A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21697 results · page 209 of 724
Li, Lai, Zou et al. · 2026 · Cellular & molecular immunology
Systemic lupus erythematosus (SLE) pathogenesis involves the dysregulated production of mutated, high-affinity autoantibodies, a process primarily orchestrated within germinal centers (GCs). However, the precise regulatory mechanisms…
Lu, Liu, Guo et al. · 2026 · Scientific reports
The prognosis of heart failure is highly dependent on patient self-management, and short-video platforms have become a key channel for the public to access information about heart failure (HF). This cross-sectional study systematically…
Gosavi, Sritharan, Bell et al. · 2026 · Annals of hepato-biliary-pancreatic surgery
Perioperative chemotherapy is frequently used for resectable colorectal liver metastases (CRLM), despite persistent uncertainty regarding the extent of its survival benefit. This perspective revisits the evidence supporting this practice…
Lizwan, Cynthia Chia · 2026 · Journal of cardiothoracic surgery
Early chest drain removal and discharge are standard in enhanced-recovery protocols after video-assisted thoracoscopic surgery (VATS) lobectomy, but rare wound complications may arise. We report a 71-year-old man who underwent uneventful…
Matsumiya, Ding, Ikegami et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
Pathogen-derived RNAs function as pathogen-associated molecular patterns (PAMPs) that activate innate immune responses through pattern recognition receptors (PRRs). While viral RNA is well established as a trigger of antiviral immunity,…
Zhang, Zhang, Kwan et al. · 2026 · Social science & medicine (1982)
Urban noise pollution has become a critical environmental issue affecting residents' quality of life. Existing research struggles to capture heterogeneity in noise sensitivity across different populations and cannot precisely quantify the…
Yang, Yang, Du et al. · 2026 · BMC cancer
Accurate prognostic assessment remains challenging in patients with hepatocellular carcinoma (HCC). Although the fibrosis-4 (FIB-4) index is widely used for non-invasive evaluation of liver fibrosis, its prognostic value in HCC remains…
Sun, Wang, Lai et al. · 2026 · Neural regeneration research
The regulatory network of the spleen, a densely innervated immune hub, undergoes pathological remodeling following spinal cord injury. Whether targeted electrical stimulation of the spleen at specific frequencies can reverse peripheral…
Chen, Hu, Peng et al. · 2026 · Journal of immunology research
This multicenter study aimed to analytically compare the performance of automated quantitative assays-chemiluminescence immunoassay (CLIA) and multiplexed bead immunoassay (MBI)-for detecting anti-Ro/La antibodies in Chinese patients with…
Tishchenko, De Boeck, Van Waesberghe et al. · 2026 · Journal of virology
Gap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We…
Li, Feng · 2026 · Infection and drug resistance
Tropheryma whipplei (TW) , a Gram-positive bacterium, is the etiologic agent of Whipple's disease, a chronic and systemic condition that primarily involves the gastrointestinal tract. Chlamydia psittaci (C. psittaci) is a zoonotic pathogen…
Lin, Lin, Chen · 2026 · Frontiers in medicine
Postoperative chylothorax is an uncommon but challenging complication after thoracic surgery. Low-dose external beam radiotherapy (RT) has been proposed as an adjunct treatment when conservative management or surgical intervention fails,…
Harder K, Thöle M · 2026 · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Objective The aim of this study was to evaluate the therapeutic success of a conservative treatment approach for macrodontic molars in guinea pigs. To this end, longitudinal data from conservative management were analyzed and parameters of…
Kashyap, Chang, Lu et al. · 2026 · Affective science
Social expectations are a ubiquitous part of human experience, yet little is known about the emotions associated with failing to fulfill others' social expectations. In two studies, we examined the effects of failing to fulfill others'…
Chi, Zheng, Guo et al. · 2026 · Drug design, development and therapy
Ischemia-percussion (I/R) injury describes a paradoxical phenomenon in which blood flow restoration following ischemia not only fails to salvage the tissue but also exacerbates tissue injury. Due to the unique physiological functions, cell…
He, Shen, Hu et al. · 2026 · The New phytologist
Interploidy hybridization in plants is constrained by a postzygotic barrier. Triploid production via 2x × 4x interploidy hybridization is an important strategy for obtaining seedless cultivar in some fruit tree crops…
Mol, van Munster, Weersma et al. · 2026 · Journal of gastroenterology
Although ursodeoxycholic acid (UDCA) is commonly prescribed for primary sclerosing cholangitis (PSC), a beneficial long-term effect on solid clinical endpoints has not yet been established. This study evaluated the efficacy of UDCA on…
Kobayashi, Naito, Tone et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
This study aimed to compare the accuracy of acetabular cup placement in total hip arthroplasty (THA) using a computed tomography (CT)-based augmented reality (AR) navigation system and a CT-based portable navigation system, both employed…
Helmy, Mahmoud Desouki, Mohamed Zayed et al. · 2026 · Medicina intensiva
To evaluate whether temporal changes in parasternal intercostal muscle thickening fraction during spontaneous breathing trials provide superior diagnostic accuracy for predicting outcomes of ventilator weaning compared to single…
Ferro, Thomas, Khattak et al. · 2026 · Clinical kidney journal
Cardiovascular disease (CVD) accounts for most of the increased morbidity and mortality associated with in chronic kidney disease (CKD). Cardiovascular risk emerges early in CKD, initially driven by atherosclerotic events but later…
Ng, Yeo, Neo · 2026 · Palliative care and social practice
This study aimed to identify how contextual, dispositional, and relational factors intersect to shape the participant experience of serious illness conversations (SICs) while exploring the nuances of appraisal across different clinical…
Kang, Zhou, Li et al. · 2026 · Frontiers in pharmacology
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by relentless cognitive decline. Despite decades of research dominated by the amyloid and tau hypotheses, clinical interventions targeting these classical…
Zhao, Fu, Li et al. · 2026 · Frontiers in neuroscience
Sleep apnea and hypopnea syndrome (SAHS) is a prevalent disorder with profound adverse effects on health and overall quality of life, thereby necessitating the development of accurate and accessible screening tools. Electrocardiogram…
Frick, Whyte-Fagundes, Baraban · 2026 · Pharmacology research & perspectives
Syntaxin-binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18-1 (STXBP1) C.…
Lou, Zhang, Chen et al. · 2026 · Frontiers in medicine
Interscalene brachial plexus block (ISB) is the first-line analgesic technique for arthroscopic shoulder surgery, but it is associated with a > 90% incidence of ipsilateral hemidiaphragmatic paresis (HDP), which severely…
Lofters, Wilks, Lee et al. · 2026 · medRxiv : the preprint server for health sciences
Fetal hemoglobin (HbF) prevents the polymerization of sickle hemoglobin (HbS). HbF, measured usually as a percent of total hemoglobin (%HbF), is inversely associated with the severity of sickle cell disease (SCD) but fails to capture the…
Rachidi, Amanallah, Benzakour et al. · 2026 · Cureus
Alcohol-induced hypoglycemia is an uncommon but potentially life-threatening metabolic complication, particularly in the setting of prolonged fasting and chronic alcohol use. We report the case of a 63-year-old man with a history of…
Jumah, Brooks, Siddiq et al. · 2026 · Missouri medicine
Chronic carotid occlusion (CCO) carries a significant risk of ischemic stroke, particularly in patients with impaired cerebrovascular reserve. Extracranial-intracranial (EC-IC) bypass emerged as a popular treatment strategy with high…
Wu, Wang, Liu et al. · 2026 · Phytomedicine : international journal of phytotherapy and phytopharmacology
Peripheral nerve injury frequently causes refractory neuropathic pain and muscle atrophy. While clinical care focuses on analgesia, effective therapies for muscle wasting are lacking. Angelica dahurica (BZ) is known for its analgesic…
Ma, Wei, Cai et al. · 2026 · IEEE transactions on image processing : a publication of the IEEE Signal Processing Society
Virtual try-on (VTON) aims to synthesize specific fashion images dressed in given garments, which possesses great potential in real-world scenarios. Existing methods generally stand on the shoulder of the single-view VTON to train a…