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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19820 results in Negative / Null Result Report · page 184 of 661

Negative / Null Result ReportMedicine

Gastric ultrasound reveals no association between prolonged fasting duration and gastric residual volume in pediatric patients.

Wu, Liu, Wang et al. · 2026 · Scientific reports

Prolonged preoperative fasting is common in pediatric anesthesia, yet its effect on gastric residual volume (GRV) remains inadequately explored. We conducted a prospective cross-sectional study to examine the association between prolonged…

View details →DOI: 10.1038/s41598-026-57602-2
Negative / Null Result ReportMedicine

Comparison between adherence to recurrence prevention recommendations, the anti-inflammatory diet, and the planetary health diet among breast cancer survivors.

Costa de Oliveira, Caminha Souza, Cândido Alves et al. · 2026 · Clinical nutrition ESPEN

Breast cancer remains a critical global public health concern, with diet representing one of the primary modifiable lifestyle factors influencing both disease prevention and the risk of recurrence. This study aimed to evaluate the…

View details →DOI: 10.1016/j.clnesp.2026.103441
Negative / Null Result ReportMedicine

Exertional leg pain is associated with ıncreased disease activity and musculoskeletal ınvolvement, but not MEFV genotype, in familial Mediterranean fever.

Ösken, Çetin · 2026 · Irish journal of medical science

Familial Mediterranean fever (FMF) is characterized by recurrent inflammatory attacks and marked clinical heterogeneity. Exertional leg pain (ELP) is a common but underrecognized manifestation. We aimed to evaluate the association of ELP…

View details →DOI: 10.1007/s11845-026-04511-y
Negative / Null Result ReportMedicine

Magnetocardiography to screen adults with arrhythmogenic cardiomyopathy: A feasibility study.

Friese, Wunderl, Jensch et al. · 2026 · American heart journal plus : cardiology research and practice

Arrhythmogenic cardiomyopathy (ACM) is a primary cardiomyopathy associated with mechanical and electrical dysfunction, making diagnosis a clinical challenge. This feasibility study investigates whether Optically Pumped Magnetometer…

View details →DOI: 10.1016/j.ahjo.2026.100813
Negative / Null Result ReportMedicine

Comparison of CO 2 Laser and Microdebrider in the Surgical Treatment of Pediatric Recurrent Respiratory Papillomatosis: A Retrospective Analysis.

Yerkezhan, Sagandykova, Baurzhan et al. · 2026 · Bioengineering (Basel, Switzerland)

Background . Recurrent respiratory papillomatosis (RRP) in children remains a pressing issue in pediatric otolaryngology, characterized by a chronic course, frequent relapses, and the need for repeat surgical interventions. The aim of this…

View details →DOI: 10.3390/bioengineering13060713
Negative / Null Result ReportMedicine

The Relationship of Vaginal Symptoms and Cervical Inflammation Severity with Cytological Abnormalities and HPV Positivity: A Prospective Observational Study.

Tigli, Deniz, Taskin et al. · 2026 · Biomedicines

Background/Objectives : This study aimed to evaluate the association between the clinical parameters of vaginal infection-specifically the presence, type, number of concurrent symptoms, and recurrence frequency-and cervical cytology…

View details →DOI: 10.3390/biomedicines14061384
Negative / Null Result ReportMedicine

Association of pretransplant pulmonary hypertension with posttransplant renal Doppler ultrasonography findings and biopsy-proven rejection.

Yagdiran, Kirisci, Uslu et al. · 2026 · BMC nephrology

Pulmonary hypertension (PH) is a complex systemic disease. There are insufficient studies in the literature regarding its effect on renal hemodynamics following transplantation. This retrospective cohort study included 244 kidney…

View details →DOI: 10.1186/s12882-026-05156-w
Negative / Null Result ReportMedicine

Prognostic Value of Right Ventricular Performance and Left Atrial Mechanical Efficiency in Paroxysmal Atrial Fibrillation.

Boulmpou, Pagourelias, Zormpas et al. · 2026 · Journal of cardiovascular development and disease

Background : Predicting atrial fibrillation (AF) recurrence remains a major clinical challenge, as conventional echocardiographic parameters often fail to capture the complex electro-mechanical substrate of the arrhythmia. The prognostic…

View details →DOI: 10.3390/jcdd13060269
Negative / Null Result ReportMedicine

Evaluating the Association of a Self-Guided, Asynchronous, Balance Exercise Application on Fall-Related Injuries.

Wain, Steiner, Daddato et al. · 2026 · Journal of the American Geriatrics Society

More than one in four older adults experience a fall each year. While exercise programs are effective in reducing fall-related injuries (FRI), participation remains low due to access barriers. The primary aim of this study was to evaluate…

View details →DOI: 10.1111/jgs.70544
Negative / Null Result ReportMedicine

Relationship between the Systemic ImmuneInflammation Index and Muscle Strength in Patients with Chronic Kidney Disease: A CrossSectional Study of Data from NHANES 2011-2014.

Zhang, Jia, Hou et al. · 2026 · Endocrine, metabolic & immune disorders drug targets

This study aimed to determine the relationship between Systemic Immune-Inflammation Index (SII) and muscle strength in patients with CKD. This cross-sectional study examined adults with CKD using data from the National Health and Nutrition…

View details →DOI: 10.2174/0118715303430103251204120642
Negative / Null Result ReportMedicine

Hypothalamo-Pituitary Dysfunction and Association with Pituitary Siderosis in Adult Subjects with Transfusion-Dependent Beta-Thalassemia: all Is not Dark.

Siddiqui, Ghosh, Ahuja et al. · 2026 · Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Transfusion-dependent beta-thalassemia (TDT) is frequently associated with endocrine dysfunction secondary to hemosiderosis involving multiple organs. This study aimed to evaluate long-term endocrine dysfunction, neuroradiological…

View details →DOI: 10.1007/s12288-025-02179-5
Negative / Null Result ReportMedicine

Elevated platelet-to-lymphocyte ratio is associated with increased breast cancer risk: A cross-sectional analysis of the NHANES 2009 to 2020.

Li, Li, Li et al. · 2026 · Medicine

Inflammation is a recognized driver of tumorigenesis, particularly in breast cancer. The platelet-to-lymphocyte ratio (PLR) has emerged as a readily available inflammatory indicator; however, its independent association with breast cancer…

View details →DOI: 10.1097/md.0000000000049311
Negative / Null Result ReportMedicine

Progesterone-induced endometrial thickness changes do not affect singleton neonatal outcomes in frozen embryo transfer: a retrospective analysis of 6,331 newborns.

Ye, Zhang, Du et al. · 2026 · BMC pregnancy and childbirth

To evaluate whether progesterone-induced changes in endometrial thickness (EMT) affect singleton infant outcomes during frozen-thawed embryo transfer (FET) cycles. This retrospective study analyzed 6,331 singleton live births following…

View details →DOI: 10.1186/s12884-026-09391-9
Negative / Null Result ReportMedicine

The association between preoperative telomere length and acute postoperative depression: a single-center prospective observational pilot study.

Takekawa, Kinoshita, Ishii et al. · 2026 · BMC anesthesiology

We hypothesized that a shorter preoperative leukocyte telomere length (TL) predicts the development of acute postoperative depression in elderly surgical patients. This single-center, prospective, observational study included 48…

View details →DOI: 10.1186/s12871-026-04040-2
Negative / Null Result ReportMedicine

Physical frailty, depression and multimorbidity among older adults in Lima, Peru: a cross-sectional study.

Flores-Flores, Zevallos-Morales, Pollard et al. · 2026 · BMC geriatrics

Multimorbidity, frailty, and depression frequently co-occur in older adults and contribute to adverse health outcomes. This study identified classes of physical multimorbidity and examined their association with depression, and whether…

View details →DOI: 10.1186/s12877-026-07850-8
Negative / Null Result ReportMedicine

Impact of Specialty-Trained Perioperative Nurses on Operative Time, Costs, and Complications in Otolaryngologic Surgery.

Bozdemir Çakıcı, Çakıcı, Seki et al. · 2026 · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

This study aimed to examine the association between perioperative nurse specialization and operative time, costs, postoperative complications, and surgical success in otolaryngologic procedures. A retrospective observational study. The…

View details →DOI: 10.1016/j.jopan.2026.05.015
Negative / Null Result ReportMedicine

Programmed cell death protein 1 (PD-1) / programmed cell death ligand 1 (PD-L1) in multiple myeloma.

El-Garf, Hammad, Kandeel et al. · 2026 · Journal of the Egyptian National Cancer Institute

The bone marrow microenvironment in multiple myeloma (MM) is characterized by complex immune dysregulation involving multiple inhibitory pathways. Among these, the programmed cell death protein 1 (PD-1)/programmed cell death ligand 1…

View details →DOI: 10.1186/s43046-026-00379-2
Negative / Null Result ReportMedicine

Comparison of inguinal hernia repair outcomes between open and laparoscopic approaches in a pediatric population: a retrospective cohort study.

Adriansyah, Fauzi, Amadeus et al. · 2026 · Annals of surgical treatment and research

Many studies compared the outcomes of hernia repair in children between open and laparoscopic techniques. However, the results still need to be clarified. Moreover, the reports from developing countries are also limited. We compared the…

View details →DOI: 10.4174/astr.2026.110.6.400
Negative / Null Result ReportMedicine

Assessment of the Diagnostic Yield of Multiple Rapid Swallows in Symptomatic Patients with Normal High-Resolution Esophageal Manometry.

Mendonça, Teixeira, Badaró et al. · 2026 · GE Portuguese journal of gastroenterology

Multiple rapid swallows (MRS) is a provocative maneuver used to assess contractile reserve (CR) in ineffective esophageal motility, but its clinical role in symptomatic patients with normal high-resolution esophageal manometry (HREM)…

View details →DOI: 10.1159/000551830
Negative / Null Result ReportMedicine

Accuracy of Ultrasound Estimation of Fetal Weight (EFW) at Term: Insights From a Malaysian Tertiary Hospital for Primary Care Implementation.

Sia, Yew, Arumugam et al. · 2026 · Obstetrics and gynecology international

Estimated fetal weight (EFW) is a key determinant of obstetrical decision-making and an independent risk factor of high perinatal morbidity and mortality. However, routine ultrasound during pregnancy test is not universally available in…

View details →DOI: 10.1155/ogi/9992291
Negative / Null Result ReportMedicine

A Prospective Evaluation of Glucagon Stimulation Test Safety in Adults With Chronic Moderate-to-Severe Traumatic Brain Injury.

Snyder, Hillaker, Weppner · 2026 · Endocrinology, diabetes & metabolism

Growth hormone deficiency (GHD) is a common and clinically significant consequence of moderate-to-severe traumatic brain injury (msTBI). The glucagon stimulation test (GST) is widely used to assess growth hormone deficiency; however, the…

View details →DOI: 10.1002/edm2.70260
Negative / Null Result ReportMedicine

Clinical Implications of Stroke Progressor Phenotypes defined based on ASPECTS decay and perfusion estimated infarct growth rate: insights from a large national thrombectomy registry.

Ciacciarelli, Nicolini, Saia et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Infarct growth rate (IGR) is highly heterogeneous among ischemic stroke patients, reflecting a spectrum of progressor phenotypes with clinical implications. We aim to compare different imaging approaches to investigate stroke progressors…

View details →DOI: 10.1007/s10072-026-09148-4
Negative / Null Result ReportMedicine

The impact of urinary catheterization on urinary tract infection and renal function in elderly patients undergoing hip fracture surgery: A prospective randomized controlled trial.

Serttas, Uysal, Deği̇rmenci̇ et al. · 2026 · Injury

Urinary tract infection(UTI) is a common complication following hip fracture surgery in elderly patients. Urinary catheterization is frequently used to improve patient comfort during prolonged preoperative immobilization; however, its…

View details →DOI: 10.1016/j.injury.2026.113449
Negative / Null Result ReportMedicine

Evaluating the impact of SDHAF3 p.F53L genetic variant on clinically significant QTc prolongation in patients prescribed high-risk medications: a retrospective pharmacogenetic study.

Aalibraheem, Lopez-Medina, Chahal et al. · 2026 · Pharmacogenetics and genomics

Drug-induced QT prolongation (diQTP) can lead to rare, but potentially fatal adverse effects of many medications, yet individual susceptibility varies due to both clinical and genetic factors. SDHAF3 p.F53L (rs62624461) is a genetic…

View details →DOI: 10.1097/fpc.0000000000000610
Negative / Null Result ReportMedicine

Vertebral Rotation in Adolescent Idiopathic Scoliosis Is Primarily Curve-Magnitude Driven Rather than Age-Dependent.

Pjanić, Grivas, Jevtić et al. · 2026 · Studies in health technology and informatics

The relationship between vertebral rotation (VR), curve magnitude, and age in adolescent idiopathic scoliosis (AIS) is not yet fully understood. Although VR represents a defining feature of scoliotic deformity, it remains unclear whether…

View details →DOI: 10.3233/shti260735