Negative / Null Result ReportOpen accessPsychology
Stephanie M Sherman, Timothy P Buckley, Elsa Baena et al. · 2016 · Frontiers in Psychology
Many college students struggle to perform well on exams in the early morning. Although students drink caffeinated beverages to feel more awake, it is unclear whether these actually improve performance. After consuming coffee (caffeinated or decaffeinated), college-age adults completed implicit and explicit memory tasks in the early morning and late afternoon (Experiment 1). During the morning, participants ingesting caffeine demonstrated a striking improvement in explicit memory, but not implicit memory. Caffeine did not alter memory performance in the afternoon. In Experiment 2, participants
View details →DOI: 10.3389/fpsyg.2016.01764 Negative / Null Result ReportOpen accessTechnology (General)
Szostek Karol, Szostek Roman · 2023 · Technical Transactions
The work presents the concept of a device for the measurement of the one-way speed of light. The minimum parameters of this device have also been determined based on the Special Theory of Ether without transverse contraction. The Special Theory of Ether is a relativistic theory of kinemat-ics with a universal frame of reference in which light propagates and is an alternative explanation for the null result of the Michelson-Morley experiment. An experiment based on the proposed device can be one of the ways to falsify the Special Theory of Relativity and Special Theory of Ether.
View details →DOI: 10.37705/techtrans/e2023003 Negative / Null Result ReportOpen accessDentistry
Dragos Epistatu, Octavian-Marius Dinca, Cristian Vladan et al. · 2023 · Dentistry Journal
The aim of this study is to evaluate the long-term changes of sinus lift material. Materials and methods: We included a total number of 35 patients (20 men and 15 women), between 32 and 80 years old, evaluated on a timeframe of up to 11.6 years. Diverse biomaterials were used (allograft, xenograft, alloplastic, combinations of them), with autologous bone in some cases. Results: The appearance of the top plane of the bone over time took a large dome shape (36% of cases), a linear shape (32% of cases), an irregular shape (23% of cases), or had micro domes above the implants (7%). No significant
View details →DOI: 10.3390/dj11120273 Negative / Null Result ReportOpen accessInternal medicine
Dae-Yeon Kim, Hee-Soon Park, Dong-Jae Han et al. · 2013 · Kidney Research and Clinical Practice
Renal failure caused by scrub typhus is known to be reversible. In most cases, renal function is almost fully restored after appropriate antibiotic treatment. A 71-year-old man was diagnosed with scrub typhus complicated by renal failure. A renal biopsy revealed histopathologic findings consistent with acute tubulointerstitial nephritis. Renal function did not improve 18 months after discharge and the patient required continuous hemodialysis. Although severe renal failure requiring dialysis is a rare complication of scrub typhus, we describe a case of scrub typhus requiring maintenance hemodia
View details →DOI: 10.1016/j.krcp.2013.09.003 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Michele Bottosso, Gaia Griguolo, Severine Guiu et al. · 2025 · npj Breast Cancer
Abstract Brain metastases (BMs) are a common complication of advanced breast cancer (BC), and their management has significantly evolved. We evaluated the clinical impact of these changes dividing patients diagnosed with BCBMs at three Institutions according to year of BMs diagnosis: 2000-2007 (group A), 2008-2014 (group B) and 2015-2022 (group C). Stereotactic radiotherapy increased (p < 0.001), and WBRT decreased (p = 0.010) over time. Among HER2+ BC patients, more received anti-HER2 therapy after BM diagnosis in recent years (p < 0.011). Overall survival (OS) did not improve in the entire c
View details →DOI: 10.1038/s41523-025-00735-w Negative / Null Result ReportOpen accessOphthalmology
Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu, Gezahen Negusse Ayane et al. · 2019 · The Pan-American Journal of Ophthalmology
A 22-year-old female patient was diagnosed to have HIV and treated by highly active antiretroviral therapy (HAART) since 2012 had developed a reduction of vision in both eyes secondary to cataract. The cataract was extracted from both eyes with no immediate postoperative complication. During follow-up, it was recognized that she had had bilateral Stage 3 macular hole in both eyes. The visual acuity in both eyes was 6/60 which did not improve with application of pinhole. Pars plana vitrectomy was done and sealed the macular hole in the left eye. The visual acuity remained the same in both eyes
View details →DOI: 10.4103/pajo.pajo_15_19 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Alexander C. Lehn, Cullen O'Gorman, Sarah Olson et al. · 2017 · Tremor and Other Hyperkinetic Movements
Background: Orthostatic tremor (OT) was first described in 1977. It is characterized by rapid tremor of 13–18 Hz and can be recorded in the lower limbs and trunk muscles. OT remains difficult to treat, although some success has been reported with deep brain stimulation (DBS). Case Report: We report a 68-year-old male with OT who did not improve significantly after bilateral thalamic stimulation. Discussion: Although some patients were described who improved after DBS surgery, more information is needed about the effect of these treatment modalities on OT, ideally i
View details →DOI: 10.7916/d8280jhr Negative / Null Result Report
Eggeling-Böcker M, Karabetsos E, Christopoulou M et al. · 2025 · Preprint
Background: Technological advancements, such as the introduction of 5G, offer opportunities but also raise concerns. Although no evidence suggests negative effects of radiofrequency electromagnetic fields (RF-EMF) within defined exposure…
View details →DOI: 10.12688/openreseurope.19236.1 Negative / Null Result ReportOpen accessAnimal culture
Samadi F, Sahneh M · 2015 · Poultry Science Journal
A total of 240, one-day-old quail chicks (Coturnix coturnix japonica) were used to study the effects of Artichoke leaf meal (ALM) and vitamin E in diet on growth performance, ileal microbial populations and intestinal morphology in a 42-d trial. This experiment was performed as a completely randomized design with 4 replicates of 15 quails each, using a 4 × 2 factorial arrangement with diet and gender as the main effects. Four dietary treatments were formulated by addition of 2 levels (1.5 and 3 percent) of ALM and 300 mg/Kg vitamin E to the basal diet. Supplementing basal diet with ALM did not
Null DatasetOpen accessMaterials of engineering and construction. Mechanics of materials
· 2009 · eXPRESS Polymer Letters
The thermal and reaction to fire characteristics of a flame retardant unsaturated polyester (UP) ternary system are presented here. Thermal gravimetric analysis showed an improved thermal stability between 200–600°C with the addition of ammonium polyphosphate (APP) and aluminium trihydroxide (ATH) formulation. Cone calorimetry tests indicated that ATH is more efficient than calcium carbonate at delaying the ignition time, lowering the carbon monoxide yield and lowering the peak heat release (PHRR). However the addition of APP and ATH to the formulation failed to demonstrate any significant syn
View details →DOI: 10.3144/expresspolymlett.2009.92 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Oh Young Bang, Mi Ji Lee, Sookyung Ryoo et al. · 2015 · Journal of Stroke
Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This
View details →DOI: 10.5853/jos.2015.17.3.229 Abandoned HypothesisOpen accessPhilosophy (General)
Mostafa Taqavi · 2019 · Journal of Philosophical Investigations
There are two main sections in this paper. First, we will show that some of the chief 20th-century theories of science either have failed to demonstrate that value judgments do not influence the context of consolidation and determination of science or have accepted the role of value judgments in the context of consolidation and determination of science and theorized accordingly. For this purpose, the ideas of logical positivists, Willard Quine, Karl Popper, Thomas Kuhn, Imre Lakatos, Paul Feyerabend, and Roy Bhaskar on science are briefly reviewed. Finally, the validity of the following statem
View details →DOI: 10.22034/jpiut.2019.27618.2029 Failed Experiment ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Ma Li, Men Yu, Feng Lingling et al. · 2019 · Radiology and Oncology
The mainstay therapy for locally advanced non-small cell lung cancer is concurrent chemoradiotherapy. Loco-regional recurrence constitutes the predominant failure patterns. Previous studies confirmed the relationship between increased biological equivalent doses and improved overall survival. However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers.
View details →DOI: 10.2478/raon-2019-0006 Short NoteOpen accessMedical physics. Medical radiology. Nuclear medicine
Farhana Ebrahim Suleman, Margaret Kisansa · 2010 · South African Journal of Radiology
Macrodystrophia lipomatosa (MDL) is described as a rare, non-hereditary, congenital condition presenting with localized macrodactyly and a proliferation of mesenchymal elements. There is in particular a marked increase in fibroadipose tissue(1). We describe two cases presenting to our department in a six month period, with a history of disproportionately large limbs since birth. While our first case demonstrated all the typical features of MDL, our second case failed to demonstrate osseous gigantism although the other features of MDL were present. An extensive search of the literature failed t
View details →DOI: 10.4102/sajr.v14i2.425 Failed Experiment ReportOpen accessMedicine
Wallon S, Williamsson C, Karlsson V et al. · 2026 · Trials
Background Routine use of surgical drains after abdominal operations has largely been abandoned over the past decades. Studies have failed to demonstrate benefits of routine drainage following liver, gallbladder, gastric, and colorectal…
View details →DOI: 10.1186/s13063-026-09762-9 Negative / Null Result ReportOpen accessEcology
Sánchez-Ledesma Judith A., Águila Bernardo, Garibay-Orijel Roberto et al. · 2025 · Folia Oecologica
Using ITS1-based metabarcoding, we investigated the structure of the soil fungal communities in the central and peripheral zones of a 25-hectare pecan nut (Carya illinoinensis) orchard located in the arid region of Coahuila, Mexico. While environmental conditions such as soil moisture and temperature varied between zones, physicochemical soil properties (pH, organic carbon, total carbon, organic matter, electrical conductivity, and zinc) remained homogeneous. A total of 4,443 fungal OTUs were detected at 97% similarity. Alpha diversity indices did not differ significantly between zones. The fu
View details →DOI: 10.2478/foecol-2025-0015 Negative / Null Result ReportOpen accessChemistry
Yu Jia, Cao Yu, Song Hang et al. · 2012 · Journal of the Serbian Chemical Society
Ab initio Hartree-Fock (HF) method and Density Functional Theory (DFT) were used to calculate the optical rotation of 26 chiral compounds. The effects of theory and basis sets used for calculation, solvents influence on the geometry and values of calculated optical rotation were all discussed. The polarizable continuum model, included in the calculation, did not improve the accuracy effectively, but it was superior to γs. Optical rotation of five or sixmembered of cyclic compound has been calculated and 17 pyrrolidine or piperidine derivatives which were calculated by HF and DFT methods gave a
View details →DOI: 10.2298/jsc110905207y Negative / Null Result ReportMedicine
Mazdarani, Miles · 2026 · Veterinary research communications
Cranial cruciate ligament (CCL) rupture is uncommon in cats but may cause persistent stifle instability. Previous ex vivo assessments of tibial plateau levelling osteotomy and tibial tuberosity advancement have failed to restore stability…
View details →DOI: 10.1007/s11259-026-11361-7 Replication FailureMedicine
Ramphul R, McCurdy SA, Lee J et al. · 2026 · Drug and alcohol dependence
Background In 2023, an estimated 39.6 million adults aged ≥ 18 years had a substance use disorder (SUD) and 94.7 % did not seek treatment. Recovery residences provide essential support for individuals recovering from SUD, yet their…
View details →DOI: 10.1016/j.drugalcdep.2026.113044 Negative / Null Result ReportMedicine
Janz C, Timpka J, Storch A et al. · 2026 · Journal of Parkinson's disease
BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient…
View details →DOI: 10.1177/1877718x261461073 Negative / Null Result ReportOpen accessMedicine
Le J, Patel M, Atschinow A et al. · 2026 · Cureus
The platelet-rich plasma in achilles tendon healing 2 (PATH-2) trial is the largest randomized study of platelet-rich plasma (PRP) in acute Achilles tendon rupture. While the original frequentist analysis showed no significant benefit,…
View details →DOI: 10.7759/cureus.102519 Negative / Null Result ReportOpen access
Vilela, Judith M · 1984
The activity of beta-amylase in crosses of Saccharum spontaneum L. and S. officinarum L. and their hybrids was determined. Results showed that the parents did not differ significantly in their enzyme activity. Variability in enzyme…
Negative / Null Result ReportOpen access
Robert Ladouceur, Marie Mayrand · 1987
The perceptions of control regarding an objectively uncontrollable task (American Roulette) by depressive and nondepressive subjects were compared. Monetary risk behavior and subjective control did not differ significantly between the two…
View details →DOI: 10.2466/pr0.1987.60.3.1019 Negative / Null Result ReportOpen accessMedicine
Wang J, Liu LL, Huang L et al. · 2026 · BMC nephrology
Background The European STOP study showed that glucocorticoids (with/without immunosuppressants) did not delay disease progression in adults with IgA nephropathy (IgAN). However, pediatric IgAN is characterized by more severe acute…
View details →DOI: 10.1186/s12882-026-05101-x Negative / Null Result ReportOpen accessMedicine
Park HJ, Park S, Heo S et al. · 2026 · Journal of microbiology and biotechnology
Leuconostoc lactis DMLL10 is a novel strain isolated from kimchi. The strain did not exhibit toxicity in genetic tests. This study aims to conduct a preclinical safety assessment by performing repeated-dose toxicity studies in animals. In…
View details →DOI: 10.4014/jmb.2601.01021 Negative / Null Result ReportMedicine
Peker Y, Saygin M, Celik Y et al. · 2026 · Annals of the American Thoracic Society
Rationale Recent randomized controlled trials failed to show cardiovascular benefits of treating obstructive sleep apnea (OSA) in intention-to-treat analyses which has been a matter of debate since publication of the results. Objectives To…
View details →DOI: 10.1093/annalsats/aaoag072 Negative / Null Result ReportMedicine
Gaub M, Shaffer KV, Patel P et al. · 2026 · Clinical neurology and neurosurgery
Objective EC-IC bypass for symptomatic atherosclerotic internal carotid and middle cerebral artery chronic occlusion (AIMCAO) failed to show benefit over medical management in previous randomized controlled trials. We explored how a…
View details →DOI: 10.1016/j.clineuro.2026.109417 Negative / Null Result ReportMedicine
Hajime T, Shiota M, Fukuchi G et al. · 2026 · Annals of surgical oncology
Background Although lymph node involvement (LNI) is a critical prognostic factor guiding adjuvant therapy, randomized trials have failed to show a survival advantage of extended versus standard pelvic lymph node dissection (PLND) but have…
View details →DOI: 10.1245/s10434-026-19088-0 Negative / Null Result ReportMedicine
Dintakurti A, Parikh MA, Silver RJ et al. · 2025 · Cardiology in review
Large-scale clinical trials of intensive glycemic control have failed to show cardiovascular benefit, with hypoglycemia implicated as a key factor. Increasing evidence suggests hypoglycemia is not merely a complication of diabetes therapy…
View details →DOI: 10.1097/crd.0000000000001114 Replication FailureMedicine
Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery
Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…
View details →DOI: 10.1097/ta.0000000000004723 