Negative / Null Result ReportOpen accessMedicine
Feola M, Landra F, Greco CA et al. · 2026 · Journal of clinical medicine
Cardiac arrest is a way of demise of patients who are affected by heart failure (HF), being more frequent in those with HF with a reduced left ventricular ejection fraction (HFrEF), and is, as such, responsible for 30-50% of cardiac death.…
View details →DOI: 10.3390/jcm15083041 Negative / Null Result ReportMedicine
Noël A, Picard L · 2025 · Emotion (Washington, D.C.)
Numerous studies have highlighted the beneficial effect of humor on memory in younger adults. While older adults are known to preferentially process positive information and appreciate humor, no study has investigated whether the effect of…
View details →DOI: 10.1037/emo0001519 Negative / Null Result Report
Kolb B, Witt-Lajeunesse A, Cioe J · 2025 · Preprint
This experiment compared the effects of a structured rehabilitation regime (skilled reaching for 5 mo) and more varied training (complex environment for 5 mo) with and without postlesion infusion of FGF-2 for 7 days in rats having…
View details →DOI: 10.1101/2025.10.02.680152 Negative / Null Result ReportMedicine
Wei Y, Meade ML, Soderstrom NC · 2025 · Memory (Hove, England)
The present study replicated and extended prior research by comparing the effects of reviewing notes in groups vs. reviewing notes individually on individual final test performance. We also examined the potential interaction between…
View details →DOI: 10.1080/09658211.2025.2573272 Negative / Null Result ReportMedicine
Silva AT, Ferreira NM, Vaz F et al. · 2025 · Journal of biomechanical engineering
Pelvic organ prolapse (POP) is a common pelvic floor disorder resulting from weakened supportive muscles and ligaments. Although the demand for surgeries involving surgical meshes is expected to increase, current options remain limited. In…
View details →DOI: 10.1115/1.4069708 Negative / Null Result ReportMedicine
Wang C, Ren J, Cui Y et al. · 2025 · Journal of Applied Ecology.
Grassland carbon storage depends on microbial‐mediated interactions between grazing and nitrogen (N) addition, which regulates the balance between soil organic carbon (SOC) retention and priming effects. However, uncertainties regarding…
Negative / Null Result ReportOpen accessMedicine
Panopoulos S, Poulia V, Vlachogiannis N et al. · 2026 · Rheumatology international
Randomized trials have demonstrated that nintedanib is beneficial for Systemic Sclerosis-associated interstitial lung disease (SSc-ILD) with an acceptable safety profile. We evaluated the long-term safety and efficacy of nintedanib in a…
View details →DOI: 10.1007/s00296-026-06173-6 Negative / Null Result ReportMedicine
Cai Y, Ren X, Ding C · 2026 · Intensive & critical care nursing
Objectives To assess the effects of various non-pharmacological interventions on long-term outcomes associated with Post-Intensive Care Syndrome (PICS) in intensive care unit (ICU) survivors, based on existing systematic reviews and…
View details →DOI: 10.1016/j.iccn.2025.104326 Negative / Null Result ReportOpen accessMedicine
Pietersen LC, Broekman N, Broekman N et al. · 2025 · Clinical transplantation
Acute kidney injury (AKI) is a common complication following liver transplantation (LT), with multifactorial etiology. It is believed that perioperative hemodynamic instability could lead to AKI. A temporary portocaval shunt (TPCS) could…
View details →DOI: 10.1111/ctr.70259 Negative / Null Result ReportMedicine
Drost M, Fuhrmann G · 2026 · ACS infectious diseases
Pseudomonas aeruginosa is a notorious bacterial pathogen causing chronic pulmonary infections in people with cystic fibrosis (CF) due to its high tolerance to antibiotics and ability to form recalcitrant biofilms. A newer approach to…
View details →DOI: 10.1021/acsinfecdis.5c00759 Negative / Null Result Report
Shynar · 2024 · Preprint
Abstract This study was carried out to determine the effect of biochar produced from different agricultural wastes on lettuce seedling development characteristics in some vegetable species. In the research, biochars obtained from 6…
View details →DOI: 10.21203/rs.3.rs-5492606/v1 Negative / Null Result ReportMedicine
Cheng J, Li F, Zhang B et al. · 2025 · Bulletin of experimental biology and medicine
We compared the therapeutic effects of dietary adjustment and fish oil in rats with experimental non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The NAFLD rats were either maintained on high-fat diet, or transferred…
View details →DOI: 10.1007/s10517-026-06577-1 Negative / Null Result ReportMedicine
Clarke JG, Dutta N, Nickel MS et al. · 2026 · ACS medicinal chemistry letters
Semisynthetic modification of mycothiazole ( 1 ) with Meerwein's salt to generate a more stable and/or potent analog than 8- O -acetylmycothiazole ( 2 ) unexpectedly yielded diastereomers devoid of the diene. Analysis of NMR, HR-LCMS, and…
View details →DOI: 10.1021/acsmedchemlett.6c00117 Negative / Null Result Report
Zhang Z, van Lieshout L, Bekkering H · 2024 · Preprint
When people are offered the opportunity to choose, they tend to learn better. To investigate cognitive mechanisms of this beneficial effect of choice on learning, a learning task was designed in which we independently manipulated choice…
View details →DOI: 10.31234/osf.io/j5fzt Negative / Null Result ReportMedicine
Doneddu PE, Collet-Vidiella R, Gallo C et al. · 2026 · Journal of the peripheral nervous system : JPNS
Background and aims Rituximab has been proposed as a potential treatment in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but formal evidence regarding its clinical effectiveness is weak. The CIDPRIT trial found no…
View details →DOI: 10.1111/jns.70107 Negative / Null Result Report
Cavazza M, Carità G, Pizzuto S et al. · 2025 · Preprint
Abstract Background Acute occlusions of the anterior circulation with an underlying intracranial atheromatous disease (ICAD) represent a diagnostic and therapeutic challenge. The aim of this study was to compare the results of the…
View details →DOI: 10.21203/rs.3.rs-7897991/v1 Negative / Null Result ReportOpen accessMedicine
Tajika A, Toyomoto R, Sakata M et al. · 2026 · BMJ mental health
Background Depression is a leading cause of global disability, and subthreshold cases contribute substantially to the burden. Cognitive behavioural therapy (CBT) is effective for depressive symptoms, but its impact on social functioning in…
View details →DOI: 10.1136/bmjment-2025-302303 Negative / Null Result ReportOpen accessMedicine
Miletić M, Kovač V, Barišić L et al. · 2025 · Pharmaceutics
Background/Objectives : Resveratrol (RSV) and curcumin (CRC) have antioxidant, anti-inflammatory, photoprotective, and cell-repairing properties. We selected them to investigate the potential role involved in human keratinocyte protection.…
View details →DOI: 10.3390/pharmaceutics17121511 Negative / Null Result ReportOpen accessMedicine
Charles AL, Tetsi L, Quiring G et al. · 2026 · Muscles (Basel, Switzerland)
Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia-reperfusion (IR) settings, but whether PDE 4 inhibition protects…
View details →DOI: 10.3390/muscles5010019 Negative / Null Result ReportOpen accessMedicine
Li J, Yang C, Li K · 2026 · BMC pregnancy and childbirth
BACKGROUND: Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.…
View details →DOI: 10.1186/s12884-026-08757-3 Negative / Null Result Report
Geertsma RC, Polinder J, Groen D et al. · 2025 · Preprint
Abstract Recent reports suggest that reef-building corals can shift from autotrophic to heterotrophic feeding during episodic heatwaves, which may have mitigating effects on thermal stress. It is yet unclear to what extent this could occur…
View details →DOI: 10.21203/rs.3.rs-7584376/v1 Negative / Null Result ReportMedicine
Stanley M, Huang K, Garlich J et al. · 2025 · Journal of orthopaedic trauma
Objectives To compare time, fluoroscopic utilization, and number of misses for placement of far interlocking screws in tibial and femoral nails using a targeting arm (Targeter) versus perfect circle technique (Control). Methods . Design…
View details →DOI: 10.1097/bot.0000000000003066 Negative / Null Result ReportMedicine
Gewiss C, Gehrdau K, Hischke S et al. · 2025 · Journal of wound care
Objective The application of cold atmospheric plasma (CAP) has been described as a promising therapeutic approach for wound healing. Its use in immunologically mediated wounds such as pyoderma gangrenosum (PG) has not yet been sufficiently…
View details →DOI: 10.12968/jowc.2024.0018 Negative / Null Result ReportOpen accessMedicine
Avetisian H, Mathew K, Myers A et al. · 2026 · Global spine journal
Study DesignCross-sectional.ObjectivesLaminoplasty (LP) and laminectomy with fusion (LF) are surgical approaches for degenerative cervical myelopathy (DCM), but their comparative effectiveness remains controversial. Systematic reviews and…
View details →DOI: 10.1177/21925682251343833 Negative / Null Result ReportMedicine
Lee J, Sun J, Lee HW · 2025 · Annals of the American Thoracic Society
Rationale: In patients with lung cancer, the impact of chronic obstructive pulmonary disease (COPD) diagnosis and subsequent management on mortality remains uncertain, because evidence supporting the efficacy of inhaled therapies in…
View details →DOI: 10.1513/annalsats.202409-990oc Negative / Null Result ReportMedicine
Tamber MS, Jensen H, Reeder R et al. · 2025 · Journal of neurosurgery. Pediatrics
Objective The Hydrocephalus Clinical Research Network-Quality (HCRNq) was established to encourage adoption of evidence-based best practices for the care of children with hydrocephalus. A shunt infection prevention initiative is ongoing…
View details →DOI: 10.3171/2025.7.peds25208 Negative / Null Result ReportMedicine
Pearson AC, Yampolsky LY · 2025 · Biogerontology
NAD + homeostasis is an important determinant of lifespan and may be a key mechanism of caloric restriction (CR) expansion of lifespan. Ketone bodies such as beta-hydroxybutyrate (BHB) that regulate NAD + abundance and NAD + precursors…
View details →DOI: 10.1007/s10522-025-10313-z Negative / Null Result ReportOpen accessMedicine
Valiensi SM, Vera VA, Folgueira AL et al. · 2025 · Brain sciences
Background . Although melatonin is widely used in Sleep Medicine for its chronobiological action, its potent antioxidant and mitochondrial regulatory effects, as well as its immunomodulatory and anti-inflammatory functions, make it of…
View details →DOI: 10.3390/brainsci15101040 Negative / Null Result ReportOpen accessMedicine
El Hajjaji A, Akasbi N, El Mezouar I et al. · 2025 · Cureus
Introduction Knee osteoarthritis (KO) is a major public health issue, that significantly affects patients' quality of life. Metabolic comorbidities, particularly dyslipidemia, have been shown to influence the incidence and progression of…
View details →DOI: 10.7759/cureus.79420 Negative / Null Result ReportMedicine
de Souza EDF, E Silva LO, Vieira LM et al. · 2026 · Theriogenology
The aim was to evaluate the effects of administering long-acting injectable progesterone (iP4) and/or hCG 3 days after timed artificial insemination (TAI) on luteal dynamics, circulating progesterone (P4) concentrations, and fertility…
View details →DOI: 10.1016/j.theriogenology.2025.117796 