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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 203 of 675

Negative / Null Result ReportMedicine

Antimitotic Naphthalene Sulfonamides Are Potent Antitumor Agents Acting Differently from Colchicine.

Marín, Fuentes-Martín, Sánchez et al. · 2026 · Pharmaceutics

Background/Objectives: Microtubule-targeting agents represent a pillar of cancer chemotherapy; however, their clinical utility is constrained by significant toxicity, pharmacokinetic instability, and susceptibility to multidrug resistance…

View details →DOI: 10.3390/pharmaceutics18060733
Negative / Null Result ReportMedicine

Optimized Extraction of Medicinal Mushroom Polysaccharides and Their Protective Effects Against 5-Fluorouracil-Induced Gastrointestinal Mucositis.

Dos Santos, Sauruk da Silva, Iacomini et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Background : Ganoderma lucidum is a medicinal mushroom widely recognized for its high content of bioactive polysaccharides, particularly β-glucans with immunomodulatory properties. This study aimed to optimize polysaccharide…

View details →DOI: 10.3390/ph19060946
Negative / Null Result ReportMedicine

A Randomized Study Evaluating the Effect of Ossein-Hydroxyapatite Complex on the Functional Outcomes of Patients After Conservative Treatment of Distal Radius Fracture.

Zaborska, Sobczak, Kubas et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Background: Distal radius fractures (DRFs) are the most common upper limb fractures worldwide. The main goal of DRF treatment is to achieve optimal functional outcomes with the lowest complication rate as rapidly as possible. Achieving…

View details →DOI: 10.3390/ph19060938
Negative / Null Result ReportMedicine

Phytochemicals from Agro-Industrial By-Products for Breast Cancer Prevention and Therapy: Molecular Mechanisms and Circular Bioeconomy Perspective.

Maffia, Marra, Battaglia et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Breast cancer remains one of the most frequently diagnosed malignancies and a leading cause of cancer-related mortality among women worldwide. The growing interest in natural bioactive compounds has highlighted plant-derived phytochemicals…

View details →DOI: 10.3390/ph19060934
Negative / Null Result ReportMedicine

Salivary Cortisol Response After Ropivacaine-Dexamethasone Administration: A Randomized Clinical Trial.

Stojanović, Burić, Kostić et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Background: This randomized parallel-group clinical study evaluated salivary cortisol as a biomarker of perioperative stress response during surgical extraction of impacted mandibular third molars performed under local anesthesia…

View details →DOI: 10.3390/ph19060930
Negative / Null Result ReportMedicine

Residual biological surrogate aerosol risk reduction during disrobing litter-bound manikin patients using two dry air treatments for cold regions.

Garner C, Sleeth D, Slagley J et al. · 2026 · American journal of disaster medicine

Objective Determine relative effectiveness of two dry air decontamination methods to reduce residual airborne surrogate biological agent on litter-bound manikin patients during disrobing. Design Fluorescent 1 µm polystyrene latex (PSL)…

View details →DOI: 10.5055/ajdm.0518
Negative / Null Result ReportMedicine

[Comparison of CNV-seq and chromosomal microarray analyses of abortive tissues].

Fu Y, Liu J, Sun H et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To compare the performance of copy number variation sequencing (CNV-seq) and chromosomal microarray analysis (CMA) for the analysis of abortive tissues. Methods Tissue samples were collected from 396 patients with missed abortion…

View details →DOI: 10.3760/cma.j.cn511374-20251016-00610
Negative / Null Result ReportOpen accessMedicine

Perception of the patient safety culture among healthcare workers.

Ibrahim MG, Hassan MH, Lotfy AMM · 2026 · BMC health services research

Background Patient safety culture (PSC) is a key determinant of care quality, influencing clinical outcomes, staff functioning, and the resiliency of organizations. While PSC has evolved globally, it remains established in developing…

View details →DOI: 10.1186/s12913-026-14788-5
Negative / Null Result ReportMedicine

Comparison of Super Mini Percutaneous Nephrolithotomy (smPCNL) and Extracorporeal Shock Wave Lithotripsy (ESWL) in Pediatric 1-2 cm Kidney Stones: A Single-Center Retrospective Controlled Study.

Sevim M, Demir M, Eryılmaz R et al. · 2026 · Urology journal

Purpose To compare outcomes of super mini percutaneous nephrolithotomy (smPCNL) with extracorporeal shock wave lithotripsy (ESWL) for stones 1-2 cm. Materials and methods After receiving ethics committee approval for this study (Date:…

View details →DOI: 10.22037/uj.v23i00.8586
Negative / Null Result ReportOpen accessMedicine

Effects of Different Carbohydrate Level Diets on Growth Performance and Glycometabolism in Mandarin Fish (<i>Siniperca chuatsi</i>) Under Saline-Alkali Stresses.

Kong Y, Fan J, Li Y et al. · 2026 · Aquaculture nutrition

Saline-alkali cultivation is a crucial approach to alleviate the fresh water crisis. However, prolonged saline-alkali stresses might bring adverse effects on fish growth, health, and even death. This study evaluated the effects of…

View details →DOI: 10.1155/anu/3315751
Negative / Null Result ReportMedicine

Reunification of displaced children in a disaster: Can children provide information necessary for reunification?

Lacayo M, Pless A, Wilde J et al. · 2026 · American journal of disaster medicine

Background Natural and man-made disasters displace millions of people each year. Children are disproportionately at risk due to their physiology and dependent living needs. Familial separation, resulting from displacement, causes physical,…

View details →DOI: 10.5055/ajdm.0522
Negative / Null Result ReportMedicine

Consistency and Objectivity in Assignment Evaluation in Dental Education: A Comparison of Different Assessment Methods.

Yiğit E, Atsü S · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Objective This study examines differences in scores assigned to dental students' assignments when evaluated by two instructors and compares assessments conducted with a structured preclinical assessment form versus those without one.…

View details →DOI: 10.1111/eje.70196
Negative / Null Result Report

Is protrusive occlusal interference a risk factor for anterior disc displacement of the temporomandibular joint: A retrospective analysis based on the superior head of the lateral pterygoid muscle

Lin J, Chen J, Wang D et al. · 2026 · Preprint

Abstract Objective :‌ To investigate whether protrusive occlusal interference is related to anterior displacement of the temporomandibular joint disc based on clinical data, and to explore the relationship between the two and the superior…

View details →DOI: 10.21203/rs.3.rs-9425170/v1
Negative / Null Result ReportOpen accessMedicine

Effects of water and fertilizer coupling on growth and development of Chinese dwarf cherry (<i>Cerasus humilis</i>) and evaluation of water and fertilizer use efficiency.

Liu S, Li Z, Chen S et al. · 2026 · Frontiers in plant science

Introduction In recent years, the demand for high-nutrition fruits has increased. As a unique fruit tree in China, Cerasus humilis has both ecological and nutritional value. Water and fertilizer nutrition is closely related to plant growth…

View details →DOI: 10.3389/fpls.2026.1841934
Negative / Null Result ReportOpen accessMedicine

Mechanical Tuning of the Cell Microenvironment Using a Biomimetic Hydrogel System for Articular Cartilage Tissue Engineering.

van Mourik M, Spierings J, Koca P et al. · 2026 · Journal of tissue engineering and regenerative medicine

Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM…

View details →DOI: 10.1155/term/9947868
Negative / Null Result ReportOpen accessMedicine

Long-Term Outcomes of Combined Phacoemulsification and Non-Penetrating Deep Sclerectomy versus Standalone Non-Penetrating Deep Sclerectomy.

Safadi K, Gutierrez Vargas GA, Cnaany Y et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To compare the efficacy and safety of combined phacoemulsification and non-penetrating deep sclerectomy (Phaco-NPDS) with standalone NPDS in a large glaucoma cohort with long-term follow-up. Methods This retrospective cohort study…

View details →DOI: 10.2147/opth.s579848
Negative / Null Result Report

Clinical Characteristics and Disease Severity Analysis of Mycoplasma pneumoniae Pneumonia in Guangxi ChildrenCarrying Drug-Resistant Genes: A Retrospective Clinical Study

Mo R, Chen J, Liu G et al. · 2026 · Preprint

Abstract ‌ Objective: ‌ To investigate the clinical characteristics of Mycoplasma pneumoniae pneumonia (MPP) in children from Guangxi carrying drug-resistant genes and to identify risk factors for predicting severe cases. ‌ Methods: ‌ A…

View details →DOI: 10.21203/rs.3.rs-10052579/v1
Negative / Null Result ReportOpen accessMedicine

Surrounding space associations affect attentional orienting and visual discrimination in frontal field.

Soret R, Charras P, Peysakhovich V · 2026 · Scientific reports

Attentional orienting is essential for the optimal processing of sensory information. In orienting studies, the visual modality related to surrounding space is often overlooked because visual cues are not directly available to individuals…

View details →DOI: 10.1038/s41598-026-39071-9
Negative / Null Result ReportMedicine

Social Media Content, Engagement, and Reliability for Infantile Hemangiomas: A Comparison Across YouTube, Instagram, and TikTok.

Rothberg SE, Barone S, Bins G et al. · 2026 · The Journal of craniofacial surgery

Background Infantile hemangiomas are a benign vascular abnormality that presents in infancy. Parents may seek a variety of resources to gather information, including social media. This study seeks to compare information on infantile…

View details →DOI: 10.1097/scs.0000000000012916
Negative / Null Result ReportOpen accessMedicine

Vonoprazan as an adjuvant to cisplatin: enhancing antitumor efficacy while mitigating nephrotoxicity and gastrointestinal adverse effects.

Alenezi FN, Abdelmageed ME, Nader MA et al. · 2026 · Frontiers in pharmacology

Background/objective Cisplatin is a popular platinum-containing chemotherapeutic agent that has been used clinically since the 1970s to manage a wide range of hematologic and solid tumors. However, its therapeutic purpose is restricted by…

View details →DOI: 10.3389/fphar.2026.1798103
Negative / Null Result ReportOpen accessMedicine

Effects of 3',4'-dihydroxyflavonol treatment on Neu N and BDNF and ICAM levels in the striatum of rats subjected to transient bilateral carotid occlusion-induced ischemia-reperfusion.

Hoşgör M, Uzdil EK, Aladag T et al. · 2026 · Journal of bioenergetics and biomembranes

Cerebral infarction is a leading cause of severe long-term disability and functional and cognitive impairment. With the advancement of acute stroke treatment, more patients are now experiencing stroke with varying degrees of impairment.…

View details →DOI: 10.1007/s10863-026-10109-x
Negative / Null Result ReportMedicine

Comparison of fibrin glue posterior fixation and omentopexy in laparoscopic sleeve gastrectomy: a propensity score-matched analysis.

Liang JL, OuYang SR, Liu ZX et al. · 2026 · Updates in surgery

Laparoscopic sleeve gastrectomy (LSG) is currently the most commonly performed weight loss surgery. Omentopexy is believed to help reduce the risk of postoperative nausea and vomiting (PONV), bleeding, gastric leakage, and gastroesophageal…

View details →DOI: 10.1007/s13304-026-02675-x
Negative / Null Result ReportOpen accessMedicine

Hemodynamic effects of high frequency oscillatory ventilation versus conventional mechanical ventilation in term neonates with persistent pulmonary hypertension: a single-center randomized trial.

El Amrousy D, Koura H, Abdou N et al. · 2026 · Italian journal of pediatrics

Background We aimed to evaluate the hemodynamics in full-term neonates with persistent pulmonary hypertension (PPH) on high frequency oscillatory ventilation (HFOV) versus conventional mechanical ventilation (CMV). Methods This trial was…

View details →DOI: 10.1186/s13052-026-02272-z
Negative / Null Result ReportMedicine

The effect of video assisted instruction on central venous catheter application skills, anxiety and satisfaction in nursing students: a randomised controlled study.

Koç G, Yüce Başaran HD, Yavuz B et al. · 2026 · BMC medical education

Objective This study aimed to evaluate the effect of video-assisted instruction on central venous catheter (CVC)-related psychomotor skills (blood collection, drug administration, and dressing care), anxiety levels, and student…

View details →DOI: 10.1186/s12909-026-09532-w
Negative / Null Result Report

Lower urinary tract symptoms are elevated with depression in Japanese male

Yamazaki M, Ninomiya S, Hashizume A et al. · 2026 · Preprint

Abstract Background About half of both men and women have lower urinary tract symptoms, and aging is reported to have a significant impact on these symptoms. Lifestyle-related diseases such as diabetes, hypertension, and metabolic syndrome…

View details →DOI: 10.21203/rs.3.rs-9310496/v1