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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 208 of 675

Negative / Null Result ReportOpen accessMedicine

Colchicine has Dose-Dependent Therapeutic Effects in a LPS-Induced Experimental Endotoxemia Model.

Demir M, Gocmen AY, Ozcelebi E et al. · 2026 · Pharmacology research & perspectives

Colchicine is an ancient medication that has long been used for anti-inflammatory properties. Because of unfavorable and toxic consequences of colchicine, selecting an appropriate dose is critical. The effects of three different doses…

View details →DOI: 10.1002/prp2.70239
Negative / Null Result ReportOpen accessMedicine

Effects of different intensities of repetitive peripheral magnetic stimulation on corticospinal excitability and motor performance in healthy humans.

Omiya A, Shitara K, Miyazaki D et al. · 2026 · PloS one

Repetitive peripheral magnetic stimulation (rPMS) has been applied in clinical settings to enhance the recovery of motor function following central nervous system lesions. However, the optimal intensity of rPMS for inducing neural…

View details →DOI: 10.1371/journal.pone.0349300
Negative / Null Result ReportMedicine

Low Vision Assessment in Virtual Reality (LVAVR): Spatial Computing in Virtual Reality and Real-World.

Bailey E, Roy P, Shifflett K et al. · 2026 · 2026 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops

The Low Vision Assessment in Virtual Reality project aims to create performance assessments of activities of daily living for a broad low vision population in virtual reality. In this study, our goal is to validate representative virtual…

View details →DOI: 10.1109/vrw70859.2026.00284
Negative / Null Result Report

Efficacy and safety of rituximab combined with glucocorticoids in patients with primary membranous nephropathy: a single-center retrospective cohort study

Zhao C, Feng S, Hu Z et al. · 2026 · Preprint

Abstract Background To compare the clinical efficacy and safety of rituximab (RTX) monotherapy versus the combination of RTX and glucocorticoids (GC) in the treatment of primary membranous nephropathy (PMN). Methods This retrospective,…

View details →DOI: 10.21203/rs.3.rs-9750129/v1
Negative / Null Result ReportMedicine

Quantitative assessment of tumor burden in multiple myeloma using MY-RADS from whole-body MRI: comparison with established prognostic biomarkers.

Xiong X, Yan Z, Wang J et al. · 2026 · Cancer imaging : the official publication of the International Cancer Imaging Society

Background To explore the value of MY-RADS from whole-body MRI in assessing tumor burden in MM with reference to established prognostic biomarkers. Methods 108 consecutive newly diagnosed MM patients were retrospectively enrolled. Bone…

View details →DOI: 10.1186/s40644-026-01076-y
Negative / Null Result ReportMedicine

Feasibility and signal quality of the Minder® implantable continuous EEG monitoring® system compared to 10-20 scalp electrodes over extended monitoring periods.

Ganguly TM, Lai A, Niemiec A et al. · 2026 · Epilepsia

Objective To evaluate the signal quality of the Minder implantable continuous EEG monitoring (iCEM) system compared to traditional scalp EEG in the context of long-term, continuous monitoring in individuals with epilepsy. Methods…

View details →DOI: 10.1002/epi.70290
Negative / Null Result ReportOpen accessMedicine

Enhancing wheat bran deconstruction with enzyme cocktails from Penicillium spp. and Trichoderma harzianum: the impact of β-glucosidase supplementation.

Hamann PRV, Martins HS, da Costa PHC et al. · 2026 · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Forests and natural environments are valuable sources of organisms capable of degrading plant cell wall carbohydrates. In the present study, two isolates, Penicillium polonicum and Penicillium chrysogenum, obtained from Brazilian Cerrado…

View details →DOI: 10.1007/s42770-026-01974-0
Negative / Null Result ReportMedicine

Comparison of 2% lidocaine with epinephrine and 4% articaine with epinephrine in local anesthesia of maxillary molars affected by molar incisor hypomineralization: a randomized controlled trial.

Haidar M, Raslan N · 2026 · Scientific reports

The use of local anesthesia is essential for pain control during the treatment of MIH-affected molars. This study aimed to compare injection-related pain and anesthetic efficacy between 2% lidocaine with epinephrine (LE) and 4% articaine…

View details →DOI: 10.1038/s41598-026-54698-4
Negative / Null Result ReportOpen accessMedicine

Protective role of lycopene against salinity-induced oxidative stress in Medicago sativa L. seedlings.

de Araujo Monteiro AA, da Silva Teles BR, Kamdem JP et al. · 2026 · Scientific reports

Soil salinization is one of the major challenges to agriculture, reducing productivity and directly affecting plant growth, germination, and physiology, especially in economically important crops such as Medicago sativa. Conventional soil…

View details →DOI: 10.1038/s41598-026-42699-2
Negative / Null Result ReportOpen accessMedicine

Effect of yeast selenium on autophagy and PINK1/Parkin expression in Diquat-induced chicken liver and kidney cells.

Jin Y, Cheng X, Tan Y et al. · 2026 · Poultry science

(Objective) This study aims to explore the effect of yeast selenium on alleviating autophagy and PINK1/Parkin expression in chicken liver and kidney cells induced by diquat. (Method) A total of 120 180-day-old Kangle Yellow chickens were…

View details →DOI: 10.1016/j.psj.2026.106786
Negative / Null Result ReportMedicine

The impact of couple-focused counseling based on the Ex-PLISSIT model on the sexual self-concept of infertile couples: a randomized trial.

Dalvand R, Otogara M, Shayan A et al. · 2026 · Scientific reports

The negative impact of infertility and its treatments on sexual health is well-documented. Self-concept plays a crucial role in sexual behavior and overall sexual health. This study aims to investigate how couple-oriented counseling, using…

View details →DOI: 10.1038/s41598-026-43203-6
Negative / Null Result ReportMedicine

Observational study on the therapeutic effects of two different negative pressure drainage devices on skin graft donor sites.

Chen P, Wang L, Gao S et al. · 2026 · Journal of tissue viability

Objective To conduct a retrospective analysis of patients who received treatment with two types of negative pressure materials for intermediate-thickness skin graft donor sites, comparing the clinical efficacy and exploring potential…

View details →DOI: 10.1016/j.jtv.2026.101005
Negative / Null Result ReportMedicine

Interplay of anemia in inborn errors of energy metabolism.

Shetye S, Bhat YR, Lewis LES et al. · 2026 · Scientific reports

Inborn errors of energy metabolism (IEEM) are inherited conditions that typically present with impaired mitochondrial energy production and multisystem involvement, leading to adverse developmental outcomes. Iron is essential for…

View details →DOI: 10.1038/s41598-026-58126-5
Negative / Null Result ReportMedicine

Repurposing traditional cerclage and suture techniques for the reduction of comminuted patellar fractures.

Pan Y, Wang T, An M et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Purpose This study aimed to compare the cerclage and suture reduction technique with the point-type reduction technique in the management of comminuted patellar fractures using the modified Kirschner wire tension band. Methods We conducted…

View details →DOI: 10.1007/s00590-026-04829-4
Negative / Null Result ReportOpen accessMedicine

Impact of Sensory Re-education Paradigm on Quality of Life, Tactile Sensation, and Proprioceptive Acuity in Patients with Post-COVID-19 Polyneuropathy: A Randomized Controlled Trial.

Alsaid HM, Khadour YA, Zakaria HM et al. · 2026 · Journal of musculoskeletal & neuronal interactions

Objectives This study evaluated the effect of sensory re-education on quality of life and sensation in patients with post-COVID-19 polyneuropathy. Methods Forty patients with post-COVID-19 polyneuropathy were randomly assigned to a study…

Negative / Null Result ReportOpen accessMedicine

Foam Versus Silver-Impregnated Foam Dressings for Pediatric Tracheostomy: A Randomized Trial.

Bostancı ŞA, Önder SŞ, Sürmeli M et al. · 2026 · Laryngoscope investigative otolaryngology

Objectives Peristomal skin complications occur in up to 29% of pediatric tracheostomy patients. While foam dressings have demonstrated superiority over traditional gauze, comparative evidence regarding silver-impregnated versus standard…

View details →DOI: 10.1002/lio2.70436
Negative / Null Result ReportMedicine

The effect of stress ball use on stress, sleep quality, and comfort in individuals receiving hemodialysis: a randomized controlled trial.

Kacaroglu Vicdan A, Gibyeli Genek D · 2026 · BMC complementary medicine and therapies

Background Hemodialysis often leads to various physiological, psychological, and social challenges for individuals receiving this treatment. This study was conducted to determine the effects of stress ball use on stress, sleep quality, and…

View details →DOI: 10.1186/s12906-026-05429-9
Negative / Null Result ReportOpen accessMedicine

Carboxymethyl cellulose-based edible coatings emulsified with Lemongrass oil for enhancing the storage stability of refrigerated broiler meat.

Ahmad U, Ishaq A, Khalid N · 2026 · Food science of animal resources

The present study aimed to analyze the effects of lemongrass essential oil emulsified with carboxymethyl cellulose (CMC) based edible coating on the physicochemical characteristics, microbial status, and oxidation level of raw chicken meat…

View details →DOI: 10.1007/s44463-025-00045-6
Negative / Null Result Report

Influence of Minor Print Parameter Variations on the Mechanical Properties of Additively Manufactured Ti-6Al-4V Parts Using Laser Powder Bed Fusion

Hall J, Radtke MP, Waterman J et al. · 2026 · Preprint

Abstract Minor variations in print parameters are an inherent aspect of modern additive manufacturing (AM) processes. This study investigated the impact of 3 distinct print parameter variations in 21 combinations on the mechanical…

View details →DOI: 10.21203/rs.3.rs-9620697/v1
Negative / Null Result ReportOpen accessMedicine

Synergistic effect and resistance prevention activity of antimicrobial peptide MPX with Tulathromycin against <i>Actinobacillus pleuropneumoniae</i>.

Wang H, Wang L, Zhang W et al. · 2026 · Frontiers in microbiology

Introduction The emergence and dissemination of multidrug-resistant Actinobacillus pleuropneumoniae (APP) have significantly hindered the advancement of the swine industry. The combination of antimicrobial peptides (AMPs) with conventional…

View details →DOI: 10.3389/fmicb.2026.1802629
Negative / Null Result ReportMedicine

[Application of the "2+3" pancreaticojejunostomy in 110 cases of pancreaticoduodenectomy].

Guo SL, Chen SH, Liu H et al. · 2026 · Zhonghua wai ke za zhi [Chinese journal of surgery]

Objective: To report the outcomes and evaluate the safety of the "2+3"pancreaticojejunostomy in pancreaticoduodenectomy. Methods: This retrospective case series analyzed clinical data from 110 consecutive pancreaticoduodenectomy patients…

View details →DOI: 10.3760/cma.j.cn112139-20251116-00534
Negative / Null Result ReportOpen accessMedicine

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ-Subunit of the Epithelial Sodium Channel During Sodium Restriction.

Essigke D, Kalo MZ, Wörn M et al. · 2026 · Acta physiologica (Oxford, England)

Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186 RKRK mediating proteolytic ENaC…

View details →DOI: 10.1111/apha.70228
Negative / Null Result ReportOpen accessMedicine

Polymerizable inhibitor can reduce shrinkage stress of resin composite.

He J, Garoushi S, Lassila L et al. · 2026 · Clinical oral investigations

Objective The purpose of this study was to prepare dental resin composites (DRCs) with low shrinkage stress and limited leachable inhibitor content by incorporating a synthesized polymerizable inhibitor PBHT…

View details →DOI: 10.1007/s00784-026-06901-z
Negative / Null Result ReportOpen accessMedicine

Three-dimensional analysis of maxillary asymmetry in patients with mandibular prognathism.

Atarashi C, Osawa K, Saito D et al. · 2026 · Maxillofacial plastic and reconstructive surgery

Background Jaw deviation is a common feature of skeletal mandibular prognathism and often extends to the maxilla, complicating diagnosis and treatment planning in surgical orthodontic treatment. Since occlusion and maxillary morphology…

View details →DOI: 10.1186/s40902-026-00506-y
Negative / Null Result ReportOpen accessMedicine

Development of engineered magnetic liposome/exosome hybrid as a novel caffeine nanocarrier for restraining liver fibrosis induced in rats.

Elakkad YE, Refai H, Ahmed HH et al. · 2026 · Scientific reports

Liver fibrosis, a severe health issue linked to liver injury, inflammation, and cell death, often progresses to liver cancer without effective treatments. In this study, an exosome-nanoliposome hybrid loaded with caffeine (Caff) was…

View details →DOI: 10.1038/s41598-025-31169-w
Negative / Null Result ReportOpen accessMedicine

Determining the Optimal Volume of Ropivacaine Combined with Dexmedetomidine for Programmed Intermittent Epidural Bolus in Labor Analgesia: A Randomized Dose-Response Study.

Song C, Ni J, Liu C et al. · 2026 · Drug design, development and therapy

Background The programmed intermittent epidural bolus (PIEB) technique is effective for labor analgesia. Although ropivacaine combined with dexmedetomidine is used for epidural labor analgesia, the optimal PIEB volume for this regimen…

View details →DOI: 10.2147/dddt.s598405