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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 214 of 675

Negative / Null Result Report

Delaying Shoulder Motion and Strengthening and Increasing Achilles Allograft Thickness for Glenoid Resurfacing Did Not Improve the Outcome for a 30-Year-Old Patient with Postarthroscopic Glenohumeral Chondrolysis

John G. Skedros, Tanner R. Henrie, Chad S. Mears · 2014 · Case Reports in Orthopedics

Although interposition soft-tissue (biologic) resurfacing of the glenoid with humeral hemiarthroplasty has been considered an option for end-stage glenohumeral arthritis, the results of this procedure are highly unsatisfactory in patients…

View details →DOI: 10.1155/2014/517801
Negative / Null Result Report

Postoperative Doxycycline Did Not Improve Early Postoperative Outcomes in Hip Arthroscopy Patients: A Retrospective Cohort Study

Zeeshan M. Akhtar, Emily R. Hunt, Brooks N. Platt et al. · 2021 · The Journal of Hip Surgery

Abstract Doxycycline has been shown to reduce fibroblast activity in the treatment of multiple pathologies, and was utilized as part of the postoperative medication protocol to help prevent adhesions from developing after hip arthroscopy.…

View details →DOI: 10.1055/s-0041-1739456
Negative / Null Result Report

Did the 2017 wage increase improve job satisfaction of academic staff? A case study of the university of Nigeria, Nsukka

Abdullahi Abubakar, Boniface Denis Umoh · 2023 · Caleb International Journal of Development Studies

Many employees are merely holding on to their current jobs for lack of alternatives. Such staff members are no longer deriving satisfaction from their current jobs. Lack of satisfaction impinges on workers productivity and attitude to work…

View details →DOI: 10.26772/cijds-2023-06-01-06
Negative / Null Result Report

P0603 Early tumour necrosis factor inhibitor initiation is associated with increased persistence in Crohn’s Disease but not Ulcerative Colitis, whereas early ustekinumab, vedolizumab and tofacitinib did not improve persistence

B Gu, J Chetwood, A Pudipeddi et al. · 2026 · Journal of Crohn’s and Colitis

Abstract Background Emerging evidence suggests early initiation of advanced therapies (AT) may improve outcomes, but optimal timing remains unclear. We aimed to assess the impact of AT timing on persistence. Methods We interrogated the…

View details →DOI: 10.1093/ecco-jcc/jjaf231.784
Negative / Null Result Report

A Novel Honey Powder-Based Supplement Containing Carbohydrate and Protein Did Not Improve Endurance Performance in Recreationally Trained Cyclists

Taíse Toniazzo, Rafael de Almeida Azevedo, Tamires Nunes Oliveira et al. · 2025 · International Journal of Sport Nutrition and Exercise Metabolism

Sports supplements composed of carbohydrate and protein are widely used by endurance athletes and recreational practitioners, mostly aimed at improving performance. This study investigated the effect of a novel carbohydrate + protein honey…

View details →DOI: 10.1123/ijsnem.2025-0021
Negative / Null Result Report

Rapamycin adjuvant therapy did not improve the outcome of severe influenza virus infection in an experimental mouse model system

Ching-Tai Huang, Avijit Dutta, Tse-Ching Chen et al. · 2016 · The Journal of Immunology

Abstract The host immune system responds to influenza virus infection for eradication of the virus but the immune response associated inflammation causes tissue injury and damage to the host as well. Severe influenza with morbidity and…

View details →DOI: 10.4049/jimmunol.196.supp.76.21
Negative / Null Result ReportMedicine

Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors.

Balcı, Saltık, Aktemur et al. · 2026 · Life (Basel, Switzerland)

The migrating myoelectric complex (MMC) is the electrical basis of fasting small intestinal motility. Although oxytocin (OT) regulates gastrointestinal functions through oxytocin receptors (OTRs), its effect on jejunal MMC activity during…

View details →DOI: 10.3390/life16061029
Negative / Null Result Report

Utility of platelet indices as a diagnostic indicator of hemodynamically significant PDA in preterm infants: a comparative cross-sectional study

Samar Mahmoud Elbahy, Ola Galal Ali, Sara Soliman Ali et al. · 2024 · Egyptian Pediatric Association Gazette

Abstract Background Among preterm babies, patent ductus arteriosus (PDA) is a prevalent condition, and hemodynamically significant patent ductus arteriosus (hsPDA) constitutes an important problem that impacts their outcome. There has…

View details →DOI: 10.1186/s43054-024-00339-2
Negative / Null Result Report

OA09 Significant association between disease duration in axial spondyloarthritis and the occurrence of uveitis and inflammatory bowel disease, with no such association found for psoriasis

Brona Dinneen, Marcus Kenyon, Finbar O'Shea · 2024 · Rheumatology

Abstract Background/Aims Axial spondyloarthritis is a chronic inflammatory condition primarily impacting the spine and sacroiliac joints. In addition to spinal inflammation and peripheral symptoms, it frequently presents with…

View details →DOI: 10.1093/rheumatology/keae163.009
Negative / Null Result Report

PATHOLOGICAL AND MOLECULAR PARAMETERS SHOW NO SIGNIFICANT ASSOCIATION WITH RESIDUAL CANCER BURDEN IN BREAST CARCINOMA

Fishella Aprista Rahmanti, Willy Sandhika, Lusiani Tjandra · 2025 · Folia Medica Indonesiana

Residual Cancer Burden (RCB) is a validated scoring system that quantifies the amount of tumour remaining after neoadjuvant chemotherapy (NAC) for breast cancer, providing prognostic information beyond binary outcomes, such as pathologic…

View details →DOI: 10.65346/2599-056x.2407
Negative / Null Result Report

THE ASSOCIATION OF LONELINESS AND CHRONIC CLINICALLY SIGNIFICANT PAIN AMONG AFRICAN AMERICAN AND WHITE OLDER ADULTS

David Camacho, Denise Burnette, Maria P Aranda et al. · 2019 · Innovation in Aging

Abstract Loneliness and pain are significant public health problems in later life, yet limited research has examined how these factors interact among racially diverse older adults. Guided by the Biopsychosocial Model of Pain, we used data…

View details →DOI: 10.1093/geroni/igz038.2281
Negative / Null Result Report

The Association Between Significant Mitral Regurgitation and Atrial Fibrillation Recurrence Post-Ablation

Arni Gershman, Rivka Farkash, Amjad Abu-Salman et al. · 2025 · Journal of Clinical Medicine

Background: Atrial fibrillation (AF) is a common tachyarrhythmia associated with increased morbidity. AF frequently occurs alongside mitral regurgitation (MR). Although the impact of MR severity on AF is well proven, its effect on AF…

View details →DOI: 10.3390/jcm14207300
Negative / Null Result Report

Association between global longitudinal strain and coronary artery calcium in the diagnosis of significant coronary artery disease

M Shvydka, M Lutay, I Golikova · 2026 · European Heart Journal - Cardiovascular Imaging

Abstract Introduction Non-invasive diagnostic methods for coronary artery disease (CAD) are gaining increasing importance due to their accessibility, diagnostic value, safety, and cost-effectiveness. Both global longitudinal strain (GLS)…

View details →DOI: 10.1093/ehjci/jeaf367.070
Negative / Null Result Report

Significant Association between Sleep Deprivation and Somato Testicular Index: an experimental study on Albino Rats

Ameera Al-Humidi, Mohammed Abdulsalam · 2025 · Yemeni Journal for Medical Sciences

Background: Sleep deprivation is total or partial absence of sleep. It is a risk factor for many diseases including disorders of reproductive system. Objective: This study aimed to investigate the correlation between sleep deprivation and…

View details →DOI: 10.20428/yjms.v19i4.2793
Negative / Null Result Report

Prognostically significant peripheral retinal degenerations: Association with axial length, refraction, and age

A. V. Myagkov, A. S. Stoyukhina, E. V. Shibalko et al. · 2025 · The EYE GLAZ

Background. Peripheral retinal degeneration (PRD) is among the key risk factors for rhegmatogenous retinal detachment (RRD), particularly in patients with myopia. Despite the accumulated data, the threshold values of axial length and…

View details →DOI: 10.33791/2222-4408-2025-4-288-296
Negative / Null Result Report

Comparative analysis of dietary patterns and depression risk: significant inverse association with HEI-2015 and mediating role of BMI

Zicheng Wang, Lei Fang, Fachao Shi et al. · 2025 · Frontiers in Nutrition

Objective Depression is a severe global mental disorder closely associated with dietary habits. This study aimed to evaluate associations between four dietary patterns [assessed by Dietary Inflammatory Index (DII), Healthy Eating…

View details →DOI: 10.3389/fnut.2025.1680741
Negative / Null Result Report

Evaluation of the departmental inter-rater reliability when scoring thyroid nodules according to the British Thyroid Association Ultrasound-classification model: Is there significant disagreement?

Nabil Rtam · 2023 · Ultrasound

Introduction: The British Thyroid Association Ultrasound-classification is a risk stratification model which grades thyroid nodules in U2–5 based on their sonographic appearance. Existence of variability between the ultrasound operators…

View details →DOI: 10.1177/1742271x231215500
Negative / Null Result Report

Investigation of Chromosomal Abnormalities and AZF Microdeletions in Iranian Infertile Men and Their Significant Association

Narges Taheri, Mahzad Nasir Shalal, Mahdi Mazloom et al. · 2025 · Andrologia

Objective Chromosomal abnormalities participate in male infertility by affecting a variety of physiological functions including spermatogenesis, hormonal homoeostasis, and semen quality. The long arm of the Y chromosome has an important…

View details →DOI: 10.1155/and/6689096
Negative / Null Result Report

The Association between a Recorded Diagnosis of Obesity and Clinically Significant Weight Loss in the Primary Care Setting: A Nationwide Registry

Michal Kasher Meron, Nira Koren-Morag, Dan Oieru · 2024 · Obesity Facts

Introduction: Overweight and obesity (OW/OB) are underdiagnosed. The primary aim was to assess whether a diagnosis of OW/OB recorded by a primary care physician (PCP) is associated with clinically significant weight loss, compared to a…

View details →DOI: 10.1159/000542080
Negative / Null Result Report

A Study on the Job Training Support Experience of Job Coach for the Vocational Rehabilitation Support Project for the People with a Significant Disability

Min-Sik Kim, Young-Ran Kim · 2024 · The K Association of Education Research

This study focuses on experience of Job Coach in Occupational Rehabilitation Support Projects that is offered by the field at the Field-Centric Occupational Rehabilitation Centers. The purpose of the study is to present better support to…

View details →DOI: 10.48033/jss.9.1.3
Negative / Null Result Report

Abstract 4364710: Association Between Pre-Operative History of Significant Bleeding and Post-Operative Cardiovascular Events Following Lower Extremity Revascularization

David Bresnahan, Yuhe Xia, Elliot Luttrell-Williams et al. · 2025 · Circulation

Background and Hypothesis: Patients with symptomatic peripheral artery disease (PAD) frequently undergo lower extremity revascularization (LER) but remain at increased risk of major adverse cardiovascular and limb events following the…

View details →DOI: 10.1161/circ.152.suppl_3.4364710
Negative / Null Result Report

Is There a Significant Association Between Body Image and Psychological Health in Moroccan Postmenopausal Women? A Cross-Sectional Study

Sara Esseffar, Said Bellahcen, Ghizlane Azizi et al. · 2025 · The Open Public Health Journal

Background Menopause and its consequences, sometimes complex, can generate discomfort in well-being and consequently affect the quality of women’s lives. Objective The present study was carried out to examine the quality of life of…

View details →DOI: 10.2174/0118749445384009250422052548
Negative / Null Result Report

AI in Portfolio Management: Can Algorithms Outperform Human Fund Managers?

Shantanu Chakravarti · 2026 · International Journal on Science and Technology

This study explores whether AI-driven portfolio management systems can outperform traditional human fund managers in terms of returns and risk-adjusted performance. Drawing on secondary research from global studies between 2020 and 2024,…

View details →DOI: 10.71097/ijsat.v17.i1.9900
Negative / Null Result Report

Significant Association Between Snapping Scapula Syndrome and Anterior Angulation of the Superomedial Scapular Angle

Peter J. Millett, Sean Smith, Charles Ho et al. · 2014 · Orthopaedic Journal of Sports Medicine

Objectives: Significant Association Between Snapping Scapula Syndrome and Anterior Angulation of the Superomedial Scapular Angle. Methods: In this Institutional Review Board approved study, bony morphologies of the scapula were evaluated…

View details →DOI: 10.1177/2325967114s00063
Negative / Null Result Report

Abstract 10858: Significant Association Between Washout Ratio of Renal 123i-metaiodobenzylguanidine and Muscle Sympathetic Nerve Activity in Patients With Hypertension

Yoshitaka Okabe, Hisayosi Murai, souichiro usui et al. · 2015 · Circulation

Background: Simplicity HTN-3 trial showed the negative result for renal denervation (RDN) in patient with resistant hypertension. One of limitations was that no appreciate evaluation of renal sympathetic nerve activity (RSNA) was applied…

View details →DOI: 10.1161/circ.132.suppl_3.10858
Negative / Null Result Report

P–212 Mitochondrial DNA content shows a significant association with timing of human embryo development and fertility diagnosis in euploid embryos

C Hur, V Nanavaty, A Chehab et al. · 2021 · Human Reproduction

Abstract Study question Does mitochondrial DNA content (mtDNA) correlate with clinical parameters and embryo morphokinetics using advanced time-lapse technology? Summary answer mtDNA correlated with embryo morphokinetics and the growth…

View details →DOI: 10.1093/humrep/deab130.211