative / Null Result ReportOpen accessMathematics

Inference in matrix-valued time series with common stochastic trends and multifactor error structure

Rong Chen, Simone Giannerini, Greta Goracci et al. · 2025 · arXiv

We develop an estimation methodology for a factor model for high-dimensional matrix-valued time series, where common stochastic trends and common stationary factors can be present. We study, in particular, the estimation of (row and column) loading spaces, of the common stochastic trends and of the common stationary factors, and the row and column ranks thereof. In a set of (negative) preliminary results, we show that a projection-based technique fails to improve the rates of convergence compared to a "flattened" estimation technique which does not take into account the matrix nature of the da