A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Zhao, Ma, Mo et al. · 2026 · Frontiers in medicine
To investigate the status of missed nursing care and examine the mediating role of calling between nursing work environment and missed nursing care. Missed nursing care (MNC) critically affects patient safety and care quality and is…
Alqannas, Taha, Abuabed et al. · 2026 · Frontiers in medicine
Mental healthcare providers (MHPs) face high burnout due to emotional demands and workload pressures. In Jordan, limited resources and public stigma may further increase occupational strain, underscoring the need to assess burnout among…
Yang, Lu · 2026 · Open medicine (Warsaw, Poland)
Portal venous gas (PVG) is commonly associated with severe gastrointestinal disease, whereas benign causes related to endoscopic procedures are uncommon. We report an unusual mechanism of PVG occurring in the setting of chronic gastric…
Lu, Bi, Gao et al. · 2026 · Frontiers in cellular and infection microbiology
Electroacupuncture (EA) serves as an effective complementary therapy in the treatment of inflammatory bowel disease (IBD) within traditional Chinese medicine, with the therapeutic efficacy significantly influenced by the selection of…
Chilundo, Xinavane, Huo et al. · 2026 · Frontiers in reproductive health
Despite national policies promoting adolescent- and youth-friendly health services, implementation gaps hinder improvements in adolescent sexual and reproductive health outcomes in Mozambique. S-NICE is a structured, participatory…
Zhou, Wang, He et al. · 2026 · JACS Au
DNA origami placement (DOP) exploits shape complementarity between DNA nanostructures and lithographically patterned binding sites to achieve precise spatial positioning, offering a promising route for integrating bottom-up self-assembly…
Boettger, Sedighi, Pallmann et al. · 2026 · Journal of the Intensive Care Society
Thyroid hormone alterations are common in critical illness and may reflect disease severity. Their prognostic significance in infarct-related cardiogenic shock remains incompletely defined. In this prospective cohort study from a…
Argaw, Jingili, Oyelere et al. · 2026 · JMIR XR and spatial computing
Anxiety-related symptoms are prevalent and can negatively affect concentration, motivation, and overall well-being. Traditional treatments such as cognitive behavioral therapy and medication work well for clinical anxiety disorders.…
Sheikh, Singh, Smith et al. · 2026 · Frontiers in cardiovascular medicine
The impact of catheter-directed thrombolysis (CDT), catheter-directed embolectomy (CDE) and surgical pulmonary embolectomy (SPE) on long term RV function among patients with acute PE remains unclear. We investigated the association of…
Elmansy, Elbqry, Qalawa et al. · 2026 · Frontiers in nutrition
Hemodialysis is a life-sustaining renal replacement therapy that removes metabolic waste products normally eliminated by the kidneys. Patients undergoing hemodialysis are required to adhere to strict fluid and dietary restrictions to…
Lin, Yu, Hu et al. · 2026 · Precision radiation oncology
The optimal management of locally advanced resectable esophageal squamous cell carcinoma (ESCC), particularly for cT3-4a disease, remains debated. This study aimed to compare the survival outcomes and toxicity profiles of neoadjuvant…
Kawakita, Hayasaka, Barake et al. · 2026 · Pregnancy (Hoboken, N.J.)
Prenatal phthalate exposure is linked to adverse reproductive and developmental outcomes and is consistently higher among non-Hispanic Black compared to non-Hispanic White pregnant individuals, yet the factors responsible for these…
Tilahun, Urge, Girma et al. · 2026 · Veterinary and animal science
The current study evaluated the effects of black cumin seed meal (BCSM) on growth performance, cecal microbiota, production efficiency, and cost efficiency in broiler chickens. A total of 144 one-day-old unsexed Cobb 500 broiler chicks…
Navidifar, Kaveh, Hosseini et al. · 2026 · Veterinary and animal science
Efficient estrus synchronization is important for improving reproductive performance in dairy herds; however, variations in ovarian activity among cows of different parities may influence responses to synchronization protocols. The present…
Naizabayev, Talgatov, Auyezkhanova et al. · 2026 · Molecules (Basel, Switzerland)
Palladium catalysts modified with chitosan (CS) and supported on MgO, SiO 2 , TiO 2 , and Al 2 O 3 were prepared by a precipitation method and evaluated in the low-temperature hydrogenation of 2-propen-1-ol. Chitosan was first deposited…
Zhou, Zhang, Wang et al. · 2026 · Molecules (Basel, Switzerland)
Recent studies indicate that ferroptosis shows unique advantages in oncotherapy, particularly in reversing multidrug resistance (MDR). Despite current therapeutic advancements, the treatment of high-incidence malignancies with dismal…
Baranowska, Kiss, Szeleszczuk · 2026 · Pharmaceutics
Dipeptidyl peptidase-4 (DPP-4) is an established therapeutic target in the treatment of type 2 diabetes mellitus (T2DM), primarily due to its role in regulating incretin activity and glucose homeostasis. Although clinically approved DPP-4…
Marín, Fuentes-Martín, Sánchez et al. · 2026 · Pharmaceutics
Background/Objectives: Microtubule-targeting agents represent a pillar of cancer chemotherapy; however, their clinical utility is constrained by significant toxicity, pharmacokinetic instability, and susceptibility to multidrug resistance…
Feroze-Bakht, Espinoza, Sosa et al. · 2026 · Pharmaceutics
Background/Objectives: Carprofen (CP) is a potent non-steroidal anti-inflammatory drug whose clinical use is limited by systemic adverse effects associated with oral administration. The aim of this study was to develop and evaluate a…
Dos Santos, Sauruk da Silva, Iacomini et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background : Ganoderma lucidum is a medicinal mushroom widely recognized for its high content of bioactive polysaccharides, particularly β-glucans with immunomodulatory properties. This study aimed to optimize polysaccharide…
Zaborska, Sobczak, Kubas et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: Distal radius fractures (DRFs) are the most common upper limb fractures worldwide. The main goal of DRF treatment is to achieve optimal functional outcomes with the lowest complication rate as rapidly as possible. Achieving…
Maffia, Marra, Battaglia et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Breast cancer remains one of the most frequently diagnosed malignancies and a leading cause of cancer-related mortality among women worldwide. The growing interest in natural bioactive compounds has highlighted plant-derived phytochemicals…
Stojanović, Burić, Kostić et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: This randomized parallel-group clinical study evaluated salivary cortisol as a biomarker of perioperative stress response during surgical extraction of impacted mandibular third molars performed under local anesthesia…
Hengirmen Acu, Erbaş · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: Methotrexate-induced oxidative stress is mechanistically linked not only to hepatocellular injury but also to DNA damage, indicating that oxidative stress, hepatotoxicity, and genotoxicity represent interconnected…
Baier, Miao, Schirrmacher et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background : Zirconium-89 ( 89 Zr) is a key PET radionuclide and the limited in vivo stability of its clinically used 89 Zr-DFO complexes has driven the pursuit of improved chelator architectures. Among these, DFO* has attracted particular…
Garner C, Sleeth D, Slagley J et al. · 2026 · American journal of disaster medicine
Objective Determine relative effectiveness of two dry air decontamination methods to reduce residual airborne surrogate biological agent on litter-bound manikin patients during disrobing. Design Fluorescent 1 µm polystyrene latex (PSL)…
Fu Y, Liu J, Sun H et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To compare the performance of copy number variation sequencing (CNV-seq) and chromosomal microarray analysis (CMA) for the analysis of abortive tissues. Methods Tissue samples were collected from 396 patients with missed abortion…
Ibrahim MG, Hassan MH, Lotfy AMM · 2026 · BMC health services research
Background Patient safety culture (PSC) is a key determinant of care quality, influencing clinical outcomes, staff functioning, and the resiliency of organizations. While PSC has evolved globally, it remains established in developing…
Akbaytürk N, Aygün T · 2026 · BMC medical education
Objective Flipped learning is a learning model in which students are active and effective. This study is a quasi-experimental study conducted using a pretest-posttest-follow-up test design with experimental and control groups to evaluate…
Sevim M, Demir M, Eryılmaz R et al. · 2026 · Urology journal
Purpose To compare outcomes of super mini percutaneous nephrolithotomy (smPCNL) with extracorporeal shock wave lithotripsy (ESWL) for stones 1-2 cm. Materials and methods After receiving ethics committee approval for this study (Date:…