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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,381Computer Science 766Biochemistry, Genetics and Molecular Biology 478Psychology 327Social Sciences 326Physics 280Neuroscience 270Economics, Econometrics and Finance 223Environmental Science 194Agricultural and Biological Sciences 164Mathematics 163Engineering 158

20227 results in Negative / Null Result Report · page 193 of 675

Negative / Null Result ReportMedicine

In Vitro Effects of 0.05% Cetylpyridinium Chloride and 1% Povidone Iodine on Flexural Strength of Nickel-titanium Orthodontic Wires :

Mohammadian, Ghiasi, Soleimani · 2025 · Galen medical journal

This study assessed the effects of 0.05% cetylpyridinium chloride (CPC) and 1% povidone iodine (PI) on flexural strength of nickel-titanium (NiTi) orthodontic wires. In this in vitro, experimental study, 27 pieces of NiTi orthodontic wires…

View details →DOI: 10.31661/gmj.v14isp1.3969
Negative / Null Result ReportMedicine

Seasonal Drought Reduces Carbon Sequestration in Coastal Wetlands.

Jia, Han, Macreadie et al. · 2026 · Global change biology

Coastal wetlands represent one of the most intensive carbon sinks, and the stability of their soil carbon reserves is critical to the global carbon balance. While existing studies have predominantly focused on the effects of changes in…

View details →DOI: 10.1111/gcb.70865
Negative / Null Result ReportMedicine

Comorbidity Burden and Length of Stay After Myocardial Infarction: A Retrospective Study Using Large Language Model-Assisted Chart Abstraction in a Tertiary Cardiac Hospital.

Lim, Chin, Chee et al. · 2026 · The American journal of cardiology

Patients' length of stay (LOS) during admission for myocardial infarction (MI) represents a closely tracked outcome metric for Cardiology services, which has declined over time. Charlson Comorbidity Index (CCI) is a validated tool for…

View details →DOI: 10.1016/j.amjcard.2026.04.019
Negative / Null Result ReportMedicine

Limited involvement of MMP2, MMP9 and MMP14 in vasculogenic mimicry formation of human tumor cell lines.

Yoshida, Fukuoka, Kawahara et al. · 2026 · Biochimica et biophysica acta. General subjects

Vasculogenic mimicry (VM) is a phenomenon in which tumor cells form capillary-like networks without endothelial cells and is associated with tumor progression and poor prognosis. Understanding mechanisms of VM and identifying its reliable…

View details →DOI: 10.1016/j.bbagen.2026.130954
Negative / Null Result ReportMedicine

Hypolipidemics reduce the rate of Alzheimer's disease development and dementia progression: A cohort study linked with genetic and neuropathological analyses.

Sternberg, Podolsky, Yu et al. · 2026 · The journal of prevention of Alzheimer's disease

High cholesterol contributes to the development and progression of dementia due to both Alzheimer's disease (A.D.) and vascular pathology. However, the effects of lipid-lowering regimen (LLR) on cognitive dysfunction and brain…

View details →DOI: 10.1016/j.tjpad.2026.100555
Negative / Null Result ReportMedicine

Effects of sex, residential area, and age on the seasonality of insomnia-related symptoms: a detailed re-analysis of the longitudinal data of Japanese community residents.

Kizuki, Kaneko, Taniguchi et al. · 2026 · Sleep and biological rhythms

We previously found that seasonal changes in sleep duration were affected by sex, residential area, and age in Japanese community residents. This study aimed to determine whether these factors also affect the seasonality of…

View details →DOI: 10.1007/s41105-025-00621-9
Negative / Null Result ReportMedicine

Treatment of Persisting Symptoms after Concussion with Repetitive Transcranial Magnetic Stimulation: A Double-Blinded, Randomized, Controlled Trial.

Campbell, Wilson, Du Plessis et al. · 2026 · Journal of neurotrauma

Following a mild traumatic brain injury (mTBI), up to 30% of individuals will experience persisting symptoms beyond 3 months. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that has shown…

View details →DOI: 10.1177/08977151261440773
Negative / Null Result ReportMedicine

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.

Antoniou, Yang, Juurlink et al. · 2026 · Clinical pharmacology and therapeutics

Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co-administration with CYP3A4-inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the…

View details →DOI: 10.1002/cpt.70267
Negative / Null Result ReportMedicine

Cerebellar Volumes Are Smaller in Veterans with PTSD and a History of Mild Traumatic Brain Injury, but Not Mild Traumatic Brain Injury Alone.

Huggins, Martinez, Baird et al. · 2026 · Journal of neurotrauma

Mild traumatic brain injury (mTBI), a common health burden among combat veterans, has been associated with alterations in brain structure. Moreover, post-traumatic stress disorder (PTSD), frequently comorbid with mTBI, is linked to smaller…

View details →DOI: 10.1177/08977151261438986
Negative / Null Result ReportMedicine

Development of Synostosis and Determination of the Risk Factors After Surgical Treatment of Ankle Fracture-Dislocations.

Yigitbay, Kural, Tanrıverdi et al. · 2026 · Foot & ankle specialist

ObjectiveThis study aimed to identify the possible risk factors for the development of partial bridging and synostosis in the distal tibiofibular joint following surgically treated ankle fracture-dislocations and to examine the effects of…

View details →DOI: 10.1177/19386400261426837
Negative / Null Result ReportMedicine

Effects of polypropylene micro- and nanoplastics from surgical masks in amphibian and echinoderm models.

Bacchetta, Vacchelli, Pica et al. · 2026 · Ecotoxicology (London, England)

Micro- and nanoplastic toxicity is a growing environmental concern, especially in aquatic ecosystems. This study investigates the acute and chronic effects of polypropylene microfibers (PP MFs), derived from artificially aged surgical face…

View details →DOI: 10.1007/s10646-026-03077-w
Negative / Null Result ReportMedicine

Effectiveness and safety of superselective ophthalmic artery thrombolysis beyond 24h in central retinal artery occlusion.

Zhang, Li, Liao et al. · 2026 · International journal of ophthalmology

To evaluate the effectiveness and safety of superselective ophthalmic artery thrombolysis (SOAT) for central retinal artery occlusion (CRAO) beyond 24h after onset. This was a retrospective cohort study of CRAO patients treated from…

View details →DOI: 10.18240/ijo.2026.04.11
Negative / Null Result ReportMedicine

Microbial-chemical synergy in the immobilization of cadmium in contaminated floodplain soils: A field-mesocosm assessment of Sporosarcina pasteurii and SiO₂ nanoparticles.

Han, Wang, Shang et al. · 2026 · Journal of hazardous materials

Cadmium (Cd) accumulation in river floodplains is threatening grain safety and agro-ecosystem sustainability. We conducted a 10-month field-mesocosm experiment to evaluate the effectiveness, side effects and underlying mechanisms of three…

View details →DOI: 10.1016/j.jhazmat.2026.141870
Negative / Null Result ReportMedicine

A web-based prognostic nomogram incorporating VETC-associated imaging markers for predicting postoperative recurrence in hepatocellular carcinoma.

Zhao, Xie, Yu et al. · 2026 · BMC cancer

BACKGROUND: Vessels that encapsulate tumor clusters (VETC) is a powerful predictor of aggressive hepatocellular carcinoma (HCC) and associated with poor outcomes of HCC. Imaging surrogates of VETC potentially help predict postsurgical…

View details →DOI: 10.1186/s12885-026-15895-6
Negative / Null Result ReportMedicine

Dual Inhibition of GSK3 and JAK by BIO Suppresses Osteoblast Differentiation and Mineralization of Human Mesenchymal Cells.

Almuraikhi, Alkhamees, Tareen et al. · 2026 · Current issues in molecular biology

Glycogen synthase kinase-3 (GSK3) inhibition is a commonly used approach to promote osteogenic differentiation through activation of Wnt signaling. However, 6-bromoindirubin-3'-oxime (BIO), which is commonly used for GSK3 inhibition, also…

View details →DOI: 10.3390/cimb48030316
Negative / Null Result ReportMedicine

Serum anti-PLA2R negativity does not exclude glomerular PLA2R expression in primary membranous nephropathy.

Yıldırım Ş, İnci A, Karaduru Avcı A et al. · 2026 · Biomolecules & biomedicine

Primary membranous nephropathy (pMN) is a principal cause of nephrotic syndrome in adults. The identification of the M-type phospholipase A2 receptor (PLA2R) antigen has significantly advanced non-invasive management; however, the precise…

View details →DOI: 10.17305/bb.2026.14167
Negative / Null Result ReportMedicine

Multimodal perioperative monitoring of intracranial pressure surrogates and cerebral oxygenation during laparoscopic surgery: implications for early cognitive outcomes.

Aba O, Yalçın Sezen G, Ersoy Karka O · 2026 · BMC anesthesiology

Purpose This study aimed to evaluate perioperative changes in optic nerve sheath diameter (ONSD) and regional cerebral oxygen saturation (rSO₂) using noninvasive monitoring techniques during laparoscopic abdominal surgery, and to assess…

View details →DOI: 10.1186/s12871-026-03978-7
Negative / Null Result ReportMedicine

The relationship between health literacy and preoperative anxiety among surgical patients: A cross-sectional survey study.

Çetinkaya F, Uslu E · 2026 · Journal of perioperative practice

Objective This study aimed to determine whether there is a relationship between patients' health literacy levels and their preoperative anxiety during the preoperative period. Design An analytical cross-sectional study. Methods The…

View details →DOI: 10.1177/17504589261441562
Negative / Null Result ReportOpen accessMedicine

Correlation between anterior teeth retraction and pharyngeal airway dimension changes in bimaxillary protrusion cases.

Sugiarta AP, Anggani HS, Purbiati M · 2025 · Journal of orthodontic science

Objective This study aims to demonstrate the correlation between anterior tooth retraction and changes in the dimensions of the pharyngeal airway in cases of bimaxillary protrusion. Materials and methods Changes in dental parameters and…

View details →DOI: 10.4103/jos.jos_23_25