A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19823 results in Negative / Null Result Report · page 214 of 661
Chen PA, Hsueh YC, Lin YC et al. · 2026 · The Journal of arthroplasty
Background Whether the addition of magnesium sulfate (MgSO 4 ) to intra-articular analgesic cocktails improves early pain after total knee arthroplasty (TKA) remains uncertain. Methods This prospective, double-blind, within-patient…
Leak M, Giambini H, Cheever K et al. · 2026 · Journal of sport rehabilitation
Context Thoracic mobility is integral to respiratory function and mobility of the neck, shoulder, and spine. The efficacy of thoracic mobility exercises in enhancing respiratory function and spinal range of motion (ROM) is well documented…
Mayer J, Al-Sheikhli J, Wang X et al. · 2026 · JACC. Clinical electrophysiology
Background Functional extra-stimulus (ES) substrate mapping has been shown to reduce the recurrence of ventricular tachycardia (VT) compared with intrinsic rhythm mapping. However, there is no standardized approach to functional ES…
Mattila N, Meinberg M, Juppo A et al. · 2026 · Scandinavian journal of gastroenterology
Objective To assess whether a gargled articaine solution makes gastroscopy more tolerable for the patient. Background Gastroscopy is an unpleasant experience for most people. A drug that is easy to use, has a fast onset, enables quick…
Hoberstorfer T, Nopp S, Steiner D et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Growth differentiation factor-15 (GDF-15) has been proposed as a bleeding biomarker. To evaluate the predictive value of GDF-15 for clinically relevant bleeding (CRB, major bleeding and clinically relevant non-major bleeding [CRNMB])…
Asmundo L, Pansini V, Monti CB et al. · 2026 · Abdominal radiology (New York)
To evaluate the diagnostic performance of hepatic extracellular volume (ECV) fraction derived from delayed single-energy CT for identifying graft rejection in liver transplant recipients and its added value over clinical parameters. This…
Li M, Xie T, Liu H et al. · 2026 · Preprint
Abstract Theileria orientalis is a group of tick‑borne protozoan parasites responsible for significant economic losses in cattle worldwide. We previously reported an outbreak of oriental theileriosis due to mixed infection of T. orientalis…
Dinç G, Öztürk B, Ciğerim SÇ · 2026 · Preprint
Abstract Objectives Sagittal skeletal classification is central to orthodontic diagnosis. This study aimed to (1) develop and validate an interpretable machine learning (ML) model for three-class sagittal skeletal classification (Class I,…
Anderson JW, Shaikh N, Cooper GF et al. · 2026 · Preprint
Abstract Fairness is an important concern in statistical models, especially in clinical prediction models. Most fairness methods focus on model predictions, aiming for parity in model performance across relevant groups. However, this…
Olgun A, Zengin S · 2026 · Preprint
Abstract Purpose. To evaluate whether prompt structure changes large language model-recommended triage in urologic patient messages and whether safety-focused prompting reduces unsafe undertriage without increasing overtriage. Methods. In…
Schwartz MA, Lue D, Mutaher M et al. · 2026 · Preprint
Stem-like TCF7+ CD8 T cells sustain anti-tumor responses and support immune checkpoint blockade. We systematically identified regulators of this cell state using genome-wide CRISPR screens in primary T cells in vitro . Using random…
Kikkawa K, Takeuchi M, Sakaguchi D et al. · 2026 · Journal of anesthesia
Purpose Monitored anesthesia care (MAC) is increasingly used for various procedures, but sedation-related upper airway obstruction may lead to hypoxemia or conversion to general anesthesia. This study evaluated whether preoperative tongue…
Jin Z, Ueda K, Higo F et al. · 2026 · Anesthesia and analgesia
Background Prehabilitation during unavoidable surgical delay after an acute femoral neck fracture may mitigate rapid functional decline but is often limited by movement-evoked pain. The pericapsular nerve group (PENG) block is a…
Navarro LP, Combes X, Galinski M et al. · 2026 · BMC emergency medicine
Introduction We aimed to assess the relationship between arterial partial pressure of carbon dioxide (PaCO 2 ) and end-tidal carbon dioxide (EtCO 2 ) according to three prehospital hemodynamic status and to evaluate whether…
Jorritsma R, Bijkerk HJC, Martina R et al. · 2026 · Irish veterinary journal
In September 2023, the official national reference laboratory confirmed the presence of BTV serotype 3 in The Netherlands. In the following weeks, it appeared that the infection caused very severe clinical signs in sheep, but it was…
Burtnett SL, Bomberger RA, Harvatine KJ · 2026 · Journal of dairy science
Oleic acid has a lower risk for biohydrogenation-induced milk fat depression (MFD) than linoleic acid and can act as an emulsifier to aid fatty acid (FA) digestion in the small intestine. Our objective was to evaluate the effect of high…
Alachkar MN, Schlegl J, Bannehr M et al. · 2026 · Journal of cardiovascular development and disease
Background The TRI-SCORE was developed to predict mortality after tricuspid valve surgery and has demonstrated prognostic value in patients undergoing transcatheter tricuspid valve interventions (TTVI). Right ventricular-pulmonary arterial…
Ptaszek B, Kurek O, Podsiadło S · 2026 · Lymphatic research and biology
Purpose In times when health and physical activity are gaining in value, the search for effective methods to support fitness and improve quality of life is becoming a priority. One of the therapies that is gaining increasing popularity is…
Eves R, Deppe M, Kandler C et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines
Background Past studies indicate significant associations between birth anthropometrics, such as relative birthweight or head circumference, and later cognitive performance. Using twin data, we investigated whether these associations are…
Toillon I, Badoud I, Ferrari S et al. · 2026 · Bone
Type 1 diabetes is associated with increased fracture risk, yet the respective contributions of insulin deficiency and replacement to skeletal fragility remain poorly understood. Using insulin-deficient male Akita mice, we characterized…
Kabuga E, Nandi D, Burrell S et al. · 2026 · The Journal of the Acoustical Society of America
Individual animal identification is essential for wildlife conservation and management, aiding in estimating abundance and related parameters. The feasibility of identifying individual field crickets (Plebeiogryllus guttiventris) from…
Garitaonaindia Y, Witteveen S, Dionisio E et al. · 2026 · Journal of the National Cancer Institute
Background Pathological complete response (pCR) and circulating tumor DNA (ctDNA) clearance are increasingly used as intermediate endpoints in neoadjuvant and perioperative immunotherapy (IO) trials. However, whether complete pathological…
Alsharif P, Strauss A, Ng W et al. · 2026 · Family medicine
Background and objectives Point-of-care ultrasound (POCUS) is increasingly used in inpatient settings to evaluate patients. Common applications include cardiac, lung, hemodynamic assessment, and venous access. Teaching and achieving…
Ghorooneh Z, Mohammadzadeh A, Farhat AS et al. · 2026 · BMC pediatrics
BACKGROUND: Whether small for gestational age adds prognostic information after NICU admission physiology is known remains uncertain in preterm infants. This distinction is clinically important because SGA is an anthropometric birth-size…
Turner D, Mehdizadeh-Shrifi A, Faateh M et al. · 2026 · World journal for pediatric & congenital heart surgery
BackgroundWe sought to characterize the epidemiology, treatment patterns, and outcomes of neonatal Ebstein anomaly using a national database.MethodsIn this descriptive analysis, the pediatric health information system (PHIS) database was…
Brodoline I, Anselmucci F, Sadeghi A et al. · 2026 · Bioinspiration & biomimetics
Earthworm-like robots represent a promising alternative to conventional soil investigation tools currently used in geotechnics. Their limited invasiveness and ability to navigate in three-dimensions underground are highly desirable…
Erdem S, Hussain T, Erdem O et al. · 2026 · Journal of the American Heart Association
Background Sarcopenia is prevalent in patients with Fontan circulation and may contribute to functional decline and adverse outcomes. It is commonly assessed using the cross-sectional area of the psoas muscle (PMA), although volumetric…
Yechezkel I, Maymon H, Tennenhouse A et al. · 2026 · Preprint
Despite effective antivirals, Hepatitis C remains a global health burden, reflecting the difficulty of eliciting broadly neutralizing antibodies (bnAbs). For the Hepatitis C virus, bnAb responses are biased toward VH1-69–encoded Abs…
Halperin JJ, Granger D · 2026 · BMC neurology
Background CSF immunoglobulin (IgG) often informs diagnosis in CNS inflammatory disease- qualitatively (oligoclonal bands; OCBs), or quantitatively (CSF: serum IgG: albumin, e.g. IgG index). Most US laboratories estimate excess CSF IgG…
Jabbar Abd Sattar Hamoudi H, Wu M, Sanches M et al. · 2026 · Preprint
Background Suicide prediction models in psychiatry often rely on purely data-driven feature selection, which can produce unstable and clinically opaque predictor sets in modest-sized samples. We developed Evidence-Based AI LASSO (EBAL), an…