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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21257 results · page 214 of 709

Negative / Null Result ReportOpen accessMedicine

Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis.

Ali R, Yazdi A, Collins K et al. · 2026 · International journal of critical illness and injury science

Background Thiamine is a vitamin that plays a role in lactate clearance. Patients with sepsis may present with elevated lactate, and also in cirrhosis, as lactate is hepatically metabolized. Prior studies showed mixed results regarding the…

View details →DOI: 10.4103/ijciis.ijciis_124_25
Negative / Null Result ReportMedicine

Euschistus heros RNase silencing: dsRNA stability and effects on RNAi susceptibility.

Quiroga-Murcia DE, Dos Santos ÉA, Schutter K et al. · 2025 · Journal of insect physiology

Nuclease (RNase) activity is a major limiting factor that reduces the effectiveness of RNAi-induced gene silencing across many insect species. In Euschistus heros, dsRNA degradation occurs predominantly upon contact with saliva, while…

View details →DOI: 10.1016/j.jinsphys.2025.104908
Negative / Null Result ReportMedicine

Transforming extracted cashew nut shell into biochar and its application as soil amender for jute mallow (Corchorus olitorius L.) cultivation.

Alaka MO, Ogunjobi JK, Omoruyi OE et al. · 2026 · Scientific reports

This study addresses the environmental challenges posed by the waste generated during the extraction of cashew nut shell (CNS) liquid by proposing a sustainable repurposing method. Extracted CNS (waste) was pyrolyzed at varying…

View details →DOI: 10.1038/s41598-026-35559-6
Negative / Null Result ReportMedicine

The influence of verbalization versus imagery on trauma memory.

Rupietta AE, Meyer T, Margraf J et al. · 2026 · Journal of behavior therapy and experimental psychiatry

Background Cognitive theories on trauma memory postulate that trauma-related intrusions are associated with more data-driven and less contextual processing. However, contextualisation can be enhanced via verbalization, suggesting that…

View details →DOI: 10.1016/j.jbtep.2026.102088
Negative / Null Result ReportMedicine

Response of juvenile Chinook salmon (Oncorhynchis tshawytscha) to the aquatic herbicide florpyrauxifen-benzyl.

Grue C, Getsinger KD, Heilman MA et al. · 2026 · Environmental toxicology and chemistry

Florpyrauxifen-benzyl (aquatic tradename ProcellaCOR) is an aquatic herbicide commonly used to control Eurasian watermilfoil (Myriophyllum spicatum) and other invasive aquatic plants. Previous studies have demonstrated effective Eurasian…

View details →DOI: 10.1093/etojnl/vgaf273
Negative / Null Result ReportMedicine

Safety, Immunogenicity of Co-Administered Vaccines, and Lot-to-Lot Consistency of a 14-Valent Pneumococcal Conjugate Vaccine (PNEUBEVAX 14<sup>®</sup>) Administered at 6-10-14 Weeks in Healthy Infants: A Multicenter, Phase IV Trial.

Thuluva S, Gunneri S, Ningaiah S et al. · 2026 · Vaccines

Background: Pneumococcal conjugate vaccines (PCVs) have substantially reduced pneumococcal disease in children; however, serotype distribution varies geographically, and residual disease due to non-PCV13 serotypes persists. Biological E's…

View details →DOI: 10.3390/vaccines14060464
Negative / Null Result ReportMedicine

DNA recovery from 3D printed firearms.

Oltrogger FT, Howe G, McNevin D et al. · 2026 · Science & justice : journal of the Forensic Science Society

Over the last few years, additive manufacturing, by means of fused deposition modelling 3D printing, has become increasingly popular and accessible due to the relative low costs, flexibility, and continually lowering barriers for entry.…

View details →DOI: 10.1016/j.scijus.2026.101409
Negative / Null Result ReportMedicine

Beyond Gram-Negative and Gram-Positive Bacteria: Virulence as a Determinant of Clinical Outcome in Periprosthetic Joint Infections.

Achatz V, Sebastian S, Mitterer JA et al. · 2026 · The Journal of arthroplasty

Background Gram-negative (GN) periprosthetic joint infections (PJIs) are still less frequent than gram-positive (GP) PJIs. There is only little data available on a direct comparison of GP- and GN-associated PJIs. Therefore, we investigated…

View details →DOI: 10.1016/j.arth.2026.02.031
Negative / Null Result ReportMedicine

Natural versus GnRHa-HRT cycle for FET in tubal infertility with prior failed natural cycles: a propensity score-matched retrospective cohort study.

Li L, Gao S, Zhu H et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Introduction Frozen embryo transfer offers improved cumulative pregnancy rates and reduces complications compared to fresh cycles. Successful outcomes depend on both embryonic potential and endometrial receptivity, necessitating…

View details →DOI: 10.1016/j.ejogrb.2026.115194
Negative / Null Result ReportMedicine

The Effect of Contrast Media Formulations with Different Iodine Preparation Concentrations at a Constant Iodine Delivery Rate in Low-kV CT Angiography: An Experimental Animal Study.

Holtkamp M, Jost G, Salhöfer L et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Purpose The effect of iodine preparation concentration on vascular attenuation during computed tomography angiography (CTA) is a topic of controversy. Iodine-based contrast media (CM) formulations are used in different iodine preparation…

View details →DOI: 10.1055/a-2818-5244
Negative / Null Result ReportMedicine

Light at the End of the Tunnel! Effects of 405 nm Visible Light Disinfection on Surgical Site Infection: A Prospective Randomized Cohort Study.

Bauerle WB, Allsbrook A, Green A et al. · 2026 · Surgical infections

Introduction Surgical site infections (SSIs) are a substantial contributor to morbidity and mortality rates. 405 nm visible light disinfection (VLD) has been shown to reduce bacterial burden in operating rooms (ORs); however, its effect on…

View details →DOI: 10.1177/10962964251410006
Negative / Null Result ReportOpen accessMedicine

Case Report: Telitacicept exposure in early pregnancy in a patient with SLE delivering an infant without any physical defect.

Huang XS, He ZY, Wang SG et al. · 2025 · Frontiers in medicine

Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by inflammatory damage to multiple organs. Its incidence rate is relatively high among women of childbearing age. The use of biologics is not…

View details →DOI: 10.3389/fmed.2025.1737355
Negative / Null Result ReportMedicine

Effects of ultralow oxygen treatments at low temperature on survival of spotted wing drosophila, Drosophila suzukii (Diptera: Drosophilidae), in blueberries and sweet cherries.

Liu YB · 2025 · Journal of economic entomology

Controlled atmosphere with ultralow oxygen (ULO) treatments were conducted to determine effects against eggs and larvae of spotted wing drosophila, Drosophila suzukii (Diptera: Drosophilidae), in blueberries and cherries at 3 °C in 19…

View details →DOI: 10.1093/jee/toaf259
Negative / Null Result ReportMedicine

Administration of EAPCI patient video animation versus standard patient information leaflets in the catheterization laboratory: Impact on patient experience assessed using the PATCATH questionnaire.

Rai H, Byrne KK, O'Callaghan D et al. · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background The Patient Experience in the Catheterization Laboratory (PATCATH) Questionnaire was developed by the European Association of Percutaneous Cardiovascular Intervention (EAPCI) to evaluate patient understanding of coronary…

View details →DOI: 10.1016/j.carrev.2026.01.004
Negative / Null Result ReportMedicine

Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial.

Zhang R, Vidoni E, Vongpatanasin W et al. · 2026 · JAMA neurology

Importance Physical inactivity, hypertension, and hyperlipidemia are modifiable cardiovascular risk factors for age-related cognitive decline and dementia. It remains unknown whether exercise training combined with intensive…

View details →DOI: 10.1001/jamaneurol.2026.0359
Negative / Null Result ReportMedicine

Identification of immune cell subsets involved in retinal ganglion cell damage following blast exposure.

Harper MM, Jones MG, Gramlich OW et al. · 2026 · Experimental eye research

Traumatic brain injury from blast exposure (bTBI) has been shown to cause functional and structural retinal ganglion cell (RGC) damage. Previous studies have shown the immune system is activated following blast exposure and that adoptive…

View details →DOI: 10.1016/j.exer.2026.110961
Negative / Null Result ReportMedicine

Cavernous ganglioneuroma of the thoracic spine: surgical nuances and outcomes following limited anterior resection.

Yılmaz MC, Tezer P, Olgaç G et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Background Spinal tumors constitute approximately 15% of all primary central nervous system neoplasms, with extradural tumors accounting for the majority. Ganglioneuromas are rare, benign tumors of neural crest origin, most often located…

View details →DOI: 10.1007/s00586-025-09711-1
Negative / Null Result Report

Silicon Application in the Plant–Insect Interaction Between Cowpea Genotypes and the Black Aphid Aphis craccivora (Hemiptera: Aphididae)

Morais JVS, Oliveira TRd, Moura ACMd et al. · 2026 · Preprint

Cowpea (Vigna unguiculata) is a crop of major socioeconomic importance in Northern and Northeastern Brazil, but its productivity is strongly constrained by infestations of the black aphid Aphis craccivora, which causes direct damage…

View details →DOI: 10.20944/preprints202601.1154.v1
Negative / Null Result Report

Absence of Sensory Cooling Activity and Cooling Agents from California’s New “Non-Menthol” Cigarettes Marketed in 2025

Jabba SV, Erythropel HC, Anastas PT et al. · 2025 · Preprint

Background Since late 2022, the sale of most flavoured tobacco products has been prohibited in California, including menthol cigarettes. Tobacco companies responded by introducing “non-menthol” cigarettes in which menthol was replaced with…

View details →DOI: 10.1101/2025.11.17.688932
Negative / Null Result ReportMedicine

Distal Radius Allograft for Posterior Glenoid Bone Loss: A Cadaveric Graft Matching Study and Biomechanical Study.

Testa EJ, Fallon RT, Badida R et al. · 2026 · The American journal of sports medicine

Background Posterior glenoid reconstruction for shoulder instability is commonly performed with distal tibia allograft (DTA), but with variable results. Recent evidence shows that distal radius allograft (DRA) has a radius of curvature…

View details →DOI: 10.1177/03635465251400313
Negative / Null Result ReportMedicine

Short-term Treatment with Metformin During Puberty Mitigates Metabolic Dysfunctions Programmed by Neonatal Overfeeding in Male Rats.

Raposo SR, Lopes RP, Barbosa LF et al. · 2026 · Archives of medical research

Objective To address the major public health problems of increased body weight and obesity, causing conditions such as hypertension and diabetes. Early obesity in childhood and adolescence has more severe long-term health consequences. The…

View details →DOI: 10.1016/j.arcmed.2026.103386
Negative / Null Result ReportOpen accessMedicine

Preliminary Assessment of Pisotriquetral Joint Kinematics Following Transverse Carpal Ligament Release: A Cadaveric Pilot Study.

Israeli R, Steinmetz C, Gannot G et al. · 2026 · Cureus

Introduction Transverse carpal ligament (TCL) release is the standard treatment for carpal tunnel syndrome; however, its potential to alter carpal biomechanics is unclear. Specifically, it has been hypothesized that TCL transection may…

View details →DOI: 10.7759/cureus.101067
Negative / Null Result ReportMedicine

4-year overall survival after the introduction of adjuvant therapy for patients with stage III melanoma: A population-based study.

Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…

View details →DOI: 10.1016/j.ejca.2025.116202