A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20227 results in Negative / Null Result Report · page 192 of 675
Senoo K · 2025 · Journal of cardiovascular electrophysiology
Atrial fibrillation (AF) is the most common sustained arrhythmia and raises ischemic stroke risk fivefold, even when asymptomatic. Early detection and timely initiation of oral anticoagulation can significantly reduce stroke incidence,…
Patel A, Esencan E, Lakhani Z et al. · 2026 · F&S reports
Objective To report an adult case of XX/XY chimera resulting from in vitro fertilization with transfer of three embryos, that was discovered with preconception genetic carrier screening. Design Case report. Subject A 33-year-old…
Phommasone K, Souksakhone C, Chanthongthip A et al. · 2025 · PloS one
Background Lao PDR reported a low number of confirmed SARS-CoV-2 cases until the introduction of COVID-19 vaccines in April 2021. This raised doubts about whether the reported number reflected the true situation and questioned about…
Carrillo Lizarazo JL, Cecchin D, Camozzi V et al. · 2025 · BJS open
Background Accurate preoperative localization is essential for successful, focused, minimally invasive surgery in primary hyperparathyroidism (PHPT). New imaging techniques have recently been proposed. This study evaluated the impact of…
D’Amario A, Ambrosini R, Gullino A et al. · 2025 · Preprint
Background: Ovarian cancer is a leading gynecological malignancy with high global mortality. Early and accurate diagnosis is essential for effective management, yet many ovarian masses remain indeterminate after initial assessment.…
Wang L, Xue C, Zhu B et al. · 2026 · Journal of nutritional science and vitaminology
Data regarding to how serum 25 hydroxyvitamin D (25(OH)D) levels affect muscle mass and function in end-stage renal disease (ESRD) patients have led to inconclusive results. The main goal of this research was to examine the relationship…
Kiala Z, Petra S, Andarcia MG · 2026 · Preprint
Abstract Irrigated agriculture accounts for nearly 70% of global freshwater withdrawals, yet monitoring consumptive water use at field scale remains challenging in fragmented smallholder systems. FAO’s WaPOR database provides global…
Maffezzoli M, Nagpal R, Elewaily M et al. · 2025 · Current oncology reports
PURPOSE OF REVIEW: Adjuvant immunotherapy has improved outcomes in several cancers, although patient selection and toxicity remain challenges. Circulating tumor DNA (ctDNA) has emerged as a biomarker for minimal residual disease (MRD)…
Viderman D, Kalikanov S, Mazhibiyeva A et al. · 2026 · Frontiers in pain research (Lausanne, Switzerland)
Background and objectives Chronic knee pain is highly prevalent in various knee diseases. It significantly decreases patients' quality of life. Among non-surgical interventions, exercise is considered a promising approach for alleviating…
Planello AC, Loureiro T, Alencar-Cupertino D et al. · 2025 · Revista da Associacao Medica Brasileira (1992)
Objective This study aimed to evaluate whether the increased use of exome sequencing as a primary next-generation sequencing test provides a higher diagnostic yield compared to multi-gene panels for various clinical indications within a…
Mansikkaniemi L, Stewart JA, Sinisalo J et al. · 2025 · Scandinavian cardiovascular journal : SCJ
Background. Invasive coronary angiography (ICA) is the gold standard in evaluating stent patency after percutaneous coronary intervention (PCI), but it carries a risk of potentially life-threatening complications. Third-generation coronary…
Naim S, Sraidi S, Salam S et al. · 2025 · Clinical case reports
We present a rare case of bone metastatic Neuroblastoma without a diagnosis of an identifiable primary lesion in a 16-year-old patient who presented with intermittent right knee pain and soft tissue swelling for 7 months. Initial…
Sabatini P, Zhang T, Boruvka N et al. · 2025 · American journal of clinical pathology
Objective Somatic hypermutation at immunoglobulin heavy chain variable (IGHV) genes, an established prognostic and predictive biomarker for chronic lymphocytic leukemia (CLL), is assessed by gene sequencing. We developed a single…
Holopainen A, Verhage ML, Schuengel C et al. · 2025 · Journal of reproductive and infant psychology
Background Fear of childbirth and negative birth experiences have suggested to been associated with parenting behaviour and thereby indirectly with child outcomes. The current study contributes to this knowledge by investigating fear of…
Young RP, Ward RC, Scott RJ et al. · 2025 · Annals of the American Thoracic Society
Rationale: Current eligibility criteria for lung cancer (LC) screening are derived from randomized controlled trials and largely based on age and smoking history. However, the individualized benefits of screening are highly variable and…
Garabedian C, Girault A · 2025 · Journal of gynecology obstetrics and human reproduction
Fetal monitoring during labor is crucial for detecting potential hypoxic situations that could lead to severe outcomes like cerebral palsy or peripartum death. The current standard, fetal heart rate (FHR) monitoring, is subjective and…
Racano E, Spinelli C, Sacco G et al. · 2026 · Scientific reports
Early detection and documentation of anterior segment opacities in infants (aged 1–6 months) is limited by resource constraints and specialist availability. This study aimed to evaluate the usefulness of digital infrared reflex testing…
Shah KV, Jung C, Talian D et al. · 2025 · OTO open
Objective While the etiology of Meniere's disease (MD) is likely multifactorial, genetics are thought to play a role. Several previous studies have yielded inconclusive results, potentially due to phenotypic uncertainty and variable…
Nguyen MD, Park D, Scott JW et al. · 2026 · Science advances
Landau predicted that transverse sound propagates in a Fermi liquid with sufficiently strong interactions such as for liquid 3 He, unlike a classical fluid that cannot support shear oscillations. Previous attempts to observe this unique…
Gay A, Laudet F, Meynard P et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Introduction Infection is a significant and challenging complication of total hip and knee arthroplasties. Diagnosing chronic periprosthetic joint infection (PJI) can be difficult, particularly when joint aspiration yields inconclusive…
Payton C, Kvaratskhelia N, Chalfin M et al. · 2025 · Journal of immigrant and minority health
Cancer screening can detect cancer at an early stage and decrease cancer morbidity and mortality. Refugee populations may have had limited access to cancer screening before arrival in the United States. A cross-sectional analysis of…
Kaseb A, Benider H, Treglia G et al. · 2025 · European journal of clinical investigation
Background 4D-CT has garnered attention as complementary imaging for patients with primary hyperparathyroidism (pHPT). Herein we evaluated a diagnostic strategy using [ 18 F]Fluorocholine Positron Emission Tomography/Computed Tomography…
Kuyucu M, Erdogan KM, Adiyaman D et al. · 2025 · Medicine
This study shares our 5-year experience with chorionic villus sampling (CVS) and analyzes the indications, results, and complications of this procedure. We conducted a retrospective analysis of data from singleton pregnancies that…
Ramasindrazana B, Rahalison ZA, Gauthier P et al. · 2025 · PLoS neglected tropical diseases
Background The plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and…
Espada-Musitu D, Manero-Azua Á, Vado Y et al. · 2025 · Anales de pediatria
Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. While exome sequencing and genome sequencing were until…
Paracino R, De Domenico P, Ricciuti RA et al. · 2025 · Surgical neurology international
Background Idiopathic normal pressure hydrocephalus (iNPH) is a benign neurologic condition with treatment response rates ranging only between 30 and 50%. Several studies have attempted to identify clinical or radiological predictive…
Pelegrín-Mateo FJ, Zambrano CB, Vázquez EB et al. · 2025 · European journal of internal medicine
Cancer-associated thrombosis (CAT) remains a leading cause of morbidity and mortality among oncology patients, with an incidence influenced by tumor type, stage, treatment, and molecular characteristics. This review explores the molecular…
Datta A, Katyayan I, Das KK et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Parent Artery Occlusion (PAO) is a valid treatment choice in giant internal carotid artery (ICA) aneurysms of the cavernous segment when the preoperative balloon test occlusion (BTO) demonstrates an adequate cross circulation from the…
Stahlmann K, Reitsma JB, Zapf A · 2023 · Statistical methods in medical research
Most diagnostic studies exclude missing values and inconclusive results from the analysis or apply simple methods resulting in biased accuracy estimates. This may be due to the lack of availability or awareness of appropriate methods. This…
Saber Tanha A, Hosseini S, Soltani E et al. · 2025 · Clinical nuclear medicine
Abstract A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99m Tc-MDP uptake in her right ovary. Extensive literature review suggested various malignant…