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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 189 of 675

Negative / Null Result ReportMedicine

Excessive biomass retention decouples ammonia-oxidizer abundance and activity in sidestream partial nitritation.

Yang J, Zhu D, Liu R et al. · 2026 · Bioresource technology

Partial nitritation (PN) underpins two-stage anaerobic ammonium oxidation-based nitrogen removal, but biomass management in sidestream PN reactors remains largely empirical. This study tested three PN sequencing batch reactors maintained…

View details →DOI: 10.1016/j.biortech.2026.135208
Negative / Null Result ReportOpen accessMedicine

Effect of two commercial energy drinks on enamel surface characteristics and orthodontic bracket shear bond strength: an in vitro study.

Ashraf A, Shamel M, Massieh C et al. · 2026 · BMC oral health

Background Energy drinks are acidic beverages with recognized erosive potential, but their effect on enamel characteristics relevant to orthodontic bonding remains incompletely described. This in vitro study evaluated the effect of…

View details →DOI: 10.1186/s12903-026-08708-6
Negative / Null Result ReportMedicine

Liquid Chromatography-High-Resolution Mass Spectrometric Determination of Nitrite Ion Concentration in the Natural Water Resources.

Ganji SK, Talari K, Maloth RK et al. · 2026 · Rapid communications in mass spectrometry : RCM

Rationale Nitrite anion is among the highly reactive anions and converts the secondary amines to their corresponding carcinogenic N-nitroso metabolites in the human body. Nitrite ion is highly abundant in natural waters and enters the body…

View details →DOI: 10.1002/rcm.70101
Negative / Null Result ReportMedicine

Exploratory comparative analysis of automated morphologic and perfusion features derived from one-stop computed tomography angiography and computed tomography perfusion in large unruptured intracranial aneurysms.

Niu J, Huang W, Zou J · 2026 · Clinical neurology and neurosurgery

Purpose To compare rupture-related signals captured by automatically extracted computed tomography angiography (CTA) morphologic features and threshold-based computed tomography perfusion (CTP) metrics in large unruptured intracranial…

View details →DOI: 10.1016/j.clineuro.2026.109547
Negative / Null Result ReportMedicine

Cinnamon-loaded PVA/gelatin/starch electrospun fibers as novel sustainable nanocomposites for active food packaging.

Vencato AA, Juchem ALM, Clerici NJ et al. · 2026 · International journal of biological macromolecules

This study produced six formulations using polyvinyl alcohol (PVA) blended with gelatin or gelatin-starch, incorporating cinnamon powder (CP) or cinnamon essential oil (CEO). Homogeneous nanofibers with diameters ranging from 367 to 532 nm…

View details →DOI: 10.1016/j.ijbiomac.2026.153149
Negative / Null Result ReportMedicine

Maxillo-mandibular changes after maxillary skeletal expansion according to skeletal subtype: a retrospective cohort study.

Park KW, Kim HY, Kim KA et al. · 2026 · European journal of orthodontics

Objective We aimed to evaluate three-dimensional (3D) maxillary displacement and secondary mandibular changes following miniscrew-assisted rapid palatal expansion (MARPE) according to pretreatment skeletal subtypes, based on the…

View details →DOI: 10.1093/ejo/cjag045
Negative / Null Result ReportMedicine

Discriminative Ability of TyG, TyG-WC, BAI, FGIR, and QUICKI Indexes in Identifying Metabolic Syndrome in a Pediatric Population with Obesity.

Tamini S, Bondesan A, Caroli D et al. · 2026 · Metabolites

Background/Objectives : Pediatric obesity is closely associated with metabolic syndrome (MetS), a condition linked to increased cardiometabolic risk. Early identification of high-risk individuals remains challenging. This study aimed to…

View details →DOI: 10.3390/metabo16060415
Negative / Null Result Report

Microbial succession in West African secondary forests: rapid internal stabilisation without convergence toward old-growth reference states

Ebou AET, Amani BH, Toure GT et al. · 2026 · Preprint

Secondary forest succession following agricultural abandonment is a dominant land-use transition across the tropics, yet whether soil microbial communities recover toward old-growth forest reference states remains poorly understood,…

View details →DOI: 10.64898/2026.06.19.733386
Negative / Null Result ReportOpen accessMedicine

Identification and multi-layered validation of seven diagnostic biomarkers for dilated cardiomyopathy via integrative machine learning, single-cell transcriptomics, and Mendelian randomization.

Li J, Song Z, Wang G et al. · 2026 · Frontiers in cell and developmental biology

Background Dilated cardiomyopathy (DCM) is the most common non-ischemic cardiomyopathy and a major cause of heart failure, but disease-specific molecular biomarkers remain limited. This study aimed to identify and prioritize tissue-level,…

View details →DOI: 10.3389/fcell.2026.1851275
Negative / Null Result Report

Predictive value of perioperative hypothermia for postoperative muscular calf vein thrombosis after total knee arthroplasty: a retrospective cohort study

li j, Chen Y, Chen Y et al. · 2026 · Preprint

Abstract Objective To investigate the association between perioperative hypothermia and postoperative muscular calf vein thrombosis (MCVT) in patients undergoing total knee arthroplasty (TKA), and to evaluate the predictive performance of…

View details →DOI: 10.21203/rs.3.rs-9873445/v1
Negative / Null Result ReportMedicine

CT-Derived Radiomic Features for the Non-Invasive Differentiation of Mediastinal Lymphadenopathy in Lung Cancer and Sarcoidosis.

Doğan D, Öksüz C, Çakır Ö et al. · 2026 · Biomedicines

Background/Objectives: Differentiating mediastinal lymphadenopathy associated with lung cancer from sarcoidosis remains a clinical challenge because of overlapping imaging findings. This study evaluated whether CT-derived radiomic…

View details →DOI: 10.3390/biomedicines14061327
Negative / Null Result ReportOpen accessMedicine

Non-Essential Element-Based Nanoparticles in Rice: Unraveling the Impacts of Yttrium Oxide and Zirconium Oxide Nanoparticles on Root Accumulation and Antioxidant Responses.

Xie B, Rui Y · 2026 · Plants (Basel, Switzerland)

Nanotechnology has attracted increasing attention in agricultural and environmental research, but the biological effects and potential risks of nanoparticles based on non-essential elements remain insufficiently understood. This study…

View details →DOI: 10.3390/plants15111727
Negative / Null Result ReportMedicine

Comparative Effects of Experimental Bioactive Glasses on Dentin Permeability and Tubule Occlusion In Vitro.

Destro JM, Reis BO, Chrisostomo DA et al. · 2026 · Journal of functional biomaterials

This study aimed to evaluate the effects of experimental bioactive glass solutions on dentinal fluid flow and hydraulic conductance in vitro. Dentin blocks of 50 bovine incisors were divided into 5 groups according to the desensitizing…

View details →DOI: 10.3390/jfb17060302
Negative / Null Result ReportMedicine

Current comorbid psychiatric symptoms in the statistical indirect association between childhood attention-deficit/hyperactivity disorder symptoms and functional impairment among university students.

Koyuncu Z, Evcil FY, Kilimci ÖS et al. · 2026 · BMC psychiatry

Objective This study investigated whether current comorbid psychiatric symptoms were involved in statistical indirect associations between childhood attention-deficit/hyperactivity disorder (ADHD) symptoms (CAS) and functional impairment…

View details →DOI: 10.1186/s12888-026-08299-0
Negative / Null Result Report

Development and Validation of Machine Learning Models for Predicting Initiation of Emergency Dialysis in Advanced Chronic Kidney Disease

Hirano K, Seki T, Watanabe A et al. · 2026 · Preprint

Background Initiation of emergency dialysis, often requiring temporary catheter owing to unprepared definitive vascular access, is associated with infectious and vascular complications and suggests advanced chronic kidney disease (CKD)…

View details →DOI: 10.64898/2026.06.21.26356128
Negative / Null Result ReportMedicine

In vivo Administration of Atorvastatin Does Not Impair Mitochondrial Function or Cellular Viability in the Prefrontal Cortex of Mice.

Gessler KB, Rescaroli J, Pires SM et al. · 2026 · Neurotoxicity research

Atorvastatin is a widely prescribed statin used for its cholesterol-lowering effects; however, it also exerts known pleiotropic effects, including antioxidant and anti-inflammatory properties. Atorvastatin´s impact on mitochondrial…

View details →DOI: 10.1007/s12640-026-00805-2
Negative / Null Result Report

High Concordance in Molecular Profiles Between Primary Tumors and Matched Lymph Node Metastases in Differentiated Thyroid Carcinoma: Implications for Clinical Sample Selection

Pan Y, Sun Y, Shi C et al. · 2026 · Preprint

Abstract Genetic testing guides personalized management of differentiated thyroid carcinoma (DTC). However, tumor heterogeneity, including spatial and temporal heterogeneity, has created an unresolved clinical problem. It remains unclear…

View details →DOI: 10.21203/rs.3.rs-9922971/v1
Negative / Null Result ReportMedicine

Influence of inhalation exposure to biogenic volatile organic compounds from Syringa oblata flowers on behavior, spatial working memory, and hematological parameters in mice.

Tuo Y, Yang S, Dai X et al. · 2026 · Journal of ethnopharmacology

Ethnopharmacological relevance Syringa oblata Lindl. emits a variety of biogenic volatile organic compounds (BVOCs) during full bloom, which forms the key chemical basis for its characteristic floral scent. Species of the genus Syringa…

View details →DOI: 10.1016/j.jep.2026.122022
Negative / Null Result ReportMedicine

Exploring Emotional Abuse, Physical Abuse and Mobile Phone Dependence in Left- and Non-Left-Behind Adolescents: Roles of Self-Esteem, Social Anxiety, and Loneliness.

Zhen B, Yang X, Yao B · 2026 · Scandinavian journal of psychology

Child abuse has been significantly associated with children's mobile phone dependence (MPD), particularly in left-behind children (LBC). However, whether distinct forms of child abuse (physical and emotional) are associated with MPD in LBC…

View details →DOI: 10.1111/sjop.70119
Negative / Null Result ReportMedicine

Ethosomal nanocarrier encapsulating curcumin for antimicrobial photodynamic therapy: efficacy analysis against mature Streptococcus mutans biofilm.

Partoazar A, Shahabi S, Afrasiabi S · 2026 · BMC oral health

Background Biofilms contribute to the dental calculus formation, which in turn deteriorates oral and systemic health. The use of antimicrobial photodynamic therapy (PDT) may be limited by problems with photosensitizer penetration. In…

View details →DOI: 10.1186/s12903-026-09022-x
Negative / Null Result ReportMedicine

Too Old for PESI?: Risk Stratification of Octogenarians with Pulmonary Embolism in the Emergency Department.

Lipa AJ, Janata-Schwatczek K, Sterz M et al. · 2026 · Seminars in thrombosis and hemostasis

Pulmonary embolism (PE) in octogenarians (i.e., patients > 80 years) is associated with substantial morbidity and mortality, yet this population remains underrepresented in major studies. We compared the predictive performance of the…

View details →DOI: 10.1055/a-2896-8297
Negative / Null Result ReportMedicine

Plasma protein biomarkers for early risk prediction of colorectal cancer.

Chen W, Ge X, Hu C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Prospective studies are necessary to determine the association between circulating proteins and colorectal cancer (CRC) risk, offering non-invasive biomarkers for early CRC risk prediction and interventions. The Olink Explore-3072 platform…

View details →DOI: 10.1158/1055-9965.epi-26-0341