Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
C. Rust, D. Tonge, L. L. van denHeuvel et al. · 2025 · Brain and Behavior
ABSTRACT Introduction Recent studies have challenged the idea of sterile blood, suggesting the presence of a blood microbiome. The detection of microbial nucleic acids in blood is thought to reflect the status of distant microbial niches, including the gut. However, the origins and viability of these microbes remain debated. In this study, blood microbiome signatures in Parkinson's disease (PD), schizophrenia (SCZ), and posttraumatic stress disorder (PTSD) were evaluated by extracting RNA‐sequencing (RNA‐seq) reads that did not map to the human genome. Furthermore, we investigated the correlat
View details →DOI: 10.1002/brb3.70629 Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Srija Balachandran, Kerstin Forsberg, Tom Lemaître et al. · 2021 · Metals
Selective leaching of Li from spent LIBs thermally pretreated by pyrolysis and incineration between 400 and 700 °C for 30, 60, and 90 min followed by water leaching at high temperature and high L/S ratio was examined. During the thermal pretreatment Li 2 CO 3 and LiF were leached. Along with Li salts, AlF 3 was also found to be leached with an efficiency not higher than 3.5%. The time of thermal pretreatment did not have a significant effect on Li leaching efficiency. The leaching efficiency of Li was higher with a higher L/S ratio. At a higher leaching temperature (80 °C), the leaching of Li
View details →DOI: 10.3390/met11081240 Negative / Null Result ReportMedicine
Fontaine E · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review Many clinical trials have failed to demonstrate the superiority of one nutritional protocol over another. This raises questions about the assessment tools used. In particular, intention-to-treat data analysis can mask…
View details →DOI: 10.1097/mco.0000000000001145 Negative / Null Result ReportOpen accessMedicine
Shi-gui Yang, Bin Cao, Li-rong Liang et al. · 2012 · PLoS ONE
BACKGROUND: There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset. METHODS: During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models. RESULTS: 920 adults and 541 children with pneumonia who didn't receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy
View details →DOI: 10.1371/journal.pone.0029652 Negative / Null Result ReportOpen accessTechnology (General)
Szostek Karol, Szostek Roman · 2023 · Technical Transactions
The work presents the concept of a device for the measurement of the one-way speed of light. The minimum parameters of this device have also been determined based on the Special Theory of Ether without transverse contraction. The Special Theory of Ether is a relativistic theory of kinemat-ics with a universal frame of reference in which light propagates and is an alternative explanation for the null result of the Michelson-Morley experiment. An experiment based on the proposed device can be one of the ways to falsify the Special Theory of Relativity and Special Theory of Ether.
View details →DOI: 10.37705/techtrans/e2023003 Negative / Null Result ReportOpen accessDentistry
Dragos Epistatu, Octavian-Marius Dinca, Cristian Vladan et al. · 2023 · Dentistry Journal
The aim of this study is to evaluate the long-term changes of sinus lift material. Materials and methods: We included a total number of 35 patients (20 men and 15 women), between 32 and 80 years old, evaluated on a timeframe of up to 11.6 years. Diverse biomaterials were used (allograft, xenograft, alloplastic, combinations of them), with autologous bone in some cases. Results: The appearance of the top plane of the bone over time took a large dome shape (36% of cases), a linear shape (32% of cases), an irregular shape (23% of cases), or had micro domes above the implants (7%). No significant
View details →DOI: 10.3390/dj11120273 Negative / Null Result ReportOpen accessInternal medicine
Dae-Yeon Kim, Hee-Soon Park, Dong-Jae Han et al. · 2013 · Kidney Research and Clinical Practice
Renal failure caused by scrub typhus is known to be reversible. In most cases, renal function is almost fully restored after appropriate antibiotic treatment. A 71-year-old man was diagnosed with scrub typhus complicated by renal failure. A renal biopsy revealed histopathologic findings consistent with acute tubulointerstitial nephritis. Renal function did not improve 18 months after discharge and the patient required continuous hemodialysis. Although severe renal failure requiring dialysis is a rare complication of scrub typhus, we describe a case of scrub typhus requiring maintenance hemodia
View details →DOI: 10.1016/j.krcp.2013.09.003 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Michele Bottosso, Gaia Griguolo, Severine Guiu et al. · 2025 · npj Breast Cancer
Abstract Brain metastases (BMs) are a common complication of advanced breast cancer (BC), and their management has significantly evolved. We evaluated the clinical impact of these changes dividing patients diagnosed with BCBMs at three Institutions according to year of BMs diagnosis: 2000-2007 (group A), 2008-2014 (group B) and 2015-2022 (group C). Stereotactic radiotherapy increased (p < 0.001), and WBRT decreased (p = 0.010) over time. Among HER2+ BC patients, more received anti-HER2 therapy after BM diagnosis in recent years (p < 0.011). Overall survival (OS) did not improve in the entire c
View details →DOI: 10.1038/s41523-025-00735-w Negative / Null Result ReportOpen accessOphthalmology
Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu, Gezahen Negusse Ayane et al. · 2019 · The Pan-American Journal of Ophthalmology
A 22-year-old female patient was diagnosed to have HIV and treated by highly active antiretroviral therapy (HAART) since 2012 had developed a reduction of vision in both eyes secondary to cataract. The cataract was extracted from both eyes with no immediate postoperative complication. During follow-up, it was recognized that she had had bilateral Stage 3 macular hole in both eyes. The visual acuity in both eyes was 6/60 which did not improve with application of pinhole. Pars plana vitrectomy was done and sealed the macular hole in the left eye. The visual acuity remained the same in both eyes
View details →DOI: 10.4103/pajo.pajo_15_19 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Alexander C. Lehn, Cullen O'Gorman, Sarah Olson et al. · 2017 · Tremor and Other Hyperkinetic Movements
Background: Orthostatic tremor (OT) was first described in 1977. It is characterized by rapid tremor of 13–18 Hz and can be recorded in the lower limbs and trunk muscles. OT remains difficult to treat, although some success has been reported with deep brain stimulation (DBS). Case Report: We report a 68-year-old male with OT who did not improve significantly after bilateral thalamic stimulation. Discussion: Although some patients were described who improved after DBS surgery, more information is needed about the effect of these treatment modalities on OT, ideally i
View details →DOI: 10.7916/d8280jhr Negative / Null Result Report
Eggeling-Böcker M, Karabetsos E, Christopoulou M et al. · 2025 · Preprint
Background: Technological advancements, such as the introduction of 5G, offer opportunities but also raise concerns. Although no evidence suggests negative effects of radiofrequency electromagnetic fields (RF-EMF) within defined exposure…
View details →DOI: 10.12688/openreseurope.19236.1 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Richard Morter, Alfred B. Tiono, Alfred B. Tiono et al. · 2022 · Frontiers in Immunology
The experimental malaria vaccine ChAd63 MVA ME-TRAP previously showed protective efficacy against Plasmodium falciparum infection in Phase IIa sporozoite challenge studies in adults in the United Kingdom and in a Phase IIb field efficacy trial in Kenyan adults. However, it failed to demonstrate efficacy in a phase IIb trial in 5-17 month-old children in an area of high malaria transmission in Burkina Faso. This secondary analysis investigated whether exposure to malaria or nutritional status might be associated with reduced responses to vaccination in this cohort. Parasite blood smears and ant
View details →DOI: 10.3389/fimmu.2022.1058227 Negative / Null Result ReportOpen accessSpecial aspects of education
Ning Zhang, Fan Ouyang · 2023 · International Journal of Educational Technology in Higher Education
Abstract Collaborative knowledge construction (CKC) involved students’ sharing of information, improvement of ideas, and construction of collective knowledge. In this process, knowledge extraction and analysis can provide valuable insights into students’ knowledge capacities, depths, and levels in order to improve the CKC quality. However, existing studies tended to extract and analyze knowledge from a single perspective (e.g., the number of certain knowledge types and knowledge structures), which failed to demonstrate the complexity and dynamics of knowledge construction and advancement. To f
View details →DOI: 10.1186/s41239-023-00414-5 Negative / Null Result ReportOpen accessMedicine
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2026 · Stroke (Hoboken, N.J.)
Background Intracranial atherosclerotic disease is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to demonstrate…
View details →DOI: 10.1161/svin.125.002111 Negative / Null Result Report
Creamer MS, Leifer AM, Pillow JW · 2024 · Preprint
A fundamental goal of neuroscience is to understand how anatomy determines the functional properties of the nervous system. However, previous work has failed to show how the functional connections between neurons are derived from the…
View details →DOI: 10.1101/2024.09.22.614271 Negative / Null Result ReportOpen accessMedicine
Said C, Hayward C, Stevens M et al. · 2026 · Bioengineering (Basel, Switzerland)
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has failed to demonstrate mortality benefit in randomised controlled trials of cardiogenic shock. We aimed to determine whether a novel 'Hemi-ECMO' configuration, involving aortic…
View details →DOI: 10.3390/bioengineering13050499 Negative / Null Result ReportMedicine
Endo S, Tanaka R, Yamaguchi T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Large type 3 (≥ 8 cm) and type 4 gastric cancers are associated with extremely poor prognoses. The phase III JCOG0501 trial, which evaluated neoadjuvant S-1 plus cisplatin, failed to demonstrate any survival benefits. Docetaxel,…
View details →DOI: 10.1007/s10120-025-01705-8 Negative / Null Result Report
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2025 · Preprint
Background Intracranial atherosclerotic disease (ICAD) is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to…
View details →DOI: 10.1101/2025.09.17.25336036 Negative / Null Result ReportMedicine
Schreiner M, Thien H, Braasch T et al. · 2025 · Abdominal radiology (New York)
Background Many patients are instructed to fast before abdominal ultrasound examinations in order to obtain better image quality. However, the few available studies on this topic have so far failed to demonstrate an advantage of several…
View details →DOI: 10.1007/s00261-025-04947-3 Negative / Null Result ReportMedicine
Thery G, Noly PE, Cavayas YA et al. · 2025 · Seminars in thoracic and cardiovascular surgery
ECLS-SHOCK is the largest randomized control trial on Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in Acute Myocardial Infarction-related Cardiogenic Shock (AMI-CS). Unfortunately, ECLS-SHOCK failed to demonstrate a…
View details →DOI: 10.1053/j.semtcvs.2025.01.004 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 Negative / Null Result ReportMedicine
Emborg C, Kothari SF, Finnerup NB et al. · 2025 · Handbook of clinical neurology
Over the past decades, a growing number of clinical trials in neurologic conditions have failed to demonstrate superiority of active treatments over placebo. A key question in this context is whether an increase in placebo response can…
View details →DOI: 10.1016/b978-0-443-29884-4.00018-2 Negative / Null Result ReportOpen accessMedicine
Hattori Y, Abe S, Kakino Y et al. · 2026 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular…
View details →DOI: 10.1016/j.neurot.2026.e00849 Negative / Null Result ReportOpen accessMedicine
Murillo-Olaizola A, Rodrigo-Gisbert M, Requena M et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized controlled trials of endovascular treatment (EVT) for distal and medium vessel occlusion (DMVO) stroke did not demonstrate clinical benefit over best medical therapy and suggested potential safety concerns. We…
View details →DOI: 10.1161/svin.125.002137 Negative / Null Result ReportMedicine
Platts CR, Groh AM, Runze J et al. · 2026 · Attachment & human development
Initial molecular genetic studies identified specific genes that contribute to variation in associations between maternal sensitivity and infant attachment, but these findings from small samples failed to replicate in larger-sample…
View details →DOI: 10.1080/14616734.2026.2690651 Negative / Null Result ReportMedicine
Kong SH · 2026 · Endocrinology and metabolism (Seoul, Korea)
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with…
View details →DOI: 10.3803/enm.2029.2938 Negative / Null Result ReportMedicine
Salwei M, Tang LA, Vogus TJ et al. · 2026 · Health care management review
Background Health care organizations have failed to replicate the performance of high-reliability organizations (HROs), systems that operate nearly error-free despite inherently complex, interdependent, and time-pressured environments.…
View details →DOI: 10.1097/hmr.0000000000000474 Negative / Null Result ReportMedicine
Zhang X, Gunderson EA · 2025 · Developmental psychology
Spatial skills in early childhood are key predictors of mathematical achievement. Previous studies have found that training mental rotation can transfer to arithmetic skills; however, some studies have failed to replicate this transfer…
View details →DOI: 10.1037/dev0002040 Negative / Null Result Report
Boyce V, Mathur MB, Frank MC · 2023 · Preprint
Cumulative scientific progress requires empirical results that are robust enough to support theory construction and extension. Yet in psychology, some prominent findings have failed to replicate, and large-scale studies suggest…
View details →DOI: 10.31234/osf.io/dpyn6 Negative / Null Result Report
Pitz V, Makarious M, Bandrés-Ciga S et al. · 2023 · Preprint
Abstract Objective Although many rare variants have been reportedly associated with Parkinson’s disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants.…
View details →DOI: 10.21203/rs.3.rs-2743857/v1 