Negative / Null Result ReportOpen accessMedicine
Darpan I. Patel, Kira Abuchowski, Bilal Sheikh et al. · 2019 · European Journal of Translational Myology
The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04).
View details →DOI: 10.4081/ejtm.2019.8520 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ju Chen, Faming Zhao, Faming Zhao et al. · 2023 · Frontiers in Pharmacology
Background and Purpose: The aim of this study was to explore the effect of half a year of evolocumab plus moderate-intensity statin treatment on carotid intraplaque neovascularization (IPN) and blood lipid levels.Methods: A total of 31 patients with 33 carotid plaques who received evolocumab plus statin treatment were included. Blood lipid levels, B-mode ultrasound and contrast-enhanced ultrasonography (CEUS) at baseline and after half a year of evolocumab plus statin therapy were collected. The area under the curve (AUC) reflected the total amount of acoustic developer entering the plaque or
View details →DOI: 10.3389/fphar.2022.999224 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Rafigheh Ghiasi, Mustafa Mohammadi, Javad Ashrafi Helan et al. · 2015 · Journal of Cardiovascular and Thoracic Research
Introduction: The previous studies have suggested that alteration in oxidative stress and antioxidant defense depends on various factors, such as mode, intensity, frequency and duration of exercise. In this study, we compared the effects of two various durations of resistance exercise (1 month and 4 month) on oxidative stress and antioxidant status in cardiac tissue. Methods: Thirty Wistar male rats divided into 3 groups: control (sedentary), exercise-1 (regular exercise for 1 month) and exercise-2 group (regular exercise for 4 months). After the final to the experiment, the rats were anesthet
View details →DOI: 10.15171/jcvtr.2015.32 Negative / Null Result ReportOpen accessDentistry
Mirian de Waele Souchois Marsillac, Alberto Carlos Botazzo Delbem, Ricardo de Sousa Vieira · 2016 · Brazilian Journal of Oral Sciences
A cross-sectional microhardness (CSMH) test was carried out in human dental enamel exposed to a demineralizing solution in order to evaluate two different times of indentation in sound tissue and artificially induced caries. Twenty caries-free extracted human molars had one of their smooth surfaces sectioned and the enamel surface was isolated with nail polish except for an area of 6 mm2 . These specimens were submitted to artificially induced enamel caries on a lactate buffer containing 0.1 ppm fluoride (F) during 28 days. All specimens were bisected to create groups A and B in which CSMH tes
View details →DOI: 10.20396/bjos.v7i24.8643022 Negative / Null Result ReportOpen accessMedicine
Jingjing Zhou, Shanshan Wu, Xiaojing Wu et al. · 2023 · PLoS ONE
The cultural landscape in traditional settlements is an important historical and cultural resource created by human beings in the process of historical evolution, and is an important resource for the development of traditional settlement tourism. This paper selected 21 representative traditional settlements for research using online comments from tourists as data and content analytical methods including high-frequency vocabulary, semantic networks and emotional attitudes to explore the public perspective on the connotations of cultural landscape features in traditional settlements. There are f
Negative / Null Result ReportOpen accessDentistry
M. A. Adedigba, O. O. Ojo, E. O. Ogunbodede et al. · 2008 · Nigerian Dental Journal
Objective: To determine the coping ability of people living with HIV/AIDS (PLWHA) across demographic variations of gender, duration of living with HIV infection, marital status and living arrangements either with the family or alone. Method: The research design adopted in this study was descriptive survey. The population consisted of all PLWHA in Nigeria. The sample comprised of 117 PLWHA attending clinic regularly at General Hospital Ilesa, Osun State, Nigeria. The subjects had all been exposed to voluntary counselling and testing (VCT). Only those who consented participated in the study. A s
View details →DOI: 10.61172/ndj.v16i1.179 Negative / Null Result ReportOpen accessSurgery
Eric R. Bain, Bistees George, Syed H. Jafri et al. · 2024 · Journal of Cardiothoracic Surgery
Abstract Background Patients with severe aortic stenosis (AS) and left ventricular (LV) dysfunction demonstrate improvement in left ventricular injection fraction (LVEF) after aortic valve replacement (AVR). The timing and magnitude of recovery in patients with very low LVEF (≤ 25%) in surgical or transcatheter AVR is not well studied. Objective Determine clinical outcomes following transcatheter aortic valve replacement (TAVR) and surgical aortic valve repair (SAVR) in the subset of patients with severely reduced EF ≤ 25%. Methods Single-center, retrospective study with primary endpoint of LV
View details →DOI: 10.1186/s13019-024-02724-9 Negative / Null Result ReportOpen accessPsychology
Sime Nkemeni Darrin, Hong Hao, Cheng Long et al. · 2026 · Frontiers in Psychology
IntroductionThis study investigates the cognitive effects of long term (years of practice) Tai Chi practice, revealing mixed outcomes for executive functions. This study equally addresses the gap in research regarding the long term effects of Tai Chi, emphasizing its influence on the executive functions of young adults.MethodsUsing the BRIEFA scale and tasks like the Flanker task, More Odd Shift Task, and Nback tasks, significant differences emerged between Tai Chi students and nonstudents.ResultsIn the results, Tai Chi students demonstrated superior inhibitory control and working memory compa
View details →DOI: 10.3389/fpsyg.2025.1702253 Negative / Null Result ReportOpen accessAnesthesiology
Volkan Hancı, Şule Özbilgin, Seda Özbal et al. · Revista Brasileira de Anestesiologia
Abstract Background: Intra-arterial injection of medications may cause acute and severe ischemia and result in morbidity and mortality. There is no information in the literature evaluating the arterial endothelial effects of sugammadex and dexmedetomidine. The hypothesis of our study is that sugammadex and dexmedetomidine will cause histological changes in arterial endothelial structure when administered intra-arterially. Methods: Rabbits were randomly divided into 4 groups. Group Control (n = 7); no intervention performed. Group Catheter (n = 7); a cannula inserted in the central artery of th
View details →DOI: 10.1016/j.bjane.2015.01.003 Negative / Null Result ReportOpen accessDentistry
Priscilla Coutinho ROMUALDO, Thaís Rodrigues GUERRA, Fábio Lourenço ROMANO et al. · Journal of Applied Oral Science
Abstract Bacterial endotoxin (LPS) adhesion to orthodontic brackets is a known contributing factor to inflammation of the adjacent gingival tissues. Objective The aim of this study was to assess whether LPS adheres to orthodontic adhesive systems, comparing two commercial brands. Material and Methods Forty specimens were fabricated from Transbond XT and Light Bond composite and bonding agent components (n=10/component), then contaminated by immersion in a bacterial endotoxin solution. Contaminated and non-contaminated acrylic resin samples were used as positive and negative control groups, res
View details →DOI: 10.1590/1678-7757-2016-0434 Negative / Null Result ReportOpen accessMedicine (General)
Olivia Anna Mair, Maren Himmler, Suna Brunnemer et al. · 2022 · Medicina
Background and Objectives : Although urogenital injuries are common in severely injured patients, their diagnosis is often delayed. Predicting genitourinary injuries (GUI), especially in the immediate stages post injury, remains a challenge. This study aims to evaluate and determine positive predictive factors for the presence of GUI in polytrauma patients. Subsequently, these factors shall be used to develop an easy-to-use scoring system, deployable directly in the emergency setting. Materials and Methods : This study evaluates all severely injured patients with an Injury Severity Score (ISS)
View details →DOI: 10.3390/medicina58111583 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology
ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv
View details →DOI: 10.3389/fneur.2024.1406293 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ghasem Rahmatpour Rokni, Massoud Golpour, Alimorad Heidari Gorji et al. · 2017 · Journal of Advanced Pharmaceutical Technology & Research
Vitiligo is one of the most primitive well-known dermatoid disorders with different suggested therapies. Therefore, this study investigated the efficiency and safety of topical tacrolimus in treatment of patients with vitiligo. This study was a clinical randomized designed study pre- post-test method, has been conducted on thirty cases with vitiligo who have referred to polyclinic and dermatology clinic. Participant′s evaluated and demographic information recorded in designed checklist. In the next stage, the disease activity scored by vitiligo index disease activity system. Photography and de
View details →DOI: 10.4103/2231-4040.197388 Negative / Null Result ReportOpen accessAgriculture
Kristýna Balážová, Jitka Kumhálová, Jan Chyba · 2024 · Agronomy
With the changing climate, there is an increasing emphasis on drought-resistant varieties, including the ability to maintain quality production. As there is also interest in ancient wheat varieties, the aim of this study was to evaluate the growth parameters of the ancient Khorasan (Kamut ® ) and modern Kabot spring wheat varieties using remote sensing data. Images from unmanned aerial vehicles during four growing seasons were processed. Based on vegetation indices, the growth of these varieties and their response to meteorological conditions were evaluated, as well as the ability to resist dr
View details →DOI: 10.3390/agronomy14010147 Negative / Null Result ReportOpen accessFood processing and manufacture
Ardiyanti Rahma Setiawati, Dedes Amertaningtyas, Ahmad Khoirul Umam · 2025 · Jurnal Ilmu dan Teknologi Hasil Ternak
Salted egg is a well-known traditional product, particularly in many Asian countries, where it is valued for its unique savory taste, extended shelf life, and convenience. Consumer demand for healthier, more appealing food has sparked interest in enriching salted eggs with natural ingredients. The purpose of this study was to analyze the effect of adding kaffir lime leaf powder (Citrus hystrix) and citronella leaf powder (Cymbopogon nardus) to salted eggs on pH, antioxidants, moisture and organoleptics. The research method used was experimental using a completely randomized design (CRD) with 6
View details →DOI: 10.21776/ub.jitek.2025.020.01.5 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Kenji Morimoto, Junji Uchino, Takashi Yokoi et al. · 2021 · OncoImmunology
Although previous studies suggest that cancer cachexia is a poor prognostic factor for immune checkpoint inhibitor monotherapy, the impact of cancer cachexia on chemoimmunotherapy is unclear. We investigated the impact of cancer cachexia on the therapeutic outcomes of chemoimmunotherapy for non-small cell lung cancer (NSCLC). We retrospectively analyzed patients’ medical records with NSCLC who received chemoimmunotherapy in 12 institutions in Japan between January and November 2019. We defined cancer cachexia as weight loss exceeding 5% of the total body weight or a body mass index of < 20 kg/
View details →DOI: 10.1080/2162402x.2021.1950411 Negative / Null Result ReportOpen accessMedicine
Hassan Talakesh, Alizamen Salehifard Jouneghani, Karamali Kasiri et al. · 2024 · Journal of Shahrekord University of Medical Sciences
Background and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 patients referred to a private gastroenterology clinic in Shahrekord, Iran. The patients were randomly assigned into two groups receiving polyethylene glycol or lactulose. Defecation patterns and complications were assessed 0, 3, 7, and 21 days after the intervention. Data were analyzed using the chi
View details →DOI: 10.34172/jsums.892 Negative / Null Result ReportOpen accessMedicine (General)
Krdžić Igor, Kenić Marko, Šćepanović Milena et al. · 2020 · Vojnosanitetski Pregled
Background/Aim. In colon and rectal cancer surgery, resection is considered radical when circumferential, proximal and distal resection margins are without the presence of tumor cells. Concept of total mesorectal excision in rectal surgery involves complete removal of the tumor with mesorectal fascia which surrounds lymph nodes, lymphatics and blood vessels. The aim of this study was to determine whether laparoscopic approach provides all parameters of oncological radicality as open surgery of colorectal cancer. Methods. The study included 122 patients with carcinoma of colon and rectum, divid
View details →DOI: 10.2298/vsp180607127k Negative / Null Result ReportOpen accessMedicine
Fuengfa Khobkhun, Jenjira Thanakamchokchai · 2023 · Scientific Reports
Abstract Biological sexes (male and female) have been reported to influence postural control and balance due to differences in musculoskeletal structures, hormonal factors, and neuromuscular control. These factors can contribute to the turning performance, potentially leading to an increased incidence of falls, particularly during turning. Therefore, this study aimed to explore the whole-body coordination and stepping characteristics and during standing turns in healthy adults to determine the effects of biological sex and turn speed. Fifty participants (25 males and 25 females) completed 180°
View details →DOI: 10.1038/s41598-023-49201-2 Negative / Null Result ReportOpen accessAnimal culture
Alberto Luiz Freire de Andrade Júnior, Patrícia Costa da Silva, Emerson Moreira de Aguiar et al. · 2012 · Revista Brasileira de Parasitologia Veterinária
Coccidiosis is a serious obstacle to sheep production, which is becoming a limiting factor, especially with regard to lamb production. However, there are few studies on this parasite in the State of Rio Grande do Norte. The aim of this study was to evaluate the action of decoquinate, added to mineral salt, for controlling Eimeria infection in lambs, and to identify which species are infecting sheep in the eastern region of the state. This study was carried out from August 2009 to January 2010, and used 76 animals. These were divided into two treatment groups: one with common mineral salt, and
View details →DOI: 10.1590/s1984-29612012000100004 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Akif Albayrak, Baris Ozkul, Mehmet Bulent Balioglu et al. · 2016 · Journal of Craniovertebral Junction and Spine
Study Design: Retrospective cohort study. Purpose: Facet joints are considered a common source of chronic low-back pain. To determine whether pathogens related to the facet joint arthritis have any effect on treatment failure. Materials and Methods: Facet joint injection was applied to 94 patients treated at our hospital between 2011 and 2012 (mean age 59.5 years; 80 women and 14 men). For the purpose of analysis, the patients were divided into two groups. Patients who only had facet hypertrophy were placed in group A (47 patients, 41 women and 6 men, mean age 55.3 years) and patients who had
View details →DOI: 10.4103/0974-8237.176622 Negative / Null Result ReportOpen accessGynecology and obstetrics
Tom Marcelissen, Tanja Hüsch, Tiago Antunes-Lopes et al. · 2022 · Clinical and Experimental Obstetrics & Gynecology
Objectives: Minimally invasive sling procedures for the treatment of stress urinary incontinence has gained a topic of great interest for the last decades. However, postoperative storage symptoms after sling implantation or conventional surgical techniques are one of the most distressing complications which can significantly impair quality of life. The current review aims to focus on the development of storage symptoms after surgical treatment in comparison of different surgical techniques. Mechanism: A narrative review has been performed to identify literature reporting the incidence of stora
View details →DOI: 10.31083/j.ceog4903061 Negative / Null Result ReportOpen accessMedicine (General)
Jae-Ik Lee, Dong-Hyun Kim, Hyun-Jin Yoo et al. · 2021 · Diagnostics
This study aimed to validate the accuracy and prediction performance of machine learning (ML), deep learning (DL), and logistic regression methods in the treatment of medial meniscus posterior root tears (MMPRT). From July 2003 to May 2018, 640 patients diagnosed with MMPRT were included. First, the affecting factors for the surgery were evaluated using statistical analysis. Second, AI technology was introduced using X-ray and MRI. Finally, the accuracy and prediction performance were compared between ML&DL and logistic regression methods. Affecting factors of the logistic regression method co
View details →DOI: 10.3390/diagnostics11071225 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Chaoyu Pang, Yongzheng Li, Ming Shi et al. · 2024 · Frontiers in Endocrinology
BackgroundCXC chemokine receptor 4 (CXCR4) is associated with the progression and metastasis of numerous malignant tumors. However, its relationship with Gastroenteropancreatic Neuroendocrine Neoplasms Grade 3 (GEP-NENs G3) is unclear. The aim of this study was to characterize the expression of CXCR4 in GEP-NENS and to explore the clinical and prognostic value of CXCR4.MethodsThis study retrospectively collected clinical and pathological data from patients with GEP-NENs who receiving surgery in Qilu Hospital of Shandong University from January 2013 to April 2021, and obtained the overall survi
View details →DOI: 10.3389/fendo.2024.1281622 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Vanessa Maria Nunes Roque, Nora Manoukian Forones · 2006 · Arquivos de Gastroenterologia
RACIONAL: O câncer colorretal é a quarta causa de câncer no Brasil e o 5-fluourouracil uma das principais drogas usadas no tratamento adjuvante e paliativo dessa doença. A toxicidade da quimioterapia e as alterações de qualidade de vida, causadas pela própria doença e pelo tratamento, são motivo de muitos estudos. OBJETIVO: Avaliar nos doentes com câncer colorretal em tratamento quimioterápico, a toxicidade e possíveis alterações da qualidade de vida. MÉTODOS: Durante o período de março de 2001 a maio de 2003 no Ambulatório de Oncologia da Disciplina de Gastroenterologia Clínica da Universidad
View details →DOI: 10.1590/s0004-28032006000200007 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Jianfeng Li, Hongjie Zhu, Nanzhi Luo et al. · 2024 · Discover Oncology
Abstract The optimal surgical approach for elderly patients with early-stage non-small cell lung cancer (NSCLC) remains a topic of debate. A retrospective analysis was conducted on patients who underwent pulmonary resection for early-stage NSCLC at our single institution between January 2018 and December 2022. Propensity score matching was used to balance baseline characteristics between the sublobar resection and lobectomy groups. Perioperative outcomes, pulmonary function recovery, postoperative quality of life, and survival were compared between the two groups. A total of 151 patients were
View details →DOI: 10.1007/s12672-024-01468-1 Negative / Null Result ReportOpen accessForestry
Michael M. Müller, Leena Hamberg, Martti Varama · 2023 · Silva Fennica
Unequivocal evidence on the antagonistic effects of endophytic fungi associated with woody plants against insect herbivores has been documented in only a few cases so far. Experimental evidence of the significance of needle endophytes to coniferous trees has remained scant because it is difficult to obtain trees with needles free of endophytes that could be used as comparable controls for trees infected with endophytes. Previously we reported a new methodology to get Norway spruce (Picea abies (L.) Karst.) saplings without needle endophytes and to inoculate them with a needle endophyte Lophode
View details →DOI: 10.14214/sf.23026 Negative / Null Result ReportOpen accessMedicine
Laura Sterian Ward, Ilda Shizue Kunii, Rui Monteiro de Barros Maciel · 2000 · São Paulo Medical Journal
CONTEXT: Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. OBJECTIVE: To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyroid stimulating hormone (TSH) screening for congenital hypothyroidism. DESIGN: Prospective non-randomized clinical trial with at least 3 months of follow-up. SETTING: A public university referral center
View details →DOI: 10.1590/s1516-31802000000500006 Negative / Null Result ReportOpen accessMedicine
Magdalena Dudek, Marta Kałużna-Oleksy, Jacek Migaj et al. · 2018 · Journal of Medical Science
Background. Coronary artery disease (CAD) is one of the most important causes of death in both men and women. There are many gender differences among patients with CAD, including risk factors and acute coronary syndrome (ACS) outcomes. The latest reports showed that mortality due to CAD is higher in women than in men. Cardiac biomarkers play an important role in risk stratification and choice of treatment strategy in patients with ACS, however some of cardiac biomarkers show worse sensitivity and specificity in women. Aim. The aim was to investigate the sex-related differences in patients with
View details →DOI: 10.20883/jms.2018.268 Negative / Null Result ReportOpen accessSurgery
Christiane Simioni, Edward Araujo Júnior, Wellington P. Martins et al. · 2012 · Brazilian Journal of Cardiovascular Surgery
OBJETIVO: Comparar do débito cardíaco (DC) e a fração de ejeção (FE) do coração de fetos masculinos e femininos obtidos por meio da ultrassonografia tridimensional, utilizando o spatio-temporal image correlation (STIC). MÉTODOS: Realizou-se um estudo de corte transversal com 216 fetos normais, entre 20 a 34 semanas de gestação, sendo 108 masculinos e 108 femininos. Os volumes ventriculares no final da sístole e diástole foram obtidos por meio do STIC, sendo as avaliações volumétricas realizadas pelo virtual organ computer-aided analysis (VOCAL) com rotação de 30º. Para o cálculo do DC utilizou
View details →DOI: 10.5935/1678-9741.20120058 