Failed Experiment ReportOpen accessMedicine
Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal
Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…
View details →DOI: 10.31661/gmj.v14i.3871 Failed Experiment ReportOpen accessMedicine
Galante H, Lane SJ, Elderbrock EK et al. · 2026 · Integrative organismal biology (Oxford, England)
Organisms in natural environments often undergo life history stage transitions that optimize behaviors (i.e., migration, reproduction, and foraging) with environmental conditions. These changes in behavior are facilitated by changes in…
View details →DOI: 10.1093/iob/obag013 Failed Experiment ReportOpen accessMedicine
García MA, Aceituno A, Díaz NB et al. · 2025 · Pharmaceutics
Background/Objectives: The static in vitro permeability assay based on cell monolayers has been widely used in the pharmaceutical industry and recognized by regulatory agencies as a surrogate method for BCS classification. However, the…
View details →DOI: 10.3390/pharmaceutics17091110 Failed Experiment ReportOpen accessMedicine
Miskelly MG, Lindqvist A, Jujić A et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Statin use is associated with increased risk of type 2 diabetes (T2D) and mild hyperglycemia. The underlying mechanisms are not well studied, and the effect of statin treatment on glucagon-like peptide 1 (GLP-1) secretion or…
View details →DOI: 10.1210/clinem/dgaf608 Failed Experiment ReportOpen accessMedicine
Khasanov TA, Maleeva EE, Koshelev SG et al. · 2024 · Marine drugs
Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic…
View details →DOI: 10.3390/md22090382 Failed Experiment ReportOpen accessMedicine
Okon-Rocha E, Taylor D · 2026 · Therapeutic advances in psychopharmacology
Cariprazine is effective in a number of conditions and has shown efficacy in the treatment of negative symptoms. Data on its use as an adjunct to other antipsychotics is growing. To evaluate the effectiveness of add-on cariprazine in…
View details →DOI: 10.1177/20451253261456389 Failed Experiment Report
Jiang H, Chase J, Fu L et al. · 2025 · Preprint
This study presents a case analysis of using AI systems as co-pilots in biological research, focusing on functional protein networks in invasive colorectal cancer. We used public proteomic data alongside ChatGPT, GitHub Copilot, and…
View details →DOI: 10.1101/2025.05.14.654152 Failed Experiment ReportOpen accessMedicine
Capucci L, Di Giovanni V, Schiavitto M et al. · 2026 · Veterinary research
Rabbit haemorrhagic disease (RHD) is a highly pathogenic and contagious disease caused by RHD virus (RHDV) and RHDV type 2 (RHDV2), two distinct Lagovirus europaeus belonging to the Caliciviridae family. Serological investigations have…
View details →DOI: 10.1186/s13567-026-01774-2 Failed Experiment ReportMedicine
Mojahedi A, Goldschmidt M, Skopicki H et al. · 2025 · International journal of physiology, pathophysiology and pharmacology
Cardiac amyloidosis (CA) is a challenging acquired heart disease caused by the deposition of β-pleated amyloid proteins, often leading to nonspecific symptoms that complicate the diagnosis. This case report describes an 83-year-old male…
View details →DOI: 10.62347/zbrq1229 Failed Experiment ReportOpen accessMedicine
Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living
Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…
View details →DOI: 10.3389/fspor.2025.1601744 Failed Experiment ReportOpen accessMedicine
Graziani L, Genovese S, Genovesi ML et al. · 2025 · Molecular cytogenetics
Background Monosomy 18p (MIM: 146390) is a well-known chromosomal disorder associated with intellectual disability, short stature, and non-specific craniofacial features resulting from partial or total deletion of the short arm of…
View details →DOI: 10.1186/s13039-025-00732-5 Failed Experiment ReportMedicine
Watrobska CM, Codd J, Portugal SJ et al. · 2026 · The Journal of experimental biology
The brain is energetically expensive. Therefore, energy availability may determine whether costly cognitive processes such as long-term memory can be expressed. However, there is a limited understanding of the metabolic costs associated…
View details →DOI: 10.1242/jeb.250403 Failed Experiment ReportMedicine
Mathis S, Putzer G, Schnegg L et al. · 2026 · BMC anesthesiology
Background Intraoperative blood salvage (IBS) reduces exposure to allogeneic blood but is accompanied by concerns in oncologic surgery regarding the potential reinfusion of residual tumor cells and subsequent metastatic dissemination. The…
View details →DOI: 10.1186/s12871-026-03994-7 Failed Experiment ReportOpen accessMedicine
Mishra A, Abelman RO, Cunneely Q et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America
Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2…
View details →DOI: 10.1073/pnas.2601563123 Failed Experiment ReportMedicine
Rogachev VV, Goltyaev MV, Varlamova EG et al. · 2026 · Biochemical and biophysical research communications
This study presents a comparative evaluation of the behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles (TeNPs) obtained by laser ablation in a chronic in vivo experiment on male BALB/c mice. TeNPs…
View details →DOI: 10.1016/j.bbrc.2026.154130 Failed Experiment ReportMedicine
Wang Y, Chen Y, Wang K et al. · 2026 · Vaccines
Background/Objectives: Canine papillomavirus (CPV) is an important viral pathogen associated with papillomatosis in dogs, with canine papillomavirus type 1 (CPV1) and type 2 (CPV2) among the most prevalent and clinically relevant…
View details →DOI: 10.3390/vaccines14060512 Failed Experiment ReportMedicine
Gower JSE, Webster R, Westaway JAF et al. · 2026 · The Journal of infectious diseases
Background The zoonotic parasite Plasmodium knowlesi is an increasing cause of human malaria in Southeast Asia. We aimed to develop a P. knowlesi induced blood-stage malaria (IBSM) model to facilitate study of parasite biology, host…
View details →DOI: 10.1093/infdis/jiag225 Failed Experiment ReportMedicine
Saad R, Sekiguchi T, Takai Y et al. · 2026 · Marine environmental research
Microplastics (MPs) are ubiquitous in marine environments and readily ingested by filter-feeding organisms, yet the ecotoxicological effects of irregularly shaped MPs remain poorly understood. This study assessed the accumulation and…
View details →DOI: 10.1016/j.marenvres.2026.108135 Failed Experiment ReportMedicine
Coronado L, Muñoz-Aguilera A, Puente-Marin S et al. · 2026 · Frontiers in veterinary science
Control of classical swine fever (CSF) in endemic regions relies heavily on vaccination of breeding herds. Optimizing vaccination strategies is essential for sustainable disease control covering pigs belonging to different categories. Data…
View details →DOI: 10.3389/fvets.2026.1827278 Failed Experiment ReportOpen accessMedicine
Bolder R, King SBS, Zahn RC et al. · 2026 · Vaccines
Background/objectives RSV is a major cause of mortality in infants, and despite recent progress to prevent RSV in the very young, an RSV vaccine for this population is still highly warranted. Clinical studies in infants in the 1960s using…
View details →DOI: 10.3390/vaccines14010087 Failed Experiment Report
Noble C, Geller D, Urs N et al. · 2026 · Preprint
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become defining therapies in the management of type 2 diabetes and obesity. Despite recent interest in the effects of GLP-1RA therapy on skeletal muscle, their influence on muscle…
View details →DOI: 10.64898/2026.06.16.732451 Failed Experiment ReportOpen accessMedicine
· 2006
Semaglutide was not detectable in the milk of mothers taking the drug subcutaneously. Their breastfed infants experienced no adverse effects. Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate…
Failed Experiment ReportOpen accessMedicine
McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations
Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…
View details →DOI: 10.1097/cce.0000000000001404 Failed Experiment ReportOpen accessMedicine
Heinemann FM, Hallensleben M, Althaus K et al. · 2026 · HLA
Single antigen (SA) tests are indispensable for an accurate HLA antibody identification in sera of transplant patients. Three commercial tests using purified single antigens combined with microbead or microarray technology are currently…
View details →DOI: 10.1111/tan.70734 Failed Experiment ReportMedicine
Zheng J, Wu M, Wang X et al. · 2026 · Cells
Prime editing (PE) is a precise genome-editing technology that avoids double-strand breaks, holding great promise for clinical and agricultural applications. However, its genome-wide off-target effects are not fully understood, raising…
View details →DOI: 10.3390/cells15050438 Failed Experiment ReportOpen accessMedicine
Ghareeb SM, Abd-Elkareem M, Abou-Elmagd A · 2026 · Biological research
Salvadora persica (miswak) has many useful biological activities. Some studies have reported that miswak can be used as a contraceptive agent. However, no available investigations explain the histomorphological structure of ovarian…
View details →DOI: 10.1186/s40659-026-00711-z Failed Experiment ReportMedicine
Li X, Yan B, Zhao B et al. · 2026 · Cognition & emotion
This study investigated whether verbal humour could preventively regulate negative emotions in high trait anxiety (HTA) and low trait anxiety (LTA) individuals, exploring underlying cognitive neural mechanisms using ERPs and ERO. In a…
View details →DOI: 10.1080/02699931.2026.2683598 Failed Experiment ReportMedicine
Washino T, Nikaido T, Burrow MF et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology
Background/aims Adhesive procedures performed after dental trauma are often carried out in emergency settings with compromised isolation due to bleeding, limited access, and patient cooperation. This study evaluated how variation in…
View details →DOI: 10.1111/edt.70087 Failed Experiment ReportOpen accessMedicine
Znazen Y, Gaddes M, Janssens GPJ et al. · 2026 · Animals : an open access journal from MDPI
This study evaluated the effects of locally sourced ingredient dietary, with or without supplementation of black soldier fly ( Hermetia illucens ; BSF) larvae, on laying hen welfare. A total of 150 Lohman White hens aged 30 weeks were…
View details →DOI: 10.3390/ani16111724 Failed Experiment ReportOpen accessMedicine
Fouad S, Abass M, Rizk A et al. · 2026 · Scientific reports
Epidural fibrosis (EF) refers to the non-physiological scar formation at the site where a surgical incision is made to access the spinal canal. This condition often results in functional disability and pain following spinal surgery and is…
View details →DOI: 10.1038/s41598-026-54270-0 