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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19821 results in Negative / Null Result Report · page 208 of 661

Negative / Null Result ReportMedicine

Differential modulation of chloride conductances by iodinated gallic and trans-ferulic acids.

Mies F, Olchowik-Grabarek E, Crutzen R et al. · 2026 · Biochemical and biophysical research communications

In this report we demonstrate that iodogallic acid (IGA) and iodoferulic acid (IFA) do not acutely affect transepithelial cation transport, however, prolonged basolateral application of IFA induced a delayed decrease in open-circuit…

View details →DOI: 10.1016/j.bbrc.2026.153909
Negative / Null Result ReportMedicine

Multimodal neuromonitoring-related complications in patients with severe acute brain injury: a retrospective cohort study.

Bodilsen TS, Andreasen TH, Olsen MH et al. · 2026 · Acta neurochirurgica

Background Invasive multimodal neuromonitoring (MMNM) is standard of care in many neuro-intensive care units for patients with severe acute brain injury. MMNM is used for monitoring of early signs of secondary brain injury. Still, the…

View details →DOI: 10.1007/s00701-026-06950-z
Negative / Null Result ReportMedicine

Impact of Far-Infrared-Radiation on the Proportion of Interventions in Arteriovenous Fistulas in Patients on Hemodialysis: A Randomized Trial.

Lindhard K, Hansen HP, Gliese K et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN

Introduction In patients on hemodialysis, the risk of arteriovenous fistula (AVF) failure is unacceptably high. Up to 67% of AVFs need an intervention within one year after placement. There are no effective treatments to prolong AVF…

View details →DOI: 10.2215/cjn.0000001079
Negative / Null Result ReportMedicine

A Retrospective Analysis of Perinatal Stroke: Hemostasis Abnormalities, Neonatal Seizures, Epilepsy Recurrence, and 2-Year Neurological Outcome.

Van Daele A, Labarque V, Dereymaeker A et al. · 2026 · Neuropediatrics

Background Neonatal stroke is a rare but potentially severe condition that may lead to long-term neurological impairment. Several factors may influence both its occurrence and outcomes. Methods In this retrospective, single-center cohort…

View details →DOI: 10.1055/a-2868-4302
Negative / Null Result ReportMedicine

Diastereoselective synthesis of 1,4,8-trisubstituted perhydroquinolines as novel κ receptor agonists.

Flämig L, Felix Zhu W, Hoffmann K et al. · 2026 · Organic & biomolecular chemistry

Agonists of the κ-opioid receptor are useful drugs for the treatment of severe pain, itching skin diseases and inflammatory and immunological diseases. Herein, novel κ agonists with the κ-pharmacophoric ethylenediamine system embedded in a…

View details →DOI: 10.1039/d6ob00422a
Negative / Null Result ReportMedicine

High-Color-Temperature Lighting Is Associated With Activation of MAPK/ERK-nNOS Signaling and MMP-2-Related Pathways in Ocular Tissues.

Chiang YW, Chang JY, Yeh KL et al. · 2026 · Investigative ophthalmology & visual science

Purpose To investigate whether exposure to artificial lighting with different correlated color temperatures (CCTs) affects ocular structure and myopia-related molecular signaling pathways before axial elongation in a murine model. Methods…

View details →DOI: 10.1167/iovs.67.6.46
Negative / Null Result ReportMedicine

Assessing inter-joint coordination during gait in hip osteoarthritis.

Yamakawa R, Sakaue Y, Okada S et al. · 2026 · Gait & posture

Background Hip osteoarthritis (HOA) often leads to compensatory movements such as trunk lateral bending during gait due to pain and restricted range of motion. Because multiple joints coordinate to control the center of mass (CoM) during…

View details →DOI: 10.1016/j.gaitpost.2026.110228
Negative / Null Result Report

Individual Differences in the Effects of Response Time-Adaptive Multiplication Practice: A Classroom Study on Experience and Effectiveness

van der Velde M, de Boer J, Arslan B et al. · 2026 · Preprint

Background. Multiplication is a key skill in primary education, but traditional teaching methods vary in effectiveness and may not suit individual needs. Adaptive learning systems personalise practice and promote the use of effective study…

View details →DOI: 10.31234/osf.io/gjqun_v1
Negative / Null Result ReportMedicine

Impact of β-glucan addition on long-term starch retrogradation and digestion depends on starch fine molecular structures.

Ma Y, Lai A, Deng X et al. · 2026 · Food chemistry

β-glucan could regulate starch retrogradation and digestion; however, its combined role with starch fine molecular structures remains unknown. Therefore, nine starches were selected, and their retrogradation and digestion properties were…

View details →DOI: 10.1016/j.foodchem.2026.149328
Negative / Null Result ReportMedicine

Diagnostic yield of gravity based diagnostic thoracentesis in suspected malignant pleural effusion (GBTIME): A pilot study.

Sharma P, Sivaramakrishnan P, Dahal S et al. · 2026 · Respiratory medicine

In malignant pleural effusion (MPE), malignant cells may settle in a gravity-dependent gradient due to the weight of cells. We aimed to compare diagnostic yield of cytology between aspirates from lower, upper and 5th intercostal spaces in…

View details →DOI: 10.1016/j.rmed.2026.108906
Negative / Null Result ReportMedicine

The effects of acute ketone monoester supplementation on brain insulin responsiveness and cognitive performance: Results of a randomized, double-blind, placebo-controlled crossover trial in older men with overweight.

Nijssen KMR, Adam TC, Mensink RP et al. · 2026 · Metabolism: clinical and experimental

Introduction Nutritional ketosis may prevent age-related cognitive decline, but underlying mechanisms remain unclear. This study investigated acute ketone monoester (KME) supplementation on brain insulin responsiveness and cognitive…

View details →DOI: 10.1016/j.metabol.2026.156672
Negative / Null Result ReportMedicine

Acute and chronic effects of mixed nuts on energy metabolism in women at cardiometabolic risk: a randomized clinical trial.

Bonifácio DB, da Silva A, Estrada YMF et al. · 2026 · Nutrition, metabolism, and cardiovascular diseases : NMCD

Background and aims The effect of consuming a mix of Brazilian nuts on energy metabolism has not been explored. Thus, the present study aimed to evaluate the effects of acute and chronic consumption of mixed nuts on markers of energy…

View details →DOI: 10.1016/j.numecd.2026.104801
Negative / Null Result ReportMedicine

Effects of Partial Replacement of Wheat Bran with Poplar Wood Composite Fiber on Growth Performance, Nutrient Apparent Digestibility, Immune Function, and Gut Microbiota in Growing Pigs.

Fan Y, Gao G, Jiang X et al. · 2026 · Veterinary sciences

The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…

View details →DOI: 10.3390/vetsci13060588
Negative / Null Result ReportMedicine

Carcass traits and gastrointestinal morphological responses to rumen-protected methionine supplementation in grazing beef heifers under tropical conditions.

Lelis ALJ, da Silva LAF, Casali DM et al. · 2026 · Scientific reports

This study evaluated the effects of rumen-protected metabolizable methionine (RPM) supplementation on performance, carcass traits, ruminal morphometry, cecal histology, and meat quality of crossbred heifers finished on Urochloa brizantha…

View details →DOI: 10.1038/s41598-026-58648-y
Negative / Null Result ReportMedicine

Outcome and factors affecting prognosis in treat and extend treatment for neovascular age-related macular degeneration-a real world study.

Akkan Aydogmus FS, Gursoy T, Ozdemir O et al. · 2026 · BMC ophthalmology

Background To evaluate the outcome of treat and extend (T&E) for neovascular age related macular degeneration (nAMD) at 12, 18 and 24 months and the impact of clinical characteristics on treatment success defined as extension of treatment…

View details →DOI: 10.1186/s12886-026-04905-7
Negative / Null Result ReportMedicine

Return to duty after non-surgical treatment of a non-neurological thoracic or lumbar spine fracture in French military patients: a retrospective analysis of 54 patients.

Lines JB, Cungi PJ, Da Silva C et al. · 2026 · BMJ military health

Introduction Non-surgical management of non-neurological thoracic or lumbar spine (TL) fractures seems to provide good results in the civilian population, leading to return to work in most cases. However, data on the military population…

View details →DOI: 10.1136/military-2024-002916
Negative / Null Result ReportMedicine

Dynamic chitosan-hyaluronic acid hydrogels for extrusion printing: Combined effects of polymer molecular weight and carbon nanofillers

García-García A, Goyoaga M, Nuño F et al. · 2026 · Carbohydrate Polymers.

Despite the increasing interest on self-healing hydrogels in the fabrication of customized scaffolds for tissue engineering applications, their optimal printability is still a challenge due to the weak mechanical stability of dynamic…

Negative / Null Result ReportMedicine

A RhoGEF activates RacM to selectively promote motility without affecting macropinocytosis in Entamoeba histolytica.

Shimoyama M, Nakada-Tsukui K, Nozaki T · 2026 · Journal of cell science

Rho guanine nucleotide-exchange factors (RhoGEFs) activate Rho and Rac small GTPases, orchestrating cellular processes, such as actin remodeling, endocytosis and migration. In the protozoan parasite Entamoeba histolytica, the causative…

View details →DOI: 10.1242/jcs.264490
Negative / Null Result ReportMedicine

Impact of atrial arrhythmias on long-term survival in non-small cell lung cancer patients.

Pu Y, Gampa A, Simon C et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Atrial arrhythmias (AA), including atrial fibrillation (AF) and atrial flutter, are a significant clinical problem in oncological patients. The effect of AA on clinical outcome of patients with non-small cell lung cancer (NSCLC) is not…

View details →DOI: 10.1177/10815589261455329
Negative / Null Result ReportOpen accessMedicine

Endocrine Disruptive Effects of the Herbicides Linuron, Chloridazon and Metribuzin on Bovine Granulosa Cells.

Kahveci ME, Yigit AA, Kabakci R · 2026 · Reproduction in domestic animals = Zuchthygiene

Linuron, chloridazon and metribuzin are herbicides thought to have potential endocrine disruption (ED) effects. This study investigated the effects of linuron, chloridazon and metribuzin on bovine granulosa cell viability and oestrogen…

View details →DOI: 10.1111/rda.70204
Negative / Null Result ReportMedicine

Development of spirulina-enriched vegan cheese by utilizing soy protein-based emulsion gel as a fat substitute: Effects of spirulina and emulsion gel on texture/rheology, antioxidant and sensory properties.

Kashiri M, Berk B, Yemenicioğlu A · 2026 · International journal of biological macromolecules

This study aimed at utilizing soy protein-based emulsion gel as a fat substitute in spirulina enriched plant-based spreadable cheese (PBC). For this purpose, spirulina enriched vegetable oil-in-water emulsions prepared using soy protein as…

View details →DOI: 10.1016/j.ijbiomac.2026.152131
Negative / Null Result ReportMedicine

Individual Branched-Chain Amino Acid Restriction Alters Body Composition Without Affecting Hemoglobin in Rats Fed a Low Protein Diet.

Jaafar LS, Sous NS, Shehadi HH et al. · 2026 · The Journal of nutrition

Background Emerging evidence suggests that each Branched-chain amino acids (BCAA; leucine, valine, and isoleucine) exert distinct physiological effects. Moreover, leucine and valine, but not isoleucine, are structural components of…

View details →DOI: 10.1016/j.tjnut.2026.101687
Negative / Null Result ReportMedicine

Recombinant bovine somatotropin at synchronization initiation, but not at embryo transfer, enhances fertility in embryo-recipient heifers: Associations with follicular, luteal, and embryonic outcomes.

Rebeis LM, Baruselli PS, Harden H et al. · 2026 · Journal of dairy science

The aim of this study was to evaluate the effects of administering 325 mg of recombinant bovine somatotropin (rbST) at the initiation of the synchronization protocol (SYNCd) and/or on the day of embryo transfer (ETd) using a 2 × 2…

View details →DOI: 10.3168/jds.2026-28503