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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,248Computer Science 750Biochemistry, Genetics and Molecular Biology 422Social Sciences 304Psychology 303Physics 280Neuroscience 250Economics, Econometrics and Finance 198Environmental Science 176Mathematics 159Agricultural and Biological Sciences 140Engineering 137

19820 results in Negative / Null Result Report · page 182 of 661

Negative / Null Result ReportMedicine

Leveraging Synchrosqueezing Transform (SST)-based representations in a dual-stream attention framework to enhance sleep apnea detection and subtyping.

Zhao, Fu, Li et al. · 2026 · Frontiers in neuroscience

Sleep apnea and hypopnea syndrome (SAHS) is a prevalent disorder with profound adverse effects on health and overall quality of life, thereby necessitating the development of accurate and accessible screening tools. Electrocardiogram…

View details →DOI: 10.3389/fnins.2026.1853573
Negative / Null Result ReportMedicine

Virtual Screening and Zebrafish Phenotype-Based Evaluation Argues Against Repurposing 4-Phenylbutyrate for STXBP1-Related Disorders.

Frick, Whyte-Fagundes, Baraban · 2026 · Pharmacology research & perspectives

Syntaxin-binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18-1 (STXBP1) C.…

View details →DOI: 10.1002/prp2.70285
Negative / Null Result ReportMedicine

HbF/F-cell and the Phenotype of Sickle Cell Disease.

Lofters, Wilks, Lee et al. · 2026 · medRxiv : the preprint server for health sciences

Fetal hemoglobin (HbF) prevents the polymerization of sickle hemoglobin (HbS). HbF, measured usually as a percent of total hemoglobin (%HbF), is inversely associated with the severity of sickle cell disease (SCD) but fails to capture the…

View details →DOI: 10.64898/2026.06.02.26354737
Negative / Null Result ReportMedicine

Diffuse Cortical, Basal Ganglia, and Bilateral Middle Cerebellar Peduncle Diffusion Restriction in Severe Alcohol-Related Hypoglycemic Encephalopathy: A Case Report.

Rachidi, Amanallah, Benzakour et al. · 2026 · Cureus

Alcohol-induced hypoglycemia is an uncommon but potentially life-threatening metabolic complication, particularly in the setting of prolonged fasting and chronic alcohol use. We report the case of a 63-year-old man with a history of…

View details →DOI: 10.7759/cureus.108648
Negative / Null Result ReportMedicine

Angelica dahurica alleviates peripheral nerve injury-induced muscle atrophy via the Phlpp2-Akt-FoxO3α axis independently of analgesia.

Wu, Wang, Liu et al. · 2026 · Phytomedicine : international journal of phytotherapy and phytopharmacology

Peripheral nerve injury frequently causes refractory neuropathic pain and muscle atrophy. While clinical care focuses on analgesia, effective therapies for muscle wasting are lacking. Angelica dahurica (BZ) is known for its analgesic…

View details →DOI: 10.1016/j.phymed.2026.158376
Negative / Null Result ReportMedicine

VC-VTON: Toward Across-View and Multi-Posture-Driven Virtual Try-On via Spatiotemporal-Aware View-Consistency Training.

Ma, Wei, Cai et al. · 2026 · IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

Virtual try-on (VTON) aims to synthesize specific fashion images dressed in given garments, which possesses great potential in real-world scenarios. Existing methods generally stand on the shoulder of the single-view VTON to train a…

View details →DOI: 10.1109/tip.2026.3700904
Negative / Null Result ReportMedicine

Defective inducible T cell costimulator signalling drives neuropilin-1 hi CD4 + T cell-mediated non-germinal centre B cell activation via impaired regulatory T cell maintenance in a lupus model.

Kang, Kim, Kim et al. · 2026 · Experimental & molecular medicine

Inducible T cell costimulator (ICOS) signalling is essential for follicular helper T (Tfh) cell activation and has emerged as a therapeutic target in B cell-dependent autoimmune diseases such as systemic lupus erythematosus (SLE). However,…

View details →DOI: 10.1038/s12276-026-01756-6
Negative / Null Result ReportMedicine

MD-DGNN: A Metadata-Driven Dual Graph Neural Network based on Brain Functional Connectivity for ASD Classification.

Li, Zhang, Leng et al. · 2026 · IEEE journal of biomedical and health informatics

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that requires early and efficient diagnosis. Functional magnetic resonance imaging (fMRI), with high temporal and spatial resolution, is a powerful tool for…

View details →DOI: 10.1109/jbhi.2026.3702096
Negative / Null Result ReportMedicine

The Indian Smell Identification Test for Parkinson's Disease: Limitations of Binary Scoring and Proposal of a Modified Graded Approach.

Nagaraj, Prasad, Bhat et al. · 2026 · Annals of Indian Academy of Neurology

Olfactory dysfunction is a common nonmotor symptom and prodromal marker of Parkinson's disease (PD). Despite its early occurrence, hyposmia is frequently underrecognized, emphasizing the need for objective, culturally appropriate tools.…

View details →DOI: 10.4103/aian.aian_1319_25
Negative / Null Result ReportMedicine

Clinical and radiological outcomes of a cartilage-preserving pinhole transtibial technique versus standard pull-out repair for traumatic posterior meniscal root tears.

Gezer, Demir · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

Traumatic posterior meniscal root tears disrupt normal load transmission, resulting in meniscal extrusion and accelerated osteoarthritis. Although transtibial pull-out repair is widely used, creation of a 4.5-mm tibial tunnel at the joint…

View details →DOI: 10.14744/tjtes.2026.68654
Negative / Null Result ReportMedicine

Role of Angiotensin II as a Vasoactive Agent to Treat Distributive Shock With a Focus on Preliminary Data in Pediatric-Aged Patients.

Ito, Spellman, Khan et al. · 2026 · Paediatric anaesthesia

In pediatric-aged patients, distributive (vasoplegic) shock is commonly caused by sepsis, anaphylaxis, or the humoral/immunologic response following cardiopulmonary bypass. In general, the first-line vasoactive agent for children is…

View details →DOI: 10.1002/pan.70237
Negative / Null Result ReportMedicine

Constructing a biomimetic ECM protective barrier: a strategic interface design for urethral repair to mitigate foreign body reaction.

Niu, Liu, Sun et al. · 2026 · Journal of nanobiotechnology

Urethral reconstruction often fails due to the foreign body reaction (FBR) triggered by the graft, leading to chronic inflammation, fibrosis, and lumen obstruction. To address this challenge, we developed an innovative strategy: a…

View details →DOI: 10.1186/s12951-026-04649-y
Negative / Null Result ReportMedicine

Peripherally located type I vestibular hair cells are required for several motor behaviors and stimulus-evoked brainstem neural responses in adult mice.

Ciani Berlingeri, Phillips, Mejia Bibriesca et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience

The mammalian vestibular system has two types of sensory receptors (hair cells), type I and type II. Understanding the roles of type I and II hair cells in the vestibular system's control of motor behaviors is difficult because most…

View details →DOI: 10.1523/jneurosci.0005-26.2026
Negative / Null Result ReportMedicine

Cellular respiration toxicity: A novel comprehensive water quality index based on universal biological processes.

Chen, Yang, Liu et al. · 2026 · Journal of hazardous materials

Assessing water quality comprehensively is crucial for predicting environmental risks. However, existing toxicity assessments are limited to specific physiological processes or reference organisms, failing to capture holistic hazards. Here…

View details →DOI: 10.1016/j.jhazmat.2026.142596
Negative / Null Result ReportMedicine

Finite-size effects and energy alignment in molecular XANES under periodic boundary conditions: A systematic comparison of core-hole treatments.

Fujikata, Muramatsu, Mizoguchi · 2026 · The Journal of chemical physics

X-ray absorption near-edge structure (XANES) provides element-specific insights into local electronic and structural environments, but quantitative interpretation of molecular XANES under periodic boundary conditions (PBC) remains…

View details →DOI: 10.1063/5.0329032
Negative / Null Result ReportMedicine

Decreased posterior tibial slope is not a risk factor for posterior cruciate ligament reconstruction failure: A multicentric analysis of 173 cases.

Pizza, Perelli, Grassi et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

To investigate whether posterior tibial slope (PTS) is associated with failure after posterior cruciate ligament reconstruction (PCLR) in a cohort of patients undergoing isolated PCLR and PCL-based multiligament knee injuries (MLKI)…

View details →DOI: 10.1002/ksa.70472
Negative / Null Result ReportMedicine

Diaphragmatic ultrasound to guide ventilator weaning and early tracheostomy in high cervical spinal cord injury: A case report.

Vivanco-Aravena, Leiva, Hidalgo · 2026 · The journal of spinal cord medicine

Ventilator dependence is a major cause of morbidity and mortality in patients with high cervical spinal cord injury (CSCI), largely due to diaphragmatic dysfunction. Conventional assessment of inspiratory muscle strength, such as maximal…

View details →DOI: 10.1080/10790268.2026.2667039
Negative / Null Result ReportMedicine

A prediction nomogram for faltering catch-up growth in full-term small-for-gestational-age infants: a retrospective cohort study.

Hu, Yang, Li et al. · 2026 · Frontiers in pediatrics

Catch-up growth (CUG) before two years of age in small-for-gestational-age (SGA) infants is a key predictor of adult short stature. We aimed to establish and temporally validate a prediction nomogram for faltering CUG (FCUG) in full-term…

View details →DOI: 10.3389/fped.2026.1792285
Negative / Null Result ReportMedicine

Bedside transcranial Doppler as a diagnostic bridge for suspected intracranial hypertension after traumatic brain injury surgery: A case report.

Prandani, Fuadi, Halimi et al. · 2026 · Surgical neurology international

Early recognition of postoperative neurologic deterioration in patients with traumatic brain injury (TBI) is essential but remains challenging, as clinical assessment may lack sensitivity and computed tomography (CT) imaging is not always…

View details →DOI: 10.25259/sni_1424_2025
Negative / Null Result ReportMedicine

The prognostic value of the early neutrophil-to-lymphocyte ratio for 28-day mortality in sepsis patients: A machine learning-based investigation of the MIMIC database.

Liao, Xiang, Chen et al. · 2026 · PloS one

The neutrophil-to-lymphocyte ratio (NLR) has shown inconsistent prognostic value in individuals with sepsis. This study aimed to clarify its ability to predict 28-day mortality via a machine learning-based analysis of a large ICU database.…

View details →DOI: 10.1371/journal.pone.0348676