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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21257 results · page 202 of 709

Negative / Null Result ReportMedicine

Equity of Access and Outcomes: A Comparison Between In-Area and Out-of-Area Patients Undergoing Ventricular Arrhythmia Ablation.

Sood, Turnbull, De Silva et al. · 2026 · Heart, lung & circulation

Improved patient outcomes after ventricular arrhythmia (VA) ablation procedure have been found to correlate with procedures being performed in high volume centres. Whether the concentration of expertise in experienced, urban centres…

View details →DOI: 10.1016/j.hlc.2025.12.026
Negative / Null Result ReportMedicine

Association between different onset types and clinical outcomes in patients with large ischemic stroke following endovascular therapy.

Cheng, Zhu, Xie et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

This study aimed to explore the association between different stroke onset types [unwitnessed stroke (UWS) vs. witnessed stroke (WS)] and clinical outcomes in patients with large ischemic stroke treated with endovascular therapy (EVT).…

View details →DOI: 10.1016/j.jocn.2026.112116
Negative / Null Result ReportMedicine

Does sealer extrusion influence endodontic treatment outcomes? Retrospective evidence from root-level and within-tooth analysis.

Sinsareekul, Chantarangsu, Hiran-Us · 2026 · Journal of dentistry

This retrospective study aimed to evaluate the influence of sealer extrusion on treatment outcomes using a within-tooth comparative design and to identify associated prognostic factors. A total of 126 patients who underwent nonsurgical…

View details →DOI: 10.1016/j.jdent.2026.106801
Negative / Null Result ReportMedicine

Increased or decreased numbers of CpG dinucleotide motifs in the genome of influenza A virus do not affect in vitro virus phenotype.

Susma, Spronken, van Nieuwkoop et al. · 2026 · Journal of virology

Cytosine-phosphate-guanine (CpG) dinucleotide motifs are the most underrepresented motifs in RNA virus genomes, including those of the influenza A viruses (IAV). Previous studies have indicated that increasing the number of CpG motifs in…

View details →DOI: 10.1128/jvi.00047-26
Negative / Null Result ReportMedicine

The effect of clinical bibliotherapy on self-esteem, hope and depressive symptoms among adolescents living with sickle cell disorder in Ibadan, Nigeria: a non-randomized controlled pilot study.

Adeoye, Ani, Egbokhare et al. · 2026 · Psychology, health & medicine

Sickle Cell Disorder (SCD) is a complex, multi-system blood condition affecting 7.78 million people, with 80% of global cases in sub-Saharan Africa, especially Nigeria. The condition is associated with physical health complications and…

View details →DOI: 10.1080/13548506.2026.2694730
Negative / Null Result ReportMedicine

Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice.

Kaewmanee, Ganesan, Choochana et al. · 2026 · PloS one

Phy-Blica-O (PBO) is a traditional Thai polyherbal formulation historically regarded as a brain tonic and memory enhancer. Despite its long-standing ethnomedicinal use, its neuroprotective mechanisms have not been scientifically validated.…

View details →DOI: 10.1371/journal.pone.0352429
Negative / Null Result ReportMedicine

Low muscle mass predicts poor response to neoadjuvant chemotherapy in advanced ovarian cancer.

Esmer, Hafızoğlu, Bardakçı et al. · 2026 · Journal of ovarian research

Advanced epithelial ovarian cancer (EOC) is commonly diagnosed at late stages, and despite improvements with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS), prognosis remains poor. Body composition has emerged…

View details →DOI: 10.1186/s13048-025-01960-4
Negative / Null Result ReportMedicine

Anti-complement and anticoagulant activities from the salivary glands and gut of Ctenocephalides felis felis (Siphonaptera: Pulicidae) in wild and domestic Carnivora hosts.

Rodrigues, Filho, Alves et al. · 2026 · Insect biochemistry and molecular biology

Ctenocephalides felis felis is an ectoparasite of global relevance, causing impacts at the One Health interface. The process of hematophagy depends on evolutionary adaptations, in which arthropods have evolved inhibitors of host hemostatic…

View details →DOI: 10.1016/j.ibmb.2026.104613
Negative / Null Result ReportMedicine

Species- and Processing-Dependent Variability of Ascorbic Acid in Fruits of 14 Rosa Species and its Redox Behavior toward Iron and Copper Ions.

Raal, Meos, Ainsaar et al. · 2026 · ACS omega

Ascorbic acid (AA) is a key phytochemical marker of rosehip ( Rosa spp.) fruits, but its functional behavior in complex plant matrices remains unclear. Here, we analyzed AA variability in fruits of 14 Rosa spp. (0.26-5.57% dry weight) and…

View details →DOI: 10.1021/acsomega.6c00617
Negative / Null Result ReportMedicine

High-Frequency Gastric Electrical Stimulation Selectively Remodels Nitrergic Neurons in the Gastric Antrum of Healthy Beagles.

Huang, Fu, Yang et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

The study aimed to investigate the effects and mechanisms of high-frequency short-pulse gastric electrical stimulation (GES) on gastric emptying and specific myenteric neurons of the gastric antrum in healthy beagle dogs. Four healthy…

View details →DOI: 10.1016/j.neurom.2026.04.013
Negative / Null Result ReportMedicine

Associations Between Social Determinants of Health and Cardiovascular Complications After Hand Surgery: Examining the Role of Income, Unemployment, Insurance, and Education.

Sabet, Young, Lowder et al. · 2026 · Journal of surgical orthopaedic advances

This study examines the impact of social determinants of health (SDoH) on cardiovascular complications after hand surgery, focusing on income, unemployment, insurance, and education. Using PearlDiver data (2011 - 2022), adult patients with…

Negative / Null Result ReportMedicine

Studies on the Identification of the SND Gene Family in Pinus massoniana Lamb. and the Function of PmSND4 in Secondary Cell Wall Formation.

Song, Li, Yao et al. · 2026 · Plants (Basel, Switzerland)

SND (Secondary wall-associated NAC domain) transcription factors are core regulators of secondary cell wall formation in plants. To identify key genes involved in wood formation in Pinus massoniana Lamb. and elucidate the molecular…

View details →DOI: 10.3390/plants15111684
Negative / Null Result ReportMedicine

1,8-Cineole Alleviates PA-Induced Lipid Accumulation, Oxidative Stress, and Inflammation via the TLR4/MyD88/NF-κB Signaling Pathway.

Li, Zhan, Zhang et al. · 2026 · Molecules (Basel, Switzerland)

The present study investigates the effect of 1,8-cineole on improving lipid metabolism disorder by regulating oxidative stress and inflammation via the TLR4/MyD88/NF-κB pathway. 1,8-Cineole is a monoterpene compound widely found in…

View details →DOI: 10.3390/molecules31111933
Negative / Null Result ReportMedicine

Unilateral Ankle Exoskeleton Assistance Reshapes Gait: Temporal Parameters, Load Distribution, and Inter-Limb Symmetry.

Wang, Ding, Jing et al. · 2026 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Wearable exoskeletons have shown efficacy in gait rehabilitation and locomotor enhancement. Despite much work on the physiological and biomechanical aspects of human-exoskeleton interaction, systematic investigations into how exoskeleton…

View details →DOI: 10.1109/tnsre.2026.3702885
Negative / Null Result ReportMedicine

Evaluation of the Effects of Diabetes Mellitus and Periodontitis on Alveolar Bone Radiodensity Using Hounsfield Unit Measurement and Fractal Analysis.

Acipinar, Deveci, Balel · 2026 · Journal of imaging informatics in medicine

This retrospective study aimed to evaluate the effects of diabetes mellitus and periodontitis on alveolar bone density and trabecular bone quality using cone-beam computed tomography (CBCT) and to compare fractal analysis with Hounsfield…

View details →DOI: 10.1007/s10278-026-02023-w
Negative / Null Result ReportMedicine

MALICoT: A pilot cross-sectional study analyzing the effects of power training and age on endomysium content and fiber area in the soleus muscle of adult males.

Clemen, Humbsch, Berwanger et al. · 2026 · Physiological reports

The cross-sectional Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) examined effects of athletic exercise and age on endomysium content in human soleus muscle. Forty-three clinically healthy male…

View details →DOI: 10.14814/phy2.70933
Negative / Null Result ReportMedicine

Serum free fatty acids and progression of coronary artery calcification: sex specific findings from a large U.S. cohort study.

Ramezankhani, Hadaegh, Esmaeili · 2026 · BMC cardiovascular disorders

Studies evaluating the longitudinal relationship between plasma free fatty acids (FFAs) and subclinical atherosclerosis remain limited. We investigated the prospective association between serum FFA levels and the progression of coronary…

View details →DOI: 10.1186/s12872-026-05692-1
Negative / Null Result ReportMedicine

Renin, Aldosterone, and Treatment Response to Dapagliflozin, Spironolactone, and Their Combination: An Analysis From SOGALDI-PEF.

Ferreira, Marques, Neves et al. · 2026 · JACC. Heart failure

Hypertension and heart failure with preserved ejection fraction (HFpEF) often coexist, and sodium retention is a common feature of both conditions. Renin levels are suppressed in the setting of sodium overload and may modulate the blood…

View details →DOI: 10.1016/j.jchf.2026.103111
Negative / Null Result ReportMedicine

Antifungal Potential of Bacillus spp., Streptomyces spp. and Trichoderma asperellum Against Phytopathogenic Fungi.

Seņkovs, Nikolajeva, Rubene et al. · 2026 · Pathogens (Basel, Switzerland)

The increasing demand for sustainable plant protection products has intensified interest in microbial biocontrol agents (BCAs). This study aimed to evaluate the antifungal activity of selected Streptomyces , Bacillus , and Trichoderma…

View details →DOI: 10.3390/pathogens15050458
Negative / Null Result ReportMedicine

The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial.

Schlemmer, Hammer, Fandler-Höfler et al. · 2026 · Nutrients

Background : The plant Griffonia simplicifolia is marketed as a dietary supplement; it is said to have antidepressant and sleep-promoting properties. Its main ingredient, 5-hydroxytryptophan (5-HTP), is the immediate precursor of serotonin…

View details →DOI: 10.3390/nu18101609
Negative / Null Result ReportMedicine

Clinical Strategies to Improve the Accuracy of Articulating Paper for Detecting Occlusal Contact Points in Adults with Natural Dentitions.

Rovira-Lastra, ElOtmani-Sabiri, Ustrell-Barral et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : This clinical study assessed the validity of articulating paper for detecting occlusal contacts points, including examining the effects of clinical technique, paper thickness, and the arch. Methods : This…

View details →DOI: 10.3390/diagnostics16101450
Negative / Null Result ReportMedicine

Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.

Ahmed, Nath, Jahan et al. · 2026 · International journal of environmental research and public health

Conventional anthropometric measures used to predict dyslipidemia, such as body mass index and waist circumference, vary over time and may not fully capture early-life influences on metabolic risk. Fixed skeletal proportions, including…

View details →DOI: 10.3390/ijerph23050662
Negative / Null Result ReportMedicine

Low-Volume Versus Standard-Volume Pericapsular Nerve Group Block with and Without Dexamethasone for Postoperative Analgesia After Total Hip Arthroplasty: A Randomized Controlled Trial.

Reysner, Ciftci, Alver et al. · 2026 · Journal of clinical medicine

Background: The pericapsular nerve group block provides motor-sparing analgesia after total hip arthroplasty, but the optimal injectate volume and the role of dexamethasone remain unclear. Methods: In this prospective, randomized,…

View details →DOI: 10.3390/jcm15103676
Negative / Null Result ReportMedicine

Hope for Romantic Relationships: Validation of a Brief Scale.

Marici, Marina, Cormoș · 2026 · Behavioral sciences (Basel, Switzerland)

This study aimed to develop and validate a brief measure of hope for romantic relationships (HRR), conceptualized as a future-oriented evaluation of relational continuity and quality. The sample consisted of 525 participants. Exploratory…

View details →DOI: 10.3390/bs16050775
Negative / Null Result ReportMedicine

Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.

Petrache, Boldeanu, Diaconu et al. · 2026 · Journal of clinical medicine

Background: Dental caries in children has been explored not only as a local oral condition but also in relation to potential systemic inflammatory changes. This study evaluated systemic inflammatory biomarkers and hematologic indices in…

View details →DOI: 10.3390/jcm15093558
Negative / Null Result ReportMedicine

Clinical features of biliary atresia complicated by cytomegalovirus infection and prognostic analysis after Kasai portoenterostomy.

Teng, Wenqing, Shuhao et al. · 2026 · Journal of pediatric surgery

To explore the unique clinical characteristics of biliary atresia (BA) combined with cytomegalovirus (CMV) infection and its impact on early and late prognosis after Kasai portoenterostomy (KPE). This was a retrospective study involving…

View details →DOI: 10.1016/j.jpedsurg.2026.163190